NO2006015I1 - Tygacil-tigecyklin - Google Patents

Tygacil-tigecyklin

Info

Publication number
NO2006015I1
NO2006015I1 NO2006015C NO2006015C NO2006015I1 NO 2006015 I1 NO2006015 I1 NO 2006015I1 NO 2006015 C NO2006015 C NO 2006015C NO 2006015 C NO2006015 C NO 2006015C NO 2006015 I1 NO2006015 I1 NO 2006015I1
Authority
NO
Norway
Prior art keywords
tygacil
tigecycline
Prior art date
Application number
NO2006015C
Other languages
English (en)
Other versions
NO2006015I2 (no
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US77157691A priority Critical
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25092264&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO2006015(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO2006015I1 publication Critical patent/NO2006015I1/no
Publication of NO2006015I2 publication Critical patent/NO2006015I2/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/44Acylated amino or imino radicals
    • C07D277/46Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30Hetero atoms other than halogen
    • C07D333/34Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/40Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/461,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
NO2006015C 1991-10-04 2006-11-15 Tigecyklin. NO2006015I2 (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US77157691A true 1991-10-04 1991-10-04

Publications (2)

Publication Number Publication Date
NO2006015I1 true NO2006015I1 (no) 2006-11-27
NO2006015I2 NO2006015I2 (no) 2011-03-14

Family

ID=25092264

Family Applications (3)

Application Number Title Priority Date Filing Date
NO923857A NO301472B1 (no) 1991-10-04 1992-10-02 Nye 7-substituerte-9-substituert amino-6-demetyl-6-deoksytetracykliner, og preparater derav
NO2006015C NO2006015I2 (no) 1991-10-04 2006-11-15 Tigecyklin.
NO2017037C NO2017037I1 (no) 1991-10-04 2017-08-01 Tygacil er et antibiotika inneholdende en tetracyklinforbindelse betegnet tigecyklin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO923857A NO301472B1 (no) 1991-10-04 1992-10-02 Nye 7-substituerte-9-substituert amino-6-demetyl-6-deoksytetracykliner, og preparater derav

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2017037C NO2017037I1 (no) 1991-10-04 2017-08-01 Tygacil er et antibiotika inneholdende en tetracyklinforbindelse betegnet tigecyklin

Country Status (28)

Country Link
EP (1) EP0536515B1 (no)
JP (1) JP3186863B2 (no)
KR (1) KR100269072B1 (no)
CN (1) CN1048240C (no)
AT (1) AT211128T (no)
AU (1) AU654049B2 (no)
BR (1) BR1100853A (no)
CA (1) CA2079692C (no)
CL (1) CL2004001623A1 (no)
CZ (2) CZ309397A3 (no)
DE (4) DE69232302T4 (no)
DK (1) DK0536515T3 (no)
ES (1) ES2168254T3 (no)
FI (1) FI114911B (no)
HK (1) HK1011348A1 (no)
HU (2) HU219973B (no)
IL (3) IL103320A (no)
LU (1) LU91279I2 (no)
MX (1) MX9205532A (no)
NL (1) NL300244I1 (no)
NO (3) NO301472B1 (no)
NZ (1) NZ244585A (no)
PL (4) PL176333B1 (no)
PT (1) PT536515E (no)
SG (1) SG52361A1 (no)
SK (2) SK284826B6 (no)
TW (1) TW275616B (no)
ZA (1) ZA9207607B (no)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
JP2784847B2 (ja) * 1994-02-17 1998-08-06 ファイザー インク. 9−(置換アミノ)−アルファ−6−デオキシ−5−オキシテトラサイクリン誘導体、それらの製造及び、抗生物質としてのそれらの使用
US8106225B2 (en) 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
CZ301835B6 (cs) 1999-09-14 2010-07-07 Trustees Of Tufts College Zpusob prípravy 7-, 9- nebo 13- substituované tetracyklinové slouceniny, reaktivní tetracyklinový chemický komplex a tetracyklinová sloucenina substituovaná v poloze 7 nebo 9
MXPA02009482A (es) 2000-03-31 2004-05-14 Tufts College SUBSTITUTED TETRACICLINE COMPOUNDS WITH GROUPS 7- AND 9- CARBAMATO, UREA, TIOUREA, THIOCARBAMATE AND HETEROARIL-AMINO.
DE60102815D1 (de) * 2000-05-15 2004-05-19 Paratek Pharm Innc 7-substituierte kondensierte ring-tetrazyclin- verbindungen
ES2271070T3 (es) * 2000-07-07 2007-04-16 Paratek Pharmaceuticals, Inc. Compuestos de minociclina 9-sustituidos.
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
EP1241160A1 (en) 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
EP2301913A1 (en) 2001-03-13 2011-03-30 Paratek Pharmaceuticals, Inc. 7,9-Substituted tetracycline compounds
AU2002250331A1 (en) 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
DE60235083D1 (de) * 2001-04-24 2010-03-04 Paratek Pharm Innc Substituierte tetracyclin-verbindungen zur behandlung von malaria
EP2332547A1 (en) 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Tetracyclines for the treatment of inflammatory bowel disease
WO2003055441A2 (en) 2001-08-02 2003-07-10 Paratek Pharmaceuticals, Inc. Medicaments
EP1474380A4 (en) 2002-01-08 2007-04-18 Paratek Pharm Innc 4-dedimethylamino tetracycline compounds
IL163931D0 (en) * 2002-03-08 2005-12-18 Paratek Pharm Innc Amino-methyl substituted tetracyline compounds
EA200600221A1 (ru) 2003-07-09 2006-06-30 Пэрэтек Фамэсьютикэлс, Инк. Замещённые соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
UA83268C2 (xx) * 2003-12-08 2008-06-25 Байер Кропсайенс Акциенгезелльшафт Інсектицидний засіб[инсектицидное средство
CA2892332C (en) 2004-05-21 2017-03-21 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
PA8652001A1 (es) 2004-11-05 2006-10-13 Wyeth Corp Metabolitos glucuronidos de tigeciclina y epimeros de los mismos
AR057649A1 (es) 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
BRPI0615300A2 (pt) * 2005-08-31 2009-07-14 Wyeth Corp composto; composição farmacêutica; método para a preparação, tratamento ou controle de infecções bacterianas em animais de sangue quente; uso de um composto; e método para a preparação de compostos representados pela fórmula (i)
WO2007133797A2 (en) 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
PL2225253T3 (xx) 2007-11-29 2012-11-30 Idorsia Pharmaceuticals Ltd Phosphonic acid derivatives and their use as P2Y12 receptor antagonists
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
ITMI20080807A1 (it) 2008-05-05 2009-11-06 Antibioticos Spa Procedimento per la preparazione di tigeciclina in forma amorfa
TWI585071B (zh) 2008-05-23 2017-06-01 派洛泰克藥物股份有限公司 Tetracycline compound tosylate and allotrope
CN102177134B (zh) * 2008-08-08 2014-04-16 麻州四期制药公司 C7-氟取代的四环素化合物
US9073829B2 (en) 2009-04-30 2015-07-07 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
EP2427425B1 (en) 2009-05-08 2017-03-08 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
EP2470500B1 (en) * 2009-08-28 2017-10-04 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
EP3135289B1 (en) 2010-05-12 2018-12-12 Rempex Pharmaceuticals, Inc. Tetracycline compositions
WO2013013504A1 (zh) * 2011-07-26 2013-01-31 山东亨利医药科技有限责任公司 替加环素衍生物
CN108276404A (zh) 2012-08-31 2018-07-13 四相制药公司 四环素化合物
EP3068370A2 (en) 2013-11-12 2016-09-21 Galenicum Health S.L. Stable pharmaceutical compositions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3579579A (en) * 1968-04-18 1971-05-18 American Cyanamid Co Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines

Also Published As

Publication number Publication date
JPH05255219A (ja) 1993-10-05
DK0536515T3 (da) 2002-04-08
IL103320D0 (en) 1993-03-15
CZ284159B6 (cs) 1998-08-12
CL2004001623A1 (es) 2005-06-03
NO2017037I2 (no) 2017-08-01
NO923857L (no) 1993-04-05
HUT63145A (en) 1993-07-28
CN1048240C (zh) 2000-01-12
IL119590D0 (en) 1997-02-18
ZA9207607B (en) 1993-04-13
PL173311B1 (xx) 1998-02-27
IL103320A (en) 1998-12-06
CZ298492A3 (en) 1993-05-12
TW275616B (no) 1996-05-11
SK298492A3 (en) 1995-03-08
PL296143A1 (en) 1993-05-31
KR100269072B1 (ko) 2000-10-16
SK280837B6 (sk) 2000-08-14
EP0536515B1 (en) 2001-12-19
LU91279I2 (fr) 2006-12-11
HK1011348A1 (en) 1999-07-09
FI924454A0 (fi) 1992-10-02
CA2079692C (en) 2004-06-08
HU211172A9 (en) 1995-11-28
AU2618392A (en) 1993-04-08
AT211128T (de) 2002-01-15
DE122006000058I1 (de) 2007-01-18
LU91279A9 (no)
NZ244585A (en) 1995-07-26
JP3186863B2 (ja) 2001-07-11
DE69232302D1 (de) 2002-01-31
SK284826B6 (sk) 2005-12-01
SK114999A3 (en) 2000-07-11
FI924454A (fi) 1993-04-05
NO2017037I1 (no) 2017-08-01
HU9203110D0 (en) 1992-12-28
KR930007894A (ko) 1993-05-20
IL119590A (en) 1999-03-12
CZ309397A3 (cs) 1998-09-16
PT536515E (pt) 2002-05-31
NL300244I1 (nl) 2007-01-02
AU654049B2 (en) 1994-10-20
FI924454D0 (no)
HU219973B (hu) 2001-10-28
CA2079692A1 (en) 1993-04-05
MX9205532A (es) 1993-04-01
NL300244I2 (nl) 2007-01-02
DE69232302T4 (de) 2003-02-13
NO923857D0 (no) 1992-10-02
ES2168254T3 (es) 2002-06-16
PL172282B1 (pl) 1997-08-29
FI114911B (fi) 2005-01-31
NO301472B1 (no) 1997-11-03
FI114911B1 (no)
BR1100853A (pt) 1999-12-07
PL176333B1 (xx) 1999-05-31
DE69232302T2 (de) 2002-08-14
DE122006000058I2 (de) 2007-09-13
EP0536515A1 (en) 1993-04-14
PL175957B1 (xx) 1999-03-31
CZ284209B6 (cs) 1998-09-16
CN1072172A (zh) 1993-05-19
SG52361A1 (en) 1998-09-28
NO2006015I2 (no) 2011-03-14

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Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: WYETH HOLDINGS LLC, US