ES8704462A1 - Un procedimiento para preparar imidazoles substituidos - Google Patents
Un procedimiento para preparar imidazoles substituidosInfo
- Publication number
- ES8704462A1 ES8704462A1 ES549178A ES549178A ES8704462A1 ES 8704462 A1 ES8704462 A1 ES 8704462A1 ES 549178 A ES549178 A ES 549178A ES 549178 A ES549178 A ES 549178A ES 8704462 A1 ES8704462 A1 ES 8704462A1
- Authority
- ES
- Spain
- Prior art keywords
- och3
- preparation
- ch2ch3
- hal
- imidazole derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Dental Preparations (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Golf Clubs (AREA)
- Lubricants (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Resins (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE IMIDAZOLES, DE FORMULA (II) PARA OBTENER EL COMPUESTO DE FORMULA (I), EN LAS QUE X Y R1-R8 PUEDEN SER VAREIOS TIPOS DE RADICALES. LA REACCION SE LLEVA A CABO A UNA TEMPERATURA COMPRENDIDA ENTRE 130JC Y 200JC. ESTOS COMPUESTOS TIENEN APLICACIONES EN VETERINARIA COMO ANTAGONISTAS DE SEDATIVOS Y ANALGESICOS, Y EN TRATAMIENTO DEL ASMA Y DE LA MIGRAÑA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB08429578A GB2167408B (en) | 1984-11-23 | 1984-11-23 | Substituted imidazole derivatives and their preparation and use |
Publications (2)
Publication Number | Publication Date |
---|---|
ES549178A0 ES549178A0 (es) | 1987-04-01 |
ES8704462A1 true ES8704462A1 (es) | 1987-04-01 |
Family
ID=10570140
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES549178A Expired ES8704462A1 (es) | 1984-11-23 | 1985-11-22 | Un procedimiento para preparar imidazoles substituidos |
ES557268A Expired ES8801248A1 (es) | 1984-11-23 | 1986-12-29 | Un procedimiento para preparar imidazoles sustituidos |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES557268A Expired ES8801248A1 (es) | 1984-11-23 | 1986-12-29 | Un procedimiento para preparar imidazoles sustituidos |
Country Status (26)
Country | Link |
---|---|
US (1) | US4689339A (es) |
EP (2) | EP0310745B1 (es) |
JP (1) | JPH064597B2 (es) |
KR (1) | KR930004673B1 (es) |
AT (2) | ATE47997T1 (es) |
AU (2) | AU586839B2 (es) |
BG (1) | BG60762B2 (es) |
CA (1) | CA1268770C (es) |
DD (1) | DD258230A1 (es) |
DE (2) | DE3574252D1 (es) |
DK (2) | DK164903C (es) |
ES (2) | ES8704462A1 (es) |
FI (1) | FI80264C (es) |
GB (1) | GB2167408B (es) |
GR (1) | GR852817B (es) |
HK (1) | HK3592A (es) |
HU (1) | HU195189B (es) |
IE (1) | IE58165B1 (es) |
IL (1) | IL77111A (es) |
NO (1) | NO166585C (es) |
NZ (1) | NZ214258A (es) |
PH (1) | PH22016A (es) |
PT (1) | PT81542B (es) |
SG (1) | SG106891G (es) |
SU (1) | SU1424736A3 (es) |
ZA (1) | ZA858942B (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2049186A1 (es) * | 1991-12-27 | 1994-04-01 | Sod Conseils Rech Applic | Procedimiento para la preparacion de nuevos derivados de benzofuranil-imidazol. |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4891431A (en) * | 1986-01-28 | 1990-01-02 | Mitsui Petrochemical Industries, Ltd. | Process for preparing 2-unsubstituted imidazoles |
FI862039A0 (fi) * | 1986-05-15 | 1986-05-15 | Farmos Oy | Nytt foerfarande foer framstaellning av 4(5)-substituerade imidazolderivat. |
FI81092C (fi) * | 1986-05-15 | 1990-09-10 | Farmos Oy | Foerfarande foer framstaellning av terapeutiskt aktiva 4(5)-(2,3-dihydro-1h-inden-2-yl)-imidazolderivat. |
JP2576493B2 (ja) * | 1987-03-20 | 1997-01-29 | アイシン精機株式会社 | 原稿読取り装置に用いられる原稿トレ− |
FR2621327B1 (fr) * | 1987-10-06 | 1990-01-05 | Commissariat Energie Atomique | Procede de production et d'extraction de polysaccharides a partir d'une culture de porphyridium cruentum et dispositif pour la mise en oeuvre du procede |
GB2225782A (en) * | 1988-12-09 | 1990-06-13 | Farmos Group Limited | Imidazole derivatives useful for treatment of diabetes |
GB8903437D0 (en) * | 1989-02-15 | 1989-04-05 | Erba Carlo Spa | Imidazolyl derivatives of 3,4-dihydro-2h-1-benzothiopyran |
CA1321751C (en) * | 1989-02-21 | 1993-08-31 | Eugene C. Crichlow | Mechanism mediating ruminal stasis in ruminal lactic acidosis |
DK344489D0 (da) * | 1989-07-12 | 1989-07-12 | Novo Nordisk As | Substituerede 2-imidazoliner og fremstilling og anvendelse deraf |
GB2244431A (en) * | 1990-05-31 | 1991-12-04 | Farmos Oy | Treatment of age related memory impairment and other cognitive disorders |
GB2256135B (en) | 1991-05-31 | 1995-01-18 | Orion Yhtymae Oy | Transdermal administration of 4-substituted imidazoles |
US5541211A (en) * | 1991-06-18 | 1996-07-30 | Orion-Yhtyma Oy | Administration of atipamezole to elicit a yohimbine-like alpha-adrenoreceptor antagonistic noradrenergic transmission |
RU2125980C1 (ru) * | 1991-11-05 | 1999-02-10 | Смитклайн Бичам Корпорейшн | Антагонисты эндотелиновых рецепторов, фармкомпозиция, способ их получения, способ подавления эндотелиновых рецепторов |
GB9127050D0 (en) * | 1991-12-20 | 1992-02-19 | Orion Yhtymae Oy | Substituted imidazole derivatives and their preparation and use |
GB9312669D0 (en) * | 1993-06-18 | 1993-08-04 | Orion Yhtymae Oy | New opticla isomers |
GB9425211D0 (en) * | 1994-12-14 | 1995-02-15 | Ucb Sa | Substituted 1H-imidazoles |
FR2733983B1 (fr) * | 1995-05-10 | 1997-08-01 | Pf Medicament | Procede de preparation d'un derive d'acide benzofurane carboxylque optiquement pur et son utilisation pour preparer l'efaroxan |
GB9520150D0 (en) * | 1995-10-03 | 1995-12-06 | Orion Yhtymae Oy | New imidazole derivatives |
FR2754709B1 (fr) | 1996-10-23 | 1999-03-05 | Sanofi Sa | Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition |
EP0986530A1 (en) * | 1997-06-05 | 2000-03-22 | Venantius Limited | Indane compounds and their pharmaceutical use |
AU3378399A (en) * | 1998-04-02 | 1999-10-25 | Ortho-Mcneil Pharmaceutical, Inc. | 4-thionaphthyl-1h-imidazoles with alpha-2-adrenergic activity |
FR2784989B1 (fr) * | 1998-09-10 | 2002-09-27 | Fabre Pierre Sante | Derive d'ester d'acide 2-ethyl-2,3-dihydrobenzofurane- carboxylique, procede de preparation et utilisation pour la preparation de derives de l'efaroxan |
EP1147092A1 (en) * | 1999-01-18 | 2001-10-24 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
US6388090B2 (en) | 2000-01-14 | 2002-05-14 | Orion Corporation | Imidazole derivatives |
US6593324B2 (en) | 2000-03-01 | 2003-07-15 | Orion Corporation | Dervatives of quinoline as alpha-2 antagonists |
CA2408290A1 (en) | 2000-05-08 | 2001-11-15 | Orion Corporation | New polycyclic indanylimidazoles with alpha2 adrenergic activity |
US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
US6543389B2 (en) | 2001-06-26 | 2003-04-08 | Pfizer Inc. | Insecticidal pet collar |
MXPA04009601A (es) | 2002-04-03 | 2004-12-13 | Orion Corp | Compuestos policiclicos como potentes antagonistas del adreno-receptor alfa-2. |
US8188126B2 (en) | 2002-05-16 | 2012-05-29 | Pierre Fabre Medicament | Imidazolic compounds and use thereof as alpha-2 adrenergic receptors |
FI116292B (fi) | 2003-01-08 | 2005-10-31 | Juvantia Pharma Ltd Oy | Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita |
DE602004017347D1 (de) * | 2003-11-04 | 2008-12-04 | Intervet Int Bv | Azol-pestiziden |
FI20050657A0 (fi) * | 2005-06-17 | 2005-06-17 | Orion Corp | Atipametsolin kiteytysmenetelmä |
CN101287470B (zh) | 2005-10-12 | 2012-10-17 | 优尼麦德药物股份有限公司 | 改良的睾酮凝胶及使用方法 |
US7592461B2 (en) * | 2005-12-21 | 2009-09-22 | Bristol-Myers Squibb Company | Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
CA2659379A1 (en) * | 2006-08-08 | 2008-02-14 | Intervet International B.V. | Composition for enhanced antiparasitic activity |
TWI457122B (zh) | 2007-07-20 | 2014-10-21 | Orion Corp | 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3-二氫苯並[1,4]戴奧辛-2-基甲基衍生物 |
CL2008003553A1 (es) * | 2007-12-05 | 2009-11-27 | Grindeks Jsc | Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso |
SG11201603218UA (en) | 2013-11-05 | 2016-05-30 | 3M Innovative Properties Co | Sesame oil based injection formulations |
TWI704145B (zh) | 2015-06-05 | 2020-09-11 | 芬蘭商奧利安公司 | 新醫藥化合物 |
WO2017079734A1 (en) * | 2015-11-05 | 2017-05-11 | University Of Louisville Research Foundation, Inc. | Local and regional anesthesia and analgesia |
JP2019519582A (ja) | 2016-06-29 | 2019-07-11 | オリオン コーポレーション | ベンゾジオキサン誘導体およびその医薬用途 |
WO2020126536A1 (en) | 2018-12-21 | 2020-06-25 | Societe Des Produits Nestle S.A. | Nutritional composition for inducing a feeling of satiety, a better sleep and/or limiting nocturnal awaking in infants or young children |
CN111978254A (zh) * | 2019-05-22 | 2020-11-24 | 南京康德祥医药科技有限公司 | 一种阿替美唑盐酸盐的制备工艺 |
CN111925330A (zh) * | 2020-09-07 | 2020-11-13 | 上海阿达玛斯试剂有限公司 | 一种阿替美唑的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2933962A1 (de) * | 1979-08-22 | 1981-03-26 | Hoechst Ag, 65929 Frankfurt | Verfahren zur herstellung von 4,5-dichlor-imidazolen. |
US4342775A (en) * | 1980-03-04 | 1982-08-03 | Farmitalia Carlo Erba S.P.A. | 3-(1-Imidazolyl)-derivatives of 2,3-dihydro-4H-1-benzopyran |
US4302469A (en) * | 1980-09-10 | 1981-11-24 | Syntex (U.S.A.) Inc. | 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants |
NZ201219A (en) * | 1981-07-28 | 1984-10-19 | Reckitt & Colmann Prod Ltd | Dihydrobenzofuranyl-2-imidazolines and pharmaceutical compositions |
ES523609A0 (es) * | 1982-07-05 | 1985-03-01 | Erba Farmitalia | Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos. |
FR2539415B1 (fr) * | 1983-01-14 | 1985-09-13 | Adir | Derives de la d-2 imidazoline, leur preparation et leur application en therapeutique |
FR2542738A1 (fr) * | 1983-03-18 | 1984-09-21 | Synthelabo | Indanyl-2 d2-imidazoline, procede pour la preparer, et compositions pharmaceutiques qui la contiennent |
-
1984
- 1984-11-23 GB GB08429578A patent/GB2167408B/en not_active Expired
-
1985
- 1985-11-05 FI FI854335A patent/FI80264C/fi not_active IP Right Cessation
- 1985-11-18 CA CA 495608 patent/CA1268770C/xx not_active Expired - Lifetime
- 1985-11-20 NZ NZ214258A patent/NZ214258A/xx unknown
- 1985-11-20 AU AU50083/85A patent/AU586839B2/en not_active Expired
- 1985-11-20 DD DD85283044A patent/DD258230A1/de not_active IP Right Cessation
- 1985-11-20 IL IL77111A patent/IL77111A/xx not_active IP Right Cessation
- 1985-11-21 AT AT85308491T patent/ATE47997T1/de not_active IP Right Cessation
- 1985-11-21 DE DE8585308491T patent/DE3574252D1/de not_active Expired
- 1985-11-21 EP EP88106210A patent/EP0310745B1/en not_active Expired - Lifetime
- 1985-11-21 PH PH33077A patent/PH22016A/en unknown
- 1985-11-21 EP EP85308491A patent/EP0183492B1/en not_active Expired
- 1985-11-21 DE DE8888106210T patent/DE3587045T2/de not_active Expired - Fee Related
- 1985-11-21 AT AT88106210T patent/ATE85050T1/de not_active IP Right Cessation
- 1985-11-21 GR GR852817A patent/GR852817B/el unknown
- 1985-11-21 IE IE292985A patent/IE58165B1/en not_active IP Right Cessation
- 1985-11-21 ZA ZA858942A patent/ZA858942B/xx unknown
- 1985-11-21 US US06/800,192 patent/US4689339A/en not_active Expired - Lifetime
- 1985-11-21 KR KR1019850008704A patent/KR930004673B1/ko not_active IP Right Cessation
- 1985-11-22 ES ES549178A patent/ES8704462A1/es not_active Expired
- 1985-11-22 NO NO854671A patent/NO166585C/no unknown
- 1985-11-22 PT PT81542A patent/PT81542B/pt unknown
- 1985-11-22 SU SU853979907A patent/SU1424736A3/ru active
- 1985-11-22 JP JP60263586A patent/JPH064597B2/ja not_active Expired - Lifetime
- 1985-11-22 DK DK540485A patent/DK164903C/da not_active IP Right Cessation
- 1985-11-22 HU HU854471A patent/HU195189B/hu unknown
-
1986
- 1986-12-29 ES ES557268A patent/ES8801248A1/es not_active Expired
-
1989
- 1989-04-21 AU AU33329/89A patent/AU3332989A/en not_active Abandoned
-
1991
- 1991-12-17 SG SG1068/91A patent/SG106891G/en unknown
-
1992
- 1992-01-09 HK HK35/92A patent/HK3592A/xx not_active IP Right Cessation
- 1992-05-04 DK DK92582A patent/DK58292D0/da not_active Application Discontinuation
-
1994
- 1994-01-18 BG BG98378A patent/BG60762B2/bg unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2049186A1 (es) * | 1991-12-27 | 1994-04-01 | Sod Conseils Rech Applic | Procedimiento para la preparacion de nuevos derivados de benzofuranil-imidazol. |
Also Published As
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ES8704462A1 (es) | Un procedimiento para preparar imidazoles substituidos | |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20000201 |