FI64367C - Foerfarande foer framstaellning av alfa-form av prazosinhydroklorid - Google Patents
Foerfarande foer framstaellning av alfa-form av prazosinhydroklorid Download PDFInfo
- Publication number
- FI64367C FI64367C FI800556A FI800556A FI64367C FI 64367 C FI64367 C FI 64367C FI 800556 A FI800556 A FI 800556A FI 800556 A FI800556 A FI 800556A FI 64367 C FI64367 C FI 64367C
- Authority
- FI
- Finland
- Prior art keywords
- prazosinhydrochloride
- prazosin
- prazosin hydrochloride
- hydrochloride
- water
- Prior art date
Links
- 229960002386 prazosin hydrochloride Drugs 0.000 title description 14
- WFXFYZULCQKPIP-UHFFFAOYSA-N prazosin hydrochloride Chemical compound [H+].[Cl-].N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 WFXFYZULCQKPIP-UHFFFAOYSA-N 0.000 title description 12
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 18
- 238000000034 method Methods 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 description 4
- 229960001289 prazosin Drugs 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 238000010533 azeotropic distillation Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000002220 antihypertensive agent Substances 0.000 description 1
- 229940127088 antihypertensive drug Drugs 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI800556A FI64367C (fi) | 1980-02-26 | 1980-02-26 | Foerfarande foer framstaellning av alfa-form av prazosinhydroklorid |
| PT72511A PT72511B (en) | 1980-02-26 | 1981-02-16 | Process for the preparation of the alpha-form of prazosin hydrochloride |
| CS811167A CS216226B2 (en) | 1980-02-26 | 1981-02-18 | Method of making the forms of hydrochloride 2-+l 4-+l2-furoyl+p-piperazin-1-yl+p-4-amino-6,7-dimethoxychinazoline |
| NO810590A NO154461C (no) | 1980-02-26 | 1981-02-20 | Fremgangsmaate til fremstilling av aaa-formen av hydroklorid av prazosin 1 eller 2-(4-(2-furoyl)-piperazin-1-yl)-4-amino-6,7-dimetoksykinazolin. |
| DD81227817A DD156532A5 (de) | 1980-02-26 | 1981-02-23 | Verfahren zur herstellung der alpha-form von prazosinhydrochlorid |
| ES499796A ES499796A0 (es) | 1980-02-26 | 1981-02-25 | Un procedimiento para la preparacion de la forma a del hi- drocloruro de prazosin |
| HU81460A HU182297B (en) | 1980-02-26 | 1981-02-25 | Process for producing alpha-modification of prazosine-hydrochloride |
| DK084581A DK157548C (da) | 1980-02-26 | 1981-02-25 | Fremgangsmaade til fremstilling af den krystallinske alfa-form af hydrochloridet af prazosinchlorid |
| SU813247560A SU980621A3 (ru) | 1980-02-26 | 1981-02-25 | Способ получени @ -формы гидрохлорида працозина |
| PL1981229865A PL128350B1 (en) | 1980-02-26 | 1981-02-25 | Process for preparing alpha-prasosine hydrochloride |
| SE8101265A SE431873B (sv) | 1980-02-26 | 1981-02-26 | Forfarande for framstellning av alfa-form av prazosinhydroklorid |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI800556A FI64367C (fi) | 1980-02-26 | 1980-02-26 | Foerfarande foer framstaellning av alfa-form av prazosinhydroklorid |
| FI800556 | 1980-02-26 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI800556A7 FI800556A7 (fi) | 1981-08-27 |
| FI64367B FI64367B (fi) | 1983-07-29 |
| FI64367C true FI64367C (fi) | 1986-08-05 |
Family
ID=8513276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI800556A FI64367C (fi) | 1980-02-26 | 1980-02-26 | Foerfarande foer framstaellning av alfa-form av prazosinhydroklorid |
Country Status (11)
| Country | Link |
|---|---|
| CS (1) | CS216226B2 (cs) |
| DD (1) | DD156532A5 (cs) |
| DK (1) | DK157548C (cs) |
| ES (1) | ES499796A0 (cs) |
| FI (1) | FI64367C (cs) |
| HU (1) | HU182297B (cs) |
| NO (1) | NO154461C (cs) |
| PL (1) | PL128350B1 (cs) |
| PT (1) | PT72511B (cs) |
| SE (1) | SE431873B (cs) |
| SU (1) | SU980621A3 (cs) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI79107C (fi) * | 1984-06-25 | 1989-11-10 | Orion Yhtymae Oy | Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid. |
| KR100453097B1 (ko) * | 1995-09-06 | 2004-12-31 | 코와 가부시키가이샤 | 피리미딘유도체 |
-
1980
- 1980-02-26 FI FI800556A patent/FI64367C/fi not_active IP Right Cessation
-
1981
- 1981-02-16 PT PT72511A patent/PT72511B/pt not_active IP Right Cessation
- 1981-02-18 CS CS811167A patent/CS216226B2/cs unknown
- 1981-02-20 NO NO810590A patent/NO154461C/no unknown
- 1981-02-23 DD DD81227817A patent/DD156532A5/de not_active IP Right Cessation
- 1981-02-25 SU SU813247560A patent/SU980621A3/ru active
- 1981-02-25 ES ES499796A patent/ES499796A0/es active Granted
- 1981-02-25 PL PL1981229865A patent/PL128350B1/pl unknown
- 1981-02-25 HU HU81460A patent/HU182297B/hu not_active IP Right Cessation
- 1981-02-25 DK DK084581A patent/DK157548C/da not_active IP Right Cessation
- 1981-02-26 SE SE8101265A patent/SE431873B/sv not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES8201577A1 (es) | 1981-12-16 |
| NO810590L (no) | 1981-08-27 |
| SE431873B (sv) | 1984-03-05 |
| DK84581A (da) | 1981-08-27 |
| PL229865A1 (cs) | 1981-10-30 |
| DK157548C (da) | 1990-06-11 |
| HU182297B (en) | 1983-12-28 |
| FI64367B (fi) | 1983-07-29 |
| DK157548B (da) | 1990-01-22 |
| FI800556A7 (fi) | 1981-08-27 |
| DD156532A5 (de) | 1982-09-01 |
| NO154461B (no) | 1986-06-16 |
| SU980621A3 (ru) | 1982-12-07 |
| PL128350B1 (en) | 1984-01-31 |
| PT72511B (en) | 1983-02-01 |
| SE8101265L (sv) | 1981-08-27 |
| PT72511A (en) | 1981-03-01 |
| ES499796A0 (es) | 1981-12-16 |
| NO154461C (no) | 1986-09-24 |
| CS216226B2 (en) | 1982-10-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI64367C (fi) | Foerfarande foer framstaellning av alfa-form av prazosinhydroklorid | |
| US4665219A (en) | Isolation of neopentyl glycol hydroxypivalate | |
| EP0801064A1 (fr) | Procédé de préparation de l'acide 2-(2-(4((4-chlorophényl) phénylméthyl)-1-pipérazinyl)éthoxy)-acétique et de ses sels | |
| US4352941A (en) | Process for purification of phenylhydrazine | |
| RU2010769C1 (ru) | Способ выделения остаточных веществ из сточных вод синтеза 5-ами- но-4-хлор-2-фенил-3(2н)-пиридазинона | |
| SU389100A1 (ru) | Способ разделения моно- и диалкиловых эфиров фосфорной кислоты | |
| JPS6154027B2 (cs) | ||
| US5591889A (en) | Method for the synthesis of trisodium phosphonoformate hexahydrate | |
| EP0479960B1 (en) | Method for the synthesis of trisodium phosphonoformate hexahydrate | |
| SU639893A1 (ru) | Способ выделени триэтилендиамина | |
| JP2009263260A (ja) | スピロ化合物の製造方法 | |
| JPH07196610A (ja) | ５−クロロ−２−オキシンドールの製造法 | |
| SU519412A1 (ru) | Способ получени кислот и спиртов фуранового р да | |
| JPH08176044A (ja) | ２−ｔ−ブチルハイドロキノンの製造方法 | |
| US2161745A (en) | Tetrahydrofurfurylaminonaphthalene compounds and process for their preparation | |
| SU1384582A1 (ru) | Способ получени 6-или 8-оксизамещенных 2,2,4-триметил-1,2-ди или 1,2,3,4-тетрагидрохинолинов | |
| JPH0312067B2 (cs) | ||
| US4571429A (en) | Process for the preparation of o-carboethoxybenzenesulfonamide | |
| RU2203278C2 (ru) | Способ получения 5-хлор-4-амино-2,1,3-бензотиадиазола | |
| SU492514A1 (ru) | Способ получени анестезина | |
| JP2002179650A (ja) | イサチンビス（ｏ−クレゾール）の製造方法 | |
| SU149784A1 (ru) | Способ получени 2-4-6-коллидина | |
| SU1016284A1 (ru) | Способ очистки 6-бром-3-метилантрапиридона | |
| SU992513A1 (ru) | Способ получени замещенных нитротриптаминов или их гидрохлоридов | |
| SU384822A1 (cs) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: ORION-YHTYMAE OY |