CO5560544A2 - Terapia de combinacion para el tratamiento del cancer - Google Patents
Terapia de combinacion para el tratamiento del cancerInfo
- Publication number
- CO5560544A2 CO5560544A2 CO04012058A CO04012058A CO5560544A2 CO 5560544 A2 CO5560544 A2 CO 5560544A2 CO 04012058 A CO04012058 A CO 04012058A CO 04012058 A CO04012058 A CO 04012058A CO 5560544 A2 CO5560544 A2 CO 5560544A2
- Authority
- CO
- Colombia
- Prior art keywords
- group
- alkyl
- hydrogen
- ylmethyl
- hydroxyl
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1.- Un método para el tratamiento o prevención de cánceres que comprende la administración a un mamífero en necesidad de tal tratamiento de una cantidad terapéuticamente efectiva de:un inhibidor de la proteinquinasa de la Fórmula (I): en donde:R es seleccionado del grupo que consta de hidrógeno, piperazin-1-ilmetilo, 4-metilpiperazin-1-ilmetilo, piperidin-1-ilmetilo, 2-hidroximetilpirrolidin-1-ilmetilo, 2-carboxipirrolidin-1-ilmetilo, y pirrolidin-1-ilmetilo;R1 es seleccionado del grupo que consta de hidrógeno, halo, alquilo, alquilo sustituido, cicloalquilo, cicloalquilo sustituido, arilo, heteroarilo, heteroalicíclico, hidroxilo, alcoxilo, -C(O)NR8R9, -NR13R14, -(CO)R15, y -(CH2)rR16;R2 es seleccionado del grupo que consta de hidrógeno, halo, alquilo, alquilo sustituido, trihalometilo, hidroxilo, alcoxilo, ciano, -NR13R14, -NR13C(O)R14, -C(O)R15, arilo, heteroarilo, y -S(O)2NR13R14;R3 es seleccionado grupo que consta de hidrógeno, halógeno, alquilo, alquilo sustituido, trihalometilo, hidroxilo, alcoxilo, arilo, heteroarilo, -NR13R14, -NR13S(O)2R14, S(O)2NR13R14, -NR13C(O)R14, -NR13C(O)OR14, -(CO)R15, y -SO2R19;R4 es seleccionado del grupo que consta de hidrógeno, halógeno, alquilo, alquilo sustituido, hidroxilo, alcoxilo, y -NR13R14;R5 es seleccionado del grupo que consta de hidrógeno, alquilo, alquilo sustituido, y -C(O)R10;R6 es seleccionado del grupo que consta de hidrógeno, alquilo, alquilo sustituido, y -C(O)R10;R7 es seleccionado grupo que consta de hidrógeno, alquilo, alquilo sustituido, arilo, heteroarilo, -C(O)R17, y -C(O)R10, y -C(O)R10; siempre y cuando R es hidrógeno entonces al menos uno entre R5, R6 y R7 es -C(O)R19; o R6 y R7 se pueden combinar para formar un grupo seleccionado del grupo que consta de -(CH2)4-, -(CH2)5- y -(CH2)6-;R8 y R9 son independientemente seleccionados del grupo que consta de hidrógeno, alquilo, alquilo sustituido, y arilo;R10 es seleccionado del grupo que consta de hidroxilo, alcoxilo, ariloxilo, -N(R11)(alquileno)nR12 en donde el grupo alquileno es opcionalmente substituido con un grupo hidroxilo, y -NR13R14; ...
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31241301P | 2001-08-15 | 2001-08-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5560544A2 true CO5560544A2 (es) | 2005-09-30 |
Family
ID=23211320
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO04012058A CO5560544A2 (es) | 2001-08-15 | 2004-02-13 | Terapia de combinacion para el tratamiento del cancer |
Country Status (36)
Country | Link |
---|---|
US (1) | US7320996B2 (es) |
EP (1) | EP1427326B1 (es) |
JP (1) | JP2005501843A (es) |
KR (1) | KR100656004B1 (es) |
CN (1) | CN1541098A (es) |
AP (1) | AP2004002995A0 (es) |
AR (1) | AR038957A1 (es) |
AT (1) | ATE414512T1 (es) |
AU (1) | AU2002329744B2 (es) |
BG (1) | BG108622A (es) |
BR (1) | BR0211978A (es) |
CA (1) | CA2457745A1 (es) |
CO (1) | CO5560544A2 (es) |
CZ (1) | CZ2004356A3 (es) |
DE (1) | DE60229959D1 (es) |
EA (1) | EA008137B1 (es) |
EC (1) | ECSP045021A (es) |
GE (1) | GEP20063868B (es) |
HR (1) | HRP20040170A2 (es) |
HU (1) | HUP0500424A3 (es) |
IL (1) | IL159887A0 (es) |
IS (1) | IS7137A (es) |
MA (1) | MA27060A1 (es) |
MX (1) | MXPA04001464A (es) |
NO (1) | NO20040516L (es) |
NZ (1) | NZ530792A (es) |
OA (1) | OA12651A (es) |
PE (1) | PE20030332A1 (es) |
PL (1) | PL368921A1 (es) |
RS (1) | RS13204A (es) |
SK (1) | SK1412004A3 (es) |
TN (1) | TNSN04015A1 (es) |
TW (1) | TWI230609B (es) |
UA (1) | UA77002C2 (es) |
WO (1) | WO2003015608A2 (es) |
ZA (1) | ZA200400849B (es) |
Families Citing this family (24)
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US6747025B1 (en) | 2002-11-27 | 2004-06-08 | Allergan, Inc. | Kinase inhibitors for the treatment of disease |
DE10393799T5 (de) * | 2002-11-27 | 2005-10-13 | Allergan, Inc., Irvine | Kinaseinhibitoren für die Behandlung von Erkrankungen |
MXPA05006676A (es) | 2002-12-19 | 2005-08-16 | Pfizer | Compuestos de indazol y composiciones farmaceuticas para inhibir proteinquinasas, y procedimientos para su uso. |
US7157577B2 (en) * | 2003-03-07 | 2007-01-02 | Sugen Inc. | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors |
AU2004281520B2 (en) * | 2003-10-08 | 2009-01-08 | Novartis Ag | Pharmaceutical composition comprising 5-methyl-2-(2'-chloro-6'-fluoroanilino)phenylacetic acid |
WO2005118543A1 (ja) * | 2004-06-03 | 2005-12-15 | Ono Pharmaceutical Co., Ltd. | キナーゼ阻害薬およびその用途 |
US20060009510A1 (en) * | 2004-07-09 | 2006-01-12 | Pharmacia & Upjohn Company Llc | Method of synthesizing indolinone compounds |
MX2007014087A (es) * | 2005-05-12 | 2008-02-07 | Pfizer | Combinaciones y procedimientos para usar un compuesto de indolinona. |
AU2006268315A1 (en) * | 2005-07-08 | 2007-01-18 | John P. Ford | Metered-dose and safety and compliance packaging for systemic anticancer therapy |
US7928136B2 (en) | 2006-09-11 | 2011-04-19 | Curis, Inc. | Substituted 2-indolinone as PTK inhibitors containing a zinc binding moiety |
US20090004213A1 (en) * | 2007-03-26 | 2009-01-01 | Immatics Biotechnologies Gmbh | Combination therapy using active immunotherapy |
WO2009030270A1 (en) * | 2007-09-03 | 2009-03-12 | Novartis Ag | Dihydroindole derivatives useful in parkinson's disease |
GB0813873D0 (en) * | 2008-07-30 | 2008-09-03 | Univ Dundee | Compounds |
EP2181991A1 (en) * | 2008-10-28 | 2010-05-05 | LEK Pharmaceuticals D.D. | Novel salts of sunitinib |
EP2186809A1 (en) * | 2008-11-13 | 2010-05-19 | LEK Pharmaceuticals D.D. | New crystal form of sunitinib malate |
WO2012042421A1 (en) | 2010-09-29 | 2012-04-05 | Pfizer Inc. | Method of treating abnormal cell growth |
RU2495628C1 (ru) * | 2012-04-18 | 2013-10-20 | Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) | Способ выбора тактики лечения актинического кератоза |
TWI646091B (zh) * | 2012-12-28 | 2019-01-01 | 日商衛斯克慧特股份有限公司 | 鹽類及晶形 |
BR112015022431A2 (pt) * | 2013-03-13 | 2017-05-09 | Boston Biomedical Inc | derivados de 3-(aril ou heteroaril) metilenoindolin-2-ona como inibidores de quinases da via de sinalização de células-tronco cancerosas para o tratamento de câncer |
CN103923014A (zh) * | 2014-05-05 | 2014-07-16 | 宁夏宝马药业有限公司 | 环肌酸制备方法 |
US20170196835A1 (en) | 2016-01-08 | 2017-07-13 | Euclises Pharmaceuticals, Inc. | Combination of a chromene compound and a second active agent |
CN111759883B (zh) * | 2020-07-23 | 2021-09-17 | 浙江农林大学 | 山核桃内果皮提取物在制备抗卵巢癌产品中的应用 |
CN114853736B (zh) * | 2022-07-06 | 2022-10-21 | 北京鑫开元医药科技有限公司 | 具有trk抑制活性的化合物、制备方法、组合物及其用途 |
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