CZ284209B6 - 7-Nitro-9-substituovaný amino-6-demethyl-6-deoxytetracykliny a způsoby jejich výroby - Google Patents

7-Nitro-9-substituovaný amino-6-demethyl-6-deoxytetracykliny a způsoby jejich výroby Download PDF

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Publication number
CZ284209B6
CZ284209B6 CZ973093A CZ309397A CZ284209B6 CZ 284209 B6 CZ284209 B6 CZ 284209B6 CZ 973093 A CZ973093 A CZ 973093A CZ 309397 A CZ309397 A CZ 309397A CZ 284209 B6 CZ284209 B6 CZ 284209B6
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CZ
Czechia
Prior art keywords
group
amino
alkyl
carbon atoms
substituted
Prior art date
Application number
CZ973093A
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Czech (cs)
English (en)
Other versions
CZ309397A3 (cs
Inventor
Joseph J. Hlavka
Phaid-Eng Sum
Yakov Gluzman
Ving J. Lee
Adma A. Ross
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American Cyanamid Company
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Application filed by American Cyanamid Company filed Critical American Cyanamid Company
Publication of CZ309397A3 publication Critical patent/CZ309397A3/cs
Publication of CZ284209B6 publication Critical patent/CZ284209B6/cs

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Moulding By Coating Moulds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
CZ973093A 1991-10-04 1992-09-30 7-Nitro-9-substituovaný amino-6-demethyl-6-deoxytetracykliny a způsoby jejich výroby CZ284209B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77157691A 1991-10-04 1991-10-04

Publications (2)

Publication Number Publication Date
CZ309397A3 CZ309397A3 (cs) 1998-09-16
CZ284209B6 true CZ284209B6 (cs) 1998-09-16

Family

ID=25092264

Family Applications (2)

Application Number Title Priority Date Filing Date
CZ973093A CZ284209B6 (cs) 1991-10-04 1992-09-30 7-Nitro-9-substituovaný amino-6-demethyl-6-deoxytetracykliny a způsoby jejich výroby
CS922984A CZ284159B6 (cs) 1991-10-04 1992-09-30 7-Substituovaný-9-substituovaný amino-6-demethyl-6-deoxytetracykliny, způsoby a meziprodukty pro jejich výrobu s farmaceutické prostředky na jejich bázi

Family Applications After (1)

Application Number Title Priority Date Filing Date
CS922984A CZ284159B6 (cs) 1991-10-04 1992-09-30 7-Substituovaný-9-substituovaný amino-6-demethyl-6-deoxytetracykliny, způsoby a meziprodukty pro jejich výrobu s farmaceutické prostředky na jejich bázi

Country Status (27)

Country Link
EP (1) EP0536515B1 (Direct)
JP (1) JP3186863B2 (Direct)
KR (1) KR100269072B1 (Direct)
CN (1) CN1048240C (Direct)
AT (1) ATE211128T1 (Direct)
AU (1) AU654049B2 (Direct)
BR (1) BR1100853A (Direct)
CA (1) CA2079692C (Direct)
CL (1) CL2004001623A1 (Direct)
CZ (2) CZ284209B6 (Direct)
DE (4) DE122006000058I1 (Direct)
DK (1) DK0536515T3 (Direct)
ES (1) ES2168254T3 (Direct)
FI (1) FI114911B (Direct)
HU (2) HU219973B (Direct)
IL (3) IL119590A (Direct)
LU (1) LU91279I2 (Direct)
MX (1) MX9205532A (Direct)
NL (1) NL300244I2 (Direct)
NO (3) NO301472B1 (Direct)
NZ (1) NZ244585A (Direct)
PL (4) PL173311B1 (Direct)
PT (1) PT536515E (Direct)
SG (1) SG52361A1 (Direct)
SK (2) SK280837B6 (Direct)
TW (1) TW275616B (Direct)
ZA (1) ZA927607B (Direct)

Families Citing this family (39)

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US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
JP2784847B2 (ja) * 1994-02-17 1998-08-06 ファイザー インク． ９−（置換アミノ）−アルファ−６−デオキシ−５−オキシテトラサイクリン誘導体、それらの製造及び、抗生物質としてのそれらの使用
CN102336680A (zh) 1999-09-14 2012-02-01 塔夫茨大学信托人 用基于过渡金属的化学制备取代四环素的方法
US8106225B2 (en) 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
EA200201046A1 (ru) * 2000-03-31 2003-04-24 Трастис Оф Тафтс Коллидж 7- или 9-замещенные соединения тетрациклина, способ их получения (варианты), фармацевтическая композиция, способ лечения состояния, чувствительного к действию тетрациклина, у млекопитающего и реакционноспособное промежуточное производное
EP1286954B1 (en) * 2000-05-15 2004-04-14 Paratek Pharmaceuticals, Inc. 7-substituted fused ring tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
ATE336481T1 (de) 2000-07-07 2006-09-15 Tufts College 9-substituierte minocyclinverbindungen
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
IL157860A0 (en) 2001-03-13 2004-03-28 Paratek Pharm Innc 7,9-substituted tetracycline compounds
WO2002072506A2 (en) 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP1241160A1 (en) 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
ES2338994T3 (es) * 2001-04-24 2010-05-14 Paratek Pharmaceuticals, Inc. Compuestos de tetraciclina sustituida para el tratamiento de la malaria.
EP1408987B1 (en) 2001-07-13 2013-04-10 Paratek Pharmaceuticals, Inc. Tetracycline compounds having target therapeutic activities
AU2002365120A1 (en) 2001-08-02 2003-07-15 Paratek Pharmaceuticals, Inc. Medicaments
AU2003235759A1 (en) 2002-01-08 2003-07-24 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
AU2003220123B2 (en) * 2002-03-08 2009-05-07 Paratek Pharmaceuticals, Inc. Amino-methyl substituted tetracycline compounds
EA201100956A1 (ru) 2003-07-09 2012-01-30 Пэрэтек Фамэсьютикэлс, Инк. Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
UA83266C2 (en) * 2003-12-08 2008-06-25 Уайет Oxazole derivatives of tetracyclines
WO2005112945A2 (en) 2004-05-21 2005-12-01 The President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
PA8652001A1 (es) 2004-11-05 2006-10-13 Wyeth Corp Metabolitos glucuronidos de tigeciclina y epimeros de los mismos
AR057649A1 (es) 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
JP2009507793A (ja) * 2005-08-31 2009-02-26 ワイス グリシルサイクリンの９−アミノカルボニル置換誘導体
CA2652346A1 (en) 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
US8518912B2 (en) 2007-11-29 2013-08-27 Actelion Pharmaceuticals Ltd. Phosphonic acid derivates and their use as P2Y12 receptor antagonists
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
ITMI20080807A1 (it) 2008-05-05 2009-11-06 Antibioticos Spa Procedimento per la preparazione di tigeciclina in forma amorfa
TW202436282A (zh) 2008-05-19 2024-09-16 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體
RS54485B1 (sr) * 2008-08-08 2016-06-30 Tetraphase Pharmaceuticals, Inc. C7-fluoro supstituisana tetraciklinska jedinjenja
WO2010126607A2 (en) 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
ES2627772T3 (es) 2009-05-08 2017-07-31 Tetraphase Pharmaceuticals, Inc. Compuestos de tetraciclina
CN102596898B (zh) * 2009-08-28 2016-01-27 四相制药公司 四环素类化合物
PT2568987T (pt) 2010-05-12 2017-02-03 Rempex Pharmaceuticals Inc Composições de tetraciclina
WO2013013504A1 (zh) * 2011-07-26 2013-01-31 山东亨利医药科技有限责任公司 替加环素衍生物
SI2890673T1 (sl) 2012-08-31 2019-05-31 Tetraphase Pharmaceuticals, Inc. Spojine tetraciklina
EP3068370A2 (en) 2013-11-12 2016-09-21 Galenicum Health S.L. Stable pharmaceutical compositions
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US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3579579A (en) * 1968-04-18 1971-05-18 American Cyanamid Co Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines

Also Published As

Publication number Publication date
HU9203110D0 (en) 1992-12-28
BR1100853A (pt) 1999-12-07
CA2079692C (en) 2004-06-08
ZA927607B (en) 1993-04-13
DE69232302D1 (de) 2002-01-31
HU219973B (hu) 2001-10-28
NO2017037I2 (no) 2017-08-01
IL103320A (en) 1998-12-06
NO301472B1 (no) 1997-11-03
DE69232302T2 (de) 2002-08-14
PT536515E (pt) 2002-05-31
HU211172A9 (en) 1995-11-28
JPH05255219A (ja) 1993-10-05
HUT63145A (en) 1993-07-28
CZ309397A3 (cs) 1998-09-16
SK114999A3 (en) 2000-07-11
DE122006000058I1 (de) 2007-01-18
LU91279I2 (fr) 2006-12-11
EP0536515B1 (en) 2001-12-19
HK1011348A1 (en) 1999-07-09
CN1072172A (zh) 1993-05-19
FI924454L (fi) 1993-04-05
CZ298492A3 (en) 1993-05-12
SG52361A1 (en) 1998-09-28
DK0536515T3 (da) 2002-04-08
FI924454A0 (fi) 1992-10-02
CL2004001623A1 (es) 2005-06-03
DE122006000058I2 (de) 2007-09-13
IL119590A (en) 1999-03-12
NL300244I1 (nl) 2007-01-02
NL300244I2 (nl) 2007-01-02
NO923857D0 (no) 1992-10-02
TW275616B (Direct) 1996-05-11
CA2079692A1 (en) 1993-04-05
PL176333B1 (pl) 1999-05-31
KR100269072B1 (ko) 2000-10-16
DE69232302T4 (de) 2003-02-13
ES2168254T3 (es) 2002-06-16
PL296143A1 (en) 1993-05-31
IL103320A0 (en) 1993-03-15
AU654049B2 (en) 1994-10-20
NO2006015I2 (no) 2011-03-14
SK280837B6 (sk) 2000-08-14
PL172282B1 (pl) 1997-08-29
PL175957B1 (pl) 1999-03-31
EP0536515A1 (en) 1993-04-14
ATE211128T1 (de) 2002-01-15
SK284826B6 (sk) 2005-12-01
JP3186863B2 (ja) 2001-07-11
AU2618392A (en) 1993-04-08
FI114911B (fi) 2005-01-31
IL119590A0 (en) 1997-02-18
CZ284159B6 (cs) 1998-08-12
CN1048240C (zh) 2000-01-12
NZ244585A (en) 1995-07-26
SK298492A3 (en) 1995-03-08
KR930007894A (ko) 1993-05-20
NO923857L (no) 1993-04-05
NO2006015I1 (no) 2006-11-27
MX9205532A (es) 1993-04-01
PL173311B1 (pl) 1998-02-27
NO2017037I1 (no) 2017-08-01

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Effective date: 20120930