DD156532A5 - Verfahren zur herstellung der alpha-form von prazosinhydrochlorid - Google Patents
Verfahren zur herstellung der alpha-form von prazosinhydrochlorid Download PDFInfo
- Publication number
- DD156532A5 DD156532A5 DD81227817A DD22781781A DD156532A5 DD 156532 A5 DD156532 A5 DD 156532A5 DD 81227817 A DD81227817 A DD 81227817A DD 22781781 A DD22781781 A DD 22781781A DD 156532 A5 DD156532 A5 DD 156532A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- prazosin hydrochloride
- water
- hydrochloride
- prazosin
- alpha form
- Prior art date
Links
- WFXFYZULCQKPIP-UHFFFAOYSA-N prazosin hydrochloride Chemical compound [H+].[Cl-].N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 WFXFYZULCQKPIP-UHFFFAOYSA-N 0.000 title claims abstract description 19
- 238000004519 manufacturing process Methods 0.000 title 1
- 229960002386 prazosin hydrochloride Drugs 0.000 claims abstract description 20
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 13
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- 150000004683 dihydrates Chemical class 0.000 claims abstract description 3
- 239000007858 starting material Substances 0.000 claims abstract description 3
- 238000009835 boiling Methods 0.000 claims abstract 2
- 239000013078 crystal Substances 0.000 claims description 4
- 238000000926 separation method Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 3
- 230000003276 anti-hypertensive effect Effects 0.000 abstract description 2
- 230000000144 pharmacologic effect Effects 0.000 abstract description 2
- 230000036571 hydration Effects 0.000 abstract 1
- 238000006703 hydration reaction Methods 0.000 abstract 1
- 229960001289 prazosin Drugs 0.000 description 3
- IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 238000010533 azeotropic distillation Methods 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000002329 infrared spectrum Methods 0.000 description 2
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 1
- CUCXXSBYLSQIJF-UHFFFAOYSA-N 1,1-dichloroethane;hydrate Chemical compound O.CC(Cl)Cl CUCXXSBYLSQIJF-UHFFFAOYSA-N 0.000 description 1
- -1 2-furoyl Chemical group 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000004434 industrial solvent Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI800556A FI64367C (fi) | 1980-02-26 | 1980-02-26 | Foerfarande foer framstaellning av alfa-form av prazosinhydroklorid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD156532A5 true DD156532A5 (de) | 1982-09-01 |
Family
ID=8513276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD81227817A DD156532A5 (de) | 1980-02-26 | 1981-02-23 | Verfahren zur herstellung der alpha-form von prazosinhydrochlorid |
Country Status (11)
| Country | Link |
|---|---|
| CS (1) | CS216226B2 (cs) |
| DD (1) | DD156532A5 (cs) |
| DK (1) | DK157548C (cs) |
| ES (1) | ES499796A0 (cs) |
| FI (1) | FI64367C (cs) |
| HU (1) | HU182297B (cs) |
| NO (1) | NO154461C (cs) |
| PL (1) | PL128350B1 (cs) |
| PT (1) | PT72511B (cs) |
| SE (1) | SE431873B (cs) |
| SU (1) | SU980621A3 (cs) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3429415A1 (de) * | 1984-06-25 | 1986-01-02 | Orion Corp. FERMION, Espoo | Wasserfreie, stabile und kristalline form von prazosinhydrochlorid und verfahren zu dessen herstellung |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100453097B1 (ko) * | 1995-09-06 | 2004-12-31 | 코와 가부시키가이샤 | 피리미딘유도체 |
-
1980
- 1980-02-26 FI FI800556A patent/FI64367C/fi not_active IP Right Cessation
-
1981
- 1981-02-16 PT PT72511A patent/PT72511B/pt not_active IP Right Cessation
- 1981-02-18 CS CS811167A patent/CS216226B2/cs unknown
- 1981-02-20 NO NO810590A patent/NO154461C/no unknown
- 1981-02-23 DD DD81227817A patent/DD156532A5/de not_active IP Right Cessation
- 1981-02-25 SU SU813247560A patent/SU980621A3/ru active
- 1981-02-25 ES ES499796A patent/ES499796A0/es active Granted
- 1981-02-25 PL PL1981229865A patent/PL128350B1/pl unknown
- 1981-02-25 HU HU81460A patent/HU182297B/hu not_active IP Right Cessation
- 1981-02-25 DK DK084581A patent/DK157548C/da not_active IP Right Cessation
- 1981-02-26 SE SE8101265A patent/SE431873B/sv not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3429415A1 (de) * | 1984-06-25 | 1986-01-02 | Orion Corp. FERMION, Espoo | Wasserfreie, stabile und kristalline form von prazosinhydrochlorid und verfahren zu dessen herstellung |
| FR2567124A1 (fr) * | 1984-06-25 | 1986-01-10 | Orion Yhtymae Oy | Nouvelle forme d cristalline, stable, anhydre du chlorhydrate de prazosine et nouveau procede pour la preparation de cette forme d cristalline |
Also Published As
| Publication number | Publication date |
|---|---|
| ES8201577A1 (es) | 1981-12-16 |
| NO810590L (no) | 1981-08-27 |
| SE431873B (sv) | 1984-03-05 |
| DK84581A (da) | 1981-08-27 |
| PL229865A1 (cs) | 1981-10-30 |
| DK157548C (da) | 1990-06-11 |
| FI64367C (fi) | 1986-08-05 |
| HU182297B (en) | 1983-12-28 |
| FI64367B (fi) | 1983-07-29 |
| DK157548B (da) | 1990-01-22 |
| FI800556A7 (fi) | 1981-08-27 |
| NO154461B (no) | 1986-06-16 |
| SU980621A3 (ru) | 1982-12-07 |
| PL128350B1 (en) | 1984-01-31 |
| PT72511B (en) | 1983-02-01 |
| SE8101265L (sv) | 1981-08-27 |
| PT72511A (en) | 1981-03-01 |
| ES499796A0 (es) | 1981-12-16 |
| NO154461C (no) | 1986-09-24 |
| CS216226B2 (en) | 1982-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ENJ | Ceased due to non-payment of renewal fee |