AR073917A1 - Sinergismo antibiotico - Google Patents

Sinergismo antibiotico

Info

Publication number
AR073917A1
AR073917A1 ARP090104058A ARP090104058A AR073917A1 AR 073917 A1 AR073917 A1 AR 073917A1 AR P090104058 A ARP090104058 A AR P090104058A AR P090104058 A ARP090104058 A AR P090104058A AR 073917 A1 AR073917 A1 AR 073917A1
Authority
AR
Argentina
Prior art keywords
identity
composition according
staphylococcus aureus
bacterial infection
antibacterial compound
Prior art date
Application number
ARP090104058A
Other languages
English (en)
Original Assignee
Novozymes Adenium Biotech As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes Adenium Biotech As filed Critical Novozymes Adenium Biotech As
Publication of AR073917A1 publication Critical patent/AR073917A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente solicitud se refiere al sinergismo antibiotico de composiciones farmacéuticas que comprenden una defensina y un antibiotico betalactámico. Reivindicacion 3: La composicion de acuerdo con la reivindicacion 2, en fa cual el primer y segundo compuesto antibacteriano exhibe un índice de FIC < o = 0,5 utilizando un organismo de prueba seleccionado entre el grupo integrado por Streptococcus pneumoniae ATCC49619, Staphylococcus aureus ATCC29213, Staphylococcus aureus ATCC34400, Staphylococcus aureus ATCC25923, y Staphylococcus epidermidis ATCC49134. Reivindicacion 4: La composicion de acuerdo con cualquiera de las reivindicaciones 1-3, en la cual el primer compuesto antibacteriano se une al precursor de la pared celular bacteriana Lípido l y/o Lípido II. Reivindicacion 8: La composicion de acuerdo con cualquiera de las reivindicaciones 1-7, en la cual la defensina comprende una secuencia de aminoácidos que tiene por lo menos 80% de identidad, con preferencia por lo menos 85% de identidad, con mayor preferencia por lo menos 90% de identidad, incluso con mayor preferencia por lo menos 95% de identidad, y muy preferentemente por lo menos 97% de identidad con la secuencia de aminoácidos de la SEC ID NO:1. Reivindicacion 9: La composicion de acuerdo con cualquiera de las reivindicaciones 1-8, en la cual el segundo compuesto antibacteriano se selecciona entre el grupo integrado por penicilinas, cefalosporinas y aminoglicosidos. Reivindicacion 11: El uso de una composicion farmacéutica de acuerdo con cualquiera de las reivindicaciones 1-10 para la elaboracion de un medicamento para el tratamiento terapéutico de una infeccion bacteriana. Reivindicacion 12: El uso de acuerdo con la reivindicacion 11, en el cual la infeccion bacteriana es causada por bacterias Gram-positivas. Reivindicacion 15: El uso de acuerdo con la reivindicacion 14, en el cual la infeccion bacteriana es causada por bacterias Gram-positivas tales como Estreptococos o Estafilococos.
ARP090104058A 2008-10-23 2009-10-22 Sinergismo antibiotico AR073917A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08167451 2008-10-23
EP08170260 2008-11-28
EP09153967 2009-02-27

Publications (1)

Publication Number Publication Date
AR073917A1 true AR073917A1 (es) 2010-12-09

Family

ID=41531663

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090104058A AR073917A1 (es) 2008-10-23 2009-10-22 Sinergismo antibiotico

Country Status (7)

Country Link
US (1) US20100104552A1 (es)
EP (1) EP2349318A1 (es)
CN (1) CN102264382A (es)
AR (1) AR073917A1 (es)
PA (1) PA8846401A1 (es)
TW (1) TW201028154A (es)
WO (1) WO2010046462A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080023218A (ko) * 2005-06-06 2008-03-12 노보자임스 에이/에스 항균성을 가진 폴리펩티드 및 그것을 코딩하는폴리뉴클레오티드
TWI498336B (zh) * 2012-02-29 2015-09-01 Univ Nat Pingtung Sci & Tech 用以抑菌之醫藥組合物及其用途
US11060148B2 (en) 2012-10-16 2021-07-13 Dana-Farber Cancer Institute, Inc. Diagnosing and treating colorectal cancer
IN2015DN04018A (es) 2012-11-23 2015-10-02 Hexima Ltd
EP3134108A4 (en) * 2014-04-24 2018-01-17 Hexima Limited Agents and methods of treatment
CN107320727A (zh) * 2016-04-29 2017-11-07 四川大学 抗菌肽与抗生素组合抗菌药物及其使用方法
US20210260070A1 (en) * 2018-06-22 2021-08-26 Contrafect Corporation Lysin cf-301 resensitizes methicillin-resistant staphylococcus aureua (mrsa) to penicillin derivatives and first generation cephalosporins

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6809181B2 (en) * 2000-06-01 2004-10-26 University Of Iowa Research Foundation Human beta-defensin-3 (HBD-3), a highly cationic beta-defensin antimicrobial peptide
AU2002349293B2 (en) * 2001-11-20 2008-07-17 Novozymes A/S Antimicrobial polypeptides from pseudoplectania nigrella
US20040194156A1 (en) * 2002-12-27 2004-09-30 Califa Llc Transgenic aquatic invertebrates as a bioreactor for production of recombinant polypeptides
WO2006008162A1 (en) * 2004-07-22 2006-01-26 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Alpha-defensins as anthrax immunotherapeutics
KR20080023218A (ko) * 2005-06-06 2008-03-12 노보자임스 에이/에스 항균성을 가진 폴리펩티드 및 그것을 코딩하는폴리뉴클레오티드
JP2009523120A (ja) * 2005-12-09 2009-06-18 アールエックス３ ファーマシューティカルズ インコーポレイテッド 抗生物質の相乗効果の同定法と応用法
JP2011516450A (ja) * 2008-04-04 2011-05-26 ノボザイムス アデニウム バイオテック アクティーゼルスカブ 髄膜炎に対するデフェンシンの使用

Also Published As

Publication number Publication date
WO2010046462A1 (en) 2010-04-29
US20100104552A1 (en) 2010-04-29
PA8846401A1 (es) 2010-05-26
TW201028154A (en) 2010-08-01
EP2349318A1 (en) 2011-08-03
CN102264382A (zh) 2011-11-30

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