CZ289278B6 - Benzimidazolové deriváty s antihistaminickou aktivitou - Google Patents

Benzimidazolové deriváty s antihistaminickou aktivitou Download PDF

Info

Publication number
CZ289278B6
CZ289278B6 CZ19971723A CZ172397A CZ289278B6 CZ 289278 B6 CZ289278 B6 CZ 289278B6 CZ 19971723 A CZ19971723 A CZ 19971723A CZ 172397 A CZ172397 A CZ 172397A CZ 289278 B6 CZ289278 B6 CZ 289278B6
Authority
CZ
Czechia
Prior art keywords
ethyl
phenyl
piperidin
dimethyl
benzimidazole
Prior art date
Application number
CZ19971723A
Other languages
Czech (cs)
English (en)
Other versions
CZ172397A3 (en
Inventor
Aurelio Orjales
Victor Rubio
Maravillas Bordell
Original Assignee
Fabrica Espaňola De Productos Quimicos Y Farmaceut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fabrica Espaňola De Productos Quimicos Y Farmaceut filed Critical Fabrica Espaňola De Productos Quimicos Y Farmaceut
Publication of CZ172397A3 publication Critical patent/CZ172397A3/cs
Publication of CZ289278B6 publication Critical patent/CZ289278B6/cs

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CZ19971723A 1996-06-04 1997-06-04 Benzimidazolové deriváty s antihistaminickou aktivitou CZ289278B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.

Publications (2)

Publication Number Publication Date
CZ172397A3 CZ172397A3 (en) 1997-12-17
CZ289278B6 true CZ289278B6 (cs) 2001-12-12

Family

ID=8295035

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ19971723A CZ289278B6 (cs) 1996-06-04 1997-06-04 Benzimidazolové deriváty s antihistaminickou aktivitou

Country Status (27)

Country Link
US (1) US5877187A (instruction)
EP (1) EP0818454B1 (instruction)
JP (1) JP4218991B2 (instruction)
CN (1) CN1105716C (instruction)
AR (1) AR008386A1 (instruction)
AT (1) ATE264317T1 (instruction)
AU (1) AU725700B2 (instruction)
BR (1) BR9703276A (instruction)
CA (1) CA2206754C (instruction)
CZ (1) CZ289278B6 (instruction)
DE (2) DE122011000006I1 (instruction)
DK (1) DK0818454T3 (instruction)
ES (1) ES2124167B1 (instruction)
FR (1) FR11C0023I2 (instruction)
HR (1) HRP970307B1 (instruction)
HU (1) HU227598B1 (instruction)
IN (1) IN186319B (instruction)
LU (1) LU91798I2 (instruction)
MX (1) MXPA97004127A (instruction)
NO (2) NO313195B1 (instruction)
PL (1) PL188908B1 (instruction)
PT (1) PT818454E (instruction)
RU (1) RU2182150C2 (instruction)
SI (1) SI0818454T1 (instruction)
TR (1) TR199700464A3 (instruction)
TW (1) TW438794B (instruction)
ZA (1) ZA974893B (instruction)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1314899A (zh) 1998-07-01 2001-09-26 武田药品工业株式会社 视黄酸类相关的受体机能调节剂
EP1133477B1 (de) 1998-11-27 2004-02-18 Abbott GmbH & Co. KG Substituierte benzimidazole und ihre verwendung als parp inhibitoren
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
RU2288917C2 (ru) * 2002-04-19 2006-12-10 Фаэс Фарма, С.А. Полиморф 4-[2-[4-[1-(2-этоксиэтил)-1h-бензимидазол-2-ил]-1-пиперидинил]этил]-альфа, альфа-диметилбензолуксусной кислоты, способ его получения, фармацевтический препарат на его основе и его применение
CZ305162B6 (cs) * 2002-04-19 2015-05-27 Faes Farma, S.A. Polymorf 1 bilastinu, způsob jeho přípravy a lékařské aplikace a farmaceutický přípravek s jeho obsahem
ES2277088T3 (es) * 2002-06-13 2007-07-01 Vertex Pharmaceuticals Incorporated Derivados del acido 2-ureido-6-heteroaril-3h-benzoimidazol-4-carboxilico y compuestos relacionados como inhibidores de girasa y/o topoisomerasa iv para el tratamiento de infecciones bacterianas.
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
CN104402773A (zh) 2008-02-12 2015-03-11 柳韩洋行 2-甲基-2’-苯基丙酸衍生物的制备方法和中间体化合物
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa 4−[2−[1−(2−エトキシエチル)−1H−ベンズイミダゾール−2−イル]−1−ピペリジニル]エチル]−α,α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
JP6284616B2 (ja) * 2013-03-15 2018-02-28 ハーキュリーズ・インコーポレーテッドHercules Incorporated 沈着特性が改善されたパーソナルケア組成物を生成する組成物及び方法
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
CA2993134A1 (en) * 2015-07-24 2017-02-02 Urquima, S.A. Crystalline forms of bilastine and preparation methods thereof
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
EP3452462A4 (en) * 2016-05-05 2019-10-23 MSN Laboratories Private Limited, R&D Center Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技(上海)有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
EP3453384B1 (en) 2017-09-07 2020-05-27 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine
AU2018353360B2 (en) 2017-10-16 2021-04-01 Faes Farma, S.A. Aqueous compositions comprising bilastine and mometasone
WO2019097091A1 (en) 2017-12-18 2019-05-23 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Pharmaceutical tablet composition comprising bilastine form 3 and a water-soluble filler
EP3470062B1 (en) 2017-12-18 2020-10-28 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine polymorphic form 3 and magnesium aluminometasilicate
CA3088740A1 (en) 2018-01-18 2019-07-25 Faes Farma, S.A. Ophthalmic compositions comprising bilastine, a beta-cyclodextrin and at least one gelling agent
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
CR20230109A (es) 2020-07-30 2023-05-11 Faes Farma Sa Sistema de liberación de fármacos descongestivos y bilastina
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
WO2022106923A1 (en) 2020-11-18 2022-05-27 BioPharma Synergies, S. L. Orodispersible powder composition comprising an antihistamine compound
EP4267109A1 (en) 2020-12-23 2023-11-01 Noucor Health S.A. A non-micronized bilastine composition
MX2024009978A (es) 2022-02-17 2024-08-26 Faes Farma Sa Composicion de bilastina para administracion parenteral una vez al dia.
WO2024224326A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine
WO2024224308A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine free of cyclodextrins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
AU7759591A (en) * 1990-04-13 1991-11-11 Smithkline Beecham Corporation Substituted benzimidazoles
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
AU675240B2 (en) * 1992-08-03 1997-01-30 Sepracor, Inc. Terfenadine metabolites and their optically pure isomers for treating allergic disorders
CN1275916C (zh) * 1993-06-25 2006-09-20 阿温蒂斯公司 用于制备抗组胺哌啶衍生物的新中间体

Also Published As

Publication number Publication date
ATE264317T1 (de) 2004-04-15
JP4218991B2 (ja) 2009-02-04
HRP970307B1 (en) 2002-02-28
JPH1059961A (ja) 1998-03-03
EP0818454A1 (en) 1998-01-14
HRP970307A2 (en) 1998-04-30
CA2206754C (en) 2007-01-23
LU91798I2 (fr) 2011-05-23
AR008386A1 (es) 2000-01-19
IN186319B (instruction) 2001-08-04
FR11C0023I1 (instruction) 2011-08-19
HUP9700997A1 (hu) 1999-09-28
NO972525L (no) 1997-12-05
PT818454E (pt) 2004-08-31
EP0818454B1 (en) 2004-04-14
BR9703276A (pt) 2004-08-17
ES2124167B1 (es) 1999-09-16
US5877187A (en) 1999-03-02
HU227598B1 (en) 2011-09-28
CA2206754A1 (en) 1997-12-04
TR199700464A2 (xx) 1997-12-21
TW438794B (en) 2001-06-07
NO313195B1 (no) 2002-08-26
FR11C0023I2 (fr) 2012-03-16
AU2467297A (en) 1997-12-11
CN1105716C (zh) 2003-04-16
HU9700997D0 (en) 1997-07-28
DE122011000006I1 (de) 2011-06-16
DE69728608D1 (de) 2004-05-19
ZA974893B (en) 1997-12-30
DE69728608T2 (de) 2005-04-21
SI0818454T1 (en) 2004-08-31
ES2124167A1 (es) 1999-01-16
DK0818454T3 (da) 2004-07-12
CZ172397A3 (en) 1997-12-17
RU2182150C2 (ru) 2002-05-10
AU725700B2 (en) 2000-10-19
NO972525D0 (no) 1997-06-03
NO2011008I1 (no) 2011-06-06
CN1176964A (zh) 1998-03-25
TR199700464A3 (tr) 1997-12-21
PL320358A1 (en) 1997-12-08
MXPA97004127A (es) 2005-07-25
NO2011008I2 (no) 2012-05-14
PL188908B1 (pl) 2005-05-31

Similar Documents

Publication Publication Date Title
CZ289278B6 (cs) Benzimidazolové deriváty s antihistaminickou aktivitou
CA2100503C (en) Piperidine derivatives of benzimidazole
US6130235A (en) Compounds and methods to treat cardiac failure and other disorders
JP3048067B2 (ja) 新規方法
EP1513826B1 (en) New indolylpiperidine derivatives as potent antihistaminic and antiallergic agents
US5019583A (en) N-phenyl-N-(4-piperidinyl)amides useful as analgesics
JP2944221B2 (ja) 新規複素環式化合物
US20030073699A1 (en) Compounds and methods to treat cardiac failure and other disorders
JP2000512646A (ja) 5ht7受容体アンタゴニストとしてのスルホンアミド誘導体
JP3060054B2 (ja) ベンゾイミダゾールから誘導される非鎮静性抗ヒスタミン作用を有する新規化合物
KR100683454B1 (ko) 항히스타민제 그리고 항알레르기제로서의 인돌일피페리딘유도체
JP2002541104A (ja) ピロリジン系ケモカイン受容体活性調節剤
CZ316497A3 (cs) Nové heterocyklické sloučeniny
US6054458A (en) Heterocyclic compounds
FI91748B (fi) Menetelmä terapeuttisesti käyttökelpoisten kinolinonijohdannaisten valmistamiseksi
DK167118B1 (da) Substituerede benzylphthalazinonderivater, fremgangsmaade til fremstilling deraf, laegemidler indeholdende derivaterne, samt anvendelse af derivaterne til fremstilling af laegemidler
JP6585718B2 (ja) 抗ヒスタミン剤としての新規ベンゾイミダゾール誘導体
RU2418794C2 (ru) ПРОИЗВОДНЫЕ ИЗОХИНОЛИНА И БЕНЗО[h]ИЗОХИНОЛИНА, ИХ ПОЛУЧЕНИЕ И ИХ ПРИМЕНЕНИЕ В ТЕРАПИИ В КАЧЕСТВЕ АНТАГОНИСТОВ РЕЦЕПТОРА ГИСТАМИНА H3
CZ46896A3 (en) Anti-migraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridinyl and -pyrimidinyl piperazines
JPH08151377A (ja) キナゾリン誘導体
KR100494448B1 (ko) 항히스타민활성을가지는신규한벤조이미다졸유도체
JP2573195B2 (ja) 環状アミン誘導体
WO1991000275A1 (en) Butane compounds or salts thereof and their medical uses

Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic
MK4A Patent expired

Effective date: 20170604

MK4A Patent expired

Effective date: 20220604