SE431873B - Forfarande for framstellning av alfa-form av prazosinhydroklorid - Google Patents
Forfarande for framstellning av alfa-form av prazosinhydrokloridInfo
- Publication number
- SE431873B SE431873B SE8101265A SE8101265A SE431873B SE 431873 B SE431873 B SE 431873B SE 8101265 A SE8101265 A SE 8101265A SE 8101265 A SE8101265 A SE 8101265A SE 431873 B SE431873 B SE 431873B
- Authority
- SE
- Sweden
- Prior art keywords
- water
- hydrochloride
- procedure
- hydrate
- prazosin hydrochloride
- Prior art date
Links
- WFXFYZULCQKPIP-UHFFFAOYSA-N prazosin hydrochloride Chemical compound [H+].[Cl-].N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 WFXFYZULCQKPIP-UHFFFAOYSA-N 0.000 title claims description 11
- 238000000034 method Methods 0.000 title claims description 8
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 229960002386 prazosin hydrochloride Drugs 0.000 claims description 10
- 150000004683 dihydrates Chemical class 0.000 claims description 2
- 238000009835 boiling Methods 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- -1 2- [2- (2-furoyl) piperazin-1-yl] -4-amino-6,7-dimethoxyquinazoline hydrochloride Chemical compound 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- 238000002329 infrared spectrum Methods 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 238000010533 azeotropic distillation Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI800556A FI64367C (fi) | 1980-02-26 | 1980-02-26 | Foerfarande foer framstaellning av alfa-form av prazosinhydroklorid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8101265L SE8101265L (sv) | 1981-08-27 |
| SE431873B true SE431873B (sv) | 1984-03-05 |
Family
ID=8513276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8101265A SE431873B (sv) | 1980-02-26 | 1981-02-26 | Forfarande for framstellning av alfa-form av prazosinhydroklorid |
Country Status (11)
| Country | Link |
|---|---|
| CS (1) | CS216226B2 (cs) |
| DD (1) | DD156532A5 (cs) |
| DK (1) | DK157548C (cs) |
| ES (1) | ES499796A0 (cs) |
| FI (1) | FI64367C (cs) |
| HU (1) | HU182297B (cs) |
| NO (1) | NO154461C (cs) |
| PL (1) | PL128350B1 (cs) |
| PT (1) | PT72511B (cs) |
| SE (1) | SE431873B (cs) |
| SU (1) | SU980621A3 (cs) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI79107C (fi) * | 1984-06-25 | 1989-11-10 | Orion Yhtymae Oy | Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid. |
| KR100453097B1 (ko) * | 1995-09-06 | 2004-12-31 | 코와 가부시키가이샤 | 피리미딘유도체 |
-
1980
- 1980-02-26 FI FI800556A patent/FI64367C/fi not_active IP Right Cessation
-
1981
- 1981-02-16 PT PT72511A patent/PT72511B/pt not_active IP Right Cessation
- 1981-02-18 CS CS811167A patent/CS216226B2/cs unknown
- 1981-02-20 NO NO810590A patent/NO154461C/no unknown
- 1981-02-23 DD DD81227817A patent/DD156532A5/de not_active IP Right Cessation
- 1981-02-25 SU SU813247560A patent/SU980621A3/ru active
- 1981-02-25 ES ES499796A patent/ES499796A0/es active Granted
- 1981-02-25 PL PL1981229865A patent/PL128350B1/pl unknown
- 1981-02-25 HU HU81460A patent/HU182297B/hu not_active IP Right Cessation
- 1981-02-25 DK DK084581A patent/DK157548C/da not_active IP Right Cessation
- 1981-02-26 SE SE8101265A patent/SE431873B/sv not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES8201577A1 (es) | 1981-12-16 |
| NO810590L (no) | 1981-08-27 |
| DK84581A (da) | 1981-08-27 |
| PL229865A1 (cs) | 1981-10-30 |
| DK157548C (da) | 1990-06-11 |
| FI64367C (fi) | 1986-08-05 |
| HU182297B (en) | 1983-12-28 |
| FI64367B (fi) | 1983-07-29 |
| DK157548B (da) | 1990-01-22 |
| FI800556A7 (fi) | 1981-08-27 |
| DD156532A5 (de) | 1982-09-01 |
| NO154461B (no) | 1986-06-16 |
| SU980621A3 (ru) | 1982-12-07 |
| PL128350B1 (en) | 1984-01-31 |
| PT72511B (en) | 1983-02-01 |
| SE8101265L (sv) | 1981-08-27 |
| PT72511A (en) | 1981-03-01 |
| ES499796A0 (es) | 1981-12-16 |
| NO154461C (no) | 1986-09-24 |
| CS216226B2 (en) | 1982-10-29 |
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