CS273152B2 - Method of mature human leucocytic interferon production - Google Patents

Method of mature human leucocytic interferon production Download PDF

Info

Publication number
CS273152B2
CS273152B2 CS503781A CS503781A CS273152B2 CS 273152 B2 CS273152 B2 CS 273152B2 CS 503781 A CS503781 A CS 503781A CS 503781 A CS503781 A CS 503781A CS 273152 B2 CS273152 B2 CS 273152B2
Authority
CS
Czechoslovakia
Prior art keywords
trp
interferon
plelf
fragment
plasmid
Prior art date
Application number
CS503781A
Other languages
Czech (cs)
English (en)
Other versions
CS503781A2 (en
Inventor
David Van Norman Goeddel
Sidney Pestka
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27496622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS273152(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/256,204 external-priority patent/US6610830B1/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to CS362687A priority Critical patent/CS273181B2/cs
Priority to CS362787A priority patent/CS273182B2/cs
Publication of CS503781A2 publication Critical patent/CS503781A2/cs
Publication of CS273152B2 publication Critical patent/CS273152B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CS503781A 1980-07-01 1981-06-30 Method of mature human leucocytic interferon production CS273152B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CS362687A CS273181B2 (en) 1980-07-01 1987-05-19 Method of escherichia coli cells production that are capable to produce mature human leucocytic interferon
CS362787A CS273182B2 (en) 1980-07-01 1987-05-19 Method of expressive vector production capable to give mature human leucocytic interferon in transformed strain of escherichia coli by means of expression

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16498680A 1980-07-01 1980-07-01
US18490980A 1980-09-08 1980-09-08
US20557880A 1980-11-10 1980-11-10
US06/256,204 US6610830B1 (en) 1980-07-01 1981-04-21 Microbial production of mature human leukocyte interferons

Publications (2)

Publication Number Publication Date
CS503781A2 CS503781A2 (en) 1990-07-12
CS273152B2 true CS273152B2 (en) 1991-03-12

Family

ID=27496622

Family Applications (1)

Application Number Title Priority Date Filing Date
CS503781A CS273152B2 (en) 1980-07-01 1981-06-30 Method of mature human leucocytic interferon production

Country Status (36)

Country Link
EP (2) EP0043980B1 (fi)
AR (1) AR242833A1 (fi)
AT (3) ATE29727T1 (fi)
AU (1) AU552004B2 (fi)
BG (1) BG42189A3 (fi)
BR (1) BR8104189A (fi)
CH (2) CH657141A5 (fi)
CS (1) CS273152B2 (fi)
DD (3) DD210304A5 (fi)
DE (3) DE3177288T3 (fi)
DK (1) DK173543B1 (fi)
DZ (1) DZ312A1 (fi)
ES (1) ES8207514A1 (fi)
FI (1) FI82712C (fi)
FR (1) FR2486098B1 (fi)
GB (1) GB2079291B (fi)
GE (1) GEP19960519B (fi)
GR (1) GR75714B (fi)
HK (1) HK49285A (fi)
HU (1) HU196457B (fi)
IE (1) IE49255B1 (fi)
IT (1) IT1137272B (fi)
KE (1) KE3534A (fi)
LU (1) LU83461A1 (fi)
MC (1) MC1396A1 (fi)
MY (1) MY8700711A (fi)
NL (1) NL8103151A (fi)
NO (1) NO159392C (fi)
NZ (1) NZ197572A (fi)
PH (1) PH18036A (fi)
PL (3) PL148260B1 (fi)
PT (1) PT73289B (fi)
RO (1) RO87590A (fi)
SE (2) SE8104093L (fi)
SU (1) SU1414319A3 (fi)
YU (1) YU47700B (fi)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
IL62552A0 (en) 1980-04-03 1981-06-29 Biogen Nv Dna sequences,recombinant dna molecules and processes for producing human fibroblast interferon-like polypeptides
ATE25985T1 (de) * 1980-06-12 1987-04-15 Japan Found Cancer Plasmid.
DK489481A (da) * 1980-11-10 1982-05-11 Searle & Co Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
JPS58501543A (ja) * 1981-08-14 1983-09-16 エイ／エス　アルフレツド　ベンツオン ヒトインタ−フエロン蛋白とヒトインタ−フエロン蛋白に対する抗体に関する改良
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
US5098703A (en) * 1982-01-15 1992-03-24 Cetus Corporation Interferon-alpha 76
US4975276A (en) * 1982-01-15 1990-12-04 Cetus Corporation Interferon-alpha 54
US4973479A (en) * 1982-01-15 1990-11-27 Cetus Corporation Interferon-α61
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
EP0088994B1 (en) * 1982-03-15 1991-06-19 Schering Corporation Hybrid dna, binding composition prepared thereby and processes therefor
CA1210714A (en) * 1982-03-23 1986-09-02 Alan Sloma .alpha.-INTERFERON GX-1
US4748233A (en) * 1982-03-23 1988-05-31 Bristol-Myers Company Alpha-interferon Gx-1
US4695543A (en) * 1982-03-23 1987-09-22 Bristol-Myers Company Alpha Interferon GX-1
US6936694B1 (en) * 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
US4751287A (en) * 1983-02-24 1988-06-14 Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr Human leukocyte interferon N and a method of producing same in bacterial cells
EP0165942A1 (en) * 1983-12-23 1986-01-02 Monash University PRODUCTION OF HUMAN INTERFERON-$g(a)
SU1364343A1 (ru) * 1984-07-13 1988-01-07 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Способ получени человеческого лейкоцитарного интерферона альфа-2
WO1986002068A1 (en) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Mutual separation of proteins
IL76360A0 (en) 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
US5196323A (en) * 1985-04-27 1993-03-23 Boehringer Ingelheim International Gmbh Process for preparing and purifying alpha-interferon
DE3515336C2 (de) * 1985-04-27 1994-01-20 Boehringer Ingelheim Int Verfahren zur Herstellung und Reinigung von â-Interferon
JP2514950B2 (ja) * 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質，その製造法および中間体
JPS6463395A (en) * 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
CA1309044C (en) * 1987-11-09 1992-10-20 Toshiya Takano Method of producing foreign gene products
GB8813032D0 (en) * 1988-06-02 1988-07-06 Boehringer Ingelheim Int Antiviral pharmaceutical composition
WO1991003251A1 (en) * 1989-09-08 1991-03-21 California Institute Of Biological Research Cr2 ligand compositions and methods for modulating immune cell functions
DE3932311A1 (de) * 1989-09-28 1991-04-11 Boehringer Ingelheim Int Verfahren zur reinigung von beta-interferon
ATE227133T1 (de) * 1994-03-07 2002-11-15 Imperial College Verwendung von interferon-alpha 8 subtype zur herstellung von medikamenten zur behandlung von viralinfektionen der leber
ES2161793T3 (es) * 1994-04-09 2001-12-16 Hoffmann La Roche Proceso para la produccion de alfa-interferona.
GB9609932D0 (en) * 1996-05-13 1996-07-17 Hoffmann La Roche Use of IL-12 and IFN alpha for the treatment of infectious diseases
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
ZA9811070B (en) 1997-12-08 2000-07-03 Genentech Inc Type I interferons.
AU761577C (en) 1997-12-08 2004-02-05 Genentech Inc. Human interferon-epsilon: a type I interferon
CN1264575C (zh) 1998-08-06 2006-07-19 山景药品公司 聚乙二醇或聚环氧乙烷－尿酸氧化酶结合物及其应用
US6783965B1 (en) 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
US6268178B1 (en) 1999-05-25 2001-07-31 Phage Biotechnology Corp. Phage-dependent super-production of biologically active protein and peptides
JP2004537964A (ja) * 2000-11-03 2004-12-24 ペストカ バイオメディカル ラボラトリーズ インコーポレイテッド インターフェロン、それに関する使用及び組成物
FR2822845B1 (fr) 2001-03-30 2003-12-12 Genodyssee Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr) 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2825716B1 (fr) 2001-06-11 2004-09-24 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
KR20080009111A (ko) 2005-04-11 2008-01-24 새비언트 파마수티컬즈 인크. 유레이트 옥시다아제의 변이형 및 이의 용도
EP2245044A2 (en) * 2008-01-18 2010-11-03 F. Hoffmann-La Roche AG Purification of non-glycosylated proteins
PL398781A1 (pl) 2009-06-25 2012-11-19 Savient Pharmaceuticals, Inc. Sposoby i zestawy do prognozowania ryzyka wystapienia reakcji na wlew oraz zaniku odpowiedzi której posrednicza przeciwciala poprzez monitorowanie kwasu moczowego w surowicy podczas terapii z zastosowaniem pegylowanej urykazy
WO2018087345A1 (en) 2016-11-14 2018-05-17 F. Hoffmann-La Roche Ag COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN150740B (fi) * 1978-11-24 1982-12-04 Hoffmann La Roche
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
DK170236B1 (da) * 1980-01-08 1995-07-10 Biogen Inc Rekombinante DNA-molekyler, fremgangsmåde til fremstilling af et polypeptid af IFN-alfa typen og fremgangsmåde til udvælgelse af DNA-sekvenser, der koder for polypeptider af IFN-alfa typen
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
ATE25985T1 (de) * 1980-06-12 1987-04-15 Japan Found Cancer Plasmid.
ES506955A0 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
FI64813C (fi) * 1980-12-31 1984-01-10 Ilkka Antero Palva Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
EP0062971B1 (en) * 1981-03-27 1990-03-07 Imperial Chemical Industries Plc Genetically modified microorganisms

Also Published As

Publication number Publication date
MY8700711A (en) 1987-12-31
PL231940A1 (en) 1983-07-18
IE811463L (en) 1982-01-01
EP0043980A3 (en) 1982-09-15
KE3534A (en) 1985-06-07
IT8122682A0 (it) 1981-07-01
SE465223B (sv) 1991-08-12
EP0211148B2 (en) 1999-11-24
PT73289A (en) 1981-07-01
GB2079291A (en) 1982-01-20
RO87590A (ro) 1986-07-30
PH18036A (en) 1985-03-06
AR242833A1 (es) 1993-05-31
ES503528A0 (es) 1982-10-01
DE3125706C2 (de) 1995-05-24
IE49255B1 (en) 1985-09-04
ATE79901T1 (de) 1992-09-15
EP0211148B1 (en) 1992-08-26
YU47700B (sh) 1996-01-08
EP0043980A2 (en) 1982-01-20
PL148276B1 (en) 1989-09-30
ATE29727T1 (de) 1987-10-15
NL8103151A (nl) 1982-02-01
FR2486098B1 (fr) 1985-12-27
FI812067L (fi) 1982-01-02
PT73289B (en) 1983-05-11
NZ197572A (en) 1985-07-31
MC1396A1 (fr) 1982-04-27
AU7246281A (en) 1982-01-07
FR2486098A1 (fr) 1982-01-08
BG42189A3 (en) 1987-10-15
PL148260B1 (en) 1989-09-30
CS503781A2 (en) 1990-07-12
EP0043980B1 (en) 1987-09-16
IT1137272B (it) 1986-09-03
HU196457B (en) 1988-11-28
NO159392B (no) 1988-09-12
DK291081A (da) 1982-01-02
AU552004B2 (en) 1986-05-22
NO159392C (no) 1988-12-21
HK49285A (en) 1985-07-05
SE8104093L (sv) 1982-01-02
PL148261B1 (en) 1989-09-30
DD210304A5 (de) 1984-06-06
ATA290981A (de) 1985-09-15
DE3125706A1 (de) 1982-04-15
DE3177288D1 (de) 1992-10-01
DE3176448D1 (en) 1987-10-22
DZ312A1 (fr) 2004-09-13
AT380272B (de) 1986-05-12
DE3177288T2 (de) 1992-12-10
GR75714B (fi) 1984-08-02
DE3177288T3 (de) 2000-03-16
NO812247L (no) 1982-01-04
SE465223C5 (sv) 1998-02-10
FI82712B (fi) 1990-12-31
GB2079291B (en) 1984-06-13
FI82712C (fi) 1991-04-10
YU162281A (en) 1984-02-29
ES8207514A1 (es) 1982-10-01
DD202307A5 (de) 1983-09-07
GEP19960519B (en) 1996-07-02
SU1414319A3 (ru) 1988-07-30
LU83461A1 (de) 1983-04-06
DD210305A5 (de) 1984-06-06
CH657141A5 (de) 1986-08-15
EP0211148A1 (en) 1987-02-25
BR8104189A (pt) 1982-03-16
DK173543B1 (da) 2001-02-05
CH651308A5 (de) 1985-09-13

Similar Documents

Publication Publication Date Title
CS273152B2 (en) Method of mature human leucocytic interferon production
CA1341583C (en) Interferons and process for their preparation
KR920007439B1 (ko) 하이브리드 인간 백혈구 인터페론
EP0118617B1 (en) Interleukin-2 polypeptides
NZ202190A (en) Human immune interferon : production by recombinant dna technology
CA1340978C (en) Purification, cloning and characterization of the gene for interleukin 1
US4801685A (en) Microbial production of mature human leukocyte interferon K and L
JPS6363199B2 (fi)
US4810645A (en) Microbial production of mature human leukocyte interferon K and L
EP0163603B1 (en) A human t-cell growth factor
FI82714C (fi) Foerfarande foer framstaellning av en transformerad stam av e.coli, som foermaor expressera ett humant moget leukocytinterferon.
CS273181B2 (en) Method of escherichia coli cells production that are capable to produce mature human leucocytic interferon
KR870000510B1 (ko) 형질전환된 미생물의 제조방법
KR870000511B1 (ko) 발현 비히클의 제조방법
KR910009901B1 (ko) 하이브리드 인간 백혈구 인터페론
IL63197A (en) Intraferons for mature human oocytes, their preparation and preparations containing them
Goeddel Microbial production of mature human leukocyte interferons
NO164178B (no) Plasmid som koder for et ferdigutviklet human leukocyttinterferon.
NZ214261A (en) Human immune interferon: production by recombinant dna technology