MX2018015872A - Derivados de benzodioxano y su uso farmaceutico. - Google Patents
Derivados de benzodioxano y su uso farmaceutico.Info
- Publication number
- MX2018015872A MX2018015872A MX2018015872A MX2018015872A MX2018015872A MX 2018015872 A MX2018015872 A MX 2018015872A MX 2018015872 A MX2018015872 A MX 2018015872A MX 2018015872 A MX2018015872 A MX 2018015872A MX 2018015872 A MX2018015872 A MX 2018015872A
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceutical use
- benzodioxane derivatives
- benzodioxane
- derivatives
- alpha2c
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Se describen compuestos de la fórmula I, (ver Fórmula) en donde Ra y Rb son como se define en las reivindicaciones, exhiben actividad antagonistica alfa2C y son de este modo útiles como antagonistas alfa2C.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI20165536 | 2016-06-29 | ||
PCT/FI2017/050484 WO2018002437A1 (en) | 2016-06-29 | 2017-06-28 | Benzodioxane derivatives and their pharmaceutical use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018015872A true MX2018015872A (es) | 2019-04-22 |
Family
ID=59501477
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018015872A MX2018015872A (es) | 2016-06-29 | 2017-06-28 | Derivados de benzodioxano y su uso farmaceutico. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20190152992A1 (es) |
EP (1) | EP3478676A1 (es) |
JP (1) | JP2019519582A (es) |
KR (1) | KR20190020343A (es) |
CN (1) | CN109415355A (es) |
AU (1) | AU2017287919A1 (es) |
CA (1) | CA3029109A1 (es) |
EA (1) | EA201990158A1 (es) |
IL (1) | IL263969A (es) |
MX (1) | MX2018015872A (es) |
WO (1) | WO2018002437A1 (es) |
ZA (1) | ZA201808060B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3543231A1 (en) * | 2018-03-19 | 2019-09-25 | ETH Zurich | Compounds for treating cns- and neurodegenerative diseases |
CA3103910A1 (en) * | 2018-06-20 | 2019-12-26 | Janssen Pharmaceutica Nv | Oga inhibitor compounds |
US20210277015A1 (en) * | 2018-06-20 | 2021-09-09 | Janssen Pharmaceutica Nv | Oga inhibitor compounds |
JP2021528412A (ja) * | 2018-06-20 | 2021-10-21 | ヤンセン ファーマシューティカ エヌ.ベー. | Oga阻害化合物 |
WO2024084360A1 (en) | 2022-10-18 | 2024-04-25 | Pfizer Inc. | Patatin-like phospholipase domain-containing protein 3 (pnpla3) modifiers |
WO2024084363A1 (en) | 2022-10-18 | 2024-04-25 | Pfizer Inc. | Use of patatin-like phospholipase domain-containing protein 3 compounds |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3622569A (en) | 1969-08-05 | 1971-11-23 | R & L Molecular Research Ltd | 6-(2-aryl-3-azido-and-3-amino-methyl-isocrotonamido)penicillanic acids |
GB2167408B (en) | 1984-11-23 | 1988-05-25 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
DE69428783T2 (de) | 1993-02-16 | 2002-07-18 | Ube Industries | Quinolin-derivate |
US5703115A (en) * | 1993-02-19 | 1997-12-30 | Janssen Pharmaceutica, N.V. | (benzodioxan, benzofuran or benzopyran) alkylamino! alkyl substituted guanidines |
GB9318431D0 (en) | 1993-09-06 | 1993-10-20 | Boots Co Plc | Therapeutic agents |
GB9409944D0 (en) | 1994-05-17 | 1994-07-06 | Rhone Poulenc Agriculture | New compositions of matter |
JPH11180979A (ja) * | 1997-10-17 | 1999-07-06 | Hokuriku Seiyaku Co Ltd | 環状アミン誘導体 |
US7202279B1 (en) | 1998-02-11 | 2007-04-10 | Georgetown University | Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders |
FR2795727B1 (fr) * | 1999-06-29 | 2001-09-21 | Pf Medicament | Nouveaux derives benzodioxanne imidazolines fluores, leur preparation et leurs applications en therapeutique |
WO2003082866A1 (en) | 2002-04-03 | 2003-10-09 | Orion Corporation | Polycyclic compounds as potent alpha2-adrenoceptor antagonists |
DOP2005000123A (es) | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | Inhibidores de cetp |
BRPI0610046A2 (pt) * | 2005-04-22 | 2010-05-25 | Wyeth Corp | derivados de benzodioxano e benzodioxolano e usos destes |
PE20071240A1 (es) | 2006-01-17 | 2008-01-14 | Schering Corp | Compuestos derivados de hidantoina para el tratamiento de trastornos inflamatorios |
MX2009001349A (es) | 2006-08-04 | 2009-04-17 | Takeda Pharmaceutical | Derivado heterociclico fusionado y su uso. |
CA2676658A1 (en) | 2007-01-30 | 2008-08-07 | Biogen Idec Ma Inc. | Modulators of mitotic kinases |
TWI457122B (zh) | 2007-07-20 | 2014-10-21 | Orion Corp | 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3-二氫苯並[1,4]戴奧辛-2-基甲基衍生物 |
TW201024282A (en) | 2008-11-20 | 2010-07-01 | Orion Corp | New pharmaceutical compounds |
WO2011004276A1 (en) | 2009-07-06 | 2011-01-13 | Pfizer Limited | Hepatitis c virus inhibitors |
WO2011085261A1 (en) | 2010-01-08 | 2011-07-14 | Selexagen Therapeutics, Inc. | Hedgehog inhibitors |
TWI704145B (zh) * | 2015-06-05 | 2020-09-11 | 芬蘭商奧利安公司 | 新醫藥化合物 |
-
2017
- 2017-06-28 EA EA201990158A patent/EA201990158A1/ru unknown
- 2017-06-28 KR KR1020197002759A patent/KR20190020343A/ko unknown
- 2017-06-28 WO PCT/FI2017/050484 patent/WO2018002437A1/en unknown
- 2017-06-28 JP JP2018568688A patent/JP2019519582A/ja active Pending
- 2017-06-28 CN CN201780040690.5A patent/CN109415355A/zh active Pending
- 2017-06-28 MX MX2018015872A patent/MX2018015872A/es unknown
- 2017-06-28 CA CA3029109A patent/CA3029109A1/en not_active Abandoned
- 2017-06-28 EP EP17746151.4A patent/EP3478676A1/en not_active Withdrawn
- 2017-06-28 AU AU2017287919A patent/AU2017287919A1/en not_active Abandoned
- 2017-06-28 US US16/313,956 patent/US20190152992A1/en not_active Abandoned
-
2018
- 2018-11-28 ZA ZA2018/08060A patent/ZA201808060B/en unknown
- 2018-12-26 IL IL263969A patent/IL263969A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN109415355A (zh) | 2019-03-01 |
US20190152992A1 (en) | 2019-05-23 |
EP3478676A1 (en) | 2019-05-08 |
IL263969A (en) | 2019-01-31 |
CA3029109A1 (en) | 2018-01-04 |
JP2019519582A (ja) | 2019-07-11 |
AU2017287919A1 (en) | 2019-01-17 |
KR20190020343A (ko) | 2019-02-28 |
EA201990158A1 (ru) | 2019-05-31 |
ZA201808060B (en) | 2019-08-28 |
WO2018002437A1 (en) | 2018-01-04 |
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