DD210305A5 - Verfahren zur herstellung von mikroorganismen - Google Patents

Verfahren zur herstellung von mikroorganismen Download PDF

Info

Publication number
DD210305A5
DD210305A5 DD81255300A DD25530081A DD210305A5 DD 210305 A5 DD210305 A5 DD 210305A5 DD 81255300 A DD81255300 A DD 81255300A DD 25530081 A DD25530081 A DD 25530081A DD 210305 A5 DD210305 A5 DD 210305A5
Authority
DD
German Democratic Republic
Prior art keywords
leif
vector
fragment
interferon
item
Prior art date
Application number
DD81255300A
Other languages
German (de)
English (en)
Inventor
Goeddel David Van Norman
Sidney Pestka
Original Assignee
Hoffmann La Roche
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27496622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DD210305(A5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/256,204 external-priority patent/US6610830B1/en
Application filed by Hoffmann La Roche, Genentech Inc filed Critical Hoffmann La Roche
Publication of DD210305A5 publication Critical patent/DD210305A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DD81255300A 1980-07-01 1981-07-01 Verfahren zur herstellung von mikroorganismen DD210305A5 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16498680A 1980-07-01 1980-07-01
US18490980A 1980-09-08 1980-09-08
US20557880A 1980-11-10 1980-11-10
US06/256,204 US6610830B1 (en) 1980-07-01 1981-04-21 Microbial production of mature human leukocyte interferons

Publications (1)

Publication Number Publication Date
DD210305A5 true DD210305A5 (de) 1984-06-06

Family

ID=27496622

Family Applications (3)

Application Number Title Priority Date Filing Date
DD81255300A DD210305A5 (de) 1980-07-01 1981-07-01 Verfahren zur herstellung von mikroorganismen
DD81231371A DD202307A5 (de) 1980-07-01 1981-07-01 Verfahren zur herstellung eines polypeptids
DD81255299A DD210304A5 (de) 1980-07-01 1981-07-01 Verfahren zur herstellung eines replikablen vektors

Family Applications After (2)

Application Number Title Priority Date Filing Date
DD81231371A DD202307A5 (de) 1980-07-01 1981-07-01 Verfahren zur herstellung eines polypeptids
DD81255299A DD210304A5 (de) 1980-07-01 1981-07-01 Verfahren zur herstellung eines replikablen vektors

Country Status (36)

Country Link
EP (2) EP0043980B1 (hu)
AR (1) AR242833A1 (hu)
AT (3) ATE29727T1 (hu)
AU (1) AU552004B2 (hu)
BG (1) BG42189A3 (hu)
BR (1) BR8104189A (hu)
CH (2) CH657141A5 (hu)
CS (1) CS273152B2 (hu)
DD (3) DD210305A5 (hu)
DE (3) DE3176448D1 (hu)
DK (1) DK173543B1 (hu)
DZ (1) DZ312A1 (hu)
ES (1) ES8207514A1 (hu)
FI (1) FI82712C (hu)
FR (1) FR2486098B1 (hu)
GB (1) GB2079291B (hu)
GE (1) GEP19960519B (hu)
GR (1) GR75714B (hu)
HK (1) HK49285A (hu)
HU (1) HU196457B (hu)
IE (1) IE49255B1 (hu)
IT (1) IT1137272B (hu)
KE (1) KE3534A (hu)
LU (1) LU83461A1 (hu)
MC (1) MC1396A1 (hu)
MY (1) MY8700711A (hu)
NL (1) NL8103151A (hu)
NO (1) NO159392C (hu)
NZ (1) NZ197572A (hu)
PH (1) PH18036A (hu)
PL (3) PL148261B1 (hu)
PT (1) PT73289B (hu)
RO (1) RO87590A (hu)
SE (2) SE465223C5 (hu)
SU (1) SU1414319A3 (hu)
YU (1) YU47700B (hu)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
KR860001471B1 (ko) 1980-04-03 1986-09-26 비오겐 엔. 브이 인체의 섬유아세포 인터페론(IFN-β)폴리펩티드의 제조방법
ATE25985T1 (de) * 1980-06-12 1987-04-15 Japan Found Cancer Plasmid.
DK489481A (da) * 1980-11-10 1982-05-11 Searle & Co Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
JPS58501543A (ja) * 1981-08-14 1983-09-16 エイ／エス　アルフレツド　ベンツオン ヒトインタ−フエロン蛋白とヒトインタ−フエロン蛋白に対する抗体に関する改良
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
US4975276A (en) * 1982-01-15 1990-12-04 Cetus Corporation Interferon-alpha 54
US4973479A (en) * 1982-01-15 1990-11-27 Cetus Corporation Interferon-α61
US5098703A (en) * 1982-01-15 1992-03-24 Cetus Corporation Interferon-alpha 76
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
EP0088994B1 (en) * 1982-03-15 1991-06-19 Schering Corporation Hybrid dna, binding composition prepared thereby and processes therefor
CA1210714A (en) * 1982-03-23 1986-09-02 Alan Sloma .alpha.-INTERFERON GX-1
US4695543A (en) * 1982-03-23 1987-09-22 Bristol-Myers Company Alpha Interferon GX-1
US4748233A (en) * 1982-03-23 1988-05-31 Bristol-Myers Company Alpha-interferon Gx-1
US6936694B1 (en) * 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
US4751287A (en) * 1983-02-24 1988-06-14 Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr Human leukocyte interferon N and a method of producing same in bacterial cells
WO1985002862A1 (en) * 1983-12-23 1985-07-04 Monash University PRODUCTION OF HUMAN INTERFERON-alpha
SU1364343A1 (ru) * 1984-07-13 1988-01-07 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Способ получени человеческого лейкоцитарного интерферона альфа-2
WO1986002068A1 (en) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Mutual separation of proteins
IL76360A0 (en) 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
DE3515336C2 (de) * 1985-04-27 1994-01-20 Boehringer Ingelheim Int Verfahren zur Herstellung und Reinigung von â-Interferon
US5196323A (en) * 1985-04-27 1993-03-23 Boehringer Ingelheim International Gmbh Process for preparing and purifying alpha-interferon
JP2514950B2 (ja) * 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質，その製造法および中間体
JPS6463395A (en) * 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
CA1309044C (en) * 1987-11-09 1992-10-20 Toshiya Takano Method of producing foreign gene products
GB8813032D0 (en) * 1988-06-02 1988-07-06 Boehringer Ingelheim Int Antiviral pharmaceutical composition
WO1991003251A1 (en) * 1989-09-08 1991-03-21 California Institute Of Biological Research Cr2 ligand compositions and methods for modulating immune cell functions
DE3932311A1 (de) * 1989-09-28 1991-04-11 Boehringer Ingelheim Int Verfahren zur reinigung von beta-interferon
WO1995024212A1 (en) * 1994-03-07 1995-09-14 Imperial College Of Science, Technology & Medicine The use of interferon subtypes in the preparation of medicaments to treat viral infections
ES2161793T3 (es) * 1994-04-09 2001-12-16 Hoffmann La Roche Proceso para la produccion de alfa-interferona.
GB9609932D0 (en) * 1996-05-13 1996-07-17 Hoffmann La Roche Use of IL-12 and IFN alpha for the treatment of infectious diseases
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
ZA9811070B (en) 1997-12-08 2000-07-03 Genentech Inc Type I interferons.
EP1037995A1 (en) 1997-12-08 2000-09-27 Genentech, Inc. Human interferon-epsilon: a type 1 interferon
US6783965B1 (en) 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
DE69925917T2 (de) 1998-08-06 2006-05-11 Mountain View Pharmaceuticals, Inc., Menlo Park PEG-Urikase Konjugate und Verwendung davon
US6268178B1 (en) 1999-05-25 2001-07-31 Phage Biotechnology Corp. Phage-dependent super-production of biologically active protein and peptides
EP1355939A2 (en) * 2000-11-03 2003-10-29 Pestka Biomedical Laboratories, Inc. Interferons, uses and compositions related thereto
FR2822845B1 (fr) 2001-03-30 2003-12-12 Genodyssee Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr) 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2825716B1 (fr) 2001-06-11 2004-09-24 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
WO2006110819A2 (en) 2005-04-11 2006-10-19 Savient Pharmaceuticals, Inc. Variant forms of urate oxidase and use thereof
CN101918430A (zh) * 2008-01-18 2010-12-15 弗·哈夫曼-拉罗切有限公司 非糖基化蛋白质的纯化
CN102803954A (zh) 2009-06-25 2012-11-28 萨文特制药公司 通过监测peg化尿酸酶治疗期间的血清尿酸预测输液反应风险和抗体介导的响应丧失的方法和试剂盒
WO2018087345A1 (en) 2016-11-14 2018-05-17 F. Hoffmann-La Roche Ag COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN150740B (hu) * 1978-11-24 1982-12-04 Hoffmann La Roche
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
EP0032134B2 (en) * 1980-01-08 1993-10-13 Biogen, Inc. Dna sequences, recombinant dna molecules and processes for producing human interferon-alpha like polypeptides
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
ATE25985T1 (de) * 1980-06-12 1987-04-15 Japan Found Cancer Plasmid.
ES506955A0 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
FI64813C (fi) * 1980-12-31 1984-01-10 Ilkka Antero Palva Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
EP0062971B1 (en) * 1981-03-27 1990-03-07 Imperial Chemical Industries Plc Genetically modified microorganisms

Also Published As

Publication number Publication date
EP0211148B1 (en) 1992-08-26
IT1137272B (it) 1986-09-03
HU196457B (en) 1988-11-28
CS503781A2 (en) 1990-07-12
AU552004B2 (en) 1986-05-22
ES503528A0 (es) 1982-10-01
FI82712B (fi) 1990-12-31
KE3534A (en) 1985-06-07
DD202307A5 (de) 1983-09-07
DE3125706C2 (de) 1995-05-24
EP0043980A3 (en) 1982-09-15
PL231940A1 (en) 1983-07-18
AU7246281A (en) 1982-01-07
NO159392C (no) 1988-12-21
DE3176448D1 (en) 1987-10-22
SE465223C5 (sv) 1998-02-10
RO87590A (ro) 1986-07-30
DE3177288D1 (de) 1992-10-01
SE465223B (sv) 1991-08-12
IE811463L (en) 1982-01-01
ES8207514A1 (es) 1982-10-01
HK49285A (en) 1985-07-05
EP0211148B2 (en) 1999-11-24
PL148261B1 (en) 1989-09-30
GB2079291A (en) 1982-01-20
FR2486098B1 (fr) 1985-12-27
FI82712C (fi) 1991-04-10
EP0043980A2 (en) 1982-01-20
CH651308A5 (de) 1985-09-13
SE8104093L (sv) 1982-01-02
ATA290981A (de) 1985-09-15
DE3125706A1 (de) 1982-04-15
CS273152B2 (en) 1991-03-12
NZ197572A (en) 1985-07-31
MY8700711A (en) 1987-12-31
NO159392B (no) 1988-09-12
NL8103151A (nl) 1982-02-01
DE3177288T2 (de) 1992-12-10
BG42189A3 (en) 1987-10-15
BR8104189A (pt) 1982-03-16
PH18036A (en) 1985-03-06
ATE29727T1 (de) 1987-10-15
LU83461A1 (de) 1983-04-06
EP0043980B1 (en) 1987-09-16
PT73289B (en) 1983-05-11
IT8122682A0 (it) 1981-07-01
CH657141A5 (de) 1986-08-15
DK291081A (da) 1982-01-02
SU1414319A3 (ru) 1988-07-30
GB2079291B (en) 1984-06-13
EP0211148A1 (en) 1987-02-25
GR75714B (hu) 1984-08-02
ATE79901T1 (de) 1992-09-15
YU162281A (en) 1984-02-29
DZ312A1 (fr) 2004-09-13
YU47700B (sh) 1996-01-08
PT73289A (en) 1981-07-01
DD210304A5 (de) 1984-06-06
IE49255B1 (en) 1985-09-04
DK173543B1 (da) 2001-02-05
GEP19960519B (en) 1996-07-02
AR242833A1 (es) 1993-05-31
FR2486098A1 (fr) 1982-01-08
PL148260B1 (en) 1989-09-30
DE3177288T3 (de) 2000-03-16
NO812247L (no) 1982-01-04
MC1396A1 (fr) 1982-04-27
PL148276B1 (en) 1989-09-30
AT380272B (de) 1986-05-12
FI812067L (fi) 1982-01-02

Similar Documents

Publication Publication Date Title
DE3177288T2 (de) Reife menschliche leukozyten-interferone, verfahren zu ihrer bacteriellen herstellung, zwischenprodukte hierfuer und zusammensetzungen diese enthaltend.
DE3238554C2 (hu)
DE3786767T3 (de) Neues Polypeptid.
DD203330A5 (de) Verfahren zur herstellung hybrider human-leukozyten-interferone
CH651309A5 (de) Human-fibroblasten-interferone und deren mikrobielle herstellung.
EP0076489B1 (de) Desoxyribonucleinsäuren, rekombinante Desoxyribonucleinsäuren, sie enthaltende Wirte, Polypeptide und Verfahren zu ihrer Herstellung
EP0147819B1 (de) Reinigung von rekombinanten Interleukin-2
DE3587605T2 (de) Interleukin-1 und dessen Derivat.
DE3144469A1 (de) Hybride human-leukozyten-interferone
DD219505A5 (de) Verfahren zur herstellung von schweine-wachstumshormonaehnlichen polypeptiden
AT394209B (de) Verfahren zur herstellung neuer mikroorganismen zur produktion von hybriden human-leukozyten-interferonen
AT394208B (de) Verfahren zur herstelluung von vektoren
AT394207B (de) Verfahren zur herstellung von human-leukozyteninterferonen
FI82713C (fi) Plasmid, som foermaor expressera humant moget leukocytinterferon, foerfarande foer dess framstaellning samt dess anvaendning vid framstaellning av humant leukocytinterferon.
AT394210B (de) Verfahren zur herstellung von doppelstraengiger dna kodierend fuer hybride human-leukozyten-interferone
IL63197A (en) Intraferons for mature human oocytes, their preparation and preparations containing them
DD259419A5 (de) Verfahren zur Herstellung von neuen Expressionsplasmiden

Legal Events

Date Code Title Description
ENJ Ceased due to non-payment of renewal fee