FR2672596B1 - Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. - Google Patents
Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.Info
- Publication number
- FR2672596B1 FR2672596B1 FR9101374A FR9101374A FR2672596B1 FR 2672596 B1 FR2672596 B1 FR 2672596B1 FR 9101374 A FR9101374 A FR 9101374A FR 9101374 A FR9101374 A FR 9101374A FR 2672596 B1 FR2672596 B1 FR 2672596B1
- Authority
- FR
- France
- Prior art keywords
- new
- medicaments
- application
- pharmaceutical compositions
- preparation process
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/28—Cinnolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Priority Applications (21)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9101374A FR2672596B1 (fr) | 1991-02-07 | 1991-02-07 | Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
MX9200299A MX9200299A (es) | 1991-02-07 | 1992-01-24 | Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen. |
EP92400296A EP0498723B1 (fr) | 1991-02-07 | 1992-02-05 | Dérivés bicycliques azotés, leur procédé de préparation, leur application à titre de médicament et les compositions pharmaceutiques les renfermant |
ES92400296T ES2161688T3 (es) | 1991-02-07 | 1992-02-05 | Derivados biciclicos nitrogenados, su procedimiento de preparacion, su aplicacion como medicamentos, y composiciones farmaceuticas que los contienen. |
JP4775092A JP3599351B2 (ja) | 1991-02-07 | 1992-02-05 | 新規の窒素系二環式誘導体、その製造方法、その薬剤としての使用及びそれを含有する製薬組成物 |
DE69232060T DE69232060T2 (de) | 1991-02-07 | 1992-02-05 | Stickstoff enthaltende bicyclische Verbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel und diese enthaltende Zusammensetzungen |
AU10709/92A AU658163B2 (en) | 1991-02-07 | 1992-02-05 | New nitrogenous bicyclic derivatives, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them |
DK92400296T DK0498723T3 (da) | 1991-02-07 | 1992-02-05 | Dobbeltcykliske nitrogenforbindelser, fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler samt farmaceutiske præparater med indhold deraf |
PT92400296T PT498723E (pt) | 1991-02-07 | 1992-02-05 | Derivados biciclicos azotados processo para a sua preparacao sua aplicacao a titulo de medicamento e composicoes farmaceuticas que os contem |
AT92400296T ATE205832T1 (de) | 1991-02-07 | 1992-02-05 | Stickstoff enthaltende bicyclische verbindungen, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende zusammensetzungen |
KR1019920001716A KR100260010B1 (ko) | 1991-02-07 | 1992-02-06 | 질소 함유 비시클릭 유도체, 그의 제조 방법, 신규 중간체, 약제로서의 그의 용도 및 그를 함유하는 제약 조성물 |
CA002060750A CA2060750A1 (fr) | 1991-02-07 | 1992-02-06 | Derives bicycliques azotes, leur procede de preparation, nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
SU5011269A RU2119481C1 (ru) | 1991-02-07 | 1992-02-06 | Бициклические азотсодержащие производные или их соли с минеральными и органическими кислотами или основаниями, способы их получения и фармацевтическая композиция на их основе |
HU9200366A HUT64522A (en) | 1991-02-07 | 1992-02-06 | Process for producing of bicyclic compounds containing nitrogen and medical preparatives containing them as active agents |
IE039692A IE920396A1 (en) | 1991-02-07 | 1992-02-06 | New nitrogenous bicyclic derivatives, their preparation¹process, the new intermediates obtained, their use as¹medicaments and the pharmaceutical compositions containing¹them |
ZA92895A ZA92895B (en) | 1991-02-07 | 1992-02-07 | Nitrogenous bicyclic derivatives,their preparation process,the intermediates obtained,their use as medicaments and the pharmaceutical compositions containing them |
BR929200424A BR9200424A (pt) | 1991-02-07 | 1992-02-07 | Processo para preparar produtos,processo para preparar composicoes farmaceuticas e utilizacao de produtos |
CN92100804A CN1063869A (zh) | 1991-02-07 | 1992-02-07 | 新的含氮双环衍生物,其制备方法,由此得到的新的中间体,其药物用途和含这类物质的药物组合物 |
US08/583,637 US5817674A (en) | 1991-02-07 | 1996-01-05 | Quinoline compounds |
US09/071,586 US6004979A (en) | 1991-02-07 | 1998-05-01 | Nitrogenous bicycles |
GR20010401668T GR3036805T3 (en) | 1991-02-07 | 2001-10-04 | Nitrogen containing bicycle compounds, method for their preparation, their use as pharmaceutical and compositions containing them. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9101374A FR2672596B1 (fr) | 1991-02-07 | 1991-02-07 | Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2672596A1 FR2672596A1 (fr) | 1992-08-14 |
FR2672596B1 true FR2672596B1 (fr) | 1995-07-13 |
Family
ID=9409441
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR9101374A Expired - Fee Related FR2672596B1 (fr) | 1991-02-07 | 1991-02-07 | Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
Country Status (3)
Country | Link |
---|---|
FR (1) | FR2672596B1 (fr) |
RU (1) | RU2119481C1 (fr) |
ZA (1) | ZA92895B (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1419788A (en) * | 1972-08-02 | 1975-12-31 | Pfizer | Herbicidal method using 2-trifuluromethyl-4-quinolinols |
US3936461A (en) * | 1973-09-24 | 1976-02-03 | Warner-Lambert Company | Substituted 4-benzylquinolines |
US4025629A (en) * | 1974-01-07 | 1977-05-24 | The Upjohn Company | P-(trifluoromethylquinolylamino)benzamides, pharmaceutical dosage forms and method of treatment |
FR2377400A2 (fr) * | 1977-01-18 | 1978-08-11 | Roussel Uclaf | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
US4466965A (en) * | 1982-07-26 | 1984-08-21 | American Hospital Supply Corporation | Phthalazine compounds, compositions and use |
GB2143814A (en) * | 1983-07-29 | 1985-02-20 | Showa Denko Kk | Quinazolines |
PH22302A (en) * | 1985-02-11 | 1988-07-22 | Fujisawa Pharmaceutical Co | Piperidine compounds |
GB8804443D0 (en) * | 1988-02-25 | 1988-03-23 | Smithkline Beckman Intercredit | Compounds |
YU155290A (sh) * | 1989-08-11 | 1993-05-28 | Imperial Chemical Industries Plc. | Dusikove spojine |
US4956371A (en) * | 1989-09-19 | 1990-09-11 | Euroceltique, S.A. | Substituted isoquinolines and methods of using same |
-
1991
- 1991-02-07 FR FR9101374A patent/FR2672596B1/fr not_active Expired - Fee Related
-
1992
- 1992-02-06 RU SU5011269A patent/RU2119481C1/ru active
- 1992-02-07 ZA ZA92895A patent/ZA92895B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
RU2119481C1 (ru) | 1998-09-27 |
ZA92895B (en) | 1993-04-28 |
FR2672596A1 (fr) | 1992-08-14 |
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FR2680510B1 (fr) | Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. | |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CA | Change of address | ||
CD | Change of name or company name | ||
TP | Transmission of property | ||
TP | Transmission of property | ||
ST | Notification of lapse |