CO6220908A2 - Derivados de 2,3 -dihidroimizazo[1,2-c]quinazolina sustituidos de utilidad en el tratamiento de trastornos hiperproliferativos y enfermedades asociadas con la angiogenesis - Google Patents
Derivados de 2,3 -dihidroimizazo[1,2-c]quinazolina sustituidos de utilidad en el tratamiento de trastornos hiperproliferativos y enfermedades asociadas con la angiogenesisInfo
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- CO6220908A2 CO6220908A2 CO09057915A CO09057915A CO6220908A2 CO 6220908 A2 CO6220908 A2 CO 6220908A2 CO 09057915 A CO09057915 A CO 09057915A CO 09057915 A CO09057915 A CO 09057915A CO 6220908 A2 CO6220908 A2 CO 6220908A2
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Abstract
1.- Un compuesto que tiene la fórmula:o una sal aceptable fisiológicamente, solvato, hidrato oestereoisómero del mismo, donde: R1 es -(CH2)n-(CHR4)-(CH2)m-N(R5)(R5'); R2 es un heteroarilo opcionalmente sustituido con 1, 2 o 3 grupos R6; R3 es alquilo o cicloalquilo; R4 es hidrógeno, hidroxi o alcoxi y R5 y R5´ pueden ser iguales o diferentes y son independientemente, hidrógeno, alquilo, cicloalquilalquilo, o alcoxialquilo o R5 y R5´ se pueden tomar junto con el átomo de nitrógeno al cual se encuentran unidos para formar un anillo heterocíclico que contiene nitrógeno de 3 a 7 miembros que contiene opcionalmente al menos un heteroátomo adicional seleccionado entre oxígeno, nitrógeno o azufre y que se puede sustituir opcionalmente con 1 o más grupos R6', o R4 y R5 se pueden tomar junto con los átomos a los cuales se encuentran unidos para formar un anillo heterocíclico que contiene nitrógeno de 5 o 6 miembros que contiene opcionalmente 1 o más átomos n es un entero entre 1-4 y m es un entero entre 0-4 con la condición de que cuando R4 y R5 se toman junto con los átomos a los cuales se encuentran unidos para formar un anillo que contiene nitrógeno de 3 a 7 miembros, n + m < 4. 2.- El compuesto de la reivindicación 1, donde R2 es un heteroarilo que contiene nitrógeno opcionalmente sustituido con 1, 2 o 3 grupos R6. 3.- El compuesto de la reivindicación 1, donde R5 y R5´ son independientemente alquilo.4.- El compuesto de la reivindicación 1, donde R5 y R5' se toman junto con el átomo de nitrógeno al cual se encuentran unidos para formar un anillo heterocíclico que contiene nitrógeno de 5 o 6 miembros que contiene al menos un heteroátomo adicional seleccionado entre oxígeno, nitrógeno o azufre y que se puede sustituir opcionalmente con 1 o más grupos R6´. 5.- El compuesto de la reivindicación 1, donde R4 es hidroxi.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87309006P | 2006-12-05 | 2006-12-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6220908A2 true CO6220908A2 (es) | 2010-11-19 |
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ID=39492563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09057915A CO6220908A2 (es) | 2006-12-05 | 2009-06-04 | Derivados de 2,3 -dihidroimizazo[1,2-c]quinazolina sustituidos de utilidad en el tratamiento de trastornos hiperproliferativos y enfermedades asociadas con la angiogenesis |
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Families Citing this family (68)
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| EP2168583A1 (en) | 2008-09-24 | 2010-03-31 | Bayer Schering Pharma Aktiengesellschaft | Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines for the treatment of myeloma |
| EP2168582A1 (en) | 2008-09-24 | 2010-03-31 | Bayer Schering Pharma Aktiengesellschaft | Combinations of substituted 2,3-dihydroimidazo[1,2-c]quinazolines |
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| EP2184276A1 (en) | 2008-11-07 | 2010-05-12 | Universite Paul Cezanne Aix-Marseille Iii | Process to prepare new substituted 1H-Benzo(d) imidazol-2(3h)-Ones, New intermediates and their use as bace 1 inhibitors |
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