ZA927607B - Novel 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines. - Google Patents

Novel 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines.

Info

Publication number
ZA927607B
ZA927607B ZA927607A ZA927607A ZA927607B ZA 927607 B ZA927607 B ZA 927607B ZA 927607 A ZA927607 A ZA 927607A ZA 927607 A ZA927607 A ZA 927607A ZA 927607 B ZA927607 B ZA 927607B
Authority
ZA
South Africa
Prior art keywords
substituted
novel
demethyl
deoxytetracyclines
substituted amino
Prior art date
Application number
ZA927607A
Other languages
English (en)
Inventor
Joseph J Hlavka
Phaik-Eng Sum
Yakov Gluzman
Ving J Lee
Adma A Ross
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25092264&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA927607(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ZA927607B publication Critical patent/ZA927607B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
ZA927607A 1991-10-04 1992-10-02 Novel 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines. ZA927607B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77157691A 1991-10-04 1991-10-04

Publications (1)

Publication Number Publication Date
ZA927607B true ZA927607B (en) 1993-04-13

Family

ID=25092264

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA927607A ZA927607B (en) 1991-10-04 1992-10-02 Novel 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines.

Country Status (28)

Country Link
EP (1) EP0536515B1 (no)
JP (1) JP3186863B2 (no)
KR (1) KR100269072B1 (no)
CN (1) CN1048240C (no)
AT (1) ATE211128T1 (no)
AU (1) AU654049B2 (no)
BR (1) BR1100853A (no)
CA (1) CA2079692C (no)
CL (1) CL2004001623A1 (no)
CZ (2) CZ284159B6 (no)
DE (4) DE69232302T4 (no)
DK (1) DK0536515T3 (no)
ES (1) ES2168254T3 (no)
FI (1) FI114911B (no)
HK (1) HK1011348A1 (no)
HU (2) HU219973B (no)
IL (3) IL103320A (no)
LU (1) LU91279I2 (no)
MX (1) MX9205532A (no)
NL (1) NL300244I1 (no)
NO (3) NO301472B1 (no)
NZ (1) NZ244585A (no)
PL (4) PL173311B1 (no)
PT (1) PT536515E (no)
SG (1) SG52361A1 (no)
SK (2) SK280837B6 (no)
TW (1) TW275616B (no)
ZA (1) ZA927607B (no)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
WO1995022529A1 (en) * 1994-02-17 1995-08-24 Pfizer Inc. 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
US8106225B2 (en) 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
CZ301835B6 (cs) 1999-09-14 2010-07-07 Trustees Of Tufts College Zpusob prípravy 7-, 9- nebo 13- substituované tetracyklinové slouceniny, reaktivní tetracyklinový chemický komplex a tetracyklinová sloucenina substituovaná v poloze 7 nebo 9
US6818634B2 (en) * 2000-03-31 2004-11-16 Paratek Pharmaceuticals, Inc. 7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds
US6642270B2 (en) * 2000-05-15 2003-11-04 Paratek Pharmaceuticals, Inc. 7-substituted fused ring tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
EP3461808A1 (en) * 2000-07-07 2019-04-03 Trustees of Tufts College 9-substituted minocycline compounds
AU2002250331A1 (en) 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
CA2440383C (en) 2001-03-13 2007-01-30 Paratek Pharmaceuticals, Inc. 7,9-substituted tetracycline compounds
EP1241160A1 (en) 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
ES2338994T3 (es) * 2001-04-24 2010-05-14 Paratek Pharmaceuticals, Inc. Compuestos de tetraciclina sustituida para el tratamiento de la malaria.
EP2301915A1 (en) 2001-07-13 2011-03-30 Paratek Pharmaceuticals, Inc. 7-(diethylamino)methyl substituted tetracycline having target therapeutic activities
WO2003055441A2 (en) 2001-08-02 2003-07-10 Paratek Pharmaceuticals, Inc. Medicaments
JP2005514410A (ja) 2002-01-08 2005-05-19 パラテック ファーマシューティカルズ インコーポレイテッド ４−デジメチルアミノテトラサイクリン化合物
WO2003075857A2 (en) * 2002-03-08 2003-09-18 Paratek Pharmaceuticals, Inc. Amino-methyl substituted tetracycline compounds
EA200600221A1 (ru) 2003-07-09 2006-06-30 Пэрэтек Фамэсьютикэлс, Инк. Замещённые соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
UA83266C2 (en) * 2003-12-08 2008-06-25 Уайет Oxazole derivatives of tetracyclines
US7807842B2 (en) 2004-05-21 2010-10-05 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
PA8652001A1 (es) 2004-11-05 2006-10-13 Wyeth Corp Metabolitos glucuronidos de tigeciclina y epimeros de los mismos
AR057649A1 (es) 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
WO2007027599A1 (en) * 2005-08-31 2007-03-08 Wyeth 9-aminocarbonylsubstituted derivatives of glycylcyclines
CA2652347A1 (en) 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
BRPI0819696B1 (pt) 2007-11-29 2018-10-23 Actelion Pharmaceuticals Ltd compostos de derivados de 2-fenil-pirimidina, composição farmacêutica e uso de um composto
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
ITMI20080807A1 (it) 2008-05-05 2009-11-06 Antibioticos Spa Procedimento per la preparazione di tigeciclina in forma amorfa
TWI585071B (zh) 2008-05-23 2017-06-01 派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
BRPI0916985B1 (pt) * 2008-08-08 2021-06-22 Tetraphase Pharmaceuticals, Inc Composto de tetraciclina c7-fluoro substituído e composição farmacêutica que o compreende
EP2424834B1 (en) 2009-04-30 2018-07-11 President and Fellows of Harvard College Synthesis of tetracyclines and intermediates thereof
CN102459153A (zh) 2009-05-08 2012-05-16 四相制药公司 四环素类化合物
CN105622496B (zh) * 2009-08-28 2019-03-05 四相制药公司 四环素类化合物
DK2568987T3 (en) 2010-05-12 2017-02-20 Rempex Pharmaceuticals Inc Tetracycline COMPOSITIONS
CN103635456B (zh) * 2011-07-26 2016-03-09 山东亨利医药科技有限责任公司 替加环素衍生物
CN108329312B (zh) 2012-08-31 2021-12-31 四相制药公司 四环素化合物
US20160143925A1 (en) 2013-11-12 2016-05-26 Galenicum Health S.L. Stable pharmaceutical compositions
SG11201903327PA (en) 2016-10-19 2019-05-30 Tetraphase Pharmaceuticals Inc Crystalline forms of eravacycline

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3579579A (en) * 1968-04-18 1971-05-18 American Cyanamid Co Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines

Also Published As

Publication number Publication date
CZ284159B6 (cs) 1998-08-12
HU219973B (hu) 2001-10-28
ES2168254T3 (es) 2002-06-16
DK0536515T3 (da) 2002-04-08
FI924454A (fi) 1993-04-05
PT536515E (pt) 2002-05-31
PL296143A1 (en) 1993-05-31
AU2618392A (en) 1993-04-08
SK298492A3 (en) 1995-03-08
IL119590A0 (en) 1997-02-18
CZ309397A3 (cs) 1998-09-16
FI114911B (fi) 2005-01-31
CN1072172A (zh) 1993-05-19
NO301472B1 (no) 1997-11-03
NL300244I2 (nl) 2007-01-02
ATE211128T1 (de) 2002-01-15
IL103320A (en) 1998-12-06
SG52361A1 (en) 1998-09-28
SK280837B6 (sk) 2000-08-14
DE122006000058I1 (de) 2007-01-18
DE122006000058I2 (de) 2007-09-13
KR930007894A (ko) 1993-05-20
MX9205532A (es) 1993-04-01
CZ298492A3 (en) 1993-05-12
AU654049B2 (en) 1994-10-20
TW275616B (no) 1996-05-11
CZ284209B6 (cs) 1998-09-16
DE69232302D1 (de) 2002-01-31
NO2006015I1 (no) 2006-11-27
KR100269072B1 (ko) 2000-10-16
HU211172A9 (en) 1995-11-28
CN1048240C (zh) 2000-01-12
NO923857L (no) 1993-04-05
EP0536515A1 (en) 1993-04-14
HUT63145A (en) 1993-07-28
CA2079692A1 (en) 1993-04-05
JPH05255219A (ja) 1993-10-05
CL2004001623A1 (es) 2005-06-03
HU9203110D0 (en) 1992-12-28
EP0536515B1 (en) 2001-12-19
DE69232302T2 (de) 2002-08-14
LU91279I2 (fr) 2006-12-11
NO2006015I2 (no) 2011-03-14
PL176333B1 (pl) 1999-05-31
PL173311B1 (pl) 1998-02-27
CA2079692C (en) 2004-06-08
SK114999A3 (en) 2000-07-11
PL175957B1 (pl) 1999-03-31
NZ244585A (en) 1995-07-26
PL172282B1 (pl) 1997-08-29
NO2017037I1 (no) 2017-08-01
NL300244I1 (nl) 2007-01-02
NO923857D0 (no) 1992-10-02
IL119590A (en) 1999-03-12
BR1100853A (pt) 1999-12-07
HK1011348A1 (en) 1999-07-09
DE69232302T4 (de) 2003-02-13
SK284826B6 (sk) 2005-12-01
IL103320A0 (en) 1993-03-15
FI924454A0 (fi) 1992-10-02
JP3186863B2 (ja) 2001-07-11
NO2017037I2 (no) 2017-08-01

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