MX9205532A - Nuevas 7-sustituidas-9-amino sustituidas 6-desmetil-6-desoxitetraciclinas, metodo para su producciony composicion farmaceutica que las contiene. - Google Patents

Nuevas 7-sustituidas-9-amino sustituidas 6-desmetil-6-desoxitetraciclinas, metodo para su producciony composicion farmaceutica que las contiene.

Info

Publication number
MX9205532A
MX9205532A MX9205532A MX9205532A MX9205532A MX 9205532 A MX9205532 A MX 9205532A MX 9205532 A MX9205532 A MX 9205532A MX 9205532 A MX9205532 A MX 9205532A MX 9205532 A MX9205532 A MX 9205532A
Authority
MX
Mexico
Prior art keywords
substituted
desoxitetraciclinas
desmetil
new
production
Prior art date
Application number
MX9205532A
Other languages
English (en)
Inventor
Joseph J Hlavka
Phaik-Eng Sum
Yacov Gluzman
Ving J Lee
Adma A Ross
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25092264&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9205532(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of MX9205532A publication Critical patent/MX9205532A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
MX9205532A 1991-10-04 1992-09-29 Nuevas 7-sustituidas-9-amino sustituidas 6-desmetil-6-desoxitetraciclinas, metodo para su producciony composicion farmaceutica que las contiene. MX9205532A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77157691A 1991-10-04 1991-10-04

Publications (1)

Publication Number Publication Date
MX9205532A true MX9205532A (es) 1993-04-01

Family

ID=25092264

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9205532A MX9205532A (es) 1991-10-04 1992-09-29 Nuevas 7-sustituidas-9-amino sustituidas 6-desmetil-6-desoxitetraciclinas, metodo para su producciony composicion farmaceutica que las contiene.

Country Status (28)

Country Link
EP (1) EP0536515B1 (es)
JP (1) JP3186863B2 (es)
KR (1) KR100269072B1 (es)
CN (1) CN1048240C (es)
AT (1) ATE211128T1 (es)
AU (1) AU654049B2 (es)
BR (1) BR1100853A (es)
CA (1) CA2079692C (es)
CL (1) CL2004001623A1 (es)
CZ (2) CZ284209B6 (es)
DE (4) DE69232302D1 (es)
DK (1) DK0536515T3 (es)
ES (1) ES2168254T3 (es)
FI (1) FI114911B (es)
HK (1) HK1011348A1 (es)
HU (2) HU219973B (es)
IL (3) IL103320A (es)
LU (1) LU91279I2 (es)
MX (1) MX9205532A (es)
NL (1) NL300244I1 (es)
NO (3) NO301472B1 (es)
NZ (1) NZ244585A (es)
PL (4) PL175957B1 (es)
PT (1) PT536515E (es)
SG (1) SG52361A1 (es)
SK (2) SK280837B6 (es)
TW (1) TW275616B (es)
ZA (1) ZA927607B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
AU1279095A (en) * 1994-02-17 1995-09-04 Pfizer Inc. 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
CN102336680A (zh) 1999-09-14 2012-02-01 塔夫茨大学信托人 用基于过渡金属的化学制备取代四环素的方法
US8106225B2 (en) 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6818634B2 (en) * 2000-03-31 2004-11-16 Paratek Pharmaceuticals, Inc. 7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds
CA2409063A1 (en) * 2000-05-15 2001-11-22 Mark L. Nelson 7-substituted fused ring tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
CA2415178C (en) * 2000-07-07 2010-05-25 Trustees Of Tufts College 9-substituted minocycline compounds
AU2002250331A1 (en) 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP2301914A1 (en) 2001-03-13 2011-03-30 Paratek Pharmaceuticals, Inc. 7,9-Substituted tetracycline compounds
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EP1241160A1 (en) 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
EP1399414B1 (en) * 2001-04-24 2010-01-13 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
EP2329828A1 (en) 2001-07-13 2011-06-08 Paratek Pharmaceuticals, Inc. Tetracyclines for the treatment of ischaemia
WO2003055441A2 (en) 2001-08-02 2003-07-10 Paratek Pharmaceuticals, Inc. Medicaments
US7056902B2 (en) 2002-01-08 2006-06-06 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
WO2003075857A2 (en) * 2002-03-08 2003-09-18 Paratek Pharmaceuticals, Inc. Amino-methyl substituted tetracycline compounds
CN101786991A (zh) 2003-07-09 2010-07-28 帕拉特克药品公司 取代的四环素化合物
UA83266C2 (en) * 2003-12-08 2008-06-25 Уайет Oxazole derivatives of tetracyclines
CA2767912C (en) 2004-05-21 2015-08-11 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
PA8652001A1 (es) 2004-11-05 2006-10-13 Wyeth Corp Metabolitos glucuronidos de tigeciclina y epimeros de los mismos
AR057649A1 (es) 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
RU2008108215A (ru) * 2005-08-31 2009-10-10 Вайет (Us) 9-аминокарбонилзамещенные производные глицилциклинов
JP2009543544A (ja) 2006-05-15 2009-12-10 パラテック ファーマシューティカルズ インコーポレイテッド 置換されたテトラサイクリン化合物を用いて、遺伝子または遺伝子産物の発現を調節する方法
RU2483072C2 (ru) 2007-11-29 2013-05-27 Актелион Фармасьютиклз Лтд Производные фосфоновой кислоты и их применение в качестве антагонистов рецептора p2y12
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
ITMI20080807A1 (it) 2008-05-05 2009-11-06 Antibioticos Spa Procedimento per la preparazione di tigeciclina in forma amorfa
TW202216656A (zh) 2008-05-23 2022-05-01 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體
RS54485B1 (en) * 2008-08-08 2016-06-30 Tetraphase Pharmaceuticals, Inc. C7-FLUORO SUBSTITUTED TETRACYCLINE UNITS
US9073829B2 (en) 2009-04-30 2015-07-07 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
CN102459153A (zh) 2009-05-08 2012-05-16 四相制药公司 四环素类化合物
CN102596898B (zh) 2009-08-28 2016-01-27 四相制药公司 四环素类化合物
SG185513A1 (en) 2010-05-12 2012-12-28 Rempex Pharmaceuticals Inc Tetracycline compositions
CN103635456B (zh) * 2011-07-26 2016-03-09 山东亨利医药科技有限责任公司 替加环素衍生物
WO2014036502A2 (en) 2012-08-31 2014-03-06 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
WO2015071299A2 (en) 2013-11-12 2015-05-21 Galenicum Health S.L. Stable pharmaceutical compositions
MA46567A (fr) 2016-10-19 2019-08-28 Tetraphase Pharmaceuticals Inc Formes cristallines de l'éravacycline

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3579579A (en) * 1968-04-18 1971-05-18 American Cyanamid Co Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines

Also Published As

Publication number Publication date
SK284826B6 (sk) 2005-12-01
NO923857L (no) 1993-04-05
TW275616B (es) 1996-05-11
SK280837B6 (sk) 2000-08-14
HK1011348A1 (en) 1999-07-09
FI114911B (fi) 2005-01-31
IL119590A (en) 1999-03-12
CA2079692A1 (en) 1993-04-05
PL175957B1 (pl) 1999-03-31
ES2168254T3 (es) 2002-06-16
NO2017037I1 (no) 2017-08-01
DE69232302D1 (de) 2002-01-31
FI924454A0 (fi) 1992-10-02
NL300244I2 (nl) 2007-01-02
CN1048240C (zh) 2000-01-12
HU219973B (hu) 2001-10-28
KR930007894A (ko) 1993-05-20
PT536515E (pt) 2002-05-31
DE69232302T2 (de) 2002-08-14
FI924454A (fi) 1993-04-05
CN1072172A (zh) 1993-05-19
BR1100853A (pt) 1999-12-07
CZ298492A3 (en) 1993-05-12
NO2006015I1 (no) 2006-11-27
SG52361A1 (en) 1998-09-28
JPH05255219A (ja) 1993-10-05
CA2079692C (en) 2004-06-08
SK298492A3 (en) 1995-03-08
LU91279I2 (fr) 2006-12-11
CZ309397A3 (cs) 1998-09-16
EP0536515A1 (en) 1993-04-14
AU2618392A (en) 1993-04-08
HU9203110D0 (en) 1992-12-28
CZ284209B6 (cs) 1998-09-16
PL296143A1 (en) 1993-05-31
NO923857D0 (no) 1992-10-02
IL103320A (en) 1998-12-06
NZ244585A (en) 1995-07-26
DK0536515T3 (da) 2002-04-08
DE69232302T4 (de) 2003-02-13
DE122006000058I1 (de) 2007-01-18
HUT63145A (en) 1993-07-28
ZA927607B (en) 1993-04-13
IL103320A0 (en) 1993-03-15
AU654049B2 (en) 1994-10-20
CL2004001623A1 (es) 2005-06-03
DE122006000058I2 (de) 2007-09-13
NO2006015I2 (no) 2011-03-14
SK114999A3 (en) 2000-07-11
NO2017037I2 (no) 2017-08-01
EP0536515B1 (en) 2001-12-19
IL119590A0 (en) 1997-02-18
ATE211128T1 (de) 2002-01-15
CZ284159B6 (cs) 1998-08-12
PL176333B1 (pl) 1999-05-31
NO301472B1 (no) 1997-11-03
PL173311B1 (pl) 1998-02-27
NL300244I1 (nl) 2007-01-02
JP3186863B2 (ja) 2001-07-11
KR100269072B1 (ko) 2000-10-16
PL172282B1 (pl) 1997-08-29
HU211172A9 (en) 1995-11-28

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