DD258230A1 - Substituierte imidazolderivate sowie deren herstellung und verwendung - Google Patents

Substituierte imidazolderivate sowie deren herstellung und verwendung Download PDF

Info

Publication number
DD258230A1
DD258230A1 DD85283044A DD28304485A DD258230A1 DD 258230 A1 DD258230 A1 DD 258230A1 DD 85283044 A DD85283044 A DD 85283044A DD 28304485 A DD28304485 A DD 28304485A DD 258230 A1 DD258230 A1 DD 258230A1
Authority
DD
German Democratic Republic
Prior art keywords
compound
dihydro
formula
inden
methyl
Prior art date
Application number
DD85283044A
Other languages
German (de)
English (en)
Inventor
Arto Karjalainen
Reimo Virtanen
Arja Karjalainen
Kauko Kurkela
Original Assignee
Farmos Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmos Oy filed Critical Farmos Oy
Publication of DD258230A1 publication Critical patent/DD258230A1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Golf Clubs (AREA)
  • Dental Preparations (AREA)
  • Lubricants (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Epoxy Resins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DD85283044A 1984-11-23 1985-11-20 Substituierte imidazolderivate sowie deren herstellung und verwendung DD258230A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB08429578A GB2167408B (en) 1984-11-23 1984-11-23 Substituted imidazole derivatives and their preparation and use

Publications (1)

Publication Number Publication Date
DD258230A1 true DD258230A1 (de) 1988-07-13

Family

ID=10570140

Family Applications (1)

Application Number Title Priority Date Filing Date
DD85283044A DD258230A1 (de) 1984-11-23 1985-11-20 Substituierte imidazolderivate sowie deren herstellung und verwendung

Country Status (26)

Country Link
US (1) US4689339A (hu)
EP (2) EP0310745B1 (hu)
JP (1) JPH064597B2 (hu)
KR (1) KR930004673B1 (hu)
AT (2) ATE47997T1 (hu)
AU (2) AU586839B2 (hu)
BG (1) BG60762B2 (hu)
CA (1) CA1268770C (hu)
DD (1) DD258230A1 (hu)
DE (2) DE3587045T2 (hu)
DK (2) DK164903C (hu)
ES (2) ES8704462A1 (hu)
FI (1) FI80264C (hu)
GB (1) GB2167408B (hu)
GR (1) GR852817B (hu)
HK (1) HK3592A (hu)
HU (1) HU195189B (hu)
IE (1) IE58165B1 (hu)
IL (1) IL77111A (hu)
NO (1) NO166585C (hu)
NZ (1) NZ214258A (hu)
PH (1) PH22016A (hu)
PT (1) PT81542B (hu)
SG (1) SG106891G (hu)
SU (1) SU1424736A3 (hu)
ZA (1) ZA858942B (hu)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4891431A (en) * 1986-01-28 1990-01-02 Mitsui Petrochemical Industries, Ltd. Process for preparing 2-unsubstituted imidazoles
FI862039A0 (fi) * 1986-05-15 1986-05-15 Farmos Oy Nytt foerfarande foer framstaellning av 4(5)-substituerade imidazolderivat.
FI81092C (fi) * 1986-05-15 1990-09-10 Farmos Oy Foerfarande foer framstaellning av terapeutiskt aktiva 4(5)-(2,3-dihydro-1h-inden-2-yl)-imidazolderivat.
JP2576493B2 (ja) * 1987-03-20 1997-01-29 アイシン精機株式会社 原稿読取り装置に用いられる原稿トレ−
FR2621327B1 (fr) * 1987-10-06 1990-01-05 Commissariat Energie Atomique Procede de production et d'extraction de polysaccharides a partir d'une culture de porphyridium cruentum et dispositif pour la mise en oeuvre du procede
GB2225782A (en) * 1988-12-09 1990-06-13 Farmos Group Limited Imidazole derivatives useful for treatment of diabetes
GB8903437D0 (en) * 1989-02-15 1989-04-05 Erba Carlo Spa Imidazolyl derivatives of 3,4-dihydro-2h-1-benzothiopyran
CA1321751C (en) * 1989-02-21 1993-08-31 Eugene C. Crichlow Mechanism mediating ruminal stasis in ruminal lactic acidosis
DK344489D0 (da) * 1989-07-12 1989-07-12 Novo Nordisk As Substituerede 2-imidazoliner og fremstilling og anvendelse deraf
GB2244431A (en) * 1990-05-31 1991-12-04 Farmos Oy Treatment of age related memory impairment and other cognitive disorders
GB2256135B (en) 1991-05-31 1995-01-18 Orion Yhtymae Oy Transdermal administration of 4-substituted imidazoles
US5541211A (en) * 1991-06-18 1996-07-30 Orion-Yhtyma Oy Administration of atipamezole to elicit a yohimbine-like alpha-adrenoreceptor antagonistic noradrenergic transmission
CA2122820A1 (en) * 1991-11-05 1993-05-13 Russell Donavan Cousins Endothelin receptor antagonists
GB9127050D0 (en) * 1991-12-20 1992-02-19 Orion Yhtymae Oy Substituted imidazole derivatives and their preparation and use
GB9127430D0 (en) * 1991-12-27 1992-02-19 Scras Benzofuranylimidazole derivatives
GB9312669D0 (en) * 1993-06-18 1993-08-04 Orion Yhtymae Oy New opticla isomers
GB9425211D0 (en) * 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles
FR2733983B1 (fr) * 1995-05-10 1997-08-01 Pf Medicament Procede de preparation d'un derive d'acide benzofurane carboxylque optiquement pur et son utilisation pour preparer l'efaroxan
GB9520150D0 (en) * 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
FR2754709B1 (fr) 1996-10-23 1999-03-05 Sanofi Sa Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition
JP2002510300A (ja) * 1997-06-05 2002-04-02 ヴィーナンティアス・リミテッド インダン化合物及びそれらの医薬学的使用
AU3378399A (en) * 1998-04-02 1999-10-25 Ortho-Mcneil Pharmaceutical, Inc. 4-thionaphthyl-1h-imidazoles with alpha-2-adrenergic activity
FR2784989B1 (fr) * 1998-09-10 2002-09-27 Fabre Pierre Sante Derive d'ester d'acide 2-ethyl-2,3-dihydrobenzofurane- carboxylique, procede de preparation et utilisation pour la preparation de derives de l'efaroxan
JP2002534511A (ja) * 1999-01-18 2002-10-15 ノボ ノルディスク アクティーゼルスカブ 置換型イミダゾール、それらの調製及び使用
US6388090B2 (en) * 2000-01-14 2002-05-14 Orion Corporation Imidazole derivatives
US6593324B2 (en) 2000-03-01 2003-07-15 Orion Corporation Dervatives of quinoline as alpha-2 antagonists
ATE302757T1 (de) 2000-05-08 2005-09-15 Orion Corp Neue polyzyklische indanylimidazole mit alpha2 adrenergik aktivität
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
US6543389B2 (en) 2001-06-26 2003-04-08 Pfizer Inc. Insecticidal pet collar
NZ535950A (en) 2002-04-03 2007-11-30 Orion Corp Polycyclic compounds as potent alpha2-adrenoceptor antagonists
US8188126B2 (en) 2002-05-16 2012-05-29 Pierre Fabre Medicament Imidazolic compounds and use thereof as alpha-2 adrenergic receptors
FI116292B (fi) 2003-01-08 2005-10-31 Juvantia Pharma Ltd Oy Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita
ES2315740T3 (es) * 2003-11-04 2009-04-01 Intervet International Bv Formulaciones ectoparasiticidas de espinosinas y pesticidas de azol.
FI20050657A0 (fi) * 2005-06-17 2005-06-17 Orion Corp Atipametsolin kiteytysmenetelmä
TR201815853T4 (tr) 2005-10-12 2018-11-21 Besins Healthcare Sarl Hipogonadizmin tedavisinde kullanıma yönelik geliştirilmiş testosteron jeli.
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
EP2053917B1 (en) * 2006-08-08 2010-03-03 Intervet International BV Composition for enhanced antiparasitic activity
TWI457122B (zh) 2007-07-20 2014-10-21 Orion Corp 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物
CL2008003553A1 (es) * 2007-12-05 2009-11-27 Grindeks Jsc Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso
SG11201603218UA (en) 2013-11-05 2016-05-30 3M Innovative Properties Co Sesame oil based injection formulations
TWI704145B (zh) 2015-06-05 2020-09-11 芬蘭商奧利安公司 新醫藥化合物
US20200383953A1 (en) * 2015-11-05 2020-12-10 University Of Louisville Research Foundation, Inc. Local and regional anesthesia and analgesia
MX2018015872A (es) 2016-06-29 2019-04-22 Orion Corp Derivados de benzodioxano y su uso farmaceutico.
CN113194750A (zh) 2018-12-21 2021-07-30 雀巢产品有限公司 用于在婴儿或幼儿中引起饱腹感、更好的睡眠和/或限制夜间觉醒的营养组合物
CN111978254A (zh) * 2019-05-22 2020-11-24 南京康德祥医药科技有限公司 一种阿替美唑盐酸盐的制备工艺
CN111925330A (zh) * 2020-09-07 2020-11-13 上海阿达玛斯试剂有限公司 一种阿替美唑的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2933962A1 (de) * 1979-08-22 1981-03-26 Hoechst Ag, 65929 Frankfurt Verfahren zur herstellung von 4,5-dichlor-imidazolen.
IL62122A0 (en) * 1980-03-04 1981-03-31 Erba Farmitalia N-imidazolyl derivatives of 1-chroman,their preparation and pharmaceutical compositions containing them
US4302469A (en) * 1980-09-10 1981-11-24 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
NZ201219A (en) * 1981-07-28 1984-10-19 Reckitt & Colmann Prod Ltd Dihydrobenzofuranyl-2-imidazolines and pharmaceutical compositions
ES523609A0 (es) * 1982-07-05 1985-03-01 Erba Farmitalia Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos.
FR2539415B1 (fr) * 1983-01-14 1985-09-13 Adir Derives de la d-2 imidazoline, leur preparation et leur application en therapeutique
FR2542738A1 (fr) * 1983-03-18 1984-09-21 Synthelabo Indanyl-2 d2-imidazoline, procede pour la preparer, et compositions pharmaceutiques qui la contiennent

Also Published As

Publication number Publication date
IE58165B1 (en) 1993-07-28
KR860004028A (ko) 1986-06-16
GB2167408B (en) 1988-05-25
NO854671L (no) 1986-05-26
PH22016A (en) 1988-05-13
ES549178A0 (es) 1987-04-01
FI854335A (fi) 1986-05-24
ES557268A0 (es) 1987-12-16
ATE47997T1 (de) 1989-12-15
AU3332989A (en) 1989-08-10
KR930004673B1 (ko) 1993-06-03
GB2167408A (en) 1986-05-29
FI80264B (fi) 1990-01-31
DK540485D0 (da) 1985-11-22
DK164903B (da) 1992-09-07
IL77111A0 (en) 1986-04-29
ATE85050T1 (de) 1993-02-15
NZ214258A (en) 1989-02-24
BG60762B2 (bg) 1996-02-29
CA1266669A1 (en) 1990-03-13
DE3587045T2 (de) 1993-06-03
HU195189B (en) 1988-04-28
ES8704462A1 (es) 1987-04-01
EP0310745A3 (en) 1989-10-11
GB8429578D0 (en) 1985-01-03
GR852817B (hu) 1986-03-21
ZA858942B (en) 1986-08-27
FI80264C (fi) 1990-05-10
SG106891G (en) 1992-02-14
HK3592A (en) 1992-01-17
DK164903C (da) 1993-01-25
SU1424736A3 (ru) 1988-09-15
DE3587045D1 (de) 1993-03-11
US4689339A (en) 1987-08-25
EP0310745A2 (en) 1989-04-12
JPS61143366A (ja) 1986-07-01
AU586839B2 (en) 1989-07-27
AU5008385A (en) 1986-05-29
FI854335A0 (fi) 1985-11-05
EP0310745B1 (en) 1993-01-27
CA1268770C (en) 1990-05-08
DE3574252D1 (en) 1989-12-21
EP0183492B1 (en) 1989-11-15
NO166585C (no) 1991-08-21
IL77111A (en) 1989-09-28
DK540485A (da) 1986-05-24
EP0183492A1 (en) 1986-06-04
DK58292D0 (da) 1992-05-04
DK58292A (da) 1992-05-04
ES8801248A1 (es) 1987-12-16
JPH064597B2 (ja) 1994-01-19
PT81542A (en) 1985-12-01
PT81542B (pt) 1988-03-03
HUT38913A (en) 1986-07-28
NO166585B (no) 1991-05-06
IE852929L (en) 1986-05-23

Similar Documents

Publication Publication Date Title
DD258230A1 (de) Substituierte imidazolderivate sowie deren herstellung und verwendung
DE2500110A1 (de) 3-aryloxy-3-phenylpropylamine und verfahren zu ihrer herstellung
DD264919A5 (de) Verfahren zur herstellung von 5-hydroxy-3-aminochromanen
DE2317710A1 (de) Dopaminderivate
DE2727047A1 (de) Indol-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
DE2528147A1 (de) Aromatische ketone, verfahren zu ihrer herstellung und diese ketone enthaltende arzneimittel
DE1942755A1 (de) 1,2,3,11b-Tetrahydropyrido[3,4,5-m,n]thioxanthene,deren Saeureadditionssalze und Verfahren zu ihrer Herstellung
DE2633889C2 (de) Neue Aminobenzocyclohepten-Derivate und deren Salze, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen
DD290880A5 (de) Substituierte imidazolderivate und ihre herstellung und verwendung
DE2314639A1 (de) Pharmakodynamisch aktive aminoalkyloximaether
DE1909408A1 (de) Tricyclische Verbindungen
DE2507429C2 (de) Aminosäureester, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE1949987A1 (de) Neue alpha-Phenylfettsaeureverbindungen
DE2354931C2 (de) trans-2-Phenylbicyclooctan-Verbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen
DE2619617A1 (de) Amine, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel
DE3520104A1 (de) Naphthoxazine, ihre herstellung und verwendung
CH513883A (de) Verfahren zur Herstellung von 1,3-Äthano-Piperazin
DE2240599C3 (de) Carbazol-Derivate, Verfahren zu deren Herstellung und Arzneimittel
DE2004354C3 (de) Phenäthanolaminäther, Verfahren zu Ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
AT356649B (de) Verfahren zur herstellung von neuen bicyclischen imidazolderivaten und ihren salzen
AT379385B (de) Verfahren zur herstellung neuer indenderivate und ihrer salze
AT353272B (de) Verfahren zur herstellung von neuen piperidin- derivaten sowie von deren salzen und optisch aktiven formen
DE1468092C3 (de) Aminopropoxy-Derivate des Tetrahydronaphthalins und des Indans, deren Säureadditionssalze, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate
DE2206961A1 (de) Verfahren zur Herstellung neuer Phenyläthylamin-Derivate
DE2227922C3 (de) Spiroverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel

Legal Events

Date Code Title Description
UW Conversion of economic patent into exclusive patent
ENJ Ceased due to non-payment of renewal fee