CN1874806B - 原位创口清洁装置 - Google Patents
原位创口清洁装置 Download PDFInfo
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- CN1874806B CN1874806B CN2004800321011A CN200480032101A CN1874806B CN 1874806 B CN1874806 B CN 1874806B CN 2004800321011 A CN2004800321011 A CN 2004800321011A CN 200480032101 A CN200480032101 A CN 200480032101A CN 1874806 B CN1874806 B CN 1874806B
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Abstract
用于清洁创口的装置,其中来自连接到可适应创口敷料的储室的冲洗剂流体和来自敷料的创口渗出物借助于用于移动流体的设备循环通过流动路径,所述流动路径通过所述敷料和流体清洁工具并回到所述敷料,并且其中在使用中所述清洁工具安置在创口中。所述清洁工具(其可以是单相例如微过滤系统或多相例如透析系统)除去对创口愈合有害的物质,并且仍旧含有对促进创口愈合有益的物质的经过清洁的流体被返回创面。以及敷料和使用该装置的治疗方法。
Description
本发明涉及用于清洁创口的装置和医疗创口敷料,以及使用这种装置处理创口的方法。
本发明特别涉及能够容易地施用到各种创口特别是慢性创口上,以便从创口清洁对创口愈合有害的物质,同时保留特别是对创口愈合有益的物质的这种装置、创口敷料和方法。
在本发明之前,抽吸和/或冲洗装置是已知的并通常用于在创口治疗期间除去创口渗出物。在这种创口治疗的已知形式中,创口的排出物,特别是当在高渗出状态时,被排放到废物例如排放到收集袋中。
通过这种方式,对创口有害的物质被除去。但是,当实施这种治疗时,对促进创口愈合有益的物质,例如生长因子、细胞基质成分和其它创口渗出物的生理活性成分,离开了它们可能是潜在地最有益的位置也就是创面(wound bed)。
因此这种已知形式的创口敷料以及抽吸和/或冲洗治疗系统通常在创口敷料下产生这样的创口环境,这种创口环境可能造成失去身体自身组织愈合过程的最优性能和造成缓慢的愈合,和/或造成弱的新组织生长,所述弱的新组织生长不具有良好地粘附到创面以及从创面生长的强三维结构。这是明显的缺点,尤其是对于慢性创口。
因此,希望提供治疗系统,其
a)能够从创口渗出物除去对创口愈合有害的物质,同时
a)保持对促进创口愈合有益的物质与创面接触。
透析是系统地体外处理身体流体例如血液以从所述流体清除对身体有害物质的已知方法。通过与透析液接触除去这些物质是透析的主要目的,同时还保留例如血液、细胞和蛋白质的物质。通过透析膜其它可能具有额外正面治疗作用的物质可能从系统损失,透析膜对这些物质也是可透过的。再循环的身体流体中这些物质的平衡因此可能进一步被减少。
希望提供能够从创口渗出物除去对创口愈合有害的物质并且基本不稀释当与创面接触时对促进创口愈合有益的物质的治疗系统,并且这种治疗系统可以同时向创口连续提供和再循环这些物质。
处理身体流体的透析也是系统治疗,因为经处理的流体被返回进入体内。这与其中被处理的流体在体外例如创口循环的局部治疗相反。
透析还需要大量的身体流体例如血液或者透析液,因此相关的设备不太可能是便携式的。即使是在高度渗出的状态下,与内部身体系统相比慢性创口也产生相对少的待处理流体和相对少的准备保留在创口中和/或其环境中的对一些治疗方面有益的物质。
本发明的一个目标是
a)消除至少一些上述已知抽吸和/或冲洗治疗系统的缺点,和
b)提供治疗系统,该系统能
i)从创口渗出物除去对创口愈合有害的物质,同时
ii)保留当与创面接触时对促进创口愈合有益的物质。
本发明的另一个目标是
a)消除至少一些上述已知透析系统的缺点,和
b)提供治疗系统,该系统能从创口渗出物除去对创口愈合有害的物质,同时保留对促进创口愈合有益的物质与创面接触,
c)不系统地影响身体。
本发明的另外一个目标是
a)消除至少一些上述已知透析系统的缺点,和
b)提供治疗系统,该系统能从创口渗出物除去对创口愈合有害的物质,同时保留对促进创口愈合有益的物质与创面接触,和
c)是便携的。
创口下面和创口周围的组织的脉管供给以及所述组织中的循环通常是受损的。本发明的另一个目标是提供治疗系统,该系统保留并提供有益于扭转这种影响的治疗活性数量的物质同时除去有害物质,从而促进创口愈合。
因此,根据本发明的第一方面,提供用于清洁创口的装置,该装置包括
可适应的(conformable)创口敷料,该创口敷料具有
能够在创口上形成相对流体不漏的密封或闭合的衬层和
特征在于其还包括
a)用于从创口渗出物选择性的除去对创口愈合有害的物质的清洁工具(cleansing means),该工具在使用中在衬层以下并且安置在下面的创口中和
b)用于移动液体通过清洁工具的移动设备,和
c)任选的用于排放所述清洁工具的排放工具。
术语‘用于排放所述清洁工具的排放工具,包括与所述清洁工具流体连接的任何排放工具(bleed means)。
对创口愈合有害的物质被所述清洁工具除去,并且经清洁的流体保留在创口中和/或被送回创口。
因此,流体以治疗活性数量保留潜在地对创口愈合有益的创口渗出物中的天然产生的物质。
本发明第一方面的清洁创口的装置是基于下面的原理:通过移动流体经过清洁工具,移动设备连续地使对创口愈合有害的物质和清洁工具发生相互的动态接触,而不是依靠这些物质的被动移动,例如通过流体中化学势梯度下的扩散。使用这种流体移动从创口渗出物除去有害物质能更加快速地发生。
对于不同类型的应用,存在本发明第一方面装置的各种实施方案,特别是包括下面详细描述的那些。不论它们可以是如何地不同,相信它们都可以被分类到下面的功能类型中,这些功能类型特征在于何种流体通过清洁工具:
1.‘单相系统’
在这种系统中,移动通过流体清洁工具的流体是任选与冲洗剂混合的创口渗出物。该流体进入、通过并流出清洁工具,例如衬层下的腔室,并回到创面。在将经过清洁的液体送回创面之前,对创口愈合有害的物质进入流体清洁工具并被流体清洁工具除去。
2.‘多相系统’
在这种系统中,创口渗出物保留在创口中并不大规模进入清洁工具。流体清洁工具通常包含含有第二清洁流体的腔室,所述第二清洁流体最通常是流体(透析液)相。后者通过可透过的整体模块(integer)与创口渗出物分开,所述可透过的整体模块通常例如是聚合物膜(film)、片或薄膜(membrane)。被流体移动设备移动通过流体清洁工具的流体是清洁流体和/或任选与冲洗剂混合的创口渗出物。
在单相和多相系统中,都可以合适的去设计并运行所述设备以移动流体通过创口或清洁工具从而作为‘循环系统’操作所述系统。
在这种系统中,相关流体只以一个方向一次或多次通过清洁工具。
或者,在合适的情况下所述系统可以以‘换向系统(reversingsystem)’形式提供。也就是说,相关流体至少一次是以相反方向通过清洁工具。
但是本发明第一方面的装置在不同应用类型中可以是既作为循环系统操作又作为换向系统操作的,其中相关流体至少一次以相同方向和以相反方向通过清洁工具。(参见后面的图2)。
所述清洁工具的类型可以确定运行本发明装置的适当设计模式。
如所希望的,所述清洁工具可以作为‘单一通过系统’进行操作,即相关流体只通过清洁工具一次。
或者,在合适的情况下所述清洁工具可以以‘多通过系统’的形式提供,其中相关流体通过清洁工具和/或创面数次。
可以看出这些参数的组合产生了本发明的一些主要实施方案。总结起来,这些实施方案是:
1.‘单相系统’
a)作为‘循环系统’,其中创口渗出物和任选的冲洗剂只以一个方向通过清洁工具一次或多次(这类系统的例子显示在后面的图2,4,8,9,11和15中。),或
b)作为‘换向系统’,即创口渗出物和任选的冲洗剂以相反方向通过清洁工具至少一次。(这类系统的例子显示在后面的图1,2,3,6,7,10和14中。)
这种类型的清洁可以作为如下的系统进行操作
i)‘单一通过系统’,即相关流体只通过清洁工具一次,或
ii)作为‘多通过系统’,其中相关流体通过清洁工具和/或创面数次。
2.‘多相系统’
a)作为‘循环系统’,其中
(i)创口渗出物和任选的冲洗剂和/或
(ii)清洁流体
只以一个方向各自通过清洁工具一次或多次(这类系统的例子显示在后面的图12和13中。),或
b)作为‘换向系统’,即
(i)创口渗出物和任选的冲洗剂和/或
(ii)清洁流体
各自至少一次以相反方向通过清洁工具。
这种类型的清洁可以作为如下的系统进行操作
i)‘单一通过系统’,即相关流体只通过清洁工具一次,或
ii)作为‘多通过系统’,其中相关流体通过清洁工具和/或创面数次。
在这种‘多相系统’中,在清洁流体和/或任选与冲洗剂混合的创口渗出物都移动的情况下,所述流动可以是同向流或逆向流,优选逆向流。
这种循环系统的例子显示在:
图12a和13中,其中渗出物是静止的而清洁流体只以一个方向通过清洁工具一次或多次,和
图12b,其中渗出物和任选的冲洗剂和清洁流体各自只以一个方向通过清洁工具一次或多次,在这里彼此是逆向流。
现在将描述本发明敷料的一般特征,然后描述与敷料内特定清洁工具有关的特定特征。
在用于清洁创口的本发明第一方面的装置的所有实施方案中,特别的优点是创口敷料符合其所施加在上面的身体部分的形状的趋势。
所述创口敷料包括具有面对创口的面的衬层,该面对创口的面能够在创口上形成相对流体不漏的密封或闭合。
术语‘相对流体不漏的密封或闭合’用在这里是指流体和微生物不可透过的并且允许正或负的高达50%atm更加常见地高达15%atm的压力施加到创口上的密封或闭合。术语‘流体’用作这里是包括,凝胶例如稠渗出物,液体例如水,和气体例如空气、氮气等。
所施加的衬层的形状可以是适合于在整个创口面积上抽吸、冲洗和/或清洁创口的任意形状。
其例子包括基本平坦的膜、片或薄膜,或能容纳所需流体的袋、室、囊或衬层的其它结构,例如聚合物膜衬层。
所述衬层可以是膜、片或薄膜,通常厚度(一般是均匀的)最高达100微米,优选最高50微米,更优选最高25微米,并且最小厚度是10微米。
它的最大横跨尺寸可以高达500mm(例如对于大的躯干创口),高达100mm(例如对于腋下和腹股沟创口)和对于四肢创口高达200mm(例如对于慢性创口,例如静脉腿部溃疡和糖尿病足部溃疡。
理想地,所述敷料是弹性可变形的,因为这可以增加患者舒适度和减少创口发炎的危险。
用于所述创口敷料的合适材料包括不吸收含水流体的合成聚合物材料,例如
聚烯烃,例如聚乙烯例如高密度聚乙烯,聚丙烯,它们的共聚物,例如与醋酸乙烯酯和聚乙烯醇的共聚物,以及它们的混合物;
聚硅氧烷;
聚酯,例如聚碳酸酯;
聚酰胺,例如6-6和6-10,和
疏水聚氨酯。
它们可以是亲水的,因此也包括亲水聚氨酯。
它们也包括热塑性弹性体和弹性体共混物,例如共聚物,例如乙烯醋酸乙烯酯共聚物,任选或按照需要与高抗冲聚苯乙烯共混。
它们进一步包括弹性体聚氨酯,特别是通过溶液流铸形成的聚氨酯。
用于本发明创口敷料的优选材料包括热塑性弹性体和可固化体系。
所述衬层能够在创口上面和/或在入口管和出口管周围形成相对流体不漏的密封或闭合。
但是,特别是在创口敷料边缘的周围,在相对流体不漏的密封以外,优选是具有高水蒸汽透过性的材料,来防止创口周围皮肤的浸软(maceration)。其也可以是当与液体例如水、血液或创口渗出物接触时具有更高的水蒸气透过性的可变换(switchable)的材料。这可以是例如用于Smith&Nephew’s AllevynTM、IV3000TM和OpSiteTM敷料中的材料。
衬层面对创口的面的边缘例如可以带有胶粘剂膜,用于将衬层粘合到创口周围的皮肤上。
这可以是例如压敏胶粘剂,如果这足以将创口敷料保持在位置上并且创口敷料面对创口的面边缘周围处于流体不漏的密封。
可选择的或额外的,在适当的情况下可以使用光可变换胶粘剂以保证敷料在位置上来防止泄漏。(光可变换胶粘剂是其附着力被光固化降低的胶粘剂。它的使用对于减少除去敷料时的损伤是有益的。)
因此,所述衬层可以具有在衬层靠近身体一面的周围延伸的凸缘(flange)或缘边(lip),所述边缘或缘边是透明或半透明材料的(对于这种材料,可以理解上述列出的材料处于合适的材料范围之内)。
所述边缘或缘边在其靠近身体的一面(proximal face)上负载有光可变换胶粘剂膜以保证敷料在位置上以防止泄漏,以及在其远离身体的一面(distal face)上负载有不透明材料层。
为了除去敷料且在除去敷料中不导致过量的损伤,在创口周围延伸的所述边缘或缘边的远离身体一面上的不透明材料层,在向所述边缘或缘边施加适当波长辐射之前被除去。
如果创口敷料的边缘,在相对流体不漏密封的外面,所述边缘负载有将其粘合到创口周围皮肤上的胶粘剂膜,是具有高水蒸气透过性的材料或是可变换材料,那么胶粘剂膜,如果是连续的,应该也具有高或可变换的水蒸汽透过性,例如是用于例如Smith&Nephew’sAllevynTM、IV3000TM和OpSiteTM敷料中的粘合剂。
在本发明的一些主要实施方案中(总结如上),冲洗剂和/或创口渗出物被移进或移出敷料。
这可以在作用于创口敷料上的负压下进行。这种真空可以用于在创口敷料面对创口的面边缘周围处于流体不漏的密封的情况下将创口敷料保持在位置上。
这除去了对胶粘剂的需求和对患者皮肤的相关损伤,创口敷料可以仅仅带有硅氧烷边缘或缘边以将创口敷料密封在创口周围。
或者,冲洗剂和/或创口渗出物流进和流出敷料可以在正压下进行,所述正压将作用于边缘点以将敷料从创口周围的皮肤提起并除去。
在装置的这种用法中,因此可能需要提供对抗这种创口上的正压用于形成并保持在创口上的密封或闭合的工具,从而为此目的作用在边缘点上。
此类工具的例子包括如上所述的光可变换胶粘剂,以保证敷料在位置上从而防止泄漏。
由于光可变换胶粘剂的附着力被光固化减小,所以减小了除去创口敷料的损伤,可以例如在凸缘上使用如上的更加具有侵略性的胶粘剂膜。
用于更加极端的其中对患者皮肤的损害可以容忍的条件中的合适流体胶粘剂的例子包括基本由氰基丙烯酸酯组成的那些和类似的组织胶粘剂,施用在创口边缘周围和/或创口敷料衬层靠近身体的那一面上,例如施用在凸缘或缘边上。
此类工具进一步合适的例子包括胶粘剂(例如压敏胶粘剂)和非胶粘剂,以及弹性和非弹性带、条、环、长条、系材、扎带,例如压迫性扎带、片、覆盖物、袖子、外套、护套、包裹材料、长袜和短袜。
后者包括例如弹性管状短袜(hose)或弹性管状长袜(stockings),当以这种方式实施治疗时,所述弹性管状短袜或弹性管状长袜压缩配合到四肢创口上以向创口施加适当的压力。
合适的例子还包括可膨胀的袖口、袖子、外套、裤子、护套、包裹材料、长袜和短袜,当以这种方式实施治疗时它们压缩配合到四肢创口上以向创口施加适当的压力。这些工具可以各自放置在创口敷料之上以延伸超出创口敷料衬层的边缘。
在合适的情况下它们可以粘附到或紧固到创口周围的皮肤和/或它自己上,并且在合适的情况下将施加压缩(例如用弹性扎带、长袜)到足以将创口敷料保持在位置上并且创口边缘周围处于流体不漏的密封的程度,
这些工具可以各自与敷料的其它组件特别是衬层是一个整体。
或者,它可以用例如胶粘剂膜永久地连接到或可释放地连接到敷料特别是衬层上,或者这些组件可以是VelcroTM、推进接头(push snap)或相互配合的扭转锁。
所述工具和创口敷料可以是分开的结构,相互永不连接。
在对于创口上的较高正压的更加合适的设计中,如前所定义的,刚性凸缘或缘边伸出创口敷料衬层靠近身体的那一面的边缘周围。
所述凸缘或缘边在其靠近身体的那一面是凹形的,从而限定了边缘通道或管道。
它具有通过凸缘或缘边与所述通道或管道连通的抽吸出口并且可以连接到用于施加真空的设备,例如泵或管供真空。
衬层可以与其靠近身体的那一面周围伸出的凸缘或缘边是一个整体或者通过例如热封连接到所述凸缘或缘边上。
在该装置的使用中,为了在创口上形成所需的相对流体不漏的密封或闭合和为了防止冲洗剂和/或渗出物在创口敷料面对创口那一面的边缘下通过,创口敷料安装在创口周围的皮肤上。
所述设备然后对所述凸缘或缘边的内部施加真空,从而形成并保持作用在创口周围边缘点上的密封或闭合,对抗创口上的正压。
根据所有前述连接工具和用于在创口上形成和保持密封或闭合在创口周围边缘点上对抗创口上的正或负压的工具,创口敷料密封边缘优选是大致圆形的形状,例如椭圆,并且特别是圆形的。
如上面指出的,用于从创口渗出物选择性除去对创口愈合有害的物质的清洁工具,所述清洁工具在衬层以下并且在使用中安置在下面的创口中,通常包含腔室。可透过整体模块,例如片、膜或薄膜,形成所述腔室壁的一部分。
在单相系统中,作为‘循环系统’或换向系统,移动流体的设备通过可透过整体模块将创口渗出物移进和移出清洁工具。
在两相系统中,所述腔室含有清洁流体,最常见的是流体(透析液)相。后者通过可透过整体模块从创口渗出物分离。被至少一个用于移动流体的设备在流体清洁工具之内移动的流体是清洁流体和/或任选与冲洗剂混合的创口渗出物。
现在将描述本发明清洁工具的一般特征,然后描述与敷料内的特定清洁工具相关的特定特征。
所述清洁腔室是回弹性柔韧的,例如弹性体的,并且优选是软的对创口形状具有良好适应性(conformability)的结构。有利地它是被它自己的弹性推动顶着衬层以在创面上施加柔和的压力。
所述清洁腔室可以与敷料的其它组件特别是衬层是一个整体。或者,它可以例如使用胶粘剂膜或通过热封永久连接到其它部件上,例如连接到从靠近身体的表面伸出的凸缘或缘边上,从而不会破坏所需的创口之上的相对流体不漏的密封或闭合。
偶尔,所述清洁腔室是例如用胶粘剂膜可释放的连接到衬层上,或这些组件可以是推进接头或相互配合的扭转锁。
清洁腔室和衬层可以是分开的结构,相互永不连接。
它可以是可适应中空体的形式或包含一个或多个可适应中空体,所述可适应中空体由膜、片或薄膜限定,例如袋、桶、囊或其它类似结构。
所述膜、片或薄膜,通常具有的厚度(通常是均匀的)是最高1mm,优选最高500微米,更优选20微米-500微米最小厚度,并且通常是回弹性柔软的,例如弹性体的,并优选是软的。
这些膜、片或薄膜通常与敷料的其它组件特别是衬层是一个整体,或者例如使用胶粘剂膜或通过热封永久连接到其它部件上,例如连接到凸缘上。
但是,当用在这里时术语‘腔室’包括膜、片或薄膜限定的任意中空体,并且不限于袋、囊或其它类似结构。
它可以由更加卷绕形式的聚合物材料的膜、片或薄膜形成。这可以是伸长结构的形式,例如管、管中空纤维或纤丝或细管,例如在其间存在空间的阵列中,在入口和出口歧管之间流动。
所述腔室,特别是当它是其中含有清洁流体的袋、桶、囊或其它类似结构时,当在创口治疗期间使用时可以合适地填充很大部分或全部创口空间。在不是这种情形的情况下,可能希望用填料来限制衬层下面的剩余创口空间体积或来调整腔室的体积来做到这一点。
在腔室和衬层是分离结构不直接相互连接的情况下,这种填料方便地可以位于腔室和衬层之间以分离所述结构,或在腔室之内,从而腔室可以处于直接与创面接触的位置。
所述填料有利地是回弹性柔韧的,例如是弹性体的,并且优选是软的对创口形状具有良好适应性的结构。所述腔室可以被它自己的回弹性和填料的回弹性推动以在创面上施加柔和的压力。
这些创口填料的合适形式的例子包括合适材料例如弹性热塑性塑料形成的泡沫体。对于本发明创口敷料的优选材料包括带有小口或孔的网状过滤聚氨酯泡沫体。(这种填料的例子示于后面的图7、10、11和13中。)
可选择的或额外的,它可以是可适应中空体的形式或包含一个或多个可适应中空体,所述可适应中空体由膜、片或薄膜限定并填充有推动它到创口形状上的流体或固体,例如袋、囊或其它类似结构。
包含在由膜、片或薄膜限定的中空体中的合适流体的例子包括气体,例如空气、氮气和氩气,更通常是空气,处在大气压之上的小正压;和液体,例如水,盐水。
例子还包括凝胶,例如硅氧烷凝胶,例如CaviCareTM凝胶,或优选纤维素凝胶,例如亲水的交联纤维素凝胶,例如IntrasiteTM交联材料。例子还包括气溶胶泡沫体,其中气溶胶体系的气相是空气或惰性气体,例如氮气或氩气,更通常是空气,处在大气压之上的小正压;和固体颗粒,例如塑料团粒。
这些填料可以是通过流体可膨胀和可收缩的,所述流体例如气体,例如空气或氮气,或液体,例如水或盐水,以向腔室和创口空间提供各种压力,如果装配有一个或多个入口和/或出口管的话。
当然,如果衬层是足够可适应的和/或例如是向下凹陷的片,那么衬层可以位于创口填料下面,而不是相反。图6给出了这种回弹性柔韧的(resiliently flexible)、气球填料,其是通过流体可膨胀和可收缩的,由衬层和刚性聚合物顶盖限定,所述刚性聚合物顶盖是不可透过的并且永久连接到衬层远离身体的那一面。
在这种类型的设计中,为了使创口填料向着创面推动创口敷料,它通常必须牢固地粘合到或可释放地连接到创口周围的皮肤上。在其中创口填料和衬层是分离结构相互永不连接的那些实施方案中,尤其是这种情况。图7显示了这种回弹性柔韧的气球填料在衬层之上的装置的变型。
腔室的特定性质将主要取决于所使用的清洁工具的类型。
本发明用于抽吸、冲洗和/或清洁创口的装置装配有用于流体清洁的工具,其可以是
a)单相系统,例如超滤单元,或化学吸附单元;或
b)两相系统,例如透析单元。
在前者中,来自创口的流体通过单一流动路径,其中对创口愈合有害的物质被除去并且仍旧含有对促进创口愈合有益物质的经清洁的流体被送回创口。
这种系统的实施例表示在下面的图1和2中。
在这样的系统中用于流体清洁的工具可包括宏观过滤(macrofiltration)或微观过滤(microfiltration)单元,所述过滤单元适当地包含一个或多个宏观和/或微观过滤器。这些是用于保留颗粒例如细胞碎片和微生物,允许蛋白质和营养物通过。
所述膜优选地可以是亲水聚合物材料,例如乙酸-硝酸纤维素混合物、聚偏二氯乙烯和例如亲水聚氨酯。
优选程度更小的材料的例子包括疏水材料,也包括聚酯,例如聚碳酸酯、PTFE和聚酰胺,例如6-6和6-10,和巯水聚氨酯,以及石英和玻璃纤维。
它具有微口或微孔,所述微口或微孔的最大横跨尺寸将主要取决于有待于通过这种方式选择性去除的物质种类和对其来说可透过的种类。
前者可以用微口或微孔除去,所述微口或微孔例如典型的最大横跨尺寸是20-700微米,例如20-50nm(例如对于不希望的蛋白质),50-100nm,100-250nm,250-500nm和500-700nm。
或者,用于创口渗出物清洁的工具的这部分基本上可以是一叠这种过滤器,所述过滤器在流体流动方向按照微口或微孔横跨尺寸下降的顺序依次连接。
它可以包括适当地包含一个或多个超滤过滤器的超滤单元,例如其中清洁整体模块是用于过滤对创口愈合有害物质的过滤器的超滤单元,例如是高处理量低蛋白质结合的聚合物膜、片或薄膜,所述聚合物膜、片或薄膜对于对创口愈合有害的物质是选择性不透过性的,对创口愈合有害的物质被除去并且仍旧含有对促进创口愈合有益的物质的经清洁的流体通过它。
在这种系统中的可透过整体模块可以是具有相对小的口或孔的选择性‘低通过’系统膜、片或薄膜。
用于该过滤器的合适材料包括上述为宏观过滤器和微观过滤器所列出的那些有机聚合物。
有利地是将带有这种类型清洁工具的装置作为‘循环’系统设计并运行,其中相关流体只以一个方向一次或多次通过清洁工具,因为这对于将过滤器残留物保持在创口渗出物以外是必需的。
(以‘换向系统’的形式来运行所述系统将是不合适的,因为流体至少一次以相反方向通过清洁工具将会把这些物质送回创口。)
所述过滤器整体模块可以是聚合物材料的平片或薄膜,或是更加卷绕的形式(不太常见),例如是伸长结构,例如管、细管等形式。
所述腔室或敷料可能倾向于分别是一次性的。在这种情况下,用于将流体移动通过创口渗出物清洁工具的设备启动并运转直到没有显著量的对创口愈合有害的材料保留在创口中。
然后除去并抛弃创口敷料和/或衬层下面的清洁腔室,以从创口渗出物除去对创口愈合有害的材料。
单相系统清洁工具可包括化学吸附单元,例如其中颗粒如沸石或层例如官能化的聚合物层位于其表面上的吸附单元,其能够在来自创口的流体在它们上面通过时除去对创口愈合有害的物质。
所述物质可以通过例如螯合剂和/或离子交换剂以及降解剂通过破坏或者结合对创口愈合有害的物质来除去,所述降解剂可以是酶。
在这种类型中,所述腔室壁的膜、片或薄膜不是对创口愈合有害的物质的选择性可透过的整体模块。但是,所述腔室含有一种或多种物质,所述一种或多种物质是对创口愈合有害的物质的拮抗剂从而可以从创口渗出物除去这些有害物质种类。
例如,在创口渗出物含有下面物质的情况下:
蛋白酶,例如丝氨酸蛋白酶,例如弹性蛋白酶和凝血酶;半胱氨酸蛋白酶,基质金属蛋白酶,例如胶原酶;和羧基(酸)蛋白酶;
内毒素,例如脂多糖;
血管生成抑制剂例如凝血栓蛋白-1(TSP-1)、纤溶酶原激活物抑制剂或血管抑素(angiostatin)(纤溶酶原片断);
促炎细胞因子例如肿瘤坏死因子α(TNFα)和白细胞介素1β(IL-1β),氧化剂,例如自由基,例如过氧化物和超氧化物;和金属离子,例如铁II和铁III;涉及创面上氧化应激的所有物质,或
负面影响创口渗出物中pH的碱性或酸性物质种类(species),例如质子,
所述清洁腔室,在可透过整体模块后面,合适地可以含有至少一种下面的拮抗剂,所述拮抗剂束缚在其中所述拮抗剂可以与冲洗剂和/或创口渗出物接触的腔室部分中:
蛋白酶抑制剂,例如丝氨酸蛋白酶抑制剂,例如4-(2-氨基乙基)-苯磺酰氟(AEBSF,PefaBloc)和Nα-p-甲苯磺酰基-L-赖氨酸氯甲基酮(TLCK)和ε-氨基己酰基-p-氯代苄基酰胺;半胱氨酸蛋白酶抑制剂;
基质金属蛋白酶抑制剂;和羧基(酸)蛋白酶抑制剂;
粘合剂和/或降解剂,例如结合或破坏脂多糖的抗炎物质,例如拟肽(peptidomimetics);
抗氧化剂,例如3-羟基酪胺(多巴胺)、抗坏血酸(维生素C),维生素E和谷胱甘肽,和它们的稳定衍生物,和它们的混合物;以减轻创面上的氧化应激;
金属离子螯合剂和/或离子交换剂,例如过渡金属离子螯合剂,例如铁III螯合剂(FeIII参予创面上的氧化应激。),例如去铁胺(DFO)、3-羟基酪胺(多巴胺);
铁III还原剂;或
适当地是将带有这种类型清洁工具的装置作为‘循环’系统或以‘换向系统’的形式设计并运行,因为至少一次以相反方向通过清洁工具的流体将不会把这些物质送回创口。)
这些系统的例子尤其表示在下面的图1、6和7(换向系统)和2、8和9(循环系统)中。
可能需要第二选择性可透过的整体模块(其同样合适地是聚合物材料的平片或薄膜)以在装置任何合适的部分形成在流动路径中的远离身体腔室壁的一部分,以在腔室中保留对创口愈合有害的物质和拮抗剂或其它活性物质。
这种形式系统的特定优点是,当能够从创口渗出物除去对创口愈合有害的物质的物质是(细胞)毒性或生物不相容的或对任何对促进创口愈合有益的组分是非惰性的情况下,所述系统不允许任何显著量的这种物质通过进入创口。
在两相系统中,所述腔室含有清洁流体,最常见是流体(透析液)相。后者通过可透过整体模块从创口渗出物分离。
至少一种流体被至少一个设备移动通过流体清洁工具,特别是穿过可透过整体模块,例如聚合物膜、片或薄膜。
这促进了相对高浓度的溶质或分散相物质种类包括有害物质从创口渗出物向清洁流体和所述腔室以及任选所述系统的通过,其中所述清洁流体在所述系统中再循环。这些系统进一步在下面描述。
被所述流体移动设备移动通过流体清洁工具的流体是
a)所述清洁流体或
b)任选与冲洗剂混合的创口渗出物,或
c)上述两者。
这些系统的例子示出在下面的图12和13中,其中
图12a和13显示了这样的系统、透析单元,其中只有从创口渗出物分离的清洁流体是移动流体。
图12b显示了这样的系统、透析单元,其中清洁流体和任选与冲洗剂混合的创口渗出物是移动流体。
清洁流体很少像图4中一样是静止的,因为这可能不是一个具有足够(动态)表面积以便以有实际意义的速率从创口渗出物除去对创口愈合有害的物质的系统。
在本发明用于抽吸、冲洗和/或清洁创口的装置中,流体清洁透析工具中的典型透析液流动速率是常规类型两相系统例如系统治疗透析单元中所使用的那些速率。所述整体模块可以是膜、片或薄膜,通常与常规两相系统例如系统治疗透析单元中所使用的那些具有相同的类型和相同的厚度(通常是均匀的)。
如上面所指出的,所述膜、片或薄膜可以基本是平的,但特别是在所述清洁流体循环的情况下,它更合适地可以是管、小管或细管的阵列的形式。
任何这些膜、片或薄膜的表面积可以合适地是不少于50mm2,例如100-1000000mm2,例如500-25000mm2。
如果两种流体都移动,那么可以是同向流或优选逆向流方向。
同样,对创口愈合有害的物质被除去进入透析液,而仍旧含有对促进创口愈合有益的物质的经清洁的流体保留下来或通过再循环送回创口。
如上所述的这些有害物质的例子包括
氧化剂,例如自由基,例如过氧化物和超氧化物;
铁II和铁III;涉及创面上氧化应激的所有物质;
蛋白酶,例如丝氨酸蛋白酶,例如弹性蛋白酶和凝血酶;半胱氨酸蛋白酶,基质金属蛋白酶,例如胶原酶;和羧基(酸)蛋白酶;
内毒素,例如脂多糖;
自体诱导物信号分子(autoinducer signalling molecules),例如高丝氨酸内酯衍生物,例如氧代-烷基衍生物;
血管生成抑制剂例如凝血栓蛋白-1(TSP-1)、纤溶酶原激活物抑制剂或血管抑素(纤溶酶原片断);
促炎细胞因子例如肿瘤坏死因子α(TNFα)和白细胞介素1β(IL-1β);和
炎症性物质(inflammatories),例如脂多糖,和例如组胺;和负面影响创口渗出物中pH的碱性或酸性物质种类,例如质子。
用于膜、片或薄膜的合适材料的例子(通常是由膜、片或薄膜限定的可适应中空体的形式,例如前面描述的结构)包括天然和合成聚合物材料。
所述薄膜可以是一种或多种亲水聚合物材料的薄膜,例如纤维素衍生物,例如再生纤维素,纤维素单、二或三酯,例如纤维素单、二或三醋酸酯,苄基纤维素和Hemophan,以及它们的混合物。
其它材料的例子包括疏水材料,例如芳香族聚砜、聚醚砜、聚醚醚砜、聚酮、聚醚酮和聚醚醚酮,和它们的磺化衍生物,和它们的混合物。
其它材料的例子包括疏水材料,例如聚酯,例如聚碳酸酯和聚酰胺,例如聚己二酰己二胺(6-6)和聚己二酰癸二胺(6-10);聚丙烯酸酯,包括例如聚(甲基丙烯酸甲酯),聚丙烯腈和它们的共聚物,例如丙烯腈-sodium metallosulphonate共聚物;和聚(偏二氯乙烯)。
用于本发明薄膜的合适材料包括热塑性聚烯烃,例如聚乙烯例如高密度聚乙烯,聚丙烯,它们的共聚物,例如与醋酸乙烯酯和聚乙烯醇的共聚物,以及它们的混合物。
所述透析膜应该选择具有允许对创口愈合有害的物质种类进行选择性灌注的截留分子量(MWCO),其中所述对创口愈合有害的物质种类已经被靶定要从创口除去。例如,丝氨酸蛋白酶弹性蛋白酶(分子量25900Dalton)的灌注将需要MWCO>25900Dalton的薄膜。MWCO阈值可以在1-3000000Dalton之间变化以适应各种应用。
优选地,MWCO应该与这个分子量尽可能的接近以排除更大一些的竞争物质种类的干扰。
例如,MWCO>25900Dalton的这种薄膜不允许任何显著量的针对弹性蛋白酶(α-1-抗胰蛋白酶(AAT)(分子量54000Dalton))的拮抗剂自由扩散出创口流体进入透析液,所述α-1-抗胰蛋白酶在创口中自然出现。对于促进慢性创口愈合有益的该抑制剂保持和创面接触并且可以有益地作用于创口上,而对创口愈合有害的弹性蛋白酶被除去。
本发明装置的这种用途是例如对慢性创口中的创口愈合过程是有利的,所述慢性创口是例如糖尿病足部溃疡特别是褥疮压疮。
如下面指出的,在薄膜透析液一侧的拮抗剂例如降解酶或弹性蛋白酶螯合剂,可以用于增强从创口渗出物除去这种蛋白酶。
一种不太常见类型的两相系统(见前面)可以用作流体清洁工具。在这种类型中,透析聚合物膜、片或薄膜不是对创口愈合有害的物质选择性可透过的整体模块,所述有害的物质例如蛋白酶,例如丝氨酸蛋白酶,例如弹性蛋白酶和凝血酶;半胱氨酸蛋白酶,基质金属蛋白酶,例如胶原酶;和羧基(酸)蛋白酶;
内毒素,例如脂多糖;
血管生成抑制剂例如凝血栓蛋白-1(TSP-1)、纤溶酶原激活物抑制剂或血管抑素(纤溶酶原片断);
促炎细胞因子例如肿瘤坏死因子α(TNFα)和白细胞介素1β(IL-1β);氧化剂,例如自由基,例如过氧化物和超氧化物;和金属离子,例如铁II和铁III;涉及创面上氧化应激的所有物质;和
负面影响创口渗出物中pH的碱性或酸性物质种类,例如质子。
但是它也将允许创口渗出物和/或冲洗剂流体的组分进入并通过它,所述组分可以是更大或更小的分子但有益地参予创口愈合。在透析液中,或优选在一个或多个具有至少一个与透析液接触的表面的固体结构整体模块中,在流体清洁工具中,存在能够从创口渗出物除去对创口有害物质的一种或多种物质,所述一种或多种物质是针对这些物质种类例如酶或其它物质的拮抗剂,例如蛋白酶抑制剂,例如丝氨酸蛋白酶抑制剂,例如4-(2-氨基乙基)-苯磺酰氟(AEBSF,PefaBloc)和Nα-p-甲苯磺酰基-L-赖氨酸氯甲基酮(TLCK)和ε-氨基己酰基-p-氯代苄基酰胺;半胱氨酸蛋白酶抑制剂;基质金属蛋白酶抑制剂;和羧基(酸)蛋白酶抑制剂;
粘合剂和/或降解剂,例如结合或破坏脂多糖的抗炎物质,例如拟肽;
抗氧化剂,例如3-羟基酪胺(多巴胺)、抗坏血酸(维生素C),维生素E和谷胱甘肽,和它们的稳定衍生物,和它们的混合物;以减轻创面上的氧化应激;
金属离子螯合剂和/或离子交换剂,例如过渡金属离子螯合剂,例如铁III螯合剂(FeIII参予创面上的氧化应激。),例如去铁胺(DFO)、3-羟基酪胺(多巴胺);
铁III还原剂;和
它们进一步包括肽(包括细胞因子,例如细菌细胞因子,例如α-氨基-γ-丁内酯和L-高肌肽);和
潜在地或实际地对促进创口愈合有益的牺牲氧化还原物质,例如铁III还原剂;和/或这种类型的可再生物质,例如谷胱甘肽氧化还原体系;和
其它生理活性组分。
在这种不太常见类型的两相系统透析单元的使用中,通常广谱的物质种类将从渗出物进入透析液。
一些(主要是离子的)物质种类将通过透析聚合物膜、片或薄膜从透析液进入冲洗剂和/或创口渗出物,其中所述透析聚合物膜、片或薄膜对于对创口愈合有害的物质不是非常选择性可透过的。
创口渗出物和/或冲洗剂流体的组分将通过它自由扩散出去以及回来。
最终在透析液和冲洗剂和/或创口渗出物之间建立稳态浓度平衡,所述冲洗剂和/或创口渗出物从创口敷料被‘装满(topped up)’。
循环创口流体促进更快的实现对促进创口愈合有益的物质的这种平衡。
它还把对促进创口愈合有益的物质送回到这些物质潜在地可以最有益的位置,即创面。
对创口愈合有害的目标物质也通过透析聚合物膜、片或薄膜从渗出物进入透析液,其中所述透析聚合物膜、片或薄膜对于对创口愈合有害的物质不是非常选择性可透过的。
不像创口渗出物和/或冲洗剂流体的其它组分,对创口愈合有害的目标物质与透析液或优选与一个或多个具有至少一个在透析液中的表面的固体结构整体模块接触,并被合适的拮抗剂、粘合剂和/或降解剂、螯合剂和/或离子交换剂和氧化还原试剂等除去。经过清洁的流体,仍旧含有一些对促进创口愈合有益的物质,被送回创口。
不像创口渗出物和/或冲洗剂流体的其它组分,目标物质被恒定地从透析液除去,非常少的这些物质种类会从透析液进入冲洗剂和/或创口渗出物,并且没有建立稳态浓度平衡,即使所述物质种类被恒定地从创口敷料‘装满’。
据信,循环一种或全部这两种流体帮助从再循环从创口渗出物除去对创口愈合有害的物质,同时保持对促进创口愈合有益的物质与创口接触。
这种形式两相系统的特定优点是,当能够从创口渗出物除去对创口愈合有害的物质的物质是(细胞)毒性或生物不相容的或对任何对促进创口愈合有益的组分是非惰性的情况下,所述系统不允许任何显著量的拮抗剂自由扩散出透析液进入创口流体。但是活性物质可以有益地作用于该流体上。
所述膜片或薄膜优选是截留分子量(MWCO)(如常规所定义的)选择为允许被靶定螯合或破坏的物质种类的灌注的透析薄膜。
例如,丝氨酸蛋白酶弹性蛋白酶的螯合(分子量25900Dalton)将需要MWCO>25900Dalton的薄膜。
MWCO阈值可以在1-3000000Dalton之间变化以适应各种应用。优选地,MWCO应该与这个分子量尽可能的接近以排除更大一些的竞争物质种类的鳌合干扰。
将会看到,在用于清洁创口的本发明第一方面装置的很多实施方案中,冲洗剂和/或创口渗出物和/或清洁流体通过或在衬层下面从创口敷料通过并经由返回路径返回创口敷料,所述衬层具有面对创口的面,所述面对创口的面能够在创口上形成相对流体不漏的密封或闭合。
每个返回路径将需要
至少一个用于连接到流体返回管的入口管,该入口管通过衬层的面对创口的面,和
至少一个用于连接到流体排出管的出口管,该出口管通过衬层的面对创口的面,
位点,该入口管或每一个入口管和该出口管或每一个出口管在所述位点通过面对创口的面或在面对创口的面下面,所述面对创口的面在创口上形成相对流体不漏的密封或闭合。
当任何管在关于所述装置的操作中被描述为连接到或用于连接到小管(接合端)的情况下,所述管和小管可以形成单一整体模块。
在本发明装置的运行模式是处于‘换向系统’形式的情况下,所述至少一个入口管和所述至少一个出口管,和所述至少一个流体提供管和所述至少一个出口管,可以分别是相同的整体模块。
这通常是冲洗剂和/或创口渗出物‘多通过系统’,其中该流体从创口敷料通过并返回创口,在这两种情况下都是经由清洁工具进行,例如在往复泵例如注射器或活塞泵运动的作用下。
该或每一个入口管或出口管可以具有口的形式,例如分别作为包容元件用于连接到作为插入部分的流体返回管或流体排出管的接合端(任选或按照需要通过用于形成小管、管或软管或喷嘴的工具)上的漏斗、洞、开口、管口、luer、槽口或端口。
在所述组件是整体的情况下,它们通常将由相同的材料制成(对于这一点可以理解上述所列材料处于合适的材料之内)。
或者,在它们是推进接头(push,snap)或相互配合的扭转锁的情况下,它们可以是相同的材料或是不同的材料。不论哪种情况,上述所列材料都处在对所有组件都合适的材料范围内。
衬层通常可具有刚性和/或回弹性柔韧或坚硬区域以抵御任何该或每一个管和该或每一个接合小管之间的实质摆动(substantialplay)或在压力下在任何方向的变形。
衬层通常可以被远离身体突出的凸出物(从创口向外)强化、加强或增强。
这通常在每一个用于连接到流体返回管或流体排出管的接合端的相关小管、管或软管、或喷嘴、洞、开口、管口、luer、槽口或端口的周围。
可选择的或额外的,在合适的情况下衬层可以具有在衬层靠近身体的那一面周围延伸的刚性凸缘或缘边以强化、加强或增强衬层。
单相系统例如超滤单元和两相系统例如透析单元都可以是可以相对容易地从本发明的装置卸除的模块化形式。
每个返回流动路径(不论是在单相系统中或是在两相系统例如透析单元中)都需要用于移动流体的工具。
合适的工具对有经验的技术人员来说是显而易见的,但是按照需要可以使用下面类型的小泵:
小往复泵,例如:
隔膜泵-其中一或两个柔韧隔膜的脉动移动液体而止回阀控制流体流动的方向。
注射器和活塞泵-其中活塞任选通过止逆阀泵送流体,特别是对于创面上变化的和/或可逆的正和/或负压以及对于闭合的单相换向系统,其中创口渗出物和/或冲洗剂来回通过清洁工具。
小旋转泵,例如:
旋转叶轮泵-用连接到驱动轴的旋转叶轮移动流体,在旋转时没有脉动。可以限制出口而不会损坏该泵。
蠕动泵-转子臂上的外围滚筒作用在柔韧流体循环小管上以驱动流体流在小管中按转子的方向流动;特别是对于多相循环系统中的透析液相,其中透析液相只以一个方向通过。
所述设备的类型和/或容积将主要取决于创口愈合过程最优性能所需的冲洗剂和/或来自创口的创口渗出物合适或希望的流体体积流速,和例如便携性、功率消耗和从污染物的分离等的因素。
此类设备也可以合适地是能够实现脉冲的、连续的、可变的、可逆的和/或自动的和/或程序化的流体移动的设备。它特别可以是这些类型泵中的任意一种。
本发明的主要功能,即有利地是便携式的用于冲洗和/或清洁创口的装置,将主要决定所述泵的主要功能,即用于移动流体例如(慢性)创口渗出物通过清洁工具的移动设备,而不是用于抽吸或加压正被清洁的创口。
但是所述泵可以用于向创口提供最高50%atm更经常是最高15%atm的正或负压,如流体移动一样,压力的提供可以是脉冲的、连续的、可变的、可逆的、自动的和/或程序化的。
如果创口清洁准备以这种方式进行的话,那么在衬层边缘周围的流体不漏的密封或闭合变得更为关键。
所述装置有利地是小蠕动泵或隔膜泵,例如优选是小型便携隔膜泵或蠕动泵。为了特别是减小或消除泵的内部表面和移动部件与(慢性)创口渗出物的接触以及为了容易清洁,这些是优选类型的泵。
在泵是隔膜泵并优选是小便携式隔膜泵的情况下,移动液体的连接到产生脉动的工具上的一个或两个柔韧隔膜可以各自是例如聚合物膜、片或薄膜。其可以以任何便利的形式提供,特别是作为机电振荡器,压电换能器,螺线管核芯或其中电流方向交替变化的铁磁体整体模块和线圈,旋转凸轮和从动件等。
在本发明第一方面的用于清洁创口具有两相系统的装置的一个实施方案中,没有流体通过衬层从创口敷料通过或经由返回路径返回创口敷料,其中所述装置例如是具有透析单元的装置。
因此它不需要任何用于连接到流体返回小管的入口管或任何用于连接到流体排出小管的出口管,其通过衬层面对创口的面。
在这种实施方案中,所述移动设备的主要目的是移动清洁流体。在这种实施方案中,其中合适的设备是:
这种敷料的合适例子包括例如使用旋转推进器(rotaryimpellers)的那些,所述旋转推进器例如:具有连接到驱动轴的旋转叶轮的叶片推进器,驱动轴上的螺旋桨,等。
此类设备可以和所述敷料是一个整体。可以看出,相应的装置不利地需要保证,在移动设备通过腔室壁或创口敷料的任何部分的周围,腔室的流体不漏密封或闭合。它们可能(不利地)不是便携性的。
使用这种类型创口敷料的可能性可能主要取决于实现这种相对流体不漏密封或闭合的能力。可能会希望移动设备的任何一部分都不通过腔室壁或创口敷料。
它们可以是分开的结构,为了在位于腔室内部的‘多相系统’中有效地沿着期望的流动路径穿过选择性可透过的整体模块移动清洁流体,能够适当地发生相互作用。
所述移动设备可以远距离地驱动腔室内的清洁流体以使该流体处于运动中。
所述装置的这种实施方案有利地使得能够实现在创口上的紧密密封或闭合,并且使得不需要移动设备的任何部分通过腔室壁或创口敷料。
这避免了需要保证其周围腔室的流体不漏的密封或闭合。
所述腔室因此可以例如以这种形式提供:在其内部封闭有至少一个磁从动件,并通过磁搅拌器作用在其上以推动清洁流体。推动清洁流体的所述磁搅拌器可以安装例如可释放地连接到敷料的其它部件特别是衬层上,例如用VelcroTM连接件、胶粘剂(例如压敏胶粘剂的)膜或弹性或非弹性带、条、系材、扎带例如压迫性扎带、片或覆盖物,或是推进接头或与它/它们配合的扭转锁。
它可以安装在衬层上,例如安装在衬层中心在有效形成环形腔室的圆形或同心环形中空体上方,在该环形腔室中提供有至少一个磁从动体。在使用中,磁搅拌器推动分别封闭在圆形或环形腔室中的磁从动体从而导致创口清洁流体循环。
所述膜、片或薄膜通常是选择性可透过的,含有清洁流体,并且应该具有合适的对抗脉冲压力的回弹性以允许腔室进行压缩或解压缩以经过腔室再循环创口清洁流体。
所有这些远距离设备都可以与所述敷料是一个整体,或用例如胶粘剂膜或通过热封永久连接到所述敷料特别是衬层上。
这些组件可以是可释放地连接的,例如通过VelcroTM连接件,用胶粘剂膜(例如用压敏胶粘剂)或用弹性或非弹性带、条、系材、扎带例如压迫性扎带、片或覆盖物。
另一个这种设备可以以至少一个球或球体例如固体金属球或球体的形式提供。
这设定了在患者身体移动的作用下清洁流体在移动中与整体模块的表面接触,其中所述整体模块对创口渗出物中的物质是选择性可透过的。
或者,可压缩腔室的顶部可以提供有轨道,在轨道周围患者可以移动他或她的手指以使流体在腔室周围移动。
在实践中,即使是高渗出状态的创口,渗出物流动的这种速率也只是最高达到75微升/cm2/hr(其中cm2是指创口面积)的级别,并且所述流体可以是高度流动的(由于存在的蛋白酶)。
随着创口愈合,渗出物水平下降并且创口渗出物稠度发生变化,例如变为更高粘度的液体,例如对于同一创口变为等同于12.5-25微升/cm2/hr的水平。
在对创口愈合有害的物质通过两相系统(见下面)例如透析单元除去的情况下,对于该系统流体通过流体清洁工具也潜在地发生损失。
这例如可以通过透析聚合物膜、片或薄膜发生,其中所述聚合物膜、片或薄膜除了对于对创口愈合有害的物质是可透过的外,对于水也是可透过的。
再循环流体的平衡因此可能进一步降低。可能希望来调节冲洗剂和/或创口渗出物的体积从而来最小化这种不希望的损失。
随着创口愈合,如果创口渗出物的稠度改变例如变成更高粘度的液体,可能希望来调节冲洗剂和/或创口渗出物的体积从而来调节该液体的粘度,例如调节到等同于起始水平的水平。
如上面所指出的,用于清洁创口的本发明第一方面的装置,可以在创口空间处于大气压或处于最高50%atm更通常的最高15%atm的正压或负压的情况下使用,其中所述压力施加到创口上。
按照可能的需要,可以在创口治疗之前和/或治疗期间加入流体到创口空间或从创口空间除去流体,以调节冲洗剂和/或创口渗出物体积和/或调节创口上的中、正或负压。
因此,通过连续向创口空间加入冲洗剂,可以增加冲洗剂和/或来自创口的创口渗出物的体积。通过例如在创口敷料施用到创口以前用期望数量的冲洗剂浸没(flooding)创口和/或通过在运行期间连续向创口加入冲洗剂,可以向创口施加正压。通过从创口除去流体例如使用小泵可以向创口施加负压。
在所有情况下,这可以通过相关流体通道实现,所述流体通道通过流体调节器可以自由出入,所述流体调节器例如是阀或其它控制设备,例如通过转动在开和关之间切换的阀,所述流体控制器安装在管或小管中,所述管或小管通过衬层或在衬层下面。
例如,在使用期间如果在衬层下面渗出物的积累变得过量,可以打开排放阀将过量流体排出例如排放到废物容器,任何额外压力都被释放。
同样地,通过冲洗剂可以调节任何创口流体的任何损失或可以向创面施加正压(即大气压以上的压力),所述冲洗剂通过类似的输入调节器通过衬层或在衬层下面到达创面,所述调节器例如是阀或其它控制设备,例如通过转动在开和关之间切换的阀。
通过从创口除去流体可以方便地向创面施加负压,例如使用小泵,通过类似的真空调节器例如阀或其它控制设备,例如一旦已经施加真空在真空源切断之前被旋转关闭的阀。
可选择的或额外的,在合适的情况下衬层可以具有调节器例如注入隔膜(injection septum),通过该隔膜期望数量的相关流体例如冲洗剂可以被从创口除去或被提供给创口,例如使用小注射器或类似的泵来实现希望的效果。
同样地,可以通过用于排放或向相关流动路径提供流体的工具来调整任何清洁流体中的平衡。用于排放或向相关流动路径提供流体的工具可以位于与清洁流体接触的装置的任何合适的部分。
用于排放或向相关流动路径提供流体的工具可以是调节器,例如是阀或其它控制设备,例如通过转动在排放和关闭之间切换的阀,用于从装置排放流体例如排放到废物容器例如收集袋中,或在供应和关闭之间切换的阀用于向装置供应流体。
可选择的或额外的,在合适的情况下流动路径可以具有调节器例如注入隔膜,通过该隔膜期望数量的相关流体清洁剂可以被从流动路径除去或被提供给流动路径,例如使用小注射器或类似的泵来实现希望的效果。
入口和/或出口管、流体返回小管和流体排出小管等,在存在的情况下可以是常规类型,例如具有椭圆或圆形截面,并合适地可以在它们的整个长度具有均匀的圆柱内腔、管道、管路或通道。
取决于冲洗剂和/或来自创口的创口渗出物的期望流体体积流动速率和期望的再循环数量,适当地对于大躯干创口内腔的最大横跨尺寸可以高达10mm,对于四肢创口可以高达2mm。
小管壁合适地应该足够厚以承受住施加在壁上的任何正或负压。
如果通过连续向创口加入创口渗出物和/或流体增加再循环中的冲洗剂和/或来自创口的创口渗出物的体积,就尤其是这种情况,其中所述流体来自清洁流体并通过选择性可透过的整体模块,所述整体模块是例如两相系统如透析单元的聚合物膜、片或薄膜。但是,如上面对于泵所指出的,这些小管的主要目的是在装置流动路径的整个长度上运输冲洗剂和渗出物,而不是作为压力脉管。小管合适地可以至少是25微米厚。
一旦在使用中创口敷料是在创口之上,那么用于抽吸、冲洗和/或清洁创口的装置的整个长度应该是微生物不可透过的。
理想地,创口敷料和本发明用于抽吸、冲洗和/或清洁创口的装置的内部是无菌的。
流体可以在该流体在其中移动的系统中通过紫外、γ或电子束辐射被灭菌,所述系统包括流体清洁工具。这种方式特别减少或消除了内部表面和流体与任何杀菌剂的接触。
其它流体灭菌方法的例子还包括例如使用
通过微口或微孔的超滤,所述微口或微孔例如具有0.22-0.45微米的最大横跨尺寸,对微生物是选择性不可透过的;和
流体杀菌剂,例如化学品的溶液,所述化学品例如氯己定和聚乙烯吡咯烷酮碘;金属离子源例如银盐如硝酸银;和过氧化氢;
虽然后者包括用杀菌剂接触内表面和所述流体。
理想地,即使是对于高渗出状态的创口,创口敷料的内部、流体在其中进行再循环的系统的其余部分和/或创面,被保持为无菌,或者至少天然发生的微生物生长被抑制。
还希望提供一种系统,其中对创口愈合有益的渗出物的生理活性组分在施加流体清洁之前或之后没有被除去,例如通过对促进创口愈合有益的物质的被动沉积被除去,所述对促进创口愈合有益的物质例如是蛋白质如生长因子。
所述沉积可以在系统中任何与对创口愈合有益的渗出物生理活性组分接触的点发生。
通常沉积将发生在系统中与渗出物接触的任何点上,通常是在单相系统中,但是沉积可以在多相系统的第二流体(透析液)相中发生其中在该装置的使用中对创口愈合潜在有益的创口渗出物中的物质自由扩散进入这个相中。
可以通过在与相关流体直接接触的任何点或任何整体模块上使用排斥涂层来对抗对促进创口愈合有益的物质的沉积。
涂覆在循环流体在其上通过的表面上的涂层材料例子包括抗凝剂,例如肝素,和
高表面张力材料,例如PTFE和聚酰胺,
其对于生长因子、酶和其它蛋白质和衍生物是有用的。
在所述装置的所有实施方案中,在本发明整个装置中的用于冲洗和/或清洁创口的任何小管的类型和材料将主要取决于它们的功能。
为了适合于使用,特别是对于长期时间尺度,所述材料应该是非毒性的并且是生物相容性的,适当地对于冲洗剂和/或创口渗出物的以及任何透析液的任何活性组分是惰性的。在所述装置的使用中所述材料应该不允许任何显著量的可提取物自由扩散出该材料。
所述材料应该是通过紫外、γ或电子束辐射和/或使用流体杀菌剂如化学品溶液可灭菌的,一旦使用应该是流体-和微生物-不可透过的,并且是柔韧的。
合适材料的例子包括合成聚合物材料,例如聚烯烃,如聚乙烯,例如高密度聚乙烯和聚丙烯。
用于本发明目的的合适材料还包括它们的共聚物例如与醋酸乙烯酯的共聚物,和它们的混合物。用于本发明目的的合适材料进一步包括医疗级聚(氯乙烯)。
在本发明装置中为了流体清洁目的,单相系统如超滤单元和两相系统如透析单元都可以具有例如下面所述的捕获(captive)(稳定的、不溶和/或固定的)物质种类,所述捕获物质种类结合到不溶和/或固定的)基质上,来自创口敷料的冲洗剂和/或创口渗出物在所述基质之上通过和/或穿过所述基质通过并接着进入流体返回小管:
抗氧化剂和自由基清除剂,例如3-羟基酪胺(多巴胺)、抗坏血酸(维生素C),维生素E和谷胱甘肽,和它们的稳定衍生物,和它们的混合物;以减轻创面上的氧化应激;
金属离子螯合剂和/或离子交换剂,例如过渡金属离子螯合剂,例如铁III螯合剂(Fe III参予创面上的氧化应激。),例如去铁胺(DFO)、3-羟基酪胺(多巴胺);
铁III还原剂;
蛋白酶抑制剂,例如TIMPs和α1-抗胰蛋白酶(AAT);丝氨酸蛋白酶抑制剂,例如4-(2-氨基乙基)-苯磺酰氟(AEBSF,PefaBloc)和N-α-p-甲苯磺酰基-L-赖氨酸氯甲基酮(TLCK)和ε-氨基己酰基-p-氯代苄基酰胺;半胱氨酸蛋白酶抑制剂;基质金属蛋白酶抑制剂;和羧基(酸)蛋白酶抑制剂;
通过除去触发氧化还原-敏感基因表达进入创口渗出物的物质而潜在地或实际地对促进创口愈合有益的牺牲氧化还原物质,其中所述氧化还原-敏感基因对创口愈合是有害的;
自体诱导物信号分子降解剂,其可以是酶;和结合或破坏脂多糖的抗炎物质例如拟肽;
用于调节创口渗出物中pH的试剂,例如碱或酸清除剂和/或离子交换剂,或其它物质种类,其可以是稳定的、不溶和/或固定的)物质种类,例如苯乙基吗啉(Aldrich)。
对创口愈合有害的渗出物的其它生理活性组分可以以这种方式除去。
这些有害物质可以使用合适的螯合剂和/或离子交换剂、降解剂或其它物质种类除去,所述降解剂可以是酶。
下述类型的官能化的基质在其表面上具有这样的位置,所述位置能够在来自创口的循环流体在它们上面通过时除去对创口愈合有害的物质:
非均相树脂,例如负载在二氧化硅上的反应剂如:
金属清除剂,
3-(二亚乙基三氨基)丙基-官能化的硅胶
2-(4-(亚乙基二氨基)苯)乙基-官能化的硅胶
3-(巯基)丙基-官能化的硅胶
3-(1-硫脲基)丙基-官能化的硅胶
三胺四乙酸盐(triamine tetraacetate)-官能化的硅胶
或亲电清除剂,
4-羧基丁基-官能化的硅胶
4-乙基苯磺酰氯-官能化的硅胶
丙酰氯-官能化的硅胶
3-(异氰基)丙基-官能化的硅胶
3-(氰硫基)丙基-官能化的硅胶
3-(2-琥珀酸酐)丙基-官能化的硅胶
3-(马来酰亚氨基)丙基-官能化的硅胶
或亲核清除剂,
3-氨基丙基-官能化的硅胶
3-(亚乙基二氨基)-官能化的硅胶
2-(4-(亚乙基二氨基)丙基-官能化的硅胶
3-(二亚乙基三氨基)丙基-官能化的硅胶
4-乙基-苯磺酰胺-官能化的硅胶
2-(4-甲苯磺酰基联氨基)乙基-官能化的硅胶
3-(巯基)丙基-官能化的硅胶
二甲基甲硅烷氧基-官能化的硅胶
或碱或酸清除剂,
3-(二甲基氨基)丙基-官能化的硅胶
3-(1,3,4,6,7,8-六氢-2H-嘧啶并-[1,2-α]嘧啶基)丙基-官能化的硅胶
3-(1-咪唑-1-基)丙基-官能化的硅胶
3-(1-吗啉代)丙基-官能化的硅胶
3-(1-哌嗪基)丙基-官能化的硅胶
3-(1-哌啶子基)丙基-官能化的硅胶
3-(4,4′-三甲基二哌啶子基)丙基-官能化的硅胶
2-(2-吡啶基)乙基-官能化的硅胶
3-(三甲基铵)丙基-官能化的硅胶
或下面的反应剂,
3-(1-环己基碳二亚氨基)丙基-官能化的硅胶
TEMPO-官能化的硅胶
2-(二苯基膦基)乙基-官能化的硅胶
2-(3,4-环己基二醇)丙基-官能化的硅胶
3-(环氧丙氧基)丙基-官能化的硅胶
2-(3,4-环氧环己基)丙基-官能化的硅胶
1-(烯丙基)甲基-官能化的硅胶
4-溴丙基-官能化的硅胶
4-溴苯基-官能化的硅胶
3-氯丙基-官能化的硅胶
4-苄基氯-官能化的硅胶
2-(甲氧羰基(carbomethoxy))丙基-官能化的硅胶
3-(4-硝基苯甲酰氨基)丙基-官能化的硅胶
3-(脲基)丙基-官能化的硅胶
或上述的任意组合。
这些捕获(稳定的、不溶和/或固定的)物质种类的使用,因为适合用于流体清洁工具,已经在此前进行了描述,其中所述捕获物质种类例如前面所述的那些,结合到不溶和/或固定的)基质上,来自创口敷料的冲洗剂和/或创口渗出物在所述基质之上通过和/或穿过所述基质通过。
但是,在合适的情况下它们可以额外地用于所述装置与冲洗剂和/或创口渗出物接触的任意部分,但通常在敷料内,以用于从创口除去对创口愈合有害的物质。
在本发明的第二方面,提供使用本发明用于清洁创口的装置治疗创口以促进创口愈合的方法。
下面将参考附图仅通过举例的方式来描述本发明,其中:
图1-15是根据本发明第一方面用于清洁创口的装置的截面图。
图1-11和14示出了具有用于创口渗出物清洁的单相工具的装置,并且在这些之中:
图1、2、3、6、7和14示出了换向系统,其中创口渗出物和任选的冲洗剂通过清洗工具一次或多次,至少一次以相反方向通过;和
图2、4、5、8、9、11和15示出了循环系统,其中它/它们只以一个方向通过;和
图12和13示出了具有用于创口渗出物清洁的两相工具的装置,并且在这些之中:
图12和13示出了其中清洁相通过清洁工具的此类装置。
参见图1-10和14,用于清洁创口的装置(1)包括
可适应创口敷料(2),具有
衬层(3),其能够在创口上形成相对流体不漏的密封或闭合并负载有胶粘剂膜以将衬层充分连接到皮肤上以便将创口敷料(2)固定在位置上;
清洁工具(4),用于从创口渗出物选择性除去对创口愈合有害的物质,该装置在衬层(3)下面并在使用中安置在下面的创口中;和
移动设备(7),用于移动流体通过清洁工具。
用于排放或用于向衬层下的清洁工具(4)或向渗出物提供流体的任选工具在多数图中都被省略了,所述任选工具例如调节器,例如阀。
在图1中,示出了换向系统(创口渗出物至少一次以相反方向通过清洁工具)。微生物不可透过的膜衬层(3)负载有连接在中心位置的靠近身体凸出的凹进凸出物(centrally attached proximallyprojecting recessed boss)。
安装在凸出物(11)的凹槽(recess)(14)中的多孔膜(12)和可透过薄膜(13)限定了清洁腔室(15),该清洁腔室(15)含有固体颗粒(未示出),所述固体颗粒用于螯合起始是从创口渗出物分离的有害物质。这些整体模块形成清洁工具(4)。
凸出物(11)周围的环形腔室(16)由流体不可透过的膜(17)限定,所述膜(17)在凸出物(11)和衬层的下面(3)之间伸展并连接到凸出物(11)和衬层(3)的下面上。所述环形腔室填充满柔韧弹性泡沫体(18)
入口和出口管(19)在中心位置穿过凸出物(11)并连通凸出物(11)内部和注射器筒体(20),注射器筒体(20)是注射器移动设备(7)的一部分。
在使用中,注射器活塞(22)的移动吸取和推动创口渗出物来回穿过清洁工具(4)。
图(2)中的装置(1)可以作为循环系统操作,或既作为循环系统又作为换向系统操作。
它与图1在结构上是相似的,不同之处主要在于入口管返回环线(19)以弯管穿过凸出物(11)并经由非返回阀(21)连通腔室(16)内部和注射器筒体(20),其对流动的阻力相对于清洁工具(4)的阻力要低。从腔室(16)排放流体的工具,例如阀,被从图2中省略了。
在使用中,注射器移动设备(7)的活塞(22)被抽出以吸取创口渗出物进入清洁工具(4),清洁工具(4)从创口渗出物螯合有害物质。
注射器移动设备(7)的活塞(22)然后返回以强制经过清洁的创口渗出物经由阀(21)进入环形腔室(16),并从那里穿过多孔膜(17)回到创口。
在注射器活塞的每次返回行程,一定比例经清洁的创口渗出物也经由清洁工具(4)被推动返回。该比例主要取决于返回环线(19)在注射器筒体上的位置。返回环线连接到注射器筒体的位置离注射器近端(proximal end)越远,泵送到环形腔室(16)的数量就越低,因为活塞在返回行程的后半段切断了返回环线(19)。
主要取决于在本发明装置的这个实施方案中所使用的清洁工具的类型,相对于清洁工具(4)的阻力阀(21)的阻力也可以影响通过腔室(16)和通过多孔膜(17)的这个比例。
腔室(16)中的多余压力,例如来自高渗出状态创口的创口渗出物,可以通过排放阀减小,如果安装有排放阀的话。
图(3)中装置(1)与图2中装置的主要不同之处在于流动路径中多孔膜(12)的位置。
使用模式是相同的:注射器活塞(22)的移动穿过清洁工具(4)吸取创口渗出物并强制创口渗出物返回。
图(4)中装置(1)与图2中装置的不同之处在于移动装置设备(7)。
这是按钮泵而不是注射器。该泵(7)安装在衬层(3)远离身体的那一面上。
它包括回弹性可压缩吸入腔室(26),腔室(26)通过出口管(19)连接到清洁工具(4)并通过转移管(27)经由低阻力第一非返回阀(31)连接到回弹性可压缩排出腔室(36),腔室(36)经由入口管(20)和低阻力第二非返回阀(32)连接到腔室(16)的内部。
在使用中,吸入腔室(26)被手工压缩并释放,它到其原始构型的恢复导致创口渗出物被抽吸通过清洁工具(4)。
排出腔室(36)然后被手工压缩并释放,它到其原始构型的恢复导致经清洁的创口渗出物被从吸入腔室(26)抽吸通过第一非返回阀(31)。
吸入腔室(26)然后再次被手工压缩并释放,它的压缩导致经清洁的创口渗出物通过第一非返回阀(31)从吸入腔室(26)被泵送进入排出腔室(36),并且它到其原始构型的恢复导致创口渗出物被抽吸通过清洁工具(4)。
排出腔室(36)然后再次被手工压缩并释放,它的压缩导致经清洁的创口渗出物从排出腔室(36)通过第二非返回阀(32)被泵送进腔室(16),并且它到其原始构型的恢复导致经清洁的创口渗出物被抽吸通过吸入腔室(26)。
只要需要可以一直重复这个循环,并且从第二个循环开始,当手工压缩排出腔室(36)时,它导致经清洁的创口渗出物被强迫通过环形腔室(16)并从那里通过多孔膜(17)返回创口。
参见图5-7和10,每幅图中的装置(1)都包括包含腔室(5)的清洁工具(4),在这里是可适应中空袋,由衬层(3)和聚合物膜(6)限定,所述聚合物膜(6)是可透过的并且永久连接到衬层(3)靠近身体的那一面上。
使用中所述清洁工具(4)在圆顶形的衬层(3)下位于下面的被处理的创口中,并含有吸收在回弹性柔韧泡沫体(41)中的清洁流体。
图5-7和10示出了将创口渗出物移进和移出清洁装置(4)的不同方法。
在图5中,与衬层(3)接触安装在中心位置的机电振荡器或压电换能器(43)安装在刚性框架(44)上并电连接到适当的交流电源(45)(示意性示出),所述刚性框架(44)安装在衬层(3)的边缘。腔室(5)装配有排放阀(8)。如果在使用期间衬层(3)下面渗出物的积累变得过量,可以打开排放阀(8)并将过量的流体排出,任何超出的压力被释放。
在图(6)中,泡沫体(41)具有回弹性柔韧的气球核芯(47),气球核芯(47)是流体可膨胀和可收缩的,所述流体例如气体如空气或氮气或者液体如水或盐水,以便经由安装在衬层(3)边缘的入口和出口管(48)向腔室(5)施加不同的压力。
管(48)连接到合适的移动设备(58)(未示出),该设备用于将膨胀流体移进和移出核芯(47)从而将创口渗出物移进和移出清洁工具(4)。这种设备合适的是能够实现任选脉冲地可逆移动流体的设备。
所述设备特别可以是小蠕动泵或隔膜泵,例如优选电池驱动的小型便携式隔膜泵或蠕动泵,例如安装在衬层(3)中心位置的上面在腔室(5)之上并可释放的连接到衬层(3)。
图7示出了图6装置(1)的变化形式。衬层(3)下面的回弹性柔韧气球核芯(47)被回弹性柔韧气球腔室(49)取代,所述气球腔室(49)由衬层(3)和刚性聚合物圆顶(50)限定,所述刚性聚合物圆顶(50)是不可透过的并且永久连接到衬层(3)远离身体的那一面。
由衬层(3)和刚性聚合物圆顶(50)限定的气球腔室(49)也是流体可膨胀和可收缩的,所述流体例如气体如空气或氮气或者液体如水或盐水,以便经由安装在背衬圆顶(50)边缘的入口和出口管(51)向腔室(5)施加不同的压力。
合适的移动设备(58)(未示出)用于将膨胀流体移进和移出气球腔室(49)从而将创口渗出物移进和移出清洁工具(4),如在图6中所指出的,该设备可以安装在圆顶(50)上面而不是衬层(3)上面。
在图10中,在电线圈(54)内部的电磁螺线管核芯(53)与衬层(3)接触在中心位置安装在刚性凸缘(55)上。电线圈(54)电连接到适当的交流电源(60)(示意性示出)。
腔室(5)在其底部提供有铁磁材料的连接盘(attached disc)(56),所述连接盘(56)针对创口渗出物和清洁流体被包覆。
随着电流的方向交替变化,螺线管核芯跟随着变化,从而压缩和释放腔室(5),因而导致创口渗出物被强迫进出清洁工具(4)。
图8和9示出了图1和4的装置(1)的变化形式。在两种情况下分别取代注射器和按钮泵的移动装置(7)是小蠕动泵或隔膜泵。所述移动装置(7)优选是电池驱动的小型便携式隔膜泵或蠕动泵,例如安装在衬层(3)中心位置的上面在腔室(5)之上并可释放的连接到衬层(3)。
图11示出了带有用于创口渗出物清洁的单相工具的装置,其中创口渗出物只以一个方向一次或多次通过清洁工具。在结构上其与图5-7和10中示出的装置相似。
装置(1)包括包含腔室(5)的清洁工具(4),所述清洁工具(4)在这里是可适应中空袋,由衬层(3)和聚合物膜(6)限定,所述聚合物膜(6)是可透过的并且永久连接到衬层(3)靠近身体的那一面上。它含有吸收在弹性柔韧泡沫体(41)中的清洁流体。
回弹性柔韧泡沫体(41)包含在可透过薄膜(43)中并含有从创口渗出物螯合有害物质的物质。
这些整体模块形成清洁工具(4)。
出口管(69)在中心位置通过衬层(3)并连通腔室(5)内部和泵,所述泵例如优选是电池驱动的小型便携式隔膜泵或蠕动泵,例如安装在衬层(3)中心位置的上面在腔室(5)之上并可释放的连接到衬层(3)。
入口管(20)在边缘位置通过衬层(3)并连通创口空间和所述泵。
在使用中,创口渗出物被泵(7)移动通过清洁工具(4),并且泡沫体(41)从创口渗出物螯合有害物质。
图12示出了具有用于创口渗出物清洁的两相工具的装置,其中清洁相移动。
图12a示出了其中只有清洁相移动的装置
图12b示出了其中清洁相和创口渗出物移动的装置。
在两个图中,装置(1)都包括包含腔室(5)的清洁工具(4),在此处清洁工具(4)是在阵列中的细管的形式,在衬层(3)下面在第一凸出物(71)和第二凸出物(72)之间,所述第一凸出物(71)和第二凸出物(72)都安装在衬层(3)中。所述细管由聚合物薄膜制成并含有透析液流体,所述聚合物薄膜对创口渗出物中的有害物质是选择性可透过的。
入口管(20)从第一凸出物(71)通过并连通腔室(5)内部和泵(7),所述泵例如优选是电池驱动的小型便携式隔膜泵或蠕动泵,例如安装在衬层(3)中心位置的上面在腔室(5)之上并可释放的连接到衬层(3)。出口管(21)从第二凸出物(72)通过并连通腔室(5)内部和泵(7)。
在使用中,透析液流体被泵(7)移动通过清洁工具(4)并且它从创口渗出物除去有害物质。
在图12b中,第三凸出物(78)具有在中心位置通过它的创口渗出物出口和第四凸出物(79)具有在中心位置通过它的创口渗出物入口,第三凸出物(78)和第四凸出物(79)都安装在衬层(3)的边缘并且相互正好相反地相对安装。
创口渗出物出口管(80)连接到第三凸出物(78)并连通创口内部和第二泵(82)(未示出)的入口,所述第二泵(82)优选是电池驱动的小型便携式隔膜泵或蠕动泵,安装在衬层(3)中心位置的上面。
创口渗出物入口管(81)连接到第四凸出物(79)并连通创口内部和第二泵的出口。
在使用中,不仅透析液流体被第一泵(7)移动通过清洁工具(4),其中所述透析液流体从创口渗出物除去有害物质,而且创口渗出物相被第二泵以逆流方向在衬层(3)下面移动通过创口空间以增强从创口渗出物的除去。
图13示出了具有用于创口渗出物清洁的两相工具的装置,其中清洁相移动。
装置(1)包括包含腔室(5)的清洁工具(4),所述清洁工具(4)在这里是袋的形式,在衬层(3)下面和在泡沫体填充物(81)下面。
所述袋由聚合物薄膜制成并含有透析液流体,所述透析液流体作为溶质或分散相物质种类含有用于螯合或降解来自创口渗出物的有害物质的物质。所述薄膜选择为是选择性可透过的,以允许被靶定螯合或破坏的有害物质物质种类从创口渗出物进入透析液的灌注,但不允许任何显著量的透析液流体相中的拮抗剂自由扩散出透析液进入创口流体。
出口管(89)通过衬层(3)并连通腔室(5)内部和泵,所述泵例如优选是电池驱动的小型便携式隔膜泵或蠕动泵,例如安装在衬层(3)中心位置的上面在腔室(5)之上并可释放地连接到衬层(3)。入口管(90)在边缘位置通过衬层(3)并连通腔室(5)和所述泵。
在使用中,透析液被泵(7)移动通过清洁工具(4)。被靶定螯合或破坏的有害物质物质种类从创口渗出物进入透析液,其中透析液流体相中的拮抗剂从创口渗出物除去有害物质而不扩散出来进入渗出物。
在图14中,示出了在结构上与图1和3中示出的装置相似的换向系统(创口渗出物至少以相反方向通过清洁工具一次)。
由溶液流铸或挤出形成的微生物不可透过的聚氨酯膜衬层(3),负载有连接在中心位置的靠近身体凸出的凸出物(11),该凸出物(11)带有用于连接到流体供应和排出小管(19)接合端的luer,小管(19)连通凸出物(11)内部和注射器筒体(20),该筒体是注射器移动设备(7)的一部分。
下面的多孔膜(12)和中间多孔薄膜(13),都是由带有小口或孔的可透过聚氨酯薄膜制成,限定了包含固体颗粒(未示出)的清洁腔室(15)。所述固体颗粒是用于从创口渗出物螯合有害物质,所述有害物质起始是从创口渗出物分离的。这些整体模块与共同延伸的不可透过上部片(24)形成上腔室(25),并且所有这些一起形成清洁工具(4),其中所述上部片(24)具有调整到与凸出物(11)中的管路相配合的上部口。上部片安装在凸出物(11)的下部面上并且所述上部口与凸出物(11)中的管路相配合。
在使用中,注射器活塞(22)的移动吸取并强迫创口渗出物来回通过清洁工具(4)。
图15中的装置(1)是循环系统(创口渗出物只以一个方向一次或多次通过清洁工具)。其是图8和9的装置(1)的变化形式。
由溶液流铸形成的微生物不可透过的聚氨酯膜衬层(3),负载有连接在中心位置的靠近身体凸出的凸出物(11),该凸出物(11)带有穿过它的均匀圆柱内腔管路和用于连接到流体供应小管(20)接合端的luer,小管(20)连通凸出物(11)内部和移动设备(7)的出口。
移动设备(7)是电池驱动的小型便携式隔膜泵或蠕动泵,安装在衬层(3)中心位置的上面并可释放的连接到衬层(3)。
带有用于连接到流体排出小管(83)接合端的luer的第二靠近身体凸出的凸出物(82),安装在衬层(3)的边缘位置。流体排出小管(83)连通创口空间和泵(7)的入口。
下面的多孔膜(12)和中间多孔薄膜(13),都是由带有小口或孔的可透过聚氨酯薄膜制成,限定了包含固体颗粒(未示出)的清洁腔室(15),所述固体颗粒是用于从创口渗出物螯合有害物质,所述有害物质起始是从创口渗出物分离的。这些整体模块与共同延伸的不可透过上部片(24)形成上腔室(25),并且所有这些一起形成清洁工具(4),其中所述上部片(24)具有调整到与凸出物(11)中的管路相配合的上部口。上部片安装在凸出物(11)的下部面上并且所述上部口与凸出物(11)中的管路相配合。
在使用中,创口渗出物被泵(7)移动通过清洁工具(4),并且所述颗粒(未示出)从创口渗出物螯合有害物质。
下面将通过举例方式仅以下述实施例说明本发明装置的用途:
实施例1:用图1的装置从水溶液清洁Fe(II):单相手动注射器泵送
的含有固体螯合剂的敷料(卡地姆-去铁胺)
组装如图14中所示的手工注射器泵送的敷料。清洁腔室(15)含有负载在卡地姆上的固体颗粒(未示出)去铁胺(50mg)以从替代渗出物中螯合并除去有害的Fe(II)离子。
多孔膜(12)和可透过薄膜(13),都是由Porvair可透过薄膜制成,选择为在注射器泵送下允许灌注和流动通过所述清洁器但是含有所述固体反应剂。
在三次试验中,将如图1所示的敷料施用到9.60ml容积的环形创口空穴(浇铸在Perspex中),所述创口空穴含有四水合氯化亚铁(Aldrich)水溶液(9.60ml,200μmolar)。
使用所述设备注射器将所述溶于重复地完全抽出并完全重新注回。在每一次抽出时,使用如下的ferrozine分析检验100微升量的溶液:将每100微升量的溶液立即加入1.5ml容积、含有1ml Ferrozine储备溶液(73.93mg Ferrozine用蒸馏水稀释至250ml(600μM))、光程长度1cm的UV比色皿中。在培养至少5min之后读取吸收率(562nm)读数。使用UNICAM UV4-100UV-Vis分光光度计V3.32(序列号022405)测量吸收率。以4分钟为间隔,总共通过六次。在没有流动(即没有注射器泵送通过清洁器)的情况下重复同样的方法并在等同的时间点取样。
结果和结论
对得到的铁浓度曲线进行平均并确定标准偏差。在3个完全循环(12分钟)之后Fe(II)浓度被有效降低到背景水平。在对照试验中,在相同的时间周期内,没有发生显著的浓度变化。如图1中所示的敷料有效地从水溶液例如水、盐水或创口渗出物螯合Fe(II)。
组装如图15中所示的再循环泵送的敷料。清洁腔室(15)含有苯乙基吗啉(Aldrich)的固体颗粒(50mg)(未示出),其是低膨胀大孔高度交联的聚苯乙烯/二乙烯基苯离子交换剂树脂基质,具有200-400微米的颗粒尺寸,用于从替代渗出物清除和除去质子,其中质子是不利地影响创口渗出物中pH的酸性物质种类。
多孔膜(12)和可透过薄膜(13),都是由Porvair可透过薄膜制成,选择为在泵送下允许灌注和流动通过所述清洁器但是含有所述离子交换反应剂。
在三次试验中,使用三份4.80ml DMEM,设备2施用到9.60ml容积的环形创口空穴(浇铸在Perspex中),所述创口空穴含有Dulbecco’s Modified Eagles Medium(DMEM)(Sigma)(4.80ml,使用盐酸(0.975N水溶液,75μl)调节pH到pH6.6)。剩余的空穴体积用玻璃珠填充。所述溶液以2.35ml min-1的流速循环通过空穴。在5min时间点取样100μl直到40min,并使用平板(flat-bed)pH计记录pH。在没有流动(即没有泵送循环溶液)的情况下重复同样的方法并在等同的时间点取样。
结果和结论
对得到的pH曲线进行平均并确定标准偏差。在40分钟内pH被有效地调节到pH 7.4。在对照试验中,在相同的时间周期内观察到pH的变化较慢,pH变化到pH 7。
实施例3:使用图12的装置利用扩散通过透析薄膜从水溶液清洁弹性
蛋白酶:两相再循环泵送的不含反应剂的敷料
组装如图12所示的再循环泵送的敷料。清洁腔室(5)是细管的形式,所述细管由对创口渗出物中的有害物质(弹性蛋白酶)是选择性可透过的聚合物薄膜制成。这些细管排成阵列,在衬层(3)下面在创口空间之内位于第一凸出物(71)和第二凸出物(72)之间,第一凸出物(71)和第二凸出物(72)都安装在衬层(3)之中。所述细管含有透析液流体并且与泵(7)处于环路之中。
在三次试验中,将如图12中所示的敷料施用到9.60ml容积的环形创口空穴(浇铸在Perspex中),所述创口空穴含有弹性蛋白酶溶液(猪胰腺弹性蛋白酶,Sigma)(4.80ml,0.5mg ml-1在TRIS缓冲液中,pH8.2,0.2M)。剩余的空穴体积用玻璃珠填充。入口和出口端口连接到循环泵。
所述透析液系统预填充有TRIS(pH8.0,0.2M)。透析液以2.35mlmin-1的流速循环通过敷料。在5min时间点取10μl循环溶液样品直到45min,并使用标准N-琥珀酰基-(丙氨酸(ala))3-对硝基苯胺比色测试测量活性。在没有流动(即没有泵送循环溶液)的情况下重复同样的方法并在等同的时间点取样。
结果和结论
使用UV/Vis分光光度计从样品在405nm的吸收率测定样品活性。平均结果并确定标准偏差。在45分钟内发现弹性蛋白酶通过透析薄膜的有效转移。在对照试验中,在相同的时间周期内没有发现有效的转移。
实施例4:使用图13的装置从水溶液清洁Fe(II):两相再循环泵送的
含有液体相螯合剂(淀粉-去铁胺(DFO)结合物(conjugate))的敷料
组装图13中装置(1)的类似装置,即具有循环系统(创口渗出物只以一个方向一次或多次通过清洁工具),该循环系统具有用于创口渗出物清洁的两相工具,其中清洁相移动。
装置(1)包括清洁工具(4),清洁工具(4)包括由聚合物薄膜制成并含有透析液流体的腔室(5),所述透析液流体作为溶质或分散相物质种类含有用于从创口渗出物螯合或降解有害物质的物质。
所述薄膜选择为是选择性可透过的,以允许被靶定螯合或破坏的有害物质物质种类从创口渗出物进入透析液的灌注,但不允许任何显著量的透析液流体相中的拮抗剂自由扩散出透析液进入创口流体。
所述类似装置是含有0.5-1.0ml容积的Slide-A-Lyzer透析单元的回路,所述透析单元具有上腔室和下腔室其中创口渗出物和清洁流体被聚合物薄膜相互分开,所述聚合物薄膜选择为具有上述性质(MWCO10000)。
清洁流体通过的下腔室,具有斜对着相对放置的用针打开的入口和出口端口,所述端口连接到5ml容积的回路,所述回路包括透析液储室和电池驱动的小型便携式隔膜泵或蠕动泵。所述回路含有高分子量淀粉-DFO结合物水溶液(5ml,4mg/ml)。
将等分量的四水合氯化亚铁(Aldrich)溶液(0.5ml 3mM)放入slide的上空穴中并用回路中3.6ml/min的流动进行透析,并且(作为对照)在回路中没有流动的情况下进行透析。
间隔以5分钟在30分钟内(包括t=0)每次取样10微升等分量。使用上述实施例1中描述的ferrozine铁(II)测试方法测定所述10微升等分量的溶液。这些试验平行进行三次。
结果和结论
对得到的铁浓度曲线进行平均并确定标准偏差。在30分钟内Fe(II)浓度被有效降低到起始水平的约50%。在相同的时间周期内,在没有回路流动的情况下,Fe(II)浓度被有效降低到起始值的约75%。
Claims (12)
1.用于清洁创口的装置,包括:
可适应创口敷料,具有
衬层,其能够在创口上形成相对流体不漏的密封,和
特征在于该装置还包括:
a)用于从创口渗出物选择性除去对创口愈合有害的物质的清洁工具,该工具在衬层下面并且使用中安置在下面的创口中,和
b)在清洁工具内移动流体的移动设备。
2.权利要求1的用于清洁创口的装置,其还包括用于排放该清洁工具的排放工具。
3.权利要求1或2的用于清洁创口的装置,特征在于所述装置是单相系统,其中被移动通过清洁工具的流体是创口渗出物或与冲洗剂混合的创口渗出物,所述创口渗出物或与冲洗剂混合的创口渗出物进入、通过并流出清洁工具回到创面。
4.权利要求3的用于清洁创口的装置,特征在于所述装置是作为循环系统操作,其中创口渗出物或与冲洗剂混合的创口渗出物只以一个方向一次或多次通过所述清洁工具。
5.权利要求3的用于清洁创口的装置,特征在于所述装置是作为换向系统操作,其中创口渗出物或与冲洗剂混合的创口渗出物至少一次以相反方向通过所述清洁工具。
6.权利要求1或2的用于清洁创口的装置,特征在于所述装置是多相系统,其中清洁工具包括含有清洁流体的腔室,所述清洁流体借助于可透过整体模块与创口渗出物分开,被移动流体的设备移动通过该清洁工具的流体是
(i)清洁流体,和/或
(ii)创口渗出物或与冲洗剂混合的创口渗出物。
7.权利要求6的用于清洁创口的装置,特征在于所述装置是作为循环系统操作,其中被移动流体的设备移动通过该清洁工具的流体只以一个方向一次或多次通过所述清洁工具。
8.权利要求6的用于清洁创口的装置,特征在于所述装置是作为换向系统操作,其中被移动流体的设备移动通过该清洁工具的流体至少一次以相反方向通过所述清洁工具。
9.权利要求6的用于清洁创口的装置,特征在于被移动流体的设备移动通过该清洁工具的流体只是所述清洁流体。
10.权利要求6的用于清洁创口的装置,特征在于被移动流体的设备移动通过该清洁工具的流体是
(i)所述清洁流体,和
(ii)创口渗出物或与冲洗剂混合的创口渗出物。
11.权利要求6的用于清洁创口的装置,特征在于所述可透过整体模块对于创口渗出物中的对创口愈合有害的物质是选择性可透过的。
12.权利要求6的用于清洁创口的装置,特征在于所述可透过整体模块不是对于对创口愈合有害的物质是选择性可透过的整体模块,并且特征在于在清洁流体中,或在一个或多个具有至少一个与清洁流体接触的表面的固体结构整体模决中,存在一种或多种能够除去创口渗出物中对创口愈合有害的物质的物质。
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PCT/GB2004/004549 WO2005051461A1 (en) | 2003-10-28 | 2004-10-28 | Wound cleansing apparatus in-situ |
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Families Citing this family (355)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9119705B2 (en) | 1998-06-08 | 2015-09-01 | Thermotek, Inc. | Method and system for thermal and compression therapy relative to the prevention of deep vein thrombosis |
US7846141B2 (en) | 2002-09-03 | 2010-12-07 | Bluesky Medical Group Incorporated | Reduced pressure treatment system |
GB0224986D0 (en) | 2002-10-28 | 2002-12-04 | Smith & Nephew | Apparatus |
US20060200100A1 (en) * | 2003-06-18 | 2006-09-07 | Rosati Coni F | Method and apparatus for supplying gas to an area |
US8574278B2 (en) | 2006-05-09 | 2013-11-05 | Thermotek, Inc. | Wound care method and system with one or both of vacuum-light therapy and thermally augmented oxygenation |
US8128672B2 (en) | 2006-05-09 | 2012-03-06 | Thermotek, Inc. | Wound care method and system with one or both of vacuum-light therapy and thermally augmented oxygenation |
EP1646351B1 (en) | 2003-07-18 | 2011-03-30 | Thermotek, Inc. | Thermal system for a blanket |
GB0325120D0 (en) | 2003-10-28 | 2003-12-03 | Smith & Nephew | Apparatus with actives |
GB0325126D0 (en) | 2003-10-28 | 2003-12-03 | Smith & Nephew | Apparatus with heat |
GB0518826D0 (en) * | 2005-09-15 | 2005-10-26 | Smith & Nephew | Apparatus with actives from tissue - exudialysis |
GB0518804D0 (en) * | 2005-09-15 | 2005-10-26 | Smith & Nephew | Exudialysis tissue cleanser |
US8758313B2 (en) | 2003-10-28 | 2014-06-24 | Smith & Nephew Plc | Apparatus and method for wound cleansing with actives |
US11298453B2 (en) | 2003-10-28 | 2022-04-12 | Smith & Nephew Plc | Apparatus and method for wound cleansing with actives |
GB0518825D0 (en) * | 2005-09-15 | 2005-10-26 | Smith & Nephew | Apparatus with actives from tissue - sai |
GB0325129D0 (en) | 2003-10-28 | 2003-12-03 | Smith & Nephew | Apparatus in situ |
GB0325130D0 (en) * | 2003-10-28 | 2003-12-03 | Smith & Nephew | Apparatus with scaffold |
GB0409443D0 (en) * | 2004-04-28 | 2004-06-02 | Smith & Nephew | Apparatus |
US7776028B2 (en) | 2004-04-05 | 2010-08-17 | Bluesky Medical Group Incorporated | Adjustable overlay reduced pressure wound treatment system |
US7708724B2 (en) | 2004-04-05 | 2010-05-04 | Blue Sky Medical Group Incorporated | Reduced pressure wound cupping treatment system |
US8062272B2 (en) | 2004-05-21 | 2011-11-22 | Bluesky Medical Group Incorporated | Flexible reduced pressure treatment appliance |
US7909805B2 (en) | 2004-04-05 | 2011-03-22 | Bluesky Medical Group Incorporated | Flexible reduced pressure treatment appliance |
US10058642B2 (en) | 2004-04-05 | 2018-08-28 | Bluesky Medical Group Incorporated | Reduced pressure treatment system |
GB0409444D0 (en) * | 2004-04-28 | 2004-06-02 | Smith & Nephew | Apparatus |
GB0409291D0 (en) | 2004-04-27 | 2004-06-02 | Smith & Nephew | Apparatus with stress |
GB0508528D0 (en) * | 2005-04-27 | 2005-06-01 | Smith & Nephew | SAI with macrostress |
GB0508531D0 (en) * | 2005-04-27 | 2005-06-01 | Smith & Nephew | Sai with ultrasound |
GB0424046D0 (en) * | 2004-10-29 | 2004-12-01 | Smith & Nephew | Apparatus |
GB0409446D0 (en) | 2004-04-28 | 2004-06-02 | Smith & Nephew | Apparatus |
US7753894B2 (en) * | 2004-04-27 | 2010-07-13 | Smith & Nephew Plc | Wound cleansing apparatus with stress |
US10413644B2 (en) | 2004-04-27 | 2019-09-17 | Smith & Nephew Plc | Wound treatment apparatus and method |
GB0409293D0 (en) * | 2004-04-27 | 2004-06-02 | Smith & Nephew | Apparatus with flow stress |
GB0508529D0 (en) * | 2005-04-27 | 2005-06-01 | Smith & Nephew | Sai with microstress |
GB0409292D0 (en) * | 2004-04-27 | 2004-06-02 | Smith & Nephew | Apparatus with ultrasound |
US8529548B2 (en) | 2004-04-27 | 2013-09-10 | Smith & Nephew Plc | Wound treatment apparatus and method |
US7998125B2 (en) * | 2004-05-21 | 2011-08-16 | Bluesky Medical Group Incorporated | Hypobaric chamber treatment system |
US10765785B2 (en) | 2004-07-19 | 2020-09-08 | Thermotek, Inc. | Wound care and infusion method and system utilizing a therapeutic agent |
US10016583B2 (en) | 2013-03-11 | 2018-07-10 | Thermotek, Inc. | Wound care and infusion method and system utilizing a thermally-treated therapeutic agent |
US8298262B2 (en) | 2006-02-03 | 2012-10-30 | Biomet Sports Medicine, Llc | Method for tissue fixation |
US8088130B2 (en) | 2006-02-03 | 2012-01-03 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US8128658B2 (en) | 2004-11-05 | 2012-03-06 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to bone |
US7905904B2 (en) | 2006-02-03 | 2011-03-15 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US8303604B2 (en) | 2004-11-05 | 2012-11-06 | Biomet Sports Medicine, Llc | Soft tissue repair device and method |
US7658751B2 (en) | 2006-09-29 | 2010-02-09 | Biomet Sports Medicine, Llc | Method for implanting soft tissue |
US7909851B2 (en) | 2006-02-03 | 2011-03-22 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US9801708B2 (en) | 2004-11-05 | 2017-10-31 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US7749250B2 (en) | 2006-02-03 | 2010-07-06 | Biomet Sports Medicine, Llc | Soft tissue repair assembly and associated method |
US8118836B2 (en) | 2004-11-05 | 2012-02-21 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US8137382B2 (en) | 2004-11-05 | 2012-03-20 | Biomet Sports Medicine, Llc | Method and apparatus for coupling anatomical features |
US8361113B2 (en) | 2006-02-03 | 2013-01-29 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US9017381B2 (en) | 2007-04-10 | 2015-04-28 | Biomet Sports Medicine, Llc | Adjustable knotless loops |
AU2006287463A1 (en) | 2005-09-06 | 2007-03-15 | Tyco Healthcare Group Lp | Self contained wound dressing with micropump |
US7699823B2 (en) | 2005-09-07 | 2010-04-20 | Tyco Healthcare Group Lp | Wound dressing with vacuum reservoir |
CA2923372C (en) | 2005-09-07 | 2019-07-30 | Smith & Nephew, Inc. | Self contained wound dressing apparatus |
EP3292846A1 (de) * | 2005-11-02 | 2018-03-14 | BSN Medical GmbH | Absorptionskörper zur anbringung an menschliche oder tierische hautoberflächen |
GB0524027D0 (en) * | 2005-11-25 | 2006-01-04 | Smith & Nephew | Fibrous dressing |
DE202005019670U1 (de) | 2005-12-14 | 2006-04-27 | Riesinger, Birgit | Wundbehandlungsvorrichtung mit elastisch verformbarem Unterdruckerzeugungselement |
US8562645B2 (en) | 2006-09-29 | 2013-10-22 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US11259792B2 (en) | 2006-02-03 | 2022-03-01 | Biomet Sports Medicine, Llc | Method and apparatus for coupling anatomical features |
US9149267B2 (en) | 2006-02-03 | 2015-10-06 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US8968364B2 (en) | 2006-02-03 | 2015-03-03 | Biomet Sports Medicine, Llc | Method and apparatus for fixation of an ACL graft |
US11311287B2 (en) | 2006-02-03 | 2022-04-26 | Biomet Sports Medicine, Llc | Method for tissue fixation |
US9078644B2 (en) | 2006-09-29 | 2015-07-14 | Biomet Sports Medicine, Llc | Fracture fixation device |
US8562647B2 (en) | 2006-09-29 | 2013-10-22 | Biomet Sports Medicine, Llc | Method and apparatus for securing soft tissue to bone |
US10517587B2 (en) | 2006-02-03 | 2019-12-31 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US8597327B2 (en) | 2006-02-03 | 2013-12-03 | Biomet Manufacturing, Llc | Method and apparatus for sternal closure |
US9538998B2 (en) | 2006-02-03 | 2017-01-10 | Biomet Sports Medicine, Llc | Method and apparatus for fracture fixation |
US8652171B2 (en) | 2006-02-03 | 2014-02-18 | Biomet Sports Medicine, Llc | Method and apparatus for soft tissue fixation |
US8801783B2 (en) | 2006-09-29 | 2014-08-12 | Biomet Sports Medicine, Llc | Prosthetic ligament system for knee joint |
US9468433B2 (en) | 2006-02-03 | 2016-10-18 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US8267918B2 (en) * | 2006-03-14 | 2012-09-18 | Kci Licensing, Inc. | System and method for percutaneously administering reduced pressure treatment using a flowable manifold |
US7615036B2 (en) | 2006-05-11 | 2009-11-10 | Kalypto Medical, Inc. | Device and method for wound therapy |
US7779625B2 (en) | 2006-05-11 | 2010-08-24 | Kalypto Medical, Inc. | Device and method for wound therapy |
US8338402B2 (en) | 2006-05-12 | 2012-12-25 | Smith & Nephew Plc | Scaffold |
US9820888B2 (en) | 2006-09-26 | 2017-11-21 | Smith & Nephew, Inc. | Wound dressing |
ES2340085T5 (es) | 2006-09-28 | 2014-04-16 | Smith & Nephew, Inc. | Sistema portátil de terapia de heridas |
US8672969B2 (en) | 2006-09-29 | 2014-03-18 | Biomet Sports Medicine, Llc | Fracture fixation device |
US11259794B2 (en) | 2006-09-29 | 2022-03-01 | Biomet Sports Medicine, Llc | Method for implanting soft tissue |
US8500818B2 (en) | 2006-09-29 | 2013-08-06 | Biomet Manufacturing, Llc | Knee prosthesis assembly with ligament link |
CN101547712B (zh) | 2006-10-13 | 2012-05-30 | 凯希特许有限公司 | 用于对低严重性伤口提供治疗的、具有手动启动泵的减压输送系统 |
US7967810B2 (en) | 2006-10-20 | 2011-06-28 | Mary Beth Kelley | Sub-atmospheric wound-care system |
US8639309B2 (en) * | 2007-07-31 | 2014-01-28 | J&M Shuler, Inc. | Method and system for monitoring oxygenation levels of compartments and tissue |
US8100834B2 (en) | 2007-02-27 | 2012-01-24 | J&M Shuler, Inc. | Method and system for monitoring oxygenation levels of a compartment for detecting conditions of a compartment syndrome |
US10117977B2 (en) | 2007-03-14 | 2018-11-06 | The Board Of Trustees Of The Leland Stanford Junior University | Devices and methods for application of reduced pressure therapy |
US8137354B2 (en) * | 2007-04-25 | 2012-03-20 | Biomet Sports Medicine, Llc | Localized cartilage defect therapy |
EP2216057A3 (en) | 2007-05-07 | 2012-05-30 | Carmeli Adahan | Suction system |
GB0712763D0 (en) | 2007-07-02 | 2007-08-08 | Smith & Nephew | Apparatus |
US9023001B2 (en) * | 2007-09-12 | 2015-05-05 | Heal-Ex, Llc | Systems and methods for providing a debriding wound vacuum |
WO2009047524A2 (en) * | 2007-10-10 | 2009-04-16 | Talley Group Limited | Medical apparatus for use in negative pressure wound therapy |
ES2555204T3 (es) | 2007-11-21 | 2015-12-29 | T.J. Smith & Nephew Limited | Dispositivo de succión y venda |
CA2705896C (en) | 2007-11-21 | 2019-01-08 | Smith & Nephew Plc | Wound dressing |
EP3000448B2 (en) | 2007-11-21 | 2022-03-09 | Smith & Nephew PLC | Wound dressing |
GB0722820D0 (en) | 2007-11-21 | 2008-01-02 | Smith & Nephew | Vacuum assisted wound dressing |
US20130096518A1 (en) | 2007-12-06 | 2013-04-18 | Smith & Nephew Plc | Wound filling apparatuses and methods |
GB0723872D0 (en) | 2007-12-06 | 2008-01-16 | Smith & Nephew | Apparatus for topical negative pressure therapy |
GB0723855D0 (en) | 2007-12-06 | 2008-01-16 | Smith & Nephew | Apparatus and method for wound volume measurement |
GB0723874D0 (en) * | 2007-12-06 | 2008-01-16 | Smith & Nephew | Dressing |
US11253399B2 (en) | 2007-12-06 | 2022-02-22 | Smith & Nephew Plc | Wound filling apparatuses and methods |
GB0724564D0 (en) * | 2007-12-18 | 2008-01-30 | Smith & Nephew | Portable wound therapy apparatus and method |
AU2009204140B9 (en) | 2008-01-08 | 2014-03-13 | Smith & Nephew Plc | Sustained variable negative pressure wound treatment and method of controlling same |
US20090177051A1 (en) * | 2008-01-09 | 2009-07-09 | Heal-Ex, Llc | Systems and methods for providing sub-dressing wound analysis and therapy |
CA3001382C (en) | 2008-02-14 | 2020-10-27 | Spiracur Inc. | Devices and methods for treatment of damaged tissue |
GB0803564D0 (en) | 2008-02-27 | 2008-04-02 | Smith & Nephew | Fluid collection |
CN101959480B (zh) | 2008-03-05 | 2013-06-05 | 凯希特许有限公司 | 用于将减压施加到组织部位并收集和存储组织部位的流体的敷料和方法 |
US9033942B2 (en) | 2008-03-07 | 2015-05-19 | Smith & Nephew, Inc. | Wound dressing port and associated wound dressing |
US8298200B2 (en) | 2009-06-01 | 2012-10-30 | Tyco Healthcare Group Lp | System for providing continual drainage in negative pressure wound therapy |
US8021347B2 (en) * | 2008-07-21 | 2011-09-20 | Tyco Healthcare Group Lp | Thin film wound dressing |
WO2009114624A2 (en) | 2008-03-12 | 2009-09-17 | Bluesky Medical Group Inc. | Negative pressure dressing and method of using same |
GB0804654D0 (en) | 2008-03-13 | 2008-04-16 | Smith & Nephew | Vacuum closure device |
US20090234306A1 (en) | 2008-03-13 | 2009-09-17 | Tyco Healthcare Group Lp | Vacuum wound therapy wound dressing with variable performance zones |
US8152785B2 (en) | 2008-03-13 | 2012-04-10 | Tyco Healthcare Group Lp | Vacuum port for vacuum wound therapy |
GB0808376D0 (en) | 2008-05-08 | 2008-06-18 | Bristol Myers Squibb Co | Wound dressing |
EP2326293B1 (en) | 2008-05-15 | 2015-12-16 | Ossur HF | Circumferential walker |
US10912869B2 (en) | 2008-05-21 | 2021-02-09 | Smith & Nephew, Inc. | Wound therapy system with related methods therefor |
US8414519B2 (en) | 2008-05-21 | 2013-04-09 | Covidien Lp | Wound therapy system with portable container apparatus |
EP2288321B1 (en) * | 2008-05-27 | 2019-10-23 | Smith & Nephew, Inc. | Control unit with pump module for a negative pressure wound therapy device |
JP2011521708A (ja) * | 2008-05-27 | 2011-07-28 | カリプト メディカル インコーポレーション | 陰圧式外傷治療具 |
RU2471461C2 (ru) * | 2008-05-30 | 2013-01-10 | КейСиАй ЛАЙСЕНЗИНГ, ИНК. | Закрывающие подушки и системы пониженного давления для линейных ран |
RU2472533C2 (ru) | 2008-05-30 | 2013-01-20 | КейСиАй ЛАЙСЕНЗИНГ, ИНК. | Системы терапии линейных ран пониженным давлением |
GB0811572D0 (en) * | 2008-06-24 | 2008-07-30 | Smith & Nephew | Negitive pressure wound theraphy device |
KR20110033264A (ko) * | 2008-07-11 | 2011-03-30 | 케이씨아이 라이센싱 인코포레이티드 | 상처 치료용 수동식 감압 시스템 |
WO2010016791A1 (en) * | 2008-08-05 | 2010-02-11 | Mölnlycke Health Care Ab | Component for securing attachment of a medical device to skin |
AU2009279525B2 (en) | 2008-08-08 | 2015-04-09 | Smith & Nephew Inc. | Wound dressing of continuous fibers |
US9414968B2 (en) | 2008-09-05 | 2016-08-16 | Smith & Nephew, Inc. | Three-dimensional porous film contact layer with improved wound healing |
GB0817796D0 (en) | 2008-09-29 | 2008-11-05 | Convatec Inc | wound dressing |
EP3614114A1 (en) | 2008-11-25 | 2020-02-26 | KCI Licensing, Inc. | Device for delivery of reduced pressure to body surfaces |
WO2010080907A1 (en) | 2009-01-07 | 2010-07-15 | Spiracur Inc. | Reduced pressure therapy of the sacral region |
GB0902816D0 (en) | 2009-02-19 | 2009-04-08 | Smith & Nephew | Fluid communication path |
EP2419157A4 (en) | 2009-04-17 | 2018-01-03 | Kalypto Medical, Inc. | Negative pressure wound therapy device |
US20100324516A1 (en) | 2009-06-18 | 2010-12-23 | Tyco Healthcare Group Lp | Apparatus for Vacuum Bridging and/or Exudate Collection |
US8447375B2 (en) * | 2009-08-13 | 2013-05-21 | J&M Shuler Medical, Inc. | Methods and dressing systems for promoting healing of injured tissue |
ES2731200T3 (es) | 2009-12-22 | 2019-11-14 | Smith & Nephew Inc | Aparatos para terapia de herida por presión negativa |
WO2011090996A2 (en) * | 2010-01-20 | 2011-07-28 | Kci Licensing, Inc. | Leak-resistant bandage systems and methods with hydrophilic foam wound insert for fluid-instillation and/or negative-pressure wound therapies |
US8814842B2 (en) | 2010-03-16 | 2014-08-26 | Kci Licensing, Inc. | Delivery-and-fluid-storage bridges for use with reduced-pressure systems |
US8702665B2 (en) * | 2010-04-16 | 2014-04-22 | Kci Licensing, Inc. | Reduced-pressure sources, systems, and methods employing a polymeric, porous, hydrophobic material |
US9061095B2 (en) | 2010-04-27 | 2015-06-23 | Smith & Nephew Plc | Wound dressing and method of use |
USRE48117E1 (en) | 2010-05-07 | 2020-07-28 | Smith & Nephew, Inc. | Apparatuses and methods for negative pressure wound therapy |
JP5905004B2 (ja) | 2010-07-23 | 2016-04-20 | アヴァセン, インコーポレイテッド | 熱エネルギーの治療的適用のための方法およびシステム |
EP2600786B1 (en) * | 2010-08-06 | 2016-06-29 | Cardia Innovation AB | A device for the supply of a gas to create a protecting atmosphere |
US8753322B2 (en) * | 2010-08-10 | 2014-06-17 | Spiracur Inc. | Controlled negative pressure apparatus and alarm mechanism |
US8795246B2 (en) * | 2010-08-10 | 2014-08-05 | Spiracur Inc. | Alarm system |
US11291760B2 (en) * | 2010-08-10 | 2022-04-05 | Kci Licensing, Inc. | Controlled negative pressure apparatus and alarm mechanism |
GB201015656D0 (en) | 2010-09-20 | 2010-10-27 | Smith & Nephew | Pressure control apparatus |
CA140188S (en) | 2010-10-15 | 2011-11-07 | Smith & Nephew | Medical dressing |
CA140189S (en) | 2010-10-15 | 2011-11-07 | Smith & Nephew | Medical dressing |
GB201020005D0 (en) | 2010-11-25 | 2011-01-12 | Smith & Nephew | Composition 1-1 |
WO2012069794A1 (en) | 2010-11-25 | 2012-05-31 | Smith & Nephew Plc | Composition i-ii and products and uses thereof |
GB201020236D0 (en) | 2010-11-30 | 2011-01-12 | Convatec Technologies Inc | A composition for detecting biofilms on viable tissues |
JP6241877B2 (ja) | 2010-12-01 | 2017-12-06 | ダニエル・エデュアード・クライナー | 管腔内減圧療法に使用される器具 |
WO2012078781A1 (en) | 2010-12-08 | 2012-06-14 | Convatec Technologies Inc. | Integrated system for assessing wound exudates |
EP2648794B1 (en) | 2010-12-08 | 2019-08-28 | ConvaTec Technologies Inc. | Wound exudate system accessory |
ES2680634T3 (es) * | 2010-12-08 | 2018-09-10 | Convatec Technologies Inc. | Apósitos autosellantes |
USD714433S1 (en) | 2010-12-22 | 2014-09-30 | Smith & Nephew, Inc. | Suction adapter |
BR112013018320A2 (pt) | 2010-12-22 | 2018-09-11 | Smith & Nephew, Inc. | aparelhos e métodos para terapia de ferimento de pressão negativa |
CA2828964A1 (en) * | 2011-02-04 | 2012-08-09 | University Of Massachusetts | Negative pressure wound closure device |
US9421132B2 (en) | 2011-02-04 | 2016-08-23 | University Of Massachusetts | Negative pressure wound closure device |
US9302034B2 (en) | 2011-04-04 | 2016-04-05 | Smith & Nephew, Inc. | Negative pressure wound therapy dressing |
AU2012243056B2 (en) | 2011-04-12 | 2016-07-07 | Kci Licensing, Inc. | Evaporative fluid pouch and systems for use with body fluids |
GB201108229D0 (en) | 2011-05-17 | 2011-06-29 | Smith & Nephew | Tissue healing |
CN103842000A (zh) | 2011-05-24 | 2014-06-04 | 卡利普托医疗公司 | 用于为伤口治疗提供负压的带有控制器和泵模块的装置 |
US9058634B2 (en) | 2011-05-24 | 2015-06-16 | Kalypto Medical, Inc. | Method for providing a negative pressure wound therapy pump device |
US8961496B2 (en) * | 2011-05-25 | 2015-02-24 | Kci Licensing, Inc. | Wound healing system using positive pressure to promote granulation at a tissue site |
US9067003B2 (en) | 2011-05-26 | 2015-06-30 | Kalypto Medical, Inc. | Method for providing negative pressure to a negative pressure wound therapy bandage |
CN106730060B (zh) * | 2011-05-27 | 2020-12-04 | 凯希特许有限公司 | 用于向伤口治疗敷件递送流体的系统和方法 |
EP3508182A1 (en) | 2011-07-14 | 2019-07-10 | Smith & Nephew PLC | Wound dressing and method of treatment |
EP3622976B1 (en) | 2011-07-26 | 2023-11-01 | Smith & Nephew plc | Systems and methods for controlling operation of a reduced pressure therapy system |
US10512587B2 (en) | 2011-07-27 | 2019-12-24 | Thermotek, Inc. | Method and apparatus for scalp thermal treatment |
US9433712B2 (en) * | 2011-08-31 | 2016-09-06 | Kci Licensing, Inc. | Inline storage pouches for use with body fluids |
GB201115182D0 (en) | 2011-09-02 | 2011-10-19 | Trio Healthcare Ltd | Skin contact material |
ES2402456B1 (es) * | 2011-10-19 | 2014-06-06 | Jesús PORTAS FREIXES | Equipo y procedimiento para la limpieza de heridas |
US9393354B2 (en) | 2011-11-01 | 2016-07-19 | J&M Shuler Medical, Inc. | Mechanical wound therapy for sub-atmospheric wound care system |
US9084845B2 (en) | 2011-11-02 | 2015-07-21 | Smith & Nephew Plc | Reduced pressure therapy apparatuses and methods of using same |
ES2672230T3 (es) | 2011-11-02 | 2018-06-13 | Smith & Nephew Plc | Aparatos de terapia de presión reducida |
US9357991B2 (en) | 2011-11-03 | 2016-06-07 | Biomet Sports Medicine, Llc | Method and apparatus for stitching tendons |
US9314241B2 (en) | 2011-11-10 | 2016-04-19 | Biomet Sports Medicine, Llc | Apparatus for coupling soft tissue to a bone |
US9381013B2 (en) | 2011-11-10 | 2016-07-05 | Biomet Sports Medicine, Llc | Method for coupling soft tissue to a bone |
EP2775974B1 (en) * | 2011-11-11 | 2016-03-23 | KCI Licensing, Inc. | Dressingsand systems for treating a wound on a patients limb employing liquid control |
US20150159066A1 (en) | 2011-11-25 | 2015-06-11 | Smith & Nephew Plc | Composition, apparatus, kit and method and uses thereof |
DE102011055782A1 (de) * | 2011-11-28 | 2013-05-29 | Birgit Riesinger | Wundpflegevorrichtung zur behandlung von wunden mittels atmosphärischem unterdruck |
GB2497406A (en) | 2011-11-29 | 2013-06-12 | Webtec Converting Llc | Dressing with a perforated binder layer |
GB201120693D0 (en) | 2011-12-01 | 2012-01-11 | Convatec Technologies Inc | Wound dressing for use in vacuum therapy |
US9861532B2 (en) | 2011-12-16 | 2018-01-09 | Kci Licensing, Inc. | Releasable medical drapes |
US10940047B2 (en) | 2011-12-16 | 2021-03-09 | Kci Licensing, Inc. | Sealing systems and methods employing a hybrid switchable drape |
US10220125B2 (en) | 2012-02-03 | 2019-03-05 | Smith & Nephew Plc | Apparatuses and methods for wound therapy |
EP2825220B2 (en) | 2012-03-12 | 2021-03-03 | Smith & Nephew PLC | Reduced pressure apparatus and methods |
JP6276251B2 (ja) | 2012-03-20 | 2018-02-07 | スミス アンド ネフュー ピーエルシーSmith & Nephew Public Limited Company | デューティサイクル閾値の動的決定に基づく減圧療法システムの動作制御 |
EP2841121B1 (en) | 2012-04-24 | 2020-12-02 | Thermotek, Inc. | System for therapeutic use of ultra-violet light |
US9427505B2 (en) | 2012-05-15 | 2016-08-30 | Smith & Nephew Plc | Negative pressure wound therapy apparatus |
AU346291S (en) | 2012-05-15 | 2013-01-09 | Smith & Nephew | Medical dressing |
US10070994B2 (en) * | 2012-05-22 | 2018-09-11 | Smith & Nephew Plc | Apparatuses and methods for wound therapy |
MX2014014265A (es) | 2012-05-22 | 2015-06-23 | Smith & Nephew | Dispositivo para cierre de heridas. |
EP3354293B1 (en) | 2012-05-23 | 2019-12-11 | Smith & Nephew plc | Apparatuses for negative pressure wound therapy |
CN104736110B (zh) | 2012-05-24 | 2019-05-31 | 史密夫和内修有限公司 | 用于利用负压来处理和封闭伤口的装置和方法 |
EP2854893B1 (en) | 2012-06-03 | 2019-10-02 | Daniel Eduard Kleiner | Endoluminal vacuum therapy device |
WO2014014871A1 (en) | 2012-07-16 | 2014-01-23 | Smith & Nephew, Inc. | Negative pressure wound closure device |
US8961454B2 (en) * | 2012-07-24 | 2015-02-24 | Chean-Shui Chen | Milk expressing device capable of simulating a baby's suckling |
US9300745B2 (en) | 2012-07-27 | 2016-03-29 | Synactive, Inc. | Dynamic execution environment in network communications |
CA3178997A1 (en) | 2012-08-01 | 2014-02-06 | Smith & Nephew Plc | Wound dressing |
EP3406231B1 (en) | 2012-08-01 | 2022-04-13 | Smith & Nephew plc | Wound dressing and method of treatment |
WO2014022548A1 (en) * | 2012-08-03 | 2014-02-06 | Kci Licensing, Inc. | Interfaces, systems, and methods for use in reduced pressure tissue treatment |
MX2015001760A (es) | 2012-08-08 | 2015-06-03 | Smith & Nephew | Aparatos hechos a la medida para el tratamiento de heridas y metodos para su uso en la terapia de heridas con presion negativa. |
AU2013344686B2 (en) | 2012-11-16 | 2018-06-21 | Solventum Intellectual Properties Company | Medical drape with pattern adhesive layers and method of manufacturing same |
US20150354096A1 (en) | 2012-12-20 | 2015-12-10 | Convatec Technologies Inc. | Processing of chemically modified cellulosic fibres |
GB201317746D0 (en) | 2013-10-08 | 2013-11-20 | Smith & Nephew | PH indicator |
US9757119B2 (en) | 2013-03-08 | 2017-09-12 | Biomet Sports Medicine, Llc | Visual aid for identifying suture limbs arthroscopically |
US10300180B1 (en) | 2013-03-11 | 2019-05-28 | Thermotek, Inc. | Wound care and infusion method and system utilizing a therapeutic agent |
US9687385B2 (en) | 2013-03-11 | 2017-06-27 | Avacen, Inc. | Methods and apparatus for therapeutic application of thermal energy including blood viscosity adjustment |
US9192509B2 (en) * | 2013-03-11 | 2015-11-24 | Avacen, Inc. | Methods and apparatus for therapeutic application of thermal energy including blood viscosity adjustment |
EP2968016B1 (en) | 2013-03-13 | 2018-07-11 | Smith&Nephew, Inc. | Negative pressure wound closure device and systems and methods of use in treating wounds with negative pressure |
US9918827B2 (en) | 2013-03-14 | 2018-03-20 | Biomet Sports Medicine, Llc | Scaffold for spring ligament repair |
JP2016517290A (ja) | 2013-03-14 | 2016-06-16 | スミス アンド ネフュー ピーエルシーSmith & Nephew Public Limited Company | 陰圧で創傷を治療する際に使用する圧縮性創傷充填材およびシステムおよび方法 |
JP2016512064A (ja) | 2013-03-14 | 2016-04-25 | ケーシーアイ ライセンシング インコーポレイテッド | 吸収性ドレッシングおよびその作製方法 |
US10695226B2 (en) | 2013-03-15 | 2020-06-30 | Smith & Nephew Plc | Wound dressing and method of treatment |
US20160120706A1 (en) | 2013-03-15 | 2016-05-05 | Smith & Nephew Plc | Wound dressing sealant and use thereof |
EP2968648B1 (en) | 2013-03-15 | 2020-12-23 | Smith & Nephew plc | Wound dressing and method of treatment |
US8893721B2 (en) | 2013-03-15 | 2014-11-25 | Futrell Medical Corporation | Surgical drape with vapor evacuation |
CA2910854A1 (en) | 2013-05-10 | 2014-11-20 | Smith & Nephew Plc | Fluidic connector for irrigation and aspiration of wounds |
WO2015042214A1 (en) | 2013-09-18 | 2015-03-26 | Ossur Hf | Insole for an orthopedic device |
EP3049035B1 (en) | 2013-09-25 | 2017-10-25 | Ossur Iceland EHF | Orthopedic device |
US9839548B2 (en) | 2013-09-25 | 2017-12-12 | Ossur Iceland Ehf | Orthopedic device |
US9668907B2 (en) | 2013-09-25 | 2017-06-06 | Ossur Iceland Ehf | Orthopedic device |
US9839549B2 (en) | 2013-09-25 | 2017-12-12 | Ossur Iceland Ehf | Orthopedic device |
WO2015061352A2 (en) | 2013-10-21 | 2015-04-30 | Smith & Nephew, Inc. | Negative pressure wound closure device |
EP3470030B1 (en) | 2013-10-28 | 2024-06-26 | Solventum Intellectual Properties Company | Hybrid sealing tape |
EP3821859A1 (en) | 2013-10-30 | 2021-05-19 | 3M Innovative Properties Co. | Dressing with differentially sized perforations |
EP3062833B1 (en) | 2013-10-30 | 2019-04-17 | KCI Licensing, Inc. | Absorbent conduit and system |
EP3656362A1 (en) | 2013-10-30 | 2020-05-27 | KCI Licensing, Inc. | Condensate absorbing and dissipating system related application |
WO2015065616A1 (en) | 2013-10-30 | 2015-05-07 | Kci Licensing, Inc. | Dressing with sealing and retention intereface |
WO2015070144A1 (en) * | 2013-11-11 | 2015-05-14 | Thermotek, Inc. | Method and system for wound care |
WO2015089261A1 (en) | 2013-12-12 | 2015-06-18 | Ossur Hf | Outsole for orthopedic device |
AU2015208299B2 (en) | 2014-01-21 | 2019-11-21 | Smith & Nephew Plc | Collapsible dressing for negative pressure wound treatment |
US10179073B2 (en) | 2014-01-21 | 2019-01-15 | Smith & Nephew Plc | Wound treatment apparatuses |
US11026844B2 (en) | 2014-03-03 | 2021-06-08 | Kci Licensing, Inc. | Low profile flexible pressure transmission conduit |
USD742017S1 (en) | 2014-03-27 | 2015-10-27 | Ossur Hf | Shell for an orthopedic device |
EP3142590B1 (en) | 2014-05-16 | 2020-05-13 | Smith & Nephew plc | Reduced pressure wound therapy kit and packaging |
USD758851S1 (en) | 2014-06-03 | 2016-06-14 | Smith & Nephew Plc | Packaging for a wound therapy system |
EP3151795B1 (en) | 2014-06-05 | 2017-09-27 | KCI Licensing, Inc. | Dressing with fluid acquisition and distribution characteristics |
WO2015193257A1 (en) | 2014-06-18 | 2015-12-23 | Smith & Nephew Plc | Wound dressing |
WO2016006496A1 (ja) * | 2014-07-11 | 2016-01-14 | 株式会社村田製作所 | 吸引装置 |
US9770369B2 (en) | 2014-08-08 | 2017-09-26 | Neogenix, Llc | Wound care devices, apparatus, and treatment methods |
US10485891B2 (en) * | 2014-10-06 | 2019-11-26 | Kci Licensing, Inc. | Multi-function dressing structure for negative-pressure therapy |
JP6725529B2 (ja) | 2014-12-22 | 2020-07-22 | スミス アンド ネフュー ピーエルシーSmith & Nephew Public Limited Company | 陰圧閉鎖療法の装置および方法 |
WO2016123049A1 (en) | 2015-01-26 | 2016-08-04 | Ossur Iceland Ehf | Negative pressure wound therapy orthopedic device |
US10898388B2 (en) | 2015-04-27 | 2021-01-26 | Smith & Nephew Plc | Reduced pressure apparatuses and methods |
EP4209201A1 (en) | 2015-04-29 | 2023-07-12 | Smith & Nephew, Inc. | Negative pressure wound closure device |
WO2016182977A1 (en) * | 2015-05-08 | 2016-11-17 | Kci Licensing, Inc. | Low acuity dressing with integral pump |
US10076594B2 (en) | 2015-05-18 | 2018-09-18 | Smith & Nephew Plc | Fluidic connector for negative pressure wound therapy |
US10299965B1 (en) * | 2015-05-20 | 2019-05-28 | Harjeet S. Brar | Antimicrobial device for wound care |
KR101810079B1 (ko) * | 2015-06-01 | 2017-12-19 | 주식회사 아모그린텍 | 항균 드레싱 |
CN107624056B (zh) | 2015-06-30 | 2020-06-09 | 恩朵罗杰克斯股份有限公司 | 锁定组件及其相关系统和方法 |
US10583228B2 (en) | 2015-07-28 | 2020-03-10 | J&M Shuler Medical, Inc. | Sub-atmospheric wound therapy systems and methods |
RU2602218C1 (ru) * | 2015-07-28 | 2016-11-10 | Федеральное Государственное бюджетное учреждение "Государственный научный центр колопроктологии имени А.Н. Рыжих" Министерства здравоохранения Российской Федерации (ФГБУ "ГНЦК им. А.Н. Рыжих" Минздрава России) | Устройство для лечения обширных послеоперационных ран промежности |
US11096830B2 (en) | 2015-09-01 | 2021-08-24 | Kci Licensing, Inc. | Dressing with increased apposition force |
CN105078690B (zh) * | 2015-09-09 | 2018-03-23 | 苏州大学附属儿童医院 | 一种小儿外科手术用伤口护理清洗台 |
US10973694B2 (en) | 2015-09-17 | 2021-04-13 | Kci Licensing, Inc. | Hybrid silicone and acrylic adhesive cover for use with wound treatment |
RU2612591C1 (ru) * | 2015-10-12 | 2017-03-09 | Дмитрий Юрьевич Андреев | Способ лечения ишемических трофических язв нижних конечностей |
CN108472157B (zh) * | 2015-10-30 | 2024-05-28 | 先进敷料有限责任公司 | 组织治疗装置和方法 |
WO2017087163A1 (en) | 2015-11-20 | 2017-05-26 | Kci Licensing, Inc. | Medical system with flexible fluid storage bridge |
US10575991B2 (en) | 2015-12-15 | 2020-03-03 | University Of Massachusetts | Negative pressure wound closure devices and methods |
US10814049B2 (en) | 2015-12-15 | 2020-10-27 | University Of Massachusetts | Negative pressure wound closure devices and methods |
US11364150B2 (en) | 2015-12-30 | 2022-06-21 | Smith & Nephew Plc | Negative pressure wound therapy apparatus |
EP3397219B1 (en) | 2015-12-30 | 2020-10-21 | Smith & Nephew plc | Absorbent negative pressure wound therapy dressing |
USD796735S1 (en) | 2016-02-29 | 2017-09-05 | Smith & Nephew Plc | Mount apparatus for portable negative pressure apparatus |
JP1586116S (zh) | 2016-02-29 | 2017-09-19 | ||
CN109069708B (zh) | 2016-03-04 | 2022-04-12 | 史密夫及内修公开有限公司 | 用于乳房外科手术后的伤口的负压伤口治疗设备 |
CN109069301B (zh) | 2016-03-07 | 2021-11-30 | 史密夫及内修公开有限公司 | 利用整合到伤口敷料中的负压源的伤口治疗设备和方法 |
WO2017212345A2 (en) | 2016-03-30 | 2017-12-14 | Synovo Gmbh | Detecting microbial infection in wounds |
EP3435941B1 (en) | 2016-03-30 | 2021-09-01 | ConvaTec Technologies Inc. | Detecting microbial infections in wounds |
EP3448451B1 (en) | 2016-04-26 | 2021-12-08 | Smith & Nephew plc | Wound dressings and methods of use with integrated negative pressure source having a fluid ingress inhibition component |
US11173240B2 (en) | 2016-05-03 | 2021-11-16 | Smith & Nephew Plc | Optimizing power transfer to negative pressure sources in negative pressure therapy systems |
WO2017191154A1 (en) | 2016-05-03 | 2017-11-09 | Smith & Nephew Plc | Negative pressure wound therapy device activation and control |
EP3452131A1 (en) | 2016-05-03 | 2019-03-13 | Smith & Nephew PLC | Systems and methods for driving negative pressure sources in negative pressure therapy systems |
ES2882336T3 (es) * | 2016-07-08 | 2021-12-01 | Convatec Technologies Inc | Sistema flexible de presión negativa |
CA3030151A1 (en) | 2016-07-08 | 2018-01-11 | Convatec Technologies Inc. | Fluid collection apparatus |
MX2019000232A (es) | 2016-07-08 | 2019-11-12 | Convatec Technologies Inc | Deteccion de flujo de fluidos. |
JP7303104B2 (ja) | 2016-08-25 | 2023-07-04 | スミス アンド ネフュー ピーエルシー | 吸収性陰圧創傷療法被覆材 |
JP7038701B2 (ja) | 2016-08-30 | 2022-03-18 | スミス アンド ネフュー ピーエルシー | 減圧療法を適用するためのシステム |
US11096832B2 (en) | 2016-09-27 | 2021-08-24 | Smith & Nephew Plc | Wound closure devices with dissolvable portions |
WO2018060417A1 (en) | 2016-09-30 | 2018-04-05 | Smith & Nephew Plc | Negative pressure wound treatment apparatuses and methods with integrated electronics |
GB2555584B (en) | 2016-10-28 | 2020-05-27 | Smith & Nephew | Multi-layered wound dressing and method of manufacture |
CA3042673A1 (en) | 2016-11-02 | 2018-05-11 | Smith & Nephew Inc. | Wound closure devices |
US11806217B2 (en) | 2016-12-12 | 2023-11-07 | Smith & Nephew Plc | Wound dressing |
JP2020511180A (ja) | 2016-12-12 | 2020-04-16 | スミス アンド ネフュー ピーエルシーSmith & Nephew Public Limited Company | 外部デバイスを介した圧力創傷療法ステータス表示 |
WO2018144948A1 (en) | 2017-02-03 | 2018-08-09 | Avacen Medical, Inc. | Systems and methods for evaluating blood circulation and early detection of cardiovascular issues |
JP7231227B2 (ja) * | 2017-02-22 | 2023-03-01 | コーネル ユニヴァーシティー | 小さい切開創を機械式に管理、保護及び吸引するための機械式真空ドレッシング |
WO2018162613A1 (en) | 2017-03-08 | 2018-09-13 | Smith & Nephew Plc | Negative pressure wound therapy device control in presence of fault condition |
CN110650755A (zh) * | 2017-03-09 | 2020-01-03 | 生物技术秘书部 | 用于联合的负压和流体输送系统的伤口敷料 |
DE102017003826A1 (de) * | 2017-04-20 | 2018-10-25 | Lohmann & Rauscher Gmbh | Wundversorgungsanordnung für die Unterdrucktherapie |
CN110612131B (zh) | 2017-05-09 | 2023-05-16 | 史密夫及内修公开有限公司 | 用于负压伤口治疗系统的冗余控件 |
CN106963555A (zh) * | 2017-05-10 | 2017-07-21 | 马世香 | 一种创伤护理装置 |
WO2018229009A1 (en) | 2017-06-13 | 2018-12-20 | Smith & Nephew Plc | Wound closure device and method of use |
EP3638169A1 (en) | 2017-06-13 | 2020-04-22 | Smith & Nephew PLC | Collapsible structure and method of use |
EP3638173A1 (en) | 2017-06-14 | 2020-04-22 | Smith & Nephew, Inc | Control of wound closure and fluid removal management in wound therapy |
AU2018285235B2 (en) | 2017-06-14 | 2023-11-02 | T.J.Smith & Nephew, Limited | Negative pressure wound therapy apparatus |
WO2018229011A1 (en) | 2017-06-14 | 2018-12-20 | Smith & Nephew Plc | Collapsible structure for wound closure and method of use |
US11123476B2 (en) | 2017-06-14 | 2021-09-21 | Smith & Nephew, Inc. | Fluid removal management and control of wound closure in wound therapy |
CA3065420A1 (en) | 2017-06-14 | 2018-12-20 | Smith & Nephew Plc | Collapsible sheet for wound closure and method of use |
CN107158491A (zh) * | 2017-07-04 | 2017-09-15 | 石嘴山市第二人民医院 | 一种创口冲洗装置及创口冲洗系统 |
EP3658090B1 (en) | 2017-07-27 | 2021-11-10 | Smith & Nephew PLC | Customizable wound closure device |
US12036353B2 (en) | 2017-07-29 | 2024-07-16 | Edward D. Lin | Apparatus and methods for pressure management within a wound chamber |
US11559622B2 (en) | 2017-07-29 | 2023-01-24 | Edward D. Lin | Deformation resistant wound therapy apparatus and related methods of use |
US11712373B2 (en) | 2017-07-29 | 2023-08-01 | Edward D. Lin | Wound therapy apparatus with scar modulation properties and related methods |
CN111343949A (zh) * | 2017-07-29 | 2020-06-26 | 林正纶 | 具有瘢痕调节性能的伤口治疗装置及相关方法 |
US10729826B2 (en) | 2017-07-29 | 2020-08-04 | Edward D. Lin | Wound cover apparatus and related methods of use |
US10780201B2 (en) | 2017-07-29 | 2020-09-22 | Edward D. Lin | Control apparatus and related methods for wound therapy delivery |
EP3664756B1 (en) | 2017-08-07 | 2024-01-24 | Smith & Nephew plc | Wound closure device with protective layer |
US11375923B2 (en) | 2017-08-29 | 2022-07-05 | Smith & Nephew Plc | Systems and methods for monitoring wound closure |
JP7394746B2 (ja) | 2017-09-13 | 2023-12-08 | スミス アンド ネフュー ピーエルシー | 一体化された電子機器を備えた陰圧創傷治療装置及び方法 |
GB201718070D0 (en) | 2017-11-01 | 2017-12-13 | Smith & Nephew | Negative pressure wound treatment apparatuses and methods with integrated electronics |
JP7288901B2 (ja) | 2017-10-24 | 2023-06-08 | スリーエム イノベイティブ プロパティズ カンパニー | 創傷清拭用の創傷包帯及びこれを使用したシステム |
WO2019083966A1 (en) * | 2017-10-26 | 2019-05-02 | Kci Licensing, Inc. | NEGATIVE PRESSURE WELD THERAPY DEVICE WITH AUTOMATED FILTER BLEED |
GB201718072D0 (en) | 2017-11-01 | 2017-12-13 | Smith & Nephew | Negative pressure wound treatment apparatuses and methods with integrated electronics |
US11497653B2 (en) | 2017-11-01 | 2022-11-15 | Smith & Nephew Plc | Negative pressure wound treatment apparatuses and methods with integrated electronics |
GB201718054D0 (en) | 2017-11-01 | 2017-12-13 | Smith & Nephew | Sterilization of integrated negative pressure wound treatment apparatuses and sterilization methods |
EP3720518A4 (en) | 2017-12-06 | 2021-09-15 | Cornell University | MANUALLY ACTUATED NEGATIVE PRESSURE DRESSING (NPWT) EQUIPPED WITH A MORE EFFICIENT PUMP, AUTOMATIC PRESSURE INDICATOR AND AUTOMATIC PRESSURE LIMITER |
CN107928873B (zh) * | 2017-12-12 | 2021-09-24 | 褚宏云 | 一种外科刀口恢复护理及消毒装置 |
WO2019135876A1 (en) * | 2018-01-02 | 2019-07-11 | Tc1 Llc | Fluid treatment system for a driveline and methods of assembly and use |
CN112165961A (zh) | 2018-04-02 | 2021-01-01 | Ic外科公司 | 负压泵及相关方法 |
US20210379273A1 (en) * | 2018-04-10 | 2021-12-09 | Kci Licensing, Inc. | Bridge dressing with fluid management |
GB201811449D0 (en) | 2018-07-12 | 2018-08-29 | Smith & Nephew | Apparatuses and methods for negative pressure wound therapy |
CN109288624B (zh) * | 2018-07-24 | 2021-08-13 | 广州中医药大学(广州中医药研究院) | 一种高效吸收止血敷料及其制备方法 |
USD898925S1 (en) | 2018-09-13 | 2020-10-13 | Smith & Nephew Plc | Medical dressing |
WO2020097529A1 (en) * | 2018-11-08 | 2020-05-14 | Kci Licensing, Inc. | Wound dressing with semi-rigid support to increase disruption using perforated dressing and negative pressure wound therapy |
GB201818824D0 (en) | 2018-11-19 | 2019-01-02 | Smith & Nephew | Absorbent yarn |
GB201818829D0 (en) | 2018-11-19 | 2019-01-02 | Smith & Nephew | Absorbent component |
GB201818811D0 (en) | 2018-11-19 | 2019-01-02 | Smith & Nephew | Method of immobilising a protein on a substrate |
CN109504024B (zh) * | 2018-12-06 | 2020-04-07 | 中国科学院长春应用化学研究所 | 一种sebs基粒料、其制备方法、输液器用挤出膜及输液器 |
EP3893825A1 (en) | 2018-12-13 | 2021-10-20 | University of Massachusetts | Negative pressure wound closure devices and methods |
GB201900407D0 (en) | 2019-01-11 | 2019-02-27 | Smith & Nephew | Method of manufacturing a component for a wound dressing |
WO2020205449A1 (en) | 2019-03-29 | 2020-10-08 | Kci Licensing, Inc. | Negative-pressure treatment with area stabilization |
JP2022527313A (ja) | 2019-03-29 | 2022-06-01 | ケーシーアイ ライセンシング インコーポレイテッド | 領域安定化を伴う陰圧治療 |
EP3946502A1 (en) * | 2019-03-29 | 2022-02-09 | KCI Licensing, Inc. | Dressing with integrated pump and releasably coupled pump actuator |
GB201907716D0 (en) | 2019-05-31 | 2019-07-17 | Smith & Nephew | Systems and methods for extending operational time of negative pressure wound treatment apparatuses |
GB201912076D0 (en) | 2019-08-22 | 2019-10-09 | Smith & Nephew | Absorbent component |
GB201912071D0 (en) | 2019-08-22 | 2019-10-09 | Smith & Nephew | Wound dressing |
GB201914427D0 (en) | 2019-10-07 | 2019-11-20 | Smith & Nephew | Negative pressure wound therapy systems and methods with multiple negative pressure sources |
US11771819B2 (en) | 2019-12-27 | 2023-10-03 | Convatec Limited | Low profile filter devices suitable for use in negative pressure wound therapy systems |
US11331221B2 (en) | 2019-12-27 | 2022-05-17 | Convatec Limited | Negative pressure wound dressing |
GB202000274D0 (en) | 2020-01-09 | 2020-02-26 | Smith & Nephew | Systems and methods for monitoring operational lifetime of negative pressure wound treatment apparatuses |
GB202000574D0 (en) | 2020-01-15 | 2020-02-26 | Smith & Nephew | Fluidic connectors for negative pressure wound therapy |
US11160917B2 (en) | 2020-01-22 | 2021-11-02 | J&M Shuler Medical Inc. | Negative pressure wound therapy barrier |
GB202001212D0 (en) | 2020-01-29 | 2020-03-11 | Smith & Nephew | Systems and methods for measuring and tracking wound volume |
US11878104B2 (en) | 2020-02-20 | 2024-01-23 | Convatec Limited | Wound dressing and a wound therapy apparatus |
WO2022073762A1 (en) | 2020-10-05 | 2022-04-14 | T.J.Smith And Nephew,Limited | Temperature monitoring and control for negative pressure wound therapy systems |
GB202104922D0 (en) | 2021-04-07 | 2021-05-19 | Smith & Nephew | Temperature monitoring and control for negative pressure wound therapy systems |
EP4217041A4 (en) * | 2020-11-27 | 2024-05-22 | J&M Shuler Medical Inc. | WOUND THERAPY SYSTEMS |
EP4094784A1 (de) * | 2021-05-27 | 2022-11-30 | Manfred Stangl | System zur entfernung bakterieller toxine aus wundflüssigkeit |
GB202109148D0 (en) | 2021-06-25 | 2021-08-11 | Smith & Nephew | Design of electronic circutry for negative pressure wound therapy systems |
GB202109154D0 (en) | 2021-06-25 | 2021-08-11 | Smith & Nephew | Liquid ingress protection for negative pressure wound therapy systems |
WO2022268874A1 (en) | 2021-06-25 | 2022-12-29 | T.J.Smith And Nephew,Limited | Liquid ingress protection and design of electronic circutry for negative pressure wound therapy systems |
GB202110240D0 (en) | 2021-07-16 | 2021-09-01 | Smith & Nephew | Reduced pressure apparatuses and methods |
GB202116857D0 (en) | 2021-11-23 | 2022-01-05 | Smith & Nephew | Soft-start mechanism for wound monitoring and treatment devices |
WO2023133142A1 (en) * | 2022-01-04 | 2023-07-13 | Dukal, Llc | Silica gel foam dressing |
WO2023131680A1 (en) | 2022-01-10 | 2023-07-13 | T.J.Smith And Nephew,Limited | Temperature detection and protection for negative pressure wound therapy systems |
WO2023135177A1 (en) | 2022-01-14 | 2023-07-20 | T.J.Smith And Nephew, Limited | Self-calibration with dynamic therapy performance for negative pressure wound therapy devices |
BR102022015836A2 (pt) * | 2022-08-10 | 2024-02-20 | Blue Hands Servicos Medicos S/S | Dispositivo para terapia com pressão negativa em pele ou ferimento, processo de fabricação do mesmo e uso de terapia com pressão negativa |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1163907A (fr) * | 1956-10-25 | 1958-10-02 | Appareils pour soins cutanés | |
CN1161235A (zh) * | 1997-04-02 | 1997-10-08 | 张凤林 | 疔疮伤口除脓用吸注器 |
DE19844355A1 (de) * | 1998-09-28 | 2000-04-06 | Rainer E Sachse | Wundverband mit integrierter Saugvorrichtung |
Family Cites Families (973)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE561757C (de) | 1932-10-18 | Georg Heuchemer | Glockenfoermiges Scheidenpessar | |
DE33446C (de) | H. SCHNEIDEWIND, Hof-Wagenfabrikant in Altona, Victoriastrafse 54 | Cykloidenrad | ||
GB114754A (zh) | 1918-04-18 | |||
US695270A (en) | 1901-12-05 | 1902-03-11 | George M Beringer | Vaccine-shield. |
US765746A (en) | 1904-02-06 | 1904-07-26 | A D Gustin | Massage apparatus. |
US779625A (en) * | 1904-03-26 | 1905-01-10 | Charles Scheetz | Corn-chopping machine. |
US846674A (en) | 1905-10-11 | 1907-03-12 | Frank Claffey | Gun-rack. |
US1385346A (en) | 1919-06-27 | 1921-07-19 | Taylor Walter Herbert | Surgical wound-dam |
US1355846A (en) | 1920-02-06 | 1920-10-19 | David A Rannells | Medical appliance |
US1355679A (en) | 1920-04-28 | 1920-10-12 | Mcconnell Thomas | Vacuum apparatus |
US1480562A (en) | 1922-11-03 | 1924-01-15 | Mock Hugo | Crumb collector |
US1585104A (en) | 1923-10-13 | 1926-05-18 | William E Montgomery | Medical applicator |
GB236350A (en) | 1924-05-27 | 1925-07-09 | Thomas Frederick Wall | Means for introducing capacity effects in alternating electric current systems and apparatus |
US1732310A (en) | 1928-11-01 | 1929-10-22 | Frank J Naibert | Vacuum skin cleanser |
US1863534A (en) | 1930-08-23 | 1932-06-14 | Carl L Odell | Vacuum cup |
US1936129A (en) | 1931-12-01 | 1933-11-21 | Andrew J Fisk | Method of treating the skin and device therefor |
US2232254A (en) | 1936-05-26 | 1941-02-18 | Samuel Schadel | Massage device |
US2122121A (en) | 1937-02-02 | 1938-06-28 | Tillotson Joseph Elmer | Surgical aspirated drainage cup |
US2338339A (en) | 1940-11-08 | 1944-01-04 | Mere | Massaging vibrator |
US2280915A (en) | 1941-04-03 | 1942-04-28 | John H Johnson | Device for irrigating and treating wounds |
US2568933A (en) | 1942-07-04 | 1951-09-25 | Cutler Hammer Inc | Mounting and operating means for electric switches |
US2366799A (en) | 1943-03-23 | 1945-01-09 | Aldo A Luisada | Method of and means for treating heart ailments |
US2367690A (en) | 1943-07-31 | 1945-01-23 | Edgar H Purdy | Wound protector |
DE847475C (de) | 1944-08-22 | 1952-08-25 | Heinrich C Ulrich | Vorrichtung zur Drainage von Wunden |
GB641061A (en) | 1947-09-06 | 1950-08-02 | James Donald Maclaurin | Improvements in method of treating wounds |
US2547758A (en) | 1949-01-05 | 1951-04-03 | Wilmer B Keeling | Instrument for treating the male urethra |
US2632443A (en) | 1949-04-18 | 1953-03-24 | Eleanor P Lesher | Surgical dressing |
US2682873A (en) | 1952-07-30 | 1954-07-06 | Johnson & Johnson | General purpose protective dressing |
NL189176B (nl) | 1956-07-13 | 1900-01-01 | Hisamitsu Pharmaceutical Co | Pleister op basis van een synthetische rubber. |
US3111948A (en) | 1956-09-07 | 1963-11-26 | Johnson & Johnson | Absorbent pad and wrapper therefor |
US2969057A (en) | 1957-11-04 | 1961-01-24 | Brady Co W H | Nematodic swab |
US3026526A (en) | 1959-01-19 | 1962-03-27 | Montrose Arthur | Bathing cap |
US3026874A (en) | 1959-11-06 | 1962-03-27 | Robert C Stevens | Wound shield |
US3042041A (en) | 1960-03-09 | 1962-07-03 | Mario E Jascalevich | Device for draining wounds |
US3115138A (en) | 1960-07-14 | 1963-12-24 | Mcelvenny | Evacuator |
NL284658A (zh) | 1961-11-02 | |||
US3238937A (en) | 1963-04-01 | 1966-03-08 | Robert J Stein | Bust developer |
US3315665A (en) | 1963-10-11 | 1967-04-25 | Norman A Macleod | Method and apparatus for therapy of skin tissue |
US3286711A (en) | 1964-06-29 | 1966-11-22 | Welton Whann R | Means and method for self-pressure cycling of limbs to improve blood circulation |
US3364931A (en) | 1964-10-12 | 1968-01-23 | Walter F. Hirsch | Sanitary napkin |
US3334626A (en) | 1965-08-03 | 1967-08-08 | Schimmel Madalyn Miller | Injury protector |
US3367332A (en) | 1965-08-27 | 1968-02-06 | Gen Electric | Product and process for establishing a sterile area of skin |
US3465748A (en) | 1966-10-25 | 1969-09-09 | Vasily Afanasievich Kravchenko | Device and method for treating vascular and other diseases of extremities |
US3520300A (en) | 1967-03-15 | 1970-07-14 | Amp Inc | Surgical sponge and suction device |
US3478736A (en) | 1967-08-16 | 1969-11-18 | William A Roberts | Massage device |
US3486504A (en) | 1967-11-20 | 1969-12-30 | Lawthan M Austin Jr | Device for applying dressing,medication and suction |
US3572340A (en) | 1968-01-11 | 1971-03-23 | Kendall & Co | Suction drainage device |
GB1273342A (en) | 1968-01-31 | 1972-05-10 | Nat Res Dev | Improvements relating to fluid mattresses |
CS161842B2 (zh) | 1968-03-09 | 1975-06-10 | ||
GB1224009A (en) | 1968-07-25 | 1971-03-03 | Beiersdorf Ag | Wound dressings |
US3568675A (en) | 1968-08-30 | 1971-03-09 | Clyde B Harvey | Fistula and penetrating wound dressing |
US4029598A (en) | 1969-03-14 | 1977-06-14 | E. Merck A. G. | Non-bleeding indicator and dyes therefor |
US3610238A (en) | 1970-04-28 | 1971-10-05 | Us Health Education & Welfare | Wound infection prevention device |
US3682180A (en) | 1970-06-08 | 1972-08-08 | Coilform Co Inc | Drain clip for surgical drain |
US3712298A (en) | 1970-08-25 | 1973-01-23 | Nat Res Dev | Medical treatment apparatus |
US3938540A (en) | 1971-10-07 | 1976-02-17 | Medical Development Corporation | Vacuum-operated fluid bottle for tandem systems |
BE792506A (fr) | 1971-12-09 | 1973-03-30 | Sherwood Medical Ind Inc | Dispositifs de drainage médical |
DE2208126B1 (de) | 1972-02-22 | 1973-07-05 | Vereinigte Papienverke Schickedanz & Co, 8500 Nürnberg | Umhulltes Saugkissen fur hygienische Zwecke |
US3794035A (en) | 1972-03-07 | 1974-02-26 | N Brenner | Suction system for skin treatment |
US3874387A (en) | 1972-07-05 | 1975-04-01 | Pasquale P Barbieri | Valved hemostatic pressure cap |
US3787882A (en) | 1972-09-25 | 1974-01-22 | Ibm | Servo control of ink jet pump |
JPS5238680B2 (zh) | 1972-12-27 | 1977-09-30 | ||
US3859989A (en) | 1973-01-05 | 1975-01-14 | Theodore E Spielberg | Therapeutic cuff |
US3826254A (en) | 1973-02-26 | 1974-07-30 | Verco Ind | Needle or catheter retaining appliance |
US3954105A (en) | 1973-10-01 | 1976-05-04 | Hollister Incorporated | Drainage system for incisions or wounds in the body of an animal |
US3872862A (en) | 1973-10-23 | 1975-03-25 | Michael Hume | Dressing and support combination for the treatment of indolent ulcers |
US3908664A (en) | 1974-03-01 | 1975-09-30 | Herbert S Loseff | Wound suction tube and retrograde flushing |
US3993080A (en) | 1974-03-01 | 1976-11-23 | Loseff Herbert S | Suction tube and retrograde flushing for wounds, body cavities and the like |
US3871376A (en) | 1974-03-13 | 1975-03-18 | Union Carbide Corp | Combination absorbent dressing and flexible cooling device |
US3961625A (en) | 1974-07-02 | 1976-06-08 | Dillon Richard S | Promoting circulation of blood |
USRE29319E (en) | 1975-04-07 | 1977-07-26 | Hollister Incorporated | Drainage system for incisions or wounds in the body of an animal |
ZA762197B (en) | 1975-04-15 | 1977-04-27 | Int Paper Co | Fluid evacuator |
US3972328A (en) | 1975-07-28 | 1976-08-03 | E. R. Squibb & Sons, Inc. | Surgical bandage |
US3988793A (en) | 1975-09-16 | 1976-11-02 | Abitbol M Maurice | Device for preventing and treating toxemia in pregnant women |
US4058123A (en) | 1975-10-01 | 1977-11-15 | International Paper Company | Combined irrigator and evacuator for closed wounds |
US4102342A (en) | 1975-12-29 | 1978-07-25 | Taichiro Akiyama | Valved device |
US4112949A (en) | 1976-11-15 | 1978-09-12 | Howmedica Inc. | Apparatus for collecting body fluid |
US4080970A (en) | 1976-11-17 | 1978-03-28 | Miller Thomas J | Post-operative combination dressing and internal drain tube with external shield and tube connector |
FR2375873A1 (fr) | 1976-12-28 | 1978-07-28 | Intertechnique Sa | Perfectionnements aux equipements respiratoires pour vols a haute altitude |
GB1549756A (en) | 1977-03-10 | 1979-08-08 | Everett W | Wound irrigating device |
US4184510A (en) | 1977-03-15 | 1980-01-22 | Fibra-Sonics, Inc. | Valued device for controlling vacuum in surgery |
DE2721752C2 (de) | 1977-05-13 | 1983-12-29 | Siemens AG, 1000 Berlin und 8000 München | In einen menschlichen oder tierischen Körper implantierbares Gerät zur Infusion einer medizinischen Flüssigkeit |
US4149541A (en) | 1977-10-06 | 1979-04-17 | Moore-Perk Corporation | Fluid circulating pad |
CH623546A5 (zh) | 1977-11-09 | 1981-06-15 | Schweiter Ag Maschf | |
US4212296A (en) | 1978-04-20 | 1980-07-15 | The Kendall Company | Bandage with protective member |
US4245637A (en) | 1978-07-10 | 1981-01-20 | Nichols Robert L | Shutoff valve sleeve |
US4224945A (en) | 1978-08-30 | 1980-09-30 | Jonathan Cohen | Inflatable expansible surgical pressure dressing |
US4224941A (en) | 1978-11-15 | 1980-09-30 | Stivala Oscar G | Hyperbaric treatment apparatus |
SE414994B (sv) | 1978-11-28 | 1980-09-01 | Landstingens Inkopscentral | Venkateterforband |
US4382441A (en) | 1978-12-06 | 1983-05-10 | Svedman Paul | Device for treating tissues, for example skin |
US4250882A (en) | 1979-01-26 | 1981-02-17 | Medical Dynamics, Inc. | Wound drainage device |
DE7902325U1 (de) | 1979-01-29 | 1979-07-12 | Sterimed Gesellschaft Fuer Medizinischen Bedarf Mbh, 6600 Saarbruecken | Saugflasche fuer die wunddrainage |
US4219019A (en) | 1979-02-07 | 1980-08-26 | The Kendall Company | Bandage |
US4266545A (en) | 1979-04-06 | 1981-05-12 | Moss James P | Portable suction device for collecting fluids from a closed wound |
US5328614A (en) | 1979-05-21 | 1994-07-12 | Matsumura Kenneth N | Methods and apparati for removing protein-bound molecules from body fluids |
US4261363A (en) | 1979-11-09 | 1981-04-14 | C. R. Bard, Inc. | Retention clips for body fluid drains |
EP0035583B1 (de) | 1980-03-11 | 1985-08-14 | Schmid, Eduard, Dr.Dr.med. | Hauttransplantations-Druckverband |
US5445604A (en) | 1980-05-22 | 1995-08-29 | Smith & Nephew Associated Companies, Ltd. | Wound dressing with conformable elastomeric wound contact layer |
US4297995A (en) | 1980-06-03 | 1981-11-03 | Key Pharmaceuticals, Inc. | Bandage containing attachment post |
US4316466A (en) | 1980-06-27 | 1982-02-23 | Biomedics, Inc. | Body fluid drainage device |
US4444548A (en) | 1980-08-08 | 1984-04-24 | University Testing Service Inc. | Suction apparatus |
DE3032092C2 (de) | 1980-08-26 | 1984-10-25 | IPOS Gesellschaft für integrierte Prothesen-Entwicklung und orthopädietechnischen Service mbH & Co KG, 2120 Lüneburg | Wundauflage |
US4527064A (en) | 1980-10-29 | 1985-07-02 | The United States Of America As Represented By The United States Department Of Energy | Imaging alpha particle detector |
US4753231A (en) | 1981-02-13 | 1988-06-28 | Smith & Nephew Associated Companies P.L.C. | Adhesive wound dressing |
US4398910A (en) | 1981-02-26 | 1983-08-16 | Blake L W | Wound drain catheter |
US4465485A (en) | 1981-03-06 | 1984-08-14 | Becton, Dickinson And Company | Suction canister with unitary shut-off valve and filter features |
US4392853A (en) | 1981-03-16 | 1983-07-12 | Rudolph Muto | Sterile assembly for protecting and fastening an indwelling device |
US4468227A (en) | 1981-05-29 | 1984-08-28 | Hollister Incorporated | Wound drainage device with resealable access cap |
MX156407A (es) | 1981-06-01 | 1988-08-19 | Kendall & Co | Mejoras a esponja quirurgica para traqueotomia |
US4373519A (en) | 1981-06-26 | 1983-02-15 | Minnesota Mining And Manufacturing Company | Composite wound dressing |
US4419097A (en) | 1981-07-31 | 1983-12-06 | Rexar Industries, Inc. | Attachment for catheter tube |
EP0086773A1 (en) | 1981-08-26 | 1983-08-31 | TOWSEND, Marvin S | Disposable article with non-leachable saline water indicator |
US4459139A (en) | 1981-09-14 | 1984-07-10 | Gelman Sciences Inc. | Disposable filter device and liquid aspirating system incorporating same |
DE3137839A1 (de) | 1981-09-23 | 1983-03-31 | IPOS Gesellschaft für integrierte Prothesen-Entwicklung und orthopädietechnischen Service mbH & Co KG, 2120 Lüneburg | Ausbildung eines flaechengebildes zur fluessigkeitsaufnahme und -speicherung |
SE429197B (sv) | 1981-10-14 | 1983-08-22 | Frese Nielsen | Anordning for behandling av sar |
DE3146266A1 (de) | 1981-11-21 | 1983-06-01 | B. Braun Melsungen Ag, 3508 Melsungen | Kombinierte vorrichtung fuer eine medizinische saugdrainage |
SE431934B (sv) | 1981-12-11 | 1984-03-12 | Carl Gustaf Kamme | Absorptionskropp med semipermeabelt membran |
US4475909A (en) | 1982-05-06 | 1984-10-09 | Eisenberg Melvin I | Male urinary device and method for applying the device |
JPS58206751A (ja) | 1982-05-26 | 1983-12-02 | 日石三菱株式会社 | 創傷被覆材 |
US4534356A (en) | 1982-07-30 | 1985-08-13 | Diamond Shamrock Chemicals Company | Solid state transcutaneous blood gas sensors |
US4569674A (en) | 1982-08-03 | 1986-02-11 | Stryker Corporation | Continuous vacuum wound drainage system |
IT211654Z2 (it) | 1985-07-17 | 1989-04-07 | Abbate Mariarosa | Apparecchio per trattamento tricologico a depressione variabile per localizzazione, ampiezza e frequenza a comando e controllo elettronico. |
US4469092A (en) | 1982-09-27 | 1984-09-04 | Marshall Walter D | Scalp stimulating system |
SE445298B (sv) * | 1982-11-17 | 1986-06-16 | Gunnar Pontus Em Swanbeck | Anordning for rengoring och behandling av sar och infekterade hudpartier |
JPS5987824U (ja) | 1982-12-03 | 1984-06-14 | 大正製薬株式会社 | 救急絆創膏 |
US4795435A (en) | 1983-02-25 | 1989-01-03 | E. R. Squibb & Sons, Inc. | Device for protecting a wound |
SU1251912A1 (ru) | 1983-04-27 | 1986-08-23 | Горьковский государственный медицинский институт им.С.М.Кирова | Способ лечени несформированных свищей |
DE3321151C2 (de) | 1983-06-11 | 1986-09-18 | Walter Küsnacht Beck | Vorrichtung zum Absaugen von Sekreten |
DE3323973A1 (de) | 1983-07-02 | 1985-01-03 | Boehringer Mannheim Gmbh, 6800 Mannheim | Erythrozyten-rueckhaltesubstrate |
US4778446A (en) | 1983-07-14 | 1988-10-18 | Squibb & Sons Inc | Wound irrigation and/or drainage device |
US4540412A (en) | 1983-07-14 | 1985-09-10 | The Kendall Company | Device for moist heat therapy |
US4624656A (en) | 1983-07-25 | 1986-11-25 | Hospitak, Inc. | Hyperbaric gas treatment device |
US4551141A (en) | 1983-08-02 | 1985-11-05 | Surgidyne Inc. | Method and apparatus for removing liquids from a drainage device |
US4543100A (en) | 1983-11-01 | 1985-09-24 | Brodsky Stuart A | Catheter and drain tube retainer |
US4573965A (en) | 1984-02-13 | 1986-03-04 | Superior Plastic Products Corp. | Device for draining wounds |
US4837285A (en) | 1984-03-27 | 1989-06-06 | Medimatrix | Collagen matrix beads for soft tissue repair |
US4643641A (en) | 1984-09-10 | 1987-02-17 | Mici Limited Partnership Iv | Method and apparatus for sterilization of a centrifugal pump |
US4592750A (en) | 1984-10-26 | 1986-06-03 | Kay Dennis M | Ostomy appliance |
US4826494A (en) | 1984-11-09 | 1989-05-02 | Stryker Corporation | Vacuum wound drainage system |
US4655754A (en) | 1984-11-09 | 1987-04-07 | Stryker Corporation | Vacuum wound drainage system and lipids baffle therefor |
DE3441891A1 (de) | 1984-11-16 | 1986-05-28 | Walter Beck | Verfahren und vorrichtung zum absaugen von sekretfluessigkeit aus einer wunde |
DE3443101A1 (de) | 1984-11-27 | 1986-05-28 | Artur 6230 Frankfurt Beudt | Abdeckgeraet fuer offene wunden |
US4605399A (en) | 1984-12-04 | 1986-08-12 | Complex, Inc. | Transdermal infusion device |
US4738249A (en) | 1985-03-01 | 1988-04-19 | The Procter & Gamble Company | Method and apparatus for augmenting blood circulation |
US4655766A (en) | 1985-08-01 | 1987-04-07 | Alza Corporation | Fluid imbibing pump with self-regulating skin patch |
US4640688A (en) | 1985-08-23 | 1987-02-03 | Mentor Corporation | Urine collection catheter |
US4710165A (en) | 1985-09-16 | 1987-12-01 | Mcneil Charles B | Wearable, variable rate suction/collection device |
DE3601363A1 (de) | 1986-01-18 | 1988-12-29 | Stierlen Maquet Ag | Elektrisches schaltelement |
EP0256060A1 (en) | 1986-01-31 | 1988-02-24 | OSMOND, Roger L. W. | Suction system for wound and gastro-intestinal drainage |
US4838883A (en) | 1986-03-07 | 1989-06-13 | Nissho Corporation | Urine-collecting device |
CH670049A5 (zh) | 1986-04-24 | 1989-05-12 | Vebo | |
JPS62281965A (ja) | 1986-05-29 | 1987-12-07 | テルモ株式会社 | カテ−テルおよびカテ−テル用固定部材 |
US4728499A (en) | 1986-08-13 | 1988-03-01 | Fehder Carl G | Carbon dioxide indicator device |
US4813931A (en) * | 1986-08-28 | 1989-03-21 | Tre Med, Inc. | Pediatric suction system and method with filter |
GB8621884D0 (en) | 1986-09-11 | 1986-10-15 | Bard Ltd | Catheter applicator |
GB2195255B (en) | 1986-09-30 | 1991-05-01 | Vacutec Uk Limited | Apparatus for vacuum treatment of an epidermal surface |
US4743232A (en) | 1986-10-06 | 1988-05-10 | The Clinipad Corporation | Package assembly for plastic film bandage |
DE3634569A1 (de) | 1986-10-10 | 1988-04-21 | Sachse Hans E | Kondomkatheter, ein harnroehrenkatheter zur verhinderung von aufsteigenden infektionen |
US4759354A (en) | 1986-11-26 | 1988-07-26 | The Kendall Company | Wound dressing |
JPS63135179A (ja) | 1986-11-26 | 1988-06-07 | 立花 俊郎 | 薬物の経皮投与具 |
US4820265A (en) | 1986-12-16 | 1989-04-11 | Minnesota Mining And Manufacturing Company | Tubing set |
US4764167A (en) | 1987-01-14 | 1988-08-16 | Tu Ho C | Safety newborn mucous suction device |
US5073172A (en) | 1987-01-20 | 1991-12-17 | Medinorm Aktiengesellschaft Medizintechnische Produkte | Device for aspirating wound fluids |
GB8706116D0 (en) | 1987-03-14 | 1987-04-15 | Smith & Nephew Ass | Adhesive dressings |
US4813942A (en) | 1987-03-17 | 1989-03-21 | Bioderm, Inc. | Three step wound treatment method and dressing therefor |
US4778456A (en) | 1987-04-03 | 1988-10-18 | Oddvin Lokken | Method of sterilizing an operating field and sterilized cassette therefor |
US4765316A (en) | 1987-04-20 | 1988-08-23 | Marshall Walter D | Scalp stimulator |
US4787888A (en) | 1987-06-01 | 1988-11-29 | University Of Connecticut | Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a) |
US5035884A (en) | 1987-06-02 | 1991-07-30 | Warner-Lambert Company | Methylene pyrrolidone copolymers for contact lens and pharmaceutical preparations |
US4851545A (en) | 1987-06-02 | 1989-07-25 | Warner-Lambert Company | N-substituted-3-alkylene-2-pyrrolidone compounds |
US4931519A (en) | 1987-06-02 | 1990-06-05 | Warner-Lambert Company | Copolymers from n-alkyl-3-alkenylene-2-pyrrolidone |
US4863449A (en) | 1987-07-06 | 1989-09-05 | Hollister Incorporated | Adhesive-lined elastic condom cathether |
JP2580248B2 (ja) * | 1987-07-07 | 1997-02-12 | 三井石油化学工業株式会社 | 培養装置 |
JPH0741061B2 (ja) * | 1987-07-09 | 1995-05-10 | 華郎 前田 | 医療用被覆材 |
FI77569C (fi) | 1987-07-13 | 1989-04-10 | Huhtamaeki Oy | Anordning foer bestaemning av saorlaekningsfoermaogan i ett operationssaor eller en vaevnad. |
US4846164A (en) | 1987-08-07 | 1989-07-11 | Martz Joel D | Vapor permeable dressing |
US4930997A (en) | 1987-08-19 | 1990-06-05 | Bennett Alan N | Portable medical suction device |
US4828546A (en) | 1987-08-21 | 1989-05-09 | Surgidyne, Inc. | Bulb evacuator for closed wound suction |
US5176663A (en) | 1987-12-02 | 1993-01-05 | Pal Svedman | Dressing having pad with compressibility limiting elements |
SE459470B (sv) | 1987-12-02 | 1989-07-10 | Moelnlycke Ab | Foerband innefattande foerstyvande element |
US4921488A (en) | 1988-01-15 | 1990-05-01 | Maitz Carlos A | Aspirator device for body fluids |
US4834110A (en) | 1988-02-01 | 1989-05-30 | Richard Patricia A | Suction clamped treatment cup saliva sampler |
CA1334926C (en) | 1988-04-28 | 1995-03-28 | Masao Yafuso | Composition, apparatus and method for sensing ionic components |
GB8812803D0 (en) | 1988-05-28 | 1988-06-29 | Smiths Industries Plc | Medico-surgical containers |
US4921492A (en) | 1988-05-31 | 1990-05-01 | Laser Technologies Group, Inc. | End effector for surgical plume evacuator |
US5197945A (en) | 1988-05-31 | 1993-03-30 | Minnesota Mining And Manufacturing Company | Alginate wound dressing of good integrity |
US4925447A (en) | 1988-06-22 | 1990-05-15 | Rosenblatt/Ima Invention Enterprises | Aspirator without partition wall for collection of bodily fluids including improved safety and efficiency elements |
US4990137A (en) | 1988-06-29 | 1991-02-05 | Memorial Hospital For Cancer And Allied Diseases | Closed wound drainage system with clearing port and method for sterile clearing of closed wound drainage system |
US4950483A (en) | 1988-06-30 | 1990-08-21 | Collagen Corporation | Collagen wound healing matrices and process for their production |
US4917112A (en) | 1988-08-22 | 1990-04-17 | Kalt Medical Corp. | Universal bandage with transparent dressing |
US5115472A (en) | 1988-10-07 | 1992-05-19 | Park Kyung T | Electroacoustic novelties |
US4972829A (en) | 1988-11-23 | 1990-11-27 | Knerr Richard P | Air cure bandage |
SU1762940A1 (ru) | 1989-01-17 | 1992-09-23 | Самарский медицинский институт им.Д.И.Ульянова | Устройство дл диализа гнойных ран |
US4994022A (en) | 1989-02-02 | 1991-02-19 | Stryker Corporation | Blood conservation system |
GB8906100D0 (en) | 1989-03-16 | 1989-04-26 | Smith & Nephew | Laminates |
DK0391219T3 (da) | 1989-03-30 | 1993-10-25 | Abbott Lab | Sugedræn-apparat med indretning til infektionsbegrænsning |
US5261893A (en) | 1989-04-03 | 1993-11-16 | Zamierowski David S | Fastening system and method |
CA2369000C (en) | 1989-04-03 | 2007-02-06 | David S. Zamierowski | Fluidic connection system and method |
US5527293A (en) | 1989-04-03 | 1996-06-18 | Kinetic Concepts, Inc. | Fastening system and method |
US4969880A (en) | 1989-04-03 | 1990-11-13 | Zamierowski David S | Wound dressing and treatment method |
US5100396A (en) | 1989-04-03 | 1992-03-31 | Zamierowski David S | Fluidic connection system and method |
US5106362A (en) | 1989-04-13 | 1992-04-21 | The Kendall Company | Vented absorbent dressing |
US5086764A (en) | 1989-04-13 | 1992-02-11 | Thomas Gilman | Absorbent dressing |
US5056510A (en) | 1989-04-13 | 1991-10-15 | The Kendall Company | Vented wound dressing |
US4997438A (en) | 1989-04-14 | 1991-03-05 | Constance Crane Langmann | Pressure applicator for thoracic wounds |
JP2719671B2 (ja) | 1989-07-11 | 1998-02-25 | 日本ゼオン株式会社 | 創傷被覆材 |
US5358494A (en) | 1989-07-11 | 1994-10-25 | Svedman Paul | Irrigation dressing |
SE462516B (sv) | 1989-07-11 | 1990-07-09 | Paal Svedman | Spolfoerband foer djupa saar |
US4979944A (en) | 1989-08-21 | 1990-12-25 | The Pullman Company | Surgical vacuum evacuation device |
GB2235877A (en) | 1989-09-18 | 1991-03-20 | Antonio Talluri | Closed wound suction apparatus |
IL91918A0 (en) | 1989-10-06 | 1990-06-10 | Rosenberg Lior | Fluid drain system for wounds |
US5106629A (en) | 1989-10-20 | 1992-04-21 | Ndm Acquisition Corp. | Transparent hydrogel wound dressing |
DE4111122A1 (de) | 1989-10-27 | 1993-04-29 | Wolfgang Dr Neher | Wundreinigungs- und therapiegeraet |
DE3935818A1 (de) | 1989-10-27 | 1991-05-02 | Wolfgang Dr Neher | Vorrichtung zur reinigung infizierter und schlecht heilender ulcera cruris (unterschenkelgeschwuere) und anderer wunden im koerperbereich |
US4969881A (en) | 1989-11-06 | 1990-11-13 | Connecticut Artcraft Corp. | Disposable hyperbaric oxygen dressing |
US5181905A (en) | 1989-11-28 | 1993-01-26 | Eric Flam | Method of monitoring the condition of the skin or wound |
US5152757A (en) | 1989-12-14 | 1992-10-06 | Brigham And Women's Hospital | System for diagnosis and treatment of wounds |
IL93045A (en) | 1990-01-12 | 1995-01-24 | Rosenberg Lior | A particularly usable vacuum device for removing wound fluid |
US5134994A (en) | 1990-02-12 | 1992-08-04 | Say Sam L | Field aspirator in a soft pack with externally mounted container |
US5055198A (en) | 1990-03-07 | 1991-10-08 | Shettigar U Ramakrishna | Autologous blood recovery membrane system and method |
US5215519A (en) | 1990-03-07 | 1993-06-01 | Shettigar U Ramakrishna | Autotransfusion membrane system with means for providing reverse filtration |
US5184077A (en) | 1990-04-05 | 1993-02-02 | G-C Acquisition, Inc. | Abrasion-resistant, high pressure dielectric sensors |
DE4012232A1 (de) | 1990-04-14 | 1991-10-17 | Franz Josef Gross | Redon- bzw. instillationsverband, insbesondere zur behandlung tieferer und fibrinoes eitriger wunden |
US5228431A (en) | 1990-04-26 | 1993-07-20 | Giarretto Ralph R | Drug-free method for treatment of the scalp for therapeutic purposes |
US5115801A (en) | 1990-05-02 | 1992-05-26 | Ndm Acquisition Corp. | Hydrogel burn dressing product |
DE4018591C2 (de) | 1990-06-09 | 1994-04-28 | Lohmann Gmbh & Co Kg | Pflaster zur Notfallbehandlung einer offenen Thoraxverletzung |
US5086763A (en) | 1990-08-06 | 1992-02-11 | Hathman Johnnie L | Protective reclosable wound dressing |
AU658845B2 (en) | 1990-08-20 | 1995-05-04 | Abbott Laboratories | Medical drug formulation and delivery system |
GB9027422D0 (en) | 1990-12-18 | 1991-02-06 | Scras | Osmotically driven infusion device |
DE9017289U1 (de) | 1990-12-21 | 1992-04-23 | Wolter, Dietmar, Prof. Dr.med., 21033 Hamburg | Vorrichtung zur Abdeckung einer Wunde bei der Hautperforation durch einen langgestreckten Gegenstand |
AU1239692A (en) | 1991-01-18 | 1992-08-27 | Delamar Gibbons | Body vacuum |
SE470052B (sv) | 1991-01-25 | 1993-11-01 | Lic Hygien Ab | Venkateterförband |
US5141503A (en) | 1991-01-29 | 1992-08-25 | Sewell Jr Frank K | Wound suction drainage system |
US5160322A (en) | 1991-02-28 | 1992-11-03 | Brunswick Biomedical Technologies, Inc. | Occlusive chest sealing valve |
US5662924A (en) | 1991-03-21 | 1997-09-02 | Smith & Nephew Plc | Wound dressing |
US5149331A (en) | 1991-05-03 | 1992-09-22 | Ariel Ferdman | Method and device for wound closure |
US5340968A (en) | 1991-05-07 | 1994-08-23 | Nippondenso Company, Ltd. | Information storage medium with electronic and visual areas |
JPH04354722A (ja) | 1991-05-30 | 1992-12-09 | Nippondenso Co Ltd | 電子荷札 |
CA2414393A1 (en) | 1991-05-14 | 1992-11-26 | David S. Zamierowski | Fastening system and method |
JP3017569B2 (ja) | 1991-05-30 | 2000-03-13 | 松下電工株式会社 | エアマッサージ制御方式 |
ATE150957T1 (de) | 1991-08-07 | 1997-04-15 | Hartmann Paul Ag | Wundverband auf rolle |
US5160328A (en) | 1991-08-07 | 1992-11-03 | Ndm Acquisition Corp. | Hydrogel bandage |
US5263922A (en) | 1991-08-26 | 1993-11-23 | Plasco, Inc. | Valved bandage |
CA2122059C (en) | 1991-10-23 | 2004-12-28 | Gary Wayne Cummings | Wound dressing system |
AU2625192A (en) | 1991-11-01 | 1993-05-06 | Ferris Mfg. Corp. | Window dressing |
US5360445A (en) | 1991-11-06 | 1994-11-01 | International Business Machines Corporation | Blood pump actuator |
US5278100A (en) | 1991-11-08 | 1994-01-11 | Micron Technology, Inc. | Chemical vapor deposition technique for depositing titanium silicide on semiconductor wafers |
US5645081A (en) | 1991-11-14 | 1997-07-08 | Wake Forest University | Method of treating tissue damage and apparatus for same |
US7198046B1 (en) | 1991-11-14 | 2007-04-03 | Wake Forest University Health Sciences | Wound treatment employing reduced pressure |
US5636643A (en) | 1991-11-14 | 1997-06-10 | Wake Forest University | Wound treatment employing reduced pressure |
US5279550A (en) | 1991-12-19 | 1994-01-18 | Gish Biomedical, Inc. | Orthopedic autotransfusion system |
US6048337A (en) | 1992-01-07 | 2000-04-11 | Principal Ab | Transdermal perfusion of fluids |
US5178157A (en) | 1992-01-14 | 1993-01-12 | Fanlo Ramon G | Phlebotomy device and method of use thereof |
JPH05200063A (ja) | 1992-01-28 | 1993-08-10 | Uni Charm Corp | 体液処理用品の通気不透液性裏面シート、およびその製造方法 |
US5167613A (en) | 1992-03-23 | 1992-12-01 | The Kendall Company | Composite vented wound dressing |
SE500973C2 (sv) | 1992-03-30 | 1994-10-10 | Moelnlycke Ab | Absorberande sårförband |
FR2690617B1 (fr) | 1992-04-29 | 1994-06-24 | Cbh Textile | Pansement adhesif transparent. |
US5266928A (en) | 1992-05-29 | 1993-11-30 | Johnson Lonnie G | Wet diaper detector |
US6406448B1 (en) | 1992-06-19 | 2002-06-18 | Augustine Medical, Inc. | Normothermic heater covering for tissue treatment |
US6465708B1 (en) | 1992-06-19 | 2002-10-15 | Augustine Medical, Inc. | Covering |
US5964723A (en) | 1992-06-19 | 1999-10-12 | Augustine Medical, Inc. | Normothermic tissue heating wound covering |
US5354261A (en) | 1992-06-22 | 1994-10-11 | Clark Francis S | Fluid-retentive bandage |
US5238732A (en) | 1992-07-16 | 1993-08-24 | Surface Coatings, Inc. | Waterproof breathable polyurethane membranes and porous substrates protected therewith |
US5678564A (en) | 1992-08-07 | 1997-10-21 | Bristol Myers Squibb | Liquid removal system |
US5222714A (en) | 1992-10-05 | 1993-06-29 | Aura Systems, Inc. | Electromagnetically actuated valve |
GB2272645B8 (en) | 1992-11-23 | 2010-02-10 | Johnson & Johnson Medical | Wound dressing |
GB2273133B (en) | 1992-12-04 | 1995-10-18 | William Alexander Courtney | Displacement pump |
US5462514A (en) | 1992-12-15 | 1995-10-31 | Harris; Jesse | Apparatus for aiding erections in males |
USD357743S (en) | 1992-12-31 | 1995-04-25 | Alza Corporation | Electrotransport drug delivery system |
DK169711B1 (da) | 1993-01-15 | 1995-01-23 | Coloplast As | Hudpladeprodukt |
GB9301258D0 (en) | 1993-01-22 | 1993-03-17 | Courtaulds Plc | Use of absorbent fibre |
CA2114290C (en) | 1993-01-27 | 2006-01-10 | Nagabushanam Totakura | Post-surgical anti-adhesion device |
US5902256A (en) | 1993-02-12 | 1999-05-11 | Jb Research, Inc. | Massage unit with replaceable hot and cold packs |
ATE183784T1 (de) | 1993-02-22 | 1999-09-15 | Keiper Recaro Gmbh Co | Abstandstextilmaterial variabler dicke, herstellungsverfahren und verwendungen dazu |
US5362543A (en) | 1993-02-23 | 1994-11-08 | Jay Medical, Ltd. | Pressure-compensating compositions and pads made therefrom |
US5336219A (en) | 1993-03-23 | 1994-08-09 | Medi-Flex Hospital Products, Inc. | Skin closure system |
GB9307312D0 (en) | 1993-04-07 | 1993-06-02 | United Surgical Services Ltd | Surgical wound dressings |
WO1994023677A2 (en) | 1993-04-13 | 1994-10-27 | Nicholas John Mills | Thermal coverings/wound dressings |
US6241747B1 (en) | 1993-05-03 | 2001-06-05 | Quill Medical, Inc. | Barbed Bodily tissue connector |
US5342376A (en) | 1993-05-03 | 1994-08-30 | Dermagraphics, Inc. | Inserting device for a barbed tissue connector |
ATE232072T1 (de) | 1993-05-04 | 2003-02-15 | Lisa Fernandez Geng | Wundverband |
US5344415A (en) | 1993-06-15 | 1994-09-06 | Deroyal Industries, Inc. | Sterile system for dressing vascular access site |
US5497788A (en) | 1993-07-16 | 1996-03-12 | Tecnol Medical Products, Inc. | Wound closure device for viewing a wound and method |
AU7009994A (en) | 1993-08-11 | 1995-02-28 | Michael John Smith | Improvements in and relating to dressings |
US5437651A (en) | 1993-09-01 | 1995-08-01 | Research Medical, Inc. | Medical suction apparatus |
CA2169543C (en) | 1993-09-13 | 1999-12-14 | Kenneth James Roach | Tableted detergent, method of manufacture and use |
EP0642779A1 (en) | 1993-09-13 | 1995-03-15 | E.R. Squibb & Sons, Inc. | Wound filler |
US5419772A (en) * | 1993-09-29 | 1995-05-30 | Teitz; Bernard R. | Surgical irrigation apparatus for cleaning and sterilizing wounds and surgical areas during surgery |
US5603946A (en) | 1993-10-08 | 1997-02-18 | Bristol-Myers Squibb Company | Wound dressing |
US5380280A (en) | 1993-11-12 | 1995-01-10 | Peterson; Erik W. | Aspiration system having pressure-controlled and flow-controlled modes |
US5456660A (en) | 1993-11-15 | 1995-10-10 | Reich; Marshall P. | Wound dressing support device |
AU1072695A (en) | 1993-11-27 | 1995-06-13 | Smith & Nephew Plc | Dressing |
DE4342457C2 (de) | 1993-12-13 | 1997-04-17 | Wim Dr Med Fleischmann | Vorrichtung zur Stimulation der Neubildung von Gewebe bei großflächigen und tiefen Gewebedefekten |
GB9325729D0 (en) | 1993-12-16 | 1994-02-16 | Seton Heathcare Group Plc | Bandages |
US5447492A (en) | 1993-12-20 | 1995-09-05 | New Dimensions In Medicine, Inc. | External fixation dressing for accommodating a retaining pin |
US5702356A (en) | 1993-12-23 | 1997-12-30 | Hathman; Johnnie L. | Disposable wound dressing permitting non-invasive examination |
GB9400994D0 (en) | 1994-01-20 | 1994-03-16 | Bristol Myers Squibb Co | Wound dressing |
US5549584A (en) | 1994-02-14 | 1996-08-27 | The Kendall Company | Apparatus for removing fluid from a wound |
US5562615A (en) | 1994-02-28 | 1996-10-08 | Corpak, Inc. | Free flow detector for an enternal feeding pump |
CA2186163A1 (en) | 1994-03-23 | 1995-09-28 | Owen L. Johns | Dressings |
US6500112B1 (en) | 1994-03-30 | 2002-12-31 | Brava, Llc | Vacuum dome with supporting rim and rim cushion |
US5536233A (en) | 1994-03-30 | 1996-07-16 | Khouri; Roger K. | Method and apparatus for soft tissue enlargement |
US5701917A (en) | 1994-03-30 | 1997-12-30 | Khouri Biomedical Research, Inc. | Method and apparatus for promoting soft tissue enlargement and wound healing |
US6786879B1 (en) | 1994-04-05 | 2004-09-07 | Kci Licensing, Inc. | Gradient sequential compression system for preventing deep vein thrombosis |
US5476664A (en) | 1994-04-15 | 1995-12-19 | Leonard Bloom | Treatment of warts using anthralins and occlusion |
US5489304A (en) | 1994-04-19 | 1996-02-06 | Brigham & Women's Hospital | Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft |
US5852126A (en) | 1994-05-02 | 1998-12-22 | Novartis Ag | Polymerisable composition and the use thereof |
US5769608A (en) | 1994-06-10 | 1998-06-23 | P.D. Coop, Inc. | Resonant system to pump liquids, measure volume, and detect bubbles |
US5556375A (en) | 1994-06-16 | 1996-09-17 | Hercules Incorporated | Wound dressing having a fenestrated base layer |
US5607388A (en) | 1994-06-16 | 1997-03-04 | Hercules Incorporated | Multi-purpose wound dressing |
US5492313A (en) | 1994-06-20 | 1996-02-20 | The Aerospace Corporation | Tangential linear flexure bearing |
US5664270A (en) | 1994-07-19 | 1997-09-09 | Kinetic Concepts, Inc. | Patient interface system |
US5559538A (en) | 1994-08-12 | 1996-09-24 | Hewlett-Packard Company | Positioning of service station and paper pick pressure plate using single motor |
WO1996005873A1 (en) | 1994-08-22 | 1996-02-29 | Kinetic Concepts Inc. | Wound drainage equipment |
USD364679S (en) | 1994-08-22 | 1995-11-28 | Kinetic Concepts, Inc. | Wound drainage disposable canister |
DE4433450A1 (de) | 1994-09-20 | 1996-03-21 | Wim Dr Med Fleischmann | Vorrichtung zum Versiegeln eines Wundgebietes |
US5588958A (en) | 1994-09-21 | 1996-12-31 | C. R. Bard, Inc. | Closed wound orthopaedic drainage and autotransfusion system |
CA2152407A1 (en) | 1994-09-30 | 1996-03-31 | Duane Girard Uitenbroek | Laminate material and absorbent garment comprising same |
US5645540A (en) | 1994-10-11 | 1997-07-08 | Stryker Corporation | Blood conservation system |
CN1160359A (zh) | 1994-10-11 | 1997-09-24 | 医药研究有限公司 | 改进的伤口抽液系统 |
US5489280A (en) | 1994-10-31 | 1996-02-06 | Zimmer, Inc. | Surgical preparation solution applicator |
US5817145A (en) | 1994-11-21 | 1998-10-06 | Augustine Medical, Inc. | Wound treatment device |
US6110197A (en) | 1994-11-21 | 2000-08-29 | Augustine Medical, Inc. | Flexible non-contact wound treatment device with a single joint |
US5624423A (en) | 1994-11-30 | 1997-04-29 | Kimberly-Clark Corporation | Absorbent article having barrier means and medial bulge |
US6225523B1 (en) | 1994-12-07 | 2001-05-01 | Masini Michael A | Invertible wound dressings and method of making the same |
US6599262B1 (en) | 1994-12-07 | 2003-07-29 | Masini Michael A | Bandage with thermal insert |
US5643189A (en) | 1994-12-07 | 1997-07-01 | Masini; Michael A. | Composite wound dressing including inversion means |
GB9500716D0 (en) | 1995-01-14 | 1995-03-08 | Giltech Ltd | Self adhesive laminate |
US5840052A (en) | 1995-01-27 | 1998-11-24 | Bertek, Inc. | Adhesive dressing applicator |
US5538500A (en) | 1995-02-08 | 1996-07-23 | Peterson; Donald A. | Postoperative wound dressing |
US6261276B1 (en) | 1995-03-13 | 2001-07-17 | I.S.I. International, Inc. | Apparatus for draining surgical wounds |
DE29504378U1 (de) | 1995-03-15 | 1995-09-14 | MTG Medizinisch, technische Gerätebau GmbH, 66299 Friedrichsthal | Elektronisch geregelte Niedervakuumpumpe für die Thorax- und Wunddrainage |
US5733337A (en) | 1995-04-07 | 1998-03-31 | Organogenesis, Inc. | Tissue repair fabric |
IL118000A0 (en) | 1995-04-25 | 1996-08-04 | Sinai School Medicine | Bandage with external anchor |
DE19517699C2 (de) | 1995-05-13 | 1999-11-04 | Wilhelm Fleischmann | Vorrichtung zur Vakuumversiegelung einer Wunde |
US5579765A (en) | 1995-05-30 | 1996-12-03 | Cox; Danny L. | Monitor to detect bleeding |
US5779657A (en) | 1995-07-21 | 1998-07-14 | Daneshvar; Yousef | Nonstretchable wound cover and protector |
US5688225A (en) | 1995-07-31 | 1997-11-18 | Walker; John W. | Therapeutic footwear |
US6257847B1 (en) | 1995-08-03 | 2001-07-10 | Medela, Inc. | Diaphragm pump and pump for double-breast pumping |
US5840049A (en) | 1995-09-07 | 1998-11-24 | Kinetic Concepts, Inc. | Medical pumping apparatus |
GB9519574D0 (en) | 1995-09-26 | 1995-11-29 | Smith & Nephew | Conformable absorbent dressing |
US5562107A (en) | 1995-09-27 | 1996-10-08 | Hollister Incorporated | Reclosable wound cover |
US5707499A (en) | 1995-10-06 | 1998-01-13 | Ceramatec, Inc. | Storage-stable, fluid dispensing device using a hydrogen gas generator |
US5704905A (en) | 1995-10-10 | 1998-01-06 | Jensen; Ole R. | Wound dressing having film-backed hydrocolloid-containing adhesive layer with linear depressions |
GB9521397D0 (en) | 1995-10-18 | 1995-12-20 | Summit Medical Ltd | Wound drainage system |
US5827213A (en) | 1995-10-19 | 1998-10-27 | Ole R. Jensen | Heel and elbow dressing |
GB2306580B (en) | 1995-10-27 | 1998-12-02 | William Alexander Courtney | Improved dual chamber displacement pumps |
GB9523253D0 (en) | 1995-11-14 | 1996-01-17 | Mediscus Prod Ltd | Portable wound treatment apparatus |
JPH09137781A (ja) | 1995-11-15 | 1997-05-27 | Matsushita Refrig Co Ltd | 振動型圧縮機 |
US5857502A (en) | 1995-11-22 | 1999-01-12 | Millburn Marketing Associates | Packaging system for concentrated materials |
CA2238413C (en) | 1995-11-23 | 2008-01-08 | Kci Medical Limited | Alternating pressure pads |
US5868933A (en) | 1995-12-15 | 1999-02-09 | Patrick; Gilbert | Antimicrobial filter cartridge |
FR2744769B1 (fr) | 1996-02-12 | 1999-02-12 | Drevet Jean Baptiste | Circulateur de fluide a membrane vibrante |
US5662599A (en) | 1996-02-20 | 1997-09-02 | No Mulligans, Llc | Disposable wound dressing and support unit |
US5827246A (en) | 1996-02-28 | 1998-10-27 | Tecnol Medical Products, Inc. | Vacuum pad for collecting potentially hazardous fluids |
GB9604645D0 (en) | 1996-03-01 | 1996-05-01 | Boc Group Plc | Improvements in vacuum pumps |
US5785688A (en) | 1996-05-07 | 1998-07-28 | Ceramatec, Inc. | Fluid delivery apparatus and method |
US5893368A (en) | 1996-05-15 | 1999-04-13 | Virginia Commonwealth University | Method for lowering abdominal pressure |
US6297423B1 (en) | 1996-05-24 | 2001-10-02 | Colorlast A/S | Permanently deformable dressing |
CN1083939C (zh) | 1996-07-09 | 2002-05-01 | 三洋电机株式会社 | 线性压缩机 |
US5730587A (en) | 1996-07-17 | 1998-03-24 | Apollo Enterprises, Inc. | Band drive dual diaphragm pump |
US6071247A (en) | 1996-07-21 | 2000-06-06 | Kennedy; William R. | Skin blister biopsy apparatus and method |
US5798266A (en) | 1996-08-27 | 1998-08-25 | K-Quay Enterprises, Llc | Methods and kits for obtaining and assaying mammary fluid samples for breast diseases, including cancer |
GB9618564D0 (en) | 1996-09-05 | 1996-10-16 | Bristol Myers Squibb Co | Multi layered wound dressing |
US6673028B1 (en) | 1996-09-26 | 2004-01-06 | Wake Forest University Health Sciences | Passive joint movement device and method for using the same |
US6783328B2 (en) | 1996-09-30 | 2004-08-31 | Terumo Cardiovascular Systems Corporation | Method and apparatus for controlling fluid pumps |
US6536056B1 (en) | 1996-11-18 | 2003-03-25 | John H. Vrzalik | Bariatric treatment system and related methods |
TW501934B (en) | 1996-11-20 | 2002-09-11 | Tapic Int Co Ltd | Collagen material and process for making the same |
CA2272399A1 (en) | 1996-11-25 | 1998-06-04 | John H. Vrzalik | Temperature control for use with patient supports |
US5876611A (en) | 1997-06-16 | 1999-03-02 | Shettigar; U. Ramakrishna | Intraoperative blood salvaging system and method |
JP2985816B2 (ja) | 1997-02-04 | 1999-12-06 | 日本電気株式会社 | 液体採取装置 |
US6113548A (en) | 1997-02-11 | 2000-09-05 | Deboisblanc; Bennet P. | Method and apparatus for estimation of beat-to-beat pulmonary wedge pressure |
AU2721597A (en) | 1997-03-05 | 1998-09-22 | Board Of Regents, The University Of Texas System | Self-sealed irrigation system |
US6333093B1 (en) | 1997-03-17 | 2001-12-25 | Westaim Biomedical Corp. | Anti-microbial coatings having indicator properties and wound dressings |
US6117444A (en) | 1997-04-10 | 2000-09-12 | Brigham & Women's Hospital | Polyethylene glycol/microfibrillar collagen composite serves as a resorbable hemostatic agent |
DE19722075C1 (de) | 1997-05-27 | 1998-10-01 | Wilhelm Dr Med Fleischmann | Vorrichtung zur Applikation von Wirkstoffen an einer Wundoberfläche |
US7759538B2 (en) | 1997-05-27 | 2010-07-20 | Wilhelm Fleischmann | Process and device for application of active substances to a wound surface |
NL1006457C2 (nl) | 1997-07-03 | 1999-01-05 | Polymedics N V | Drainagesysteem toe te passen bij een open wond, hierbij gebruikt element voor het aanbrengen van een drainagebuis of -slang en werkwijze voor het toepassen van het drainagesysteem. |
US6250005B1 (en) | 1997-07-21 | 2001-06-26 | Eric W. Richards | Removable display surface |
US7214202B1 (en) | 1997-07-28 | 2007-05-08 | Kci Licensing, Inc. | Therapeutic apparatus for treating ulcers |
US6135116A (en) | 1997-07-28 | 2000-10-24 | Kci Licensing, Inc. | Therapeutic method for treating ulcers |
AU727585B2 (en) | 1997-07-31 | 2000-12-14 | Convatec Technologies Inc. | Improved wound dressing |
US6420622B1 (en) | 1997-08-01 | 2002-07-16 | 3M Innovative Properties Company | Medical article having fluid control film |
US5843011A (en) | 1997-08-11 | 1998-12-01 | Lucas; Gregory | Self adhesive bandage roll |
US6124520A (en) | 1997-08-25 | 2000-09-26 | Tri-State Hospital Supply Corporation | Window dressing |
US6402724B1 (en) | 1997-09-09 | 2002-06-11 | Wolfe Tory Medical, Inc. | Wound irrigation shield |
GB9719520D0 (en) | 1997-09-12 | 1997-11-19 | Kci Medical Ltd | Surgical drape and suction heads for wound treatment |
CA2471780C (en) | 1997-09-12 | 2008-01-29 | Kci Licensing, Inc. | Surgical drape and suction head for wound treatment |
US7273054B2 (en) | 1997-09-12 | 2007-09-25 | Kci Licensing, Inc. | Surgical drape and head for wound treatment |
US6362390B1 (en) | 1997-12-18 | 2002-03-26 | The Procter & Gamble Company | Use of stain masking backsheets in absorbent articles |
WO1999038929A1 (en) | 1998-01-30 | 1999-08-05 | Coloplast A/S | An article having a surface showing adhesive properties |
EP0934737A1 (en) | 1998-02-05 | 1999-08-11 | The Procter & Gamble Company | Absorbent article comprising topsheet with masking capabilities |
US6071267A (en) | 1998-02-06 | 2000-06-06 | Kinetic Concepts, Inc. | Medical patient fluid management interface system and method |
EP0941726A1 (en) | 1998-03-12 | 1999-09-15 | Coloplast A/S | A dressing |
US6616413B2 (en) | 1998-03-20 | 2003-09-09 | James C. Humpheries | Automatic optimizing pump and sensor system |
DE19813663A1 (de) * | 1998-03-27 | 1999-10-07 | Beiersdorf Ag | Wundauflagen zur Entfernung von Störfaktoren aus Wundflüssigkeit |
US6040493A (en) | 1998-04-24 | 2000-03-21 | Replication Medical, Inc. | Bioreactor wound dressing |
GB2339336B (en) | 1998-06-16 | 2000-08-16 | Huntleigh Technology Plc | Magnetic actuator |
GB9813529D0 (en) | 1998-06-23 | 1998-08-19 | Courtaulds Plc | Nonwoven fabrics and their manufacture and use |
US5938626A (en) | 1998-07-24 | 1999-08-17 | Virginia Commonwealth University | Apparatus for lowering intra-abdominal pressure |
US6458109B1 (en) | 1998-08-07 | 2002-10-01 | Hill-Rom Services, Inc. | Wound treatment apparatus |
US6168800B1 (en) * | 1998-08-20 | 2001-01-02 | Medwrap Corporation | Antimcrobial multi-layer island dressing |
GB2341098B (en) | 1998-09-03 | 2003-03-05 | Bid Instr Ltd | Eye protector |
BR9803560A (pt) | 1998-09-09 | 2000-04-18 | Brasil Compressores Sa | Compressor alternativo de acionamento por motor linear. |
US6325788B1 (en) | 1998-09-16 | 2001-12-04 | Mckay Douglas William | Treatment of wound or joint for relief of pain and promotion of healing |
US6673982B1 (en) | 1998-10-02 | 2004-01-06 | Kimberly-Clark Worldwide, Inc. | Absorbent article with center fill performance |
US6488643B1 (en) | 1998-10-08 | 2002-12-03 | Kci Licensing, Inc. | Wound healing foot wrap |
US6103951A (en) | 1998-10-13 | 2000-08-15 | Freeman; Frank | Releasable wound dressing for efficient removal of exuded fluid |
GB9822341D0 (en) | 1998-10-13 | 1998-12-09 | Kci Medical Ltd | Negative pressure therapy using wall suction |
US6291050B1 (en) | 1998-10-30 | 2001-09-18 | The Procter & Gamble Company | Topsheet systems for absorbent articles exhibiting improved hydrophilicity gradients |
GB9826133D0 (en) | 1998-11-27 | 1999-01-20 | Kci Medical Ltd | Rotary valve |
CA2292961A1 (en) | 1998-12-17 | 2000-06-17 | Jennifer Nicole Wergin | Multi-layered absorbent composites having one or more apertured transfer layers |
US6767334B1 (en) | 1998-12-23 | 2004-07-27 | Kci Licensing, Inc. | Method and apparatus for wound treatment |
US6719742B1 (en) | 1998-12-30 | 2004-04-13 | Kimberly-Clark Worldwide, Inc. | Pattern embossed multilayer microporous films |
US6068588A (en) | 1999-01-07 | 2000-05-30 | International Business Machines Corporation | Counterbalanced pump |
IL128085A0 (en) | 1999-01-17 | 1999-11-30 | Nachum Zabar | Electromagnetic vibrator pump and leaf spring particularly useful therein |
GB9901085D0 (en) | 1999-01-20 | 1999-03-10 | Tudorose Decorative Trims Limi | Bandage |
JP2000220570A (ja) | 1999-01-28 | 2000-08-08 | Tokico Ltd | プランジャポンプおよびこれを用いたブレーキ装置 |
SE515881C2 (sv) | 1999-02-02 | 2001-10-22 | Artema Medical Ab | Membranpump |
US6176307B1 (en) | 1999-02-08 | 2001-01-23 | Union Oil Company Of California | Tubing-conveyed gravel packing tool and method |
US6254567B1 (en) * | 1999-02-26 | 2001-07-03 | Nxstage Medical, Inc. | Flow-through peritoneal dialysis systems and methods with on-line dialysis solution regeneration |
US6124521A (en) | 1999-03-10 | 2000-09-26 | Tri-State Hospital Supply Corporation | Dermal wound window dressing securement system |
US6287316B1 (en) | 1999-03-26 | 2001-09-11 | Ethicon, Inc. | Knitted surgical mesh |
US6506175B1 (en) | 1999-03-26 | 2003-01-14 | Samuel A. Goldstein | Therapeutic bandage |
SE9903331D0 (sv) | 1999-09-16 | 1999-09-16 | Gambro Lundia Ab | Method and apparatus for sterilising a heat sensitive fluid |
CN1226973C (zh) | 1999-04-02 | 2005-11-16 | 凯希特许有限公司 | 具有药剂导入构造的真空辅助闭合系统 |
US20070021697A1 (en) | 2004-07-26 | 2007-01-25 | Kci Licensing, Inc. | System and method for use of agent in combination with subatmospheric tissue treatment |
BR0009519A (pt) | 1999-04-02 | 2003-03-05 | Kinetic Concepts Inc | Processo para promover cicatrização de ferimento em mamìferos |
US20070014837A1 (en) | 1999-04-02 | 2007-01-18 | Kci Licensing, Inc. | System and method for use of agent in combination with subatmospheric pressure tissue treatment |
US20060029675A1 (en) | 2004-07-26 | 2006-02-09 | Kci Licensing, Inc. | Method for coating substrate with antimicrobial agent and product formed thereby |
US6994702B1 (en) | 1999-04-06 | 2006-02-07 | Kci Licensing, Inc. | Vacuum assisted closure pad with adaptation for phototherapy |
US7799004B2 (en) | 2001-03-05 | 2010-09-21 | Kci Licensing, Inc. | Negative pressure wound treatment apparatus and infection identification system and method |
US6856821B2 (en) | 2000-05-26 | 2005-02-15 | Kci Licensing, Inc. | System for combined transcutaneous blood gas monitoring and vacuum assisted wound closure |
DE60003647T2 (de) | 1999-04-07 | 2004-06-03 | Coloplast A/S | Druckentlastender wundverband |
JP5153974B2 (ja) | 1999-04-09 | 2013-02-27 | ケーシーアイ ライセンシング インコーポレイテッド | 創傷部治療装置 |
US6695823B1 (en) | 1999-04-09 | 2004-02-24 | Kci Licensing, Inc. | Wound therapy device |
GB9909301D0 (en) | 1999-04-22 | 1999-06-16 | Kci Medical Ltd | Wound treatment apparatus employing reduced pressure |
USD434150S (en) | 1999-05-11 | 2000-11-21 | Kci Licensing, Inc. | Portable medical pumping unit |
US6203563B1 (en) | 1999-05-26 | 2001-03-20 | Ernesto Ramos Fernandez | Healing device applied to persistent wounds, fistulas, pancreatitis, varicose ulcers, and other medical or veterinary pathologies of a patient |
EP1196079A1 (en) | 1999-06-18 | 2002-04-17 | The University Of Virginia Patent Foundation | An apparatus for fluid transport and related method thereof |
DE60035045T2 (de) | 1999-06-21 | 2008-02-07 | Fisher & Paykel Appliances Ltd., East Tamaki | Linearmotor |
US6991643B2 (en) | 2000-12-20 | 2006-01-31 | Usgi Medical Inc. | Multi-barbed device for retaining tissue in apposition and methods of use |
EP1177781B1 (en) | 1999-07-13 | 2012-08-22 | ConvaTec Technologies Inc. | Pouch for collecting matter excreted by the body |
US6604908B1 (en) | 1999-07-20 | 2003-08-12 | Deka Products Limited Partnership | Methods and systems for pulsed delivery of fluids from a pump |
DE29924058U1 (de) | 1999-08-09 | 2002-01-10 | Riesinger, geb. Dahlmann, Birgit, 48346 Ostbevern | Vorrichtung zum Auffangen und Sammeln von aus einem Stoma oder aus einer anderen nässenden Öffnung austretenden Ausscheidungen |
KR100304587B1 (ko) | 1999-08-19 | 2001-09-24 | 구자홍 | 리니어 압축기 |
US6261283B1 (en) | 1999-08-31 | 2001-07-17 | Alcon Universal Ltd. | Liquid venting surgical system and cassette |
US6557704B1 (en) | 1999-09-08 | 2003-05-06 | Kci Licensing, Inc. | Arrangement for portable pumping unit |
BR9904532A (pt) | 1999-09-09 | 2001-04-24 | Brasil Compressores Sa | Conjunto ressonante para compressor alternativo de motor linear |
EP1088589A3 (en) | 1999-09-30 | 2003-06-18 | Pfizer Products Inc. | Micro-equilibrium dialysis vertically loaded apparatus |
AU7645100A (en) | 1999-10-07 | 2001-05-10 | Coloplast A/S | Wound care device |
GB9926538D0 (en) | 1999-11-09 | 2000-01-12 | Kci Medical Ltd | Multi-lumen connector |
US7087807B2 (en) | 1999-11-10 | 2006-08-08 | Arizant Technologies, Llc | Tissue treatment device for an extremity |
US6824533B2 (en) | 2000-11-29 | 2004-11-30 | Hill-Rom Services, Inc. | Wound treatment apparatus |
US6764462B2 (en) | 2000-11-29 | 2004-07-20 | Hill-Rom Services Inc. | Wound treatment apparatus |
JP4681185B2 (ja) | 1999-11-29 | 2011-05-11 | ケーシーアイ メディカル リソーシーズ | 外傷治療装置 |
US6183438B1 (en) | 2000-01-04 | 2001-02-06 | Ramon Berguer | Catheter with centering wire |
US6528696B1 (en) | 2000-01-11 | 2003-03-04 | Christine M. Ireland | Pliable contact bandage |
US20050119737A1 (en) | 2000-01-12 | 2005-06-02 | Bene Eric A. | Ocular implant and methods for making and using same |
DE20000887U1 (de) | 2000-01-19 | 2001-06-07 | Riesinger, geb. Dahlmann, Birgit, 48346 Ostbevern | Auffangbeutel mit Aufsaugvorrichtung |
US6794554B2 (en) | 2000-02-01 | 2004-09-21 | Ferris Pharmaceuticals, Inc. | Wound packing material |
US6977323B1 (en) | 2000-02-17 | 2005-12-20 | 3M Innovative Properties Company | Foam-on-film medical articles |
CA2401869A1 (en) | 2000-03-03 | 2001-09-07 | Syntacoll Ag | Agent for the treatment of wounds |
GB2359755A (en) | 2000-03-03 | 2001-09-05 | Mediplus Ltd | Apparatus for assisting wound healing |
US20020019602A1 (en) | 2000-03-07 | 2002-02-14 | Geng Lisa Fernandez | Wound dressing |
AU7984900A (en) | 2000-03-10 | 2001-09-24 | 3M Innovative Properties Co | Medical dressings with multiple adhesives and methods of manufacturing |
WO2001068919A2 (en) * | 2000-03-10 | 2001-09-20 | Ana-Gen Technologies, Inc. | Mutation detection using denaturing gradients |
US6966760B1 (en) | 2000-03-17 | 2005-11-22 | Brp Us Inc. | Reciprocating fluid pump employing reversing polarity motor |
AU2001259153A1 (en) | 2000-04-26 | 2001-11-07 | Brigham Young University | Compliant, ortho-planar, linear motion spring |
AU2001249946B2 (en) | 2000-04-26 | 2006-03-16 | Dow Global Technologies Inc. | Durable, absorbent latex foam composition having high vertical wicking |
US6966901B2 (en) | 2000-05-08 | 2005-11-22 | Coloplast A/S | Ostomy carrier device with flexible flange |
GB0011202D0 (en) | 2000-05-09 | 2000-06-28 | Kci Licensing Inc | Abdominal wound dressing |
NL1015146C2 (nl) | 2000-05-10 | 2001-11-13 | Two Beats B V | Inrichting voor het behandelen van een wond in de huid van een patiÙnt. |
KR100332816B1 (ko) | 2000-05-18 | 2002-04-19 | 구자홍 | 리니어 압축기의 스프링 지지구조 |
US6471685B1 (en) * | 2000-05-18 | 2002-10-29 | David James Johnson | Medical dressing assembly and associated method of using the same |
KR100332818B1 (ko) | 2000-05-19 | 2002-04-19 | 구자홍 | 리니어 압축기의 고정자 고정구조 |
JP2004509658A (ja) * | 2000-05-22 | 2004-04-02 | コフィー,アーサー,シー. | 小腸粘膜下組織と真空包帯の組合せとその使用方法 |
US6520982B1 (en) | 2000-06-08 | 2003-02-18 | Kci Licensing, Inc. | Localized liquid therapy and thermotherapy device |
US6551280B1 (en) | 2000-06-30 | 2003-04-22 | Embro Corporation | Therapeutic device and system |
GB0017080D0 (en) | 2000-07-12 | 2000-08-30 | Bristol Myers Squibb Co | Multi layered wound dresssing |
BR0003293A (pt) | 2000-07-17 | 2002-02-26 | Brasil Compressores Sa | Sistema amortecedor de vibração para compressor alternativo com motor linear |
IL137689A0 (en) | 2000-08-03 | 2001-10-31 | L R Res & Dev Ltd | System for enhanced chemical debridement |
WO2002017840A1 (en) | 2000-08-28 | 2002-03-07 | Merrild Bente Kaethe Yonne | Bandage for treatment of pressure sores, bedsores and similar ailments |
US6595949B1 (en) | 2000-09-05 | 2003-07-22 | Jeffrey Bryan Shapiro | Automatic mucus removal device |
GB2367245B (en) | 2000-09-29 | 2004-11-17 | Johnson & Johnson Medical Ltd | Adaptable dressings |
NL1016375C2 (nl) | 2000-10-10 | 2002-04-11 | Lely Entpr Ag | Inrichting en werkwijze voor het reinigen van spenen. |
US6685622B2 (en) | 2000-10-17 | 2004-02-03 | O'connor Michael | Controlled environment device |
AU2001290955A1 (en) | 2000-10-24 | 2002-05-21 | Velcro Industries B.V. | Wound covering |
JP3876611B2 (ja) | 2000-11-02 | 2007-02-07 | 株式会社日立製作所 | 流体搬送装置 |
EP1341498A4 (en) | 2000-11-16 | 2005-01-19 | Chris Lipper | MEDICAL TATTOOS |
US6855135B2 (en) | 2000-11-29 | 2005-02-15 | Hill-Rom Services, Inc. | Vacuum therapy and cleansing dressing for wounds |
US6685681B2 (en) | 2000-11-29 | 2004-02-03 | Hill-Rom Services, Inc. | Vacuum therapy and cleansing dressing for wounds |
US6976977B2 (en) | 2000-12-06 | 2005-12-20 | Sherwood Services Ag | Vacuum setting and indication system for a drainage device |
CN1529621A (zh) | 2001-01-18 | 2004-09-15 | - | 敷料和用于所述敷料的治疗溶液 |
US20020151836A1 (en) | 2001-02-01 | 2002-10-17 | Burden Bill E. | Portable aspirating and irrigating apparatus and method |
US20020110672A1 (en) | 2001-02-12 | 2002-08-15 | Joanne Muratore-Pallatino | Cosmetic skin tattoo |
US7700819B2 (en) | 2001-02-16 | 2010-04-20 | Kci Licensing, Inc. | Biocompatible wound dressing |
US7070584B2 (en) | 2001-02-20 | 2006-07-04 | Kci Licensing, Inc. | Biocompatible wound dressing |
JP4822198B2 (ja) | 2001-02-21 | 2011-11-24 | 並木精密宝石株式会社 | 空気強制供給用アクチュエータ装置並びに空気強制供給型空気電池 |
BR0100781A (pt) | 2001-02-21 | 2002-11-12 | Brasil Compressores Sa | Compressor alternativo com motor linear |
US6540705B2 (en) | 2001-02-22 | 2003-04-01 | Core Products International, Inc. | Ankle brace providing upper and lower ankle adjustment |
US6706940B2 (en) | 2001-02-22 | 2004-03-16 | George Medical, L.L.C. | Transparent film dressing and a method for applying and making the same |
US6450773B1 (en) | 2001-03-13 | 2002-09-17 | Terabeam Corporation | Piezoelectric vacuum pump and method |
US6671905B2 (en) | 2001-03-29 | 2004-01-06 | Kci Licensing, Inc. | Prone positioning therapeutic bed |
US6586653B2 (en) | 2001-04-03 | 2003-07-01 | Mcneil-Ppc, Inc. | Discrete absorbent article |
US6695824B2 (en) | 2001-04-16 | 2004-02-24 | The United States Of America As Represented By The Secretary Of The Army | Wound dressing system |
BR0101879B1 (pt) | 2001-04-23 | 2008-11-18 | compressor linear. | |
US7108683B2 (en) | 2001-04-30 | 2006-09-19 | Kci Licensing, Inc | Wound therapy and tissue management system and method with fluid differentiation |
US7645269B2 (en) | 2001-04-30 | 2010-01-12 | Kci Licensing, Inc. | Gradient wound treatment system and method |
US6514047B2 (en) | 2001-05-04 | 2003-02-04 | Macrosonix Corporation | Linear resonance pump and methods for compressing fluid |
US6618221B2 (en) | 2001-05-07 | 2003-09-09 | International Business Machines Corporation | System and method for utilizing an actuator-activated pumping mechanism for reducing the operating pressure of a disk drive assembly |
US6841715B2 (en) | 2001-05-10 | 2005-01-11 | Tri-State Hospital Supply, Corp. | Window dressing |
AU2002315027A1 (en) * | 2001-05-15 | 2002-11-25 | Children's Medical Center Corporation | Methods and apparatus for application of micro-mechanical forces to tissues |
US6491684B1 (en) | 2001-05-22 | 2002-12-10 | Durect Corporation | Fluid delivery device having a water generating electrochemical/chemical pump and associated method |
JP4064827B2 (ja) | 2001-05-25 | 2008-03-19 | エルジー エレクトロニクス インコーポレイティド | 往復動式圧縮機 |
US6866994B2 (en) | 2001-05-30 | 2005-03-15 | Neomatrix, Llc | Noninvasive intraductal fluid diagnostic screen |
US6689931B2 (en) | 2001-06-12 | 2004-02-10 | Tiax Llc | Wound dressing and method of making |
GB0115054D0 (en) | 2001-06-20 | 2001-08-15 | Recuperatio Ltd | Fluid transfer device |
US7002054B2 (en) | 2001-06-29 | 2006-02-21 | The Procter & Gamble Company | Absorbent article having a fever indicator |
WO2003005943A2 (en) | 2001-07-12 | 2003-01-23 | Hill-Rom Services, Inc. | Control of vacuum level rate of change |
WO2003009796A1 (en) | 2001-07-24 | 2003-02-06 | Kci Licensing, Inc. | Medical bed system with interchangeable modules for mattress systems and related methods |
US20030021775A1 (en) | 2001-07-27 | 2003-01-30 | Ramot University Authority For Applied Research & Industrial Development Ltd. | Device for and method of controlled enzymatic removal and retrieval of tissue |
US7364565B2 (en) | 2001-07-27 | 2008-04-29 | Ramot At Tel Aviv University Ltd. | Controlled enzymatic removal and retrieval of cells |
KR20040034670A (ko) | 2001-08-03 | 2004-04-28 | 아사히 가세이 라이프 앤드 리빙 가부시키가이샤 | 여성용 생리대 등의 제품에 사용하기 위한 컬러 차폐성분 |
KR100438605B1 (ko) | 2001-08-17 | 2004-07-02 | 엘지전자 주식회사 | 왕복동식 압축기의 가스 압축장치 |
US7004915B2 (en) | 2001-08-24 | 2006-02-28 | Kci Licensing, Inc. | Negative pressure assisted tissue treatment system |
PT1425050E (pt) | 2001-09-12 | 2008-01-16 | Convatec Ltd | Penso antibacteriano para feridas |
US8426670B2 (en) | 2001-09-19 | 2013-04-23 | Nippon Shokubai Co., Ltd. | Absorbent structure, absorbent article, water-absorbent resin, and its production process and evaluation method |
GB2380135B (en) | 2001-09-27 | 2005-01-12 | Johnson & Johnson Medical Ltd | Therapeutic wound dressing |
WO2003030966A1 (en) | 2001-10-11 | 2003-04-17 | Hill-Rom Services, Inc. | Waste container for negative pressure therapy |
US20030125649A1 (en) | 2001-10-31 | 2003-07-03 | Mcintosh Laura Janet | Method and system apparatus using temperature and pressure for treating medical disorders |
US20030009122A1 (en) | 2001-11-02 | 2003-01-09 | Veras Harry George | Visi-band |
US6787682B2 (en) | 2001-11-05 | 2004-09-07 | Hollister Incorporated | Absorbent foam wound dressing |
CN100467867C (zh) | 2001-11-08 | 2009-03-11 | Lg电子株式会社 | 往复式压缩机 |
US7645253B2 (en) * | 2001-11-16 | 2010-01-12 | National Quality Care, Inc. | Wearable ultrafiltration device |
US6960179B2 (en) | 2001-11-16 | 2005-11-01 | National Quality Care, Inc | Wearable continuous renal replacement therapy device |
KR20030041289A (ko) | 2001-11-19 | 2003-05-27 | 엘지전자 주식회사 | 왕복동식 압축기의 피스톤 지지구조 |
US6648862B2 (en) | 2001-11-20 | 2003-11-18 | Spheric Products, Ltd. | Personally portable vacuum desiccator |
GB2382305B (en) * | 2001-11-23 | 2004-12-15 | Johnson & Johnson Medical Ltd | Absorbent wound dressings containing a hydrogel layer |
ES2258669T3 (es) | 2001-11-23 | 2006-09-01 | Coloplast A/S | Un aposito para heridas. |
KR100449009B1 (ko) | 2001-11-27 | 2004-09-18 | 삼성전자주식회사 | 리니어 압축기 |
JP3973886B2 (ja) | 2001-11-29 | 2007-09-12 | 岡本レース株式会社 | セリシン抽出方法、その抽出液及び繊維または布帛の改質加工方法 |
JP2003176788A (ja) | 2001-12-10 | 2003-06-27 | Matsushita Electric Ind Co Ltd | リニアコンプレッサの駆動装置 |
DE60222801T2 (de) | 2001-12-10 | 2008-07-03 | Lg Electronics Inc. | Zuverlässigkeitsverbessernde konstruktion für hubkolbenverdichter |
EP1627662B1 (en) | 2004-06-10 | 2011-03-02 | Candela Corporation | Apparatus for vacuum-assisted light-based treatments of the skin |
WO2003057307A1 (en) | 2001-12-26 | 2003-07-17 | Hill-Rom Services, Inc. | Wound vacuum therapy dressing kit |
EP1478313B2 (en) | 2001-12-26 | 2018-03-07 | KCI Medical Resources | Vented vacuum bandage |
ATE387919T1 (de) | 2001-12-26 | 2008-03-15 | Hill Rom Services Inc | Vakuumbindenverpackung |
US20030125646A1 (en) | 2001-12-29 | 2003-07-03 | Whitlock Russell Ward | Device and method for relieving pain |
USD469175S1 (en) | 2002-01-16 | 2003-01-21 | Kci Licensing, Inc. | Fluid drainage canister and tube |
USD469176S1 (en) | 2002-01-16 | 2003-01-21 | Kci Licensing, Inc. | Pump housing for medical equipment |
US6762337B2 (en) | 2002-01-24 | 2004-07-13 | Stanley Boukanov | Pressure bandages for wounds |
US20030219469A1 (en) | 2002-02-11 | 2003-11-27 | Kci Licensing, Inc. | Environmental control device for tissue treatment |
AU2002360757A1 (en) | 2002-02-28 | 2003-09-16 | Hill-Rom Services, Inc. | External catheter access to vacuum bandage |
US7401703B2 (en) | 2002-02-28 | 2008-07-22 | Kimberly-Clark Worldwide, Inc. | Surgical kit with accessory item container |
WO2003075968A2 (en) | 2002-03-04 | 2003-09-18 | Georgia Tech Research Corporation | Biocompatible hydrophilic films from polymeric mini-emulsions for application to skin |
CN1291761C (zh) | 2002-03-04 | 2006-12-27 | 新技术国际交流株式会社 | 封闭型细胞培养系统 |
CA2478320A1 (en) | 2002-03-07 | 2003-09-18 | Board Of Regents, The University Of Texas System | Conformable bi-laminate compression bolster and method for using same |
BR0201154A (pt) | 2002-03-13 | 2003-12-02 | Brasil Compressores Sa | Arranjo construtivo para compressor ressonante |
KR100451233B1 (ko) | 2002-03-16 | 2004-10-02 | 엘지전자 주식회사 | 왕복동식 압축기의 운전제어방법 |
BR0201189B1 (pt) | 2002-03-22 | 2010-06-29 | compressor alternativo acionado por motor linear. | |
US6613953B1 (en) | 2002-03-22 | 2003-09-02 | Dan Altura | Insulator-conductor device for maintaining a wound near normal body temperature |
US6942633B2 (en) | 2002-03-22 | 2005-09-13 | Twin Star Medical, Inc. | System for treating tissue swelling |
ITPN20020022A1 (it) | 2002-04-05 | 2003-10-06 | Zanussi Elettromecc | Motore lineare e compressore azionato da detto motore. |
CA2481016C (en) | 2002-04-10 | 2012-04-03 | Hill-Rom Services, Inc. | Access openings in vacuum bandage |
US20030199800A1 (en) | 2002-04-17 | 2003-10-23 | Levin John M. | Bandage including perforated gel |
DE20207356U1 (de) | 2002-05-08 | 2003-06-12 | Riesinger, Birgit, 48346 Ostbevern | Absorptionskörper zum Anschluß an Haut- und Schleimhautoberflächen |
US20030212357A1 (en) | 2002-05-10 | 2003-11-13 | Pace Edgar Alan | Method and apparatus for treating wounds with oxygen and reduced pressure |
WO2003094790A2 (en) * | 2002-05-13 | 2003-11-20 | Salviac Limited | Catheter system with procedural catheter and embolic proctection system |
JP2003339188A (ja) | 2002-05-21 | 2003-11-28 | Matsushita Electric Ind Co Ltd | リニアモータの駆動装置 |
ES2642724T3 (es) | 2002-05-31 | 2017-11-17 | Kci Medical Resources | Aparato de tratamiento de heridas |
US20030225347A1 (en) | 2002-06-03 | 2003-12-04 | Argenta Louis C. | Directed tissue growth employing reduced pressure |
DE20209581U1 (de) | 2002-06-20 | 2003-10-30 | Braun Melsungen Ag | Spritzenpumpe |
US20040001878A1 (en) * | 2002-06-26 | 2004-01-01 | Deroyal Industries, Inc. | Infused wound care dressings |
USD475134S1 (en) | 2002-06-26 | 2003-05-27 | Kci Licensing, Inc. | Pump housing for medical equipment |
BR0202830B1 (pt) | 2002-07-10 | 2010-11-16 | arranjo ressonante para compressor linear. | |
US7591781B2 (en) * | 2002-07-15 | 2009-09-22 | Olympus Corporation | Endoscope system with insertion direction changing guides |
JP2004064852A (ja) | 2002-07-26 | 2004-02-26 | Matsushita Refrig Co Ltd | リニアモータ及びリニアモータコンプレッサ |
US6775807B2 (en) * | 2002-08-19 | 2004-08-10 | Intersil Americas Inc. | Numerically modeling inductive circuit elements |
US8062331B2 (en) | 2002-08-21 | 2011-11-22 | Kci Licensing, Inc. | Internal and external medical closure screen systems and methods |
US7410495B2 (en) | 2002-08-21 | 2008-08-12 | Kci Licensing, Inc. | Medical closure clip system and method |
JP2005536275A (ja) | 2002-08-21 | 2005-12-02 | ヒル−ロム サービシズ,インコーポレイテッド | 創傷閉鎖を防止するための創傷用パッキング |
US7413571B2 (en) | 2002-08-21 | 2008-08-19 | Kci Licensing, Inc. | Flexible medical closure screen and method |
US7413570B2 (en) | 2002-08-21 | 2008-08-19 | Kci Licensing, Inc. | Medical closure screen installation systems and methods |
US7351250B2 (en) | 2002-08-21 | 2008-04-01 | Kci Licensing, Inc. | Circumferential medical closure device and method |
US7381211B2 (en) | 2002-08-21 | 2008-06-03 | Kci Licensing, Inc. | Medical closure screen device and method |
US20040039391A1 (en) | 2002-08-23 | 2004-02-26 | Argenta Louis C. | Bone treatment employing reduced pressure |
US20040122434A1 (en) | 2002-08-23 | 2004-06-24 | Argenta Louis C. | Bone treatment employing reduced pressure |
US7846141B2 (en) | 2002-09-03 | 2010-12-07 | Bluesky Medical Group Incorporated | Reduced pressure treatment system |
US7048706B2 (en) | 2002-09-11 | 2006-05-23 | Cea Beverly V | Hypoallergenic bandage |
AU2003272310A1 (en) | 2002-09-11 | 2004-04-30 | The Cleveland Clinic Foundation | Ultrafiltration membrane, device, bioartificial organ and methods |
US6979324B2 (en) | 2002-09-13 | 2005-12-27 | Neogen Technologies, Inc. | Closed wound drainage system |
US7520872B2 (en) | 2002-09-13 | 2009-04-21 | Neogen Technologies, Inc. | Closed wound drainage system |
US7625362B2 (en) | 2003-09-16 | 2009-12-01 | Boehringer Technologies, L.P. | Apparatus and method for suction-assisted wound healing |
US7815616B2 (en) | 2002-09-16 | 2010-10-19 | Boehringer Technologies, L.P. | Device for treating a wound |
GB2393120A (en) | 2002-09-18 | 2004-03-24 | Johnson & Johnson Medical Ltd | Compositions for wound treatment |
US6887263B2 (en) | 2002-10-18 | 2005-05-03 | Radiant Medical, Inc. | Valved connector assembly and sterility barriers for heat exchange catheters and other closed loop catheters |
JP4211351B2 (ja) | 2002-10-21 | 2009-01-21 | パナソニック株式会社 | レシプロ型電動圧縮機 |
US6960181B2 (en) | 2002-10-22 | 2005-11-01 | Carol J. Stevens | Irrigation dressing with a tubular dam |
GB0224986D0 (en) | 2002-10-28 | 2002-12-04 | Smith & Nephew | Apparatus |
AU2003294238A1 (en) | 2002-10-30 | 2004-06-07 | Joel S. Rossen | Simplified one-handed preemptive medical procedure site dressing to prevent sharps injuries and exposure to bloodborne pathogens |
US20040087884A1 (en) | 2002-10-31 | 2004-05-06 | Haddock Teresa H. | Textured breathable films and their use as backing material for bandages |
ATE431170T1 (de) | 2002-11-07 | 2009-05-15 | Rolf Weidenhagen | Endoskopisches wundpflegebehandlungssystem |
US7367342B2 (en) | 2002-12-02 | 2008-05-06 | Life Support Technologies, Inc. | Wound management systems and methods for using the same |
US7122712B2 (en) | 2002-12-02 | 2006-10-17 | Lutri Thomas P | Surgical bandage and methods for treating open wounds |
AU2003301024A1 (en) | 2002-12-16 | 2004-07-22 | Velcro Industries B.V. | Inflatable products and methods of their formation and use |
US7612248B2 (en) | 2002-12-19 | 2009-11-03 | 3M Innovative Properties Company | Absorbent medical articles |
US6951553B2 (en) | 2002-12-31 | 2005-10-04 | Kci Licensing, Inc | Tissue closure treatment system and method with externally-applied patient interface |
US7423193B2 (en) | 2002-12-31 | 2008-09-09 | Ossur, Hf | Wound dressing |
US7976519B2 (en) | 2002-12-31 | 2011-07-12 | Kci Licensing, Inc. | Externally-applied patient interface system and method |
GB0300625D0 (en) | 2003-01-10 | 2003-02-12 | Bristol Myers Squibb Co | Wound dressing |
US7244251B2 (en) | 2003-02-07 | 2007-07-17 | Alfred E. Mann Institute For Biomedical Engineering | Implanted surgical drain with multiple sensing elements for monitoring internal tissue condition |
US6838589B2 (en) | 2003-02-19 | 2005-01-04 | 3M Innovative Properties Company | Conformable wound dressing |
WO2004073566A1 (ja) | 2003-02-21 | 2004-09-02 | Menicon Co., Ltd. | 医療用被覆材 |
AU2003227020A1 (en) | 2003-02-27 | 2004-09-17 | Bang And Olufsen A/S | Metal structure with translucent region |
USD488558S1 (en) | 2003-02-27 | 2004-04-13 | Kci Licensing, Inc. | Drainage canister |
KR20040080470A (ko) | 2003-03-11 | 2004-09-20 | 엘지전자 주식회사 | 일체형 공기조화기의 콘트롤박스 장착구조 |
KR100518013B1 (ko) | 2003-03-11 | 2005-09-30 | 엘지전자 주식회사 | 왕복동식 압축기의 스프링 고정 구조 |
US7169151B1 (en) | 2003-04-10 | 2007-01-30 | Kci Licensing, Inc. | Bone regeneration device for long bones, and method of use |
US7151348B1 (en) | 2003-04-14 | 2006-12-19 | Matsushita Electric Industrila Co., Ltd. | Motor driving apparatus |
BR0301492A (pt) | 2003-04-23 | 2004-12-07 | Brasil Compressores Sa | Sistema de ajuste de frequências de ressonância em compressor linear |
JP3874416B2 (ja) | 2003-05-02 | 2007-01-31 | 日本ピラー工業株式会社 | 往復動ポンプ |
US6998511B2 (en) | 2003-05-03 | 2006-02-14 | George Medical | Dressing and a method for applying the same |
US20040243042A1 (en) | 2003-05-20 | 2004-12-02 | Lipman Roger D. A. | Facial masks for managing skin wounds |
WO2005000372A1 (ja) | 2003-06-26 | 2005-01-06 | Zuiko Corporation | 創傷被覆材および創傷被覆材キット |
EP2264649A3 (en) | 2003-07-07 | 2011-01-26 | Avery Dennison Corporation | RFID device with changeable characteristics |
DE112004001236T5 (de) | 2003-07-11 | 2006-06-08 | Tribotek, Inc., Burlington | Elektrische Mehrkontakt-Gewebeschalter |
ES2582936T3 (es) | 2003-07-11 | 2016-09-16 | Nonwovens Innovation & Research Institute Limited | Tela espaciadora no tejida |
US20050015036A1 (en) | 2003-07-17 | 2005-01-20 | Lutri Thomas Placido | Surgical bandage for use with tissue adhesives and other medicaments |
US20100210986A1 (en) | 2003-07-22 | 2010-08-19 | Sanders T Blane | Negative pressure wound treatment dressings and systems |
US8444611B2 (en) | 2003-07-22 | 2013-05-21 | Kci Licensing, Inc. | Negative pressure wound treatment dressing |
KR100941422B1 (ko) | 2003-08-04 | 2010-02-10 | 삼성전자주식회사 | 리니어 압축기 및 그 제어 장치 |
US20050033211A1 (en) | 2003-08-08 | 2005-02-10 | Samuel Scheinberg | Friction reducing bandage |
WO2005016179A2 (en) | 2003-08-08 | 2005-02-24 | Advance Wound Systems, Llc | Friction reducing devices |
US7942866B2 (en) | 2003-08-28 | 2011-05-17 | Boehringer Technologies, L.P. | Device for treating a wound |
US7361184B2 (en) | 2003-09-08 | 2008-04-22 | Joshi Ashok V | Device and method for wound therapy |
EP1673139A2 (en) | 2003-09-10 | 2006-06-28 | Power Paper Ltd. | Disposable electric bandage |
NL1025938C2 (nl) | 2003-09-17 | 2005-03-18 | Broockeville Corp N V | Wonddrainage-inrichting. |
US20050065471A1 (en) | 2003-09-23 | 2005-03-24 | Charles Kuntz | Continuous safe suction device |
GB2406519B (en) | 2003-09-30 | 2007-04-25 | David John Chapman-Jones | Dressing for tissue treatment |
DE10394227B4 (de) | 2003-10-06 | 2011-11-03 | Lg Electronics Inc. | Kolbenverdichter |
US7118545B2 (en) | 2003-10-14 | 2006-10-10 | Boyde Sandra M | Wound dressing retainer and fastening device |
AU2003272129A1 (en) | 2003-10-24 | 2005-05-11 | Lg Electronics Inc. | Reciprocating compressor |
GB0325120D0 (en) * | 2003-10-28 | 2003-12-03 | Smith & Nephew | Apparatus with actives |
GB0518804D0 (en) | 2005-09-15 | 2005-10-26 | Smith & Nephew | Exudialysis tissue cleanser |
GB0325126D0 (en) | 2003-10-28 | 2003-12-03 | Smith & Nephew | Apparatus with heat |
GB0518826D0 (en) | 2005-09-15 | 2005-10-26 | Smith & Nephew | Apparatus with actives from tissue - exudialysis |
GB0325129D0 (en) | 2003-10-28 | 2003-12-03 | Smith & Nephew | Apparatus in situ |
GB0409443D0 (en) | 2004-04-28 | 2004-06-02 | Smith & Nephew | Apparatus |
GB0325130D0 (en) | 2003-10-28 | 2003-12-03 | Smith & Nephew | Apparatus with scaffold |
GB0518825D0 (en) | 2005-09-15 | 2005-10-26 | Smith & Nephew | Apparatus with actives from tissue - sai |
US8758313B2 (en) | 2003-10-28 | 2014-06-24 | Smith & Nephew Plc | Apparatus and method for wound cleansing with actives |
EP1691852A2 (en) | 2003-11-10 | 2006-08-23 | Angiotech International AG | Medical implants and fibrosis-inducing agents |
US7182758B2 (en) | 2003-11-17 | 2007-02-27 | Mccraw John B | Apparatus and method for drainage |
DE102004054690B4 (de) | 2003-11-26 | 2013-08-14 | Lg Electronics Inc. | Vorrichtung und Verfahren zum Steuern des Betriebs eines Kolbenverdichters |
JP4185445B2 (ja) | 2003-12-02 | 2008-11-26 | 大王製紙株式会社 | 吸収性物品 |
KR100512748B1 (ko) | 2003-12-18 | 2005-09-07 | 삼성전자주식회사 | 리니어 압축기 |
KR100548292B1 (ko) | 2003-12-29 | 2006-02-02 | 엘지전자 주식회사 | 왕복동식 압축기의 편마모 저감 장치 |
KR100548296B1 (ko) | 2003-12-30 | 2006-02-02 | 엘지전자 주식회사 | 왕복동식 압축기의 공진스프링 지지구조 |
US7128735B2 (en) | 2004-01-02 | 2006-10-31 | Richard Scott Weston | Reduced pressure wound treatment appliance |
DE102004001594B4 (de) | 2004-01-09 | 2006-09-21 | Bio-Gate Ag | Wundauflage und Verfahren zu deren Herstellung |
JP4660171B2 (ja) | 2004-02-05 | 2011-03-30 | 阿蘇製薬株式会社 | 救急用絆創膏 |
PT1718257E (pt) | 2004-02-13 | 2010-10-21 | Convatec Technologies Inc | Penso multicamada para ferida |
GB0403969D0 (en) | 2004-02-24 | 2004-03-31 | Huntleigh Technology Plc | Tissue treatment device |
US7052167B2 (en) | 2004-02-25 | 2006-05-30 | Vanderschuit Carl R | Therapeutic devices and methods for applying therapy |
US8100887B2 (en) | 2004-03-09 | 2012-01-24 | Bluesky Medical Group Incorporated | Enclosure-based reduced pressure treatment system |
US7511187B2 (en) | 2004-03-12 | 2009-03-31 | Mcneil - Ppc Inc. | Absorbent article having stain masking characteristics |
US7049478B1 (en) | 2004-03-16 | 2006-05-23 | Patricia Ann Smith | Tri-lobe planar heel wound dressing |
US8062272B2 (en) | 2004-05-21 | 2011-11-22 | Bluesky Medical Group Incorporated | Flexible reduced pressure treatment appliance |
US7776028B2 (en) | 2004-04-05 | 2010-08-17 | Bluesky Medical Group Incorporated | Adjustable overlay reduced pressure wound treatment system |
US10058642B2 (en) | 2004-04-05 | 2018-08-28 | Bluesky Medical Group Incorporated | Reduced pressure treatment system |
US7909805B2 (en) | 2004-04-05 | 2011-03-22 | Bluesky Medical Group Incorporated | Flexible reduced pressure treatment appliance |
US7790945B1 (en) | 2004-04-05 | 2010-09-07 | Kci Licensing, Inc. | Wound dressing with absorption and suction capabilities |
US7708724B2 (en) | 2004-04-05 | 2010-05-04 | Blue Sky Medical Group Incorporated | Reduced pressure wound cupping treatment system |
US7884258B2 (en) | 2004-04-13 | 2011-02-08 | Boehringer Technologies, L.P. | Wound contact device |
GB0508531D0 (en) | 2005-04-27 | 2005-06-01 | Smith & Nephew | Sai with ultrasound |
GB0508528D0 (en) | 2005-04-27 | 2005-06-01 | Smith & Nephew | SAI with macrostress |
GB0508529D0 (en) | 2005-04-27 | 2005-06-01 | Smith & Nephew | Sai with microstress |
GB0409446D0 (en) | 2004-04-28 | 2004-06-02 | Smith & Nephew | Apparatus |
US7753894B2 (en) | 2004-04-27 | 2010-07-13 | Smith & Nephew Plc | Wound cleansing apparatus with stress |
GB0409444D0 (en) | 2004-04-28 | 2004-06-02 | Smith & Nephew | Apparatus |
US8529548B2 (en) | 2004-04-27 | 2013-09-10 | Smith & Nephew Plc | Wound treatment apparatus and method |
GB0424046D0 (en) | 2004-10-29 | 2004-12-01 | Smith & Nephew | Apparatus |
US7998125B2 (en) | 2004-05-21 | 2011-08-16 | Bluesky Medical Group Incorporated | Hypobaric chamber treatment system |
US20050271526A1 (en) | 2004-06-04 | 2005-12-08 | Samsung Electronics Co., Ltd. | Reciprocating compressor, driving unit and control method for the same |
GB2415382A (en) | 2004-06-21 | 2005-12-28 | Johnson & Johnson Medical Ltd | Wound dressings for vacuum therapy |
MY139135A (en) | 2004-06-30 | 2009-08-28 | Uni Charm Corp | Disposable wearing article |
GB0415065D0 (en) | 2004-07-05 | 2004-08-04 | Isis Innovation | Control of reciprocating linear machines |
US20060009744A1 (en) | 2004-07-09 | 2006-01-12 | Erdman Edward P | Decorative component for an absorbent article |
GB2415908A (en) | 2004-07-09 | 2006-01-11 | Ethicon Inc | Vacuum wound dressings |
US7104767B2 (en) | 2004-07-19 | 2006-09-12 | Wilson Greatbatch Technologies, Inc. | Diaphragm pump for medical applications |
US20060020234A1 (en) | 2004-07-21 | 2006-01-26 | Lin-Shing Chou | Absorbent sac wound dressing |
KR100608681B1 (ko) | 2004-07-26 | 2006-08-08 | 엘지전자 주식회사 | 왕복동식 압축기 |
KR100619731B1 (ko) | 2004-07-26 | 2006-09-08 | 엘지전자 주식회사 | 왕복동모터 및 이를 구비한 왕복동식 압축기 |
KR100641112B1 (ko) | 2004-07-28 | 2006-11-02 | 엘지전자 주식회사 | 왕복동식 압축기 및 그의 제조 방법 |
CN102019030B (zh) | 2004-08-09 | 2013-08-21 | 泰科保健集团有限合伙公司 | 医疗皮肤施加器装置 |
US7364145B2 (en) | 2004-09-08 | 2008-04-29 | Equipment Solutions, Inc | High stiffness flexure |
EP1635060B1 (en) | 2004-09-11 | 2012-09-19 | LG Electronics, Inc. | Apparatus and method for controlling a compressor |
KR100608690B1 (ko) | 2004-09-11 | 2006-08-09 | 엘지전자 주식회사 | 왕복동식 압축기의 운전제어장치 및 방법 |
SG158151A1 (en) | 2004-09-20 | 2010-01-29 | Medela Holding Ag | Suction pump with air release valve |
US7612247B2 (en) | 2004-09-29 | 2009-11-03 | Oyaski Michael F | Wound alternative treatment system |
US20060069365A1 (en) | 2004-09-30 | 2006-03-30 | Sperl Michael D | Absorbent composite having selective regions for improved attachment |
GB2418738A (en) | 2004-10-02 | 2006-04-05 | David Arthur Jones | A fluid flow sensor |
US7717313B2 (en) | 2004-10-18 | 2010-05-18 | Tyco Healthcare Group Lp | Surgical apparatus and structure for applying sprayable wound treatment material |
US7030329B1 (en) | 2004-10-22 | 2006-04-18 | Solectron Invotronics | Switch contact |
US20110313373A1 (en) | 2004-11-02 | 2011-12-22 | Birgit Riesinger | Device for the treatment of wounds using a vacuum |
DE202004017052U1 (de) | 2004-11-02 | 2005-06-09 | Riesinger, Birgit | Vorrichtung zur Wundbehandlung unter Einsatz von Unterdruck |
EP1807145B1 (en) | 2004-11-05 | 2016-03-23 | ConvaTec Technologies Inc. | Vacuum wound dressing |
US7361803B2 (en) | 2004-11-08 | 2008-04-22 | Mark Miskie | Multi-layer moisture management fabric composite |
US7485112B2 (en) | 2004-11-08 | 2009-02-03 | Boehringer Technologies, L.P. | Tube attachment device for wound treatment |
DE202004018245U1 (de) | 2004-11-24 | 2005-07-07 | Riesinger, Birgit | Drainagevorrichtung zur Wundbehandlung unter Einsatz von Unterdruck |
USD544092S1 (en) | 2004-12-03 | 2007-06-05 | Kci Licensing, Inc. | Wearable negative pressure wound care appliance |
US20060122548A1 (en) | 2004-12-06 | 2006-06-08 | Leonard Abrams | Devices and methods of treatment of wounds and burns and related impaired blood circulation problems |
US7576256B2 (en) | 2004-12-10 | 2009-08-18 | Abigo Medical Ab | Wound dressing with a bacterial adsorbing composition |
US7465156B2 (en) | 2004-12-17 | 2008-12-16 | Lg Electronics Inc. | Apparatus for mounting compressor |
KR100690656B1 (ko) | 2004-12-22 | 2007-03-09 | 엘지전자 주식회사 | 왕복동식 압축기 |
DE102004062298A1 (de) | 2004-12-23 | 2006-07-13 | BSH Bosch und Siemens Hausgeräte GmbH | Linearverdichter |
DE102004062302A1 (de) | 2004-12-23 | 2006-07-13 | BSH Bosch und Siemens Hausgeräte GmbH | Linearverdichter und Antriebsaggregat dafür |
DE102004062301A1 (de) | 2004-12-23 | 2006-07-13 | BSH Bosch und Siemens Hausgeräte GmbH | Linearverdichter und Antriebsaggregat dafür |
DE102004062307A1 (de) | 2004-12-23 | 2006-07-13 | BSH Bosch und Siemens Hausgeräte GmbH | Linearverdichter |
DE102005007016A1 (de) | 2005-02-15 | 2006-08-24 | Fleischmann, Wilhelm, Dr.med. | Vorrichtung zur Behandlung von Wunden |
US20060206047A1 (en) | 2005-03-14 | 2006-09-14 | Lampe John K | Bandage with splint |
GB0506308D0 (en) | 2005-03-29 | 2005-05-04 | Taylor Michael | Bandage pressure monitor |
DE102005015878A1 (de) | 2005-04-06 | 2006-10-12 | Inmeditec Medizintechnik Gmbh | Schlauchanschluss für Vakuumtherapiegerät |
US7408310B2 (en) | 2005-04-08 | 2008-08-05 | Lg Electronics Inc. | Apparatus for controlling driving of reciprocating compressor and method thereof |
GB0508194D0 (en) | 2005-04-22 | 2005-06-01 | The Technology Partnership Plc | Pump |
KR100690663B1 (ko) | 2005-05-06 | 2007-03-09 | 엘지전자 주식회사 | 용량 가변형 왕복동식 압축기의 운전 제어장치 및 방법 |
WO2006127905A2 (en) | 2005-05-24 | 2006-11-30 | Chrono Therapeutics, Inc. | Portable drug delivery device |
US7749531B2 (en) | 2005-06-08 | 2010-07-06 | Indicator Systems International | Apparatus and method for detecting bacterial growth beneath a wound dressing |
DE102005026771B4 (de) | 2005-06-10 | 2007-04-19 | Erdmann, Alfons, Dr. med. | Vorrichtung zur Behandlung von Patienten, die unter an der Hautoberfläche verteilten Hautläsionen leiden sowie Körperabdeckung |
EP1895940A4 (en) | 2005-06-16 | 2011-03-16 | Biolase Tech Inc | ELEMENTS FOR COVERING A HUMAN TISSUE WITH PERSONALIZED FABRIC IMAGES |
US7931630B2 (en) | 2005-07-05 | 2011-04-26 | C. R. Bard, Inc. | Multi-functional and modular urine collection system |
US7857806B2 (en) | 2005-07-14 | 2010-12-28 | Boehringer Technologies, L.P. | Pump system for negative pressure wound therapy |
US7438705B2 (en) | 2005-07-14 | 2008-10-21 | Boehringer Technologies, L.P. | System for treating a wound with suction and method detecting loss of suction |
US7988673B2 (en) | 2005-07-14 | 2011-08-02 | Venetec International, Inc. | Protective dressing and methods of use thereof |
CA2614794C (en) | 2005-07-24 | 2014-02-18 | Carmeli Adahan | Wound closure and drainage system |
US7503910B2 (en) | 2006-02-01 | 2009-03-17 | Carmeli Adahan | Suctioning system, method and kit |
NZ541466A (en) | 2005-07-25 | 2007-02-23 | Fisher & Paykel Appliances Ltd | Controller for free piston linear compressor |
US20070027414A1 (en) | 2005-07-28 | 2007-02-01 | Integra Lifesciences Corporation | Laminar construction negative pressure wound dressing including bioabsorbable material |
US20070032754A1 (en) | 2005-08-02 | 2007-02-08 | Walsh Richard F | Method and apparatus for treating a wound |
US20070032755A1 (en) | 2005-08-02 | 2007-02-08 | Medica-Rents Co., Ltd. | Method and apparatus for treating a wound |
US7837673B2 (en) | 2005-08-08 | 2010-11-23 | Innovative Therapies, Inc. | Wound irrigation device |
DE102005038783A1 (de) | 2005-08-17 | 2007-02-22 | Danfoss Compressors Gmbh | Linearverdichter |
US7294751B2 (en) | 2005-08-23 | 2007-11-13 | Tri-State Hospital Supply Corporation | Window dressing |
US7812212B2 (en) | 2005-08-23 | 2010-10-12 | Centurion Medical Products Corporation | Window dressing |
WO2007024230A1 (en) | 2005-08-26 | 2007-03-01 | Spheric Products, Ltd. | Chest tube drainage system |
WO2007027755A2 (en) | 2005-08-30 | 2007-03-08 | Mayo Foundation For Medical Education And Research | Inflatable compression dressing |
AU2006287463A1 (en) | 2005-09-06 | 2007-03-15 | Tyco Healthcare Group Lp | Self contained wound dressing with micropump |
CA2923372C (en) | 2005-09-07 | 2019-07-30 | Smith & Nephew, Inc. | Self contained wound dressing apparatus |
US7699823B2 (en) | 2005-09-07 | 2010-04-20 | Tyco Healthcare Group Lp | Wound dressing with vacuum reservoir |
US7723561B2 (en) | 2005-09-09 | 2010-05-25 | Centurion Medical Products Corporation | PIV dressing assembly |
US20070078467A1 (en) | 2005-09-13 | 2007-04-05 | Mullen Gary J | Surgical depilatory device |
JP2007125155A (ja) | 2005-11-02 | 2007-05-24 | Meditech:Kk | 血液拡散機能及び血液吸収機能を有する止血用具 |
EP3292846A1 (de) | 2005-11-02 | 2018-03-14 | BSN Medical GmbH | Absorptionskörper zur anbringung an menschliche oder tierische hautoberflächen |
US7596193B2 (en) * | 2005-11-09 | 2009-09-29 | Via Telecom, Inc. | Variable bandwidth automatic gain control |
SE529284C2 (sv) | 2005-11-14 | 2007-06-19 | Johan Stenberg | Membranpump |
DE202005019670U1 (de) | 2005-12-14 | 2006-04-27 | Riesinger, Birgit | Wundbehandlungsvorrichtung mit elastisch verformbarem Unterdruckerzeugungselement |
US7601129B2 (en) | 2005-12-15 | 2009-10-13 | Aalnex, Inc. | Wound shield and warming apparatus and method |
US7622629B2 (en) | 2005-12-15 | 2009-11-24 | Aalnex, Inc. | Wound shield for exudate management |
ITMO20050343A1 (it) | 2005-12-23 | 2007-06-24 | Lorenz Biotech Spa | Supporto per medicazione |
US7896823B2 (en) | 2006-01-17 | 2011-03-01 | Theranova, Llc | Method and apparatus for treating wound using negative pressure therapy |
US20110137222A1 (en) | 2006-01-18 | 2011-06-09 | Masini Michael A | Healing wound bandaging kit and method |
AU2007211739A1 (en) | 2006-02-02 | 2007-08-09 | Coloplast A/S | A suction system |
CN101900105A (zh) | 2006-02-02 | 2010-12-01 | Lg电子株式会社 | 用于直线压缩机的控制装置 |
US20090036873A1 (en) | 2006-02-02 | 2009-02-05 | Coloplast A/S | Device, Pump and System for Stimulating the Healing of a Wound |
CA2634276A1 (en) | 2006-02-02 | 2007-08-09 | Coloplast A/S | A suction method and a wound suction system |
MX348927B (es) | 2006-02-07 | 2017-07-04 | Smith & Nephew Inc | Vendaje quirúrgico para heridas. |
US7816577B2 (en) | 2006-02-13 | 2010-10-19 | Aalnex, Inc. | Wound shield |
US8079825B2 (en) | 2006-02-21 | 2011-12-20 | International Rectifier Corporation | Sensor-less control method for linear compressors |
DE102006009232A1 (de) | 2006-02-28 | 2007-08-30 | BSH Bosch und Siemens Hausgeräte GmbH | Linearverdichter und Antriebsaggregat dafür |
BRPI0708652A2 (pt) | 2006-03-07 | 2011-06-07 | Influent Corp | dispositivos de transferência de energia fluìdica |
GB0606661D0 (en) | 2006-04-03 | 2006-05-10 | Brightwake Ltd | Improvements relating to dressings |
EP2012678A4 (en) | 2006-04-13 | 2015-07-22 | Kci Licensing Inc | MEDICAL CLOSURE CLAMPING SYSTEM AND METHOD |
CA2648063C (en) | 2006-04-13 | 2014-06-03 | Kci Licensing, Inc. | Medical closure screen installation systems and methods |
BRPI0601645B1 (pt) | 2006-04-18 | 2018-06-05 | Whirlpool S.A. | Compressor linear |
SE529829C3 (sv) | 2006-04-26 | 2007-12-27 | Forskarpatent I Syd Ab | Mekanish barrier for anvandning med negativt tryck, I synnerhet for sternumsar |
US20070256428A1 (en) | 2006-05-05 | 2007-11-08 | Sunpower, Inc. | Vibration control of free piston machines through frequency adjustment |
US7779625B2 (en) | 2006-05-11 | 2010-08-24 | Kalypto Medical, Inc. | Device and method for wound therapy |
US7615036B2 (en) | 2006-05-11 | 2009-11-10 | Kalypto Medical, Inc. | Device and method for wound therapy |
US7576257B2 (en) | 2006-06-06 | 2009-08-18 | Lagreca Sr Alfred J | Reclosable wound dressing system |
US8025650B2 (en) | 2006-06-12 | 2011-09-27 | Wound Care Technologies, Inc. | Negative pressure wound treatment device, and methods |
US20070292397A1 (en) | 2006-06-19 | 2007-12-20 | Mcnulty Amy K | Method for the detection and neutralization of bacteria |
US7294752B1 (en) | 2006-06-27 | 2007-11-13 | Tri-State Hospital Supply Corporation | Window dressing having integral anchor |
SE0601536L (sv) | 2006-07-11 | 2008-01-12 | Moelnlycke Health Care Ab | Spolförband |
GB0712735D0 (en) | 2006-07-26 | 2007-08-08 | Smith & Nephew | Dressing |
US7858838B2 (en) | 2006-08-10 | 2010-12-28 | 3M Innovative Properties Company | Conformable wound dressing |
ZA200901707B (en) | 2006-08-11 | 2010-06-30 | Payload Systems Inc | High speed swelling, pressure exerting hemostatic device |
KR20090061022A (ko) | 2006-08-30 | 2009-06-15 | 사우쓰이스턴 메디칼 테크놀로지스, 엘엘씨 | 대기압에서 변경된 압력으로 상처를 치료하는 방법, 조성물및 기구 |
US20080058691A1 (en) | 2006-08-31 | 2008-03-06 | Bradford Tyler Sorensen | Bullet plug gunshot wound first aid, open operation device |
US8366690B2 (en) | 2006-09-19 | 2013-02-05 | Kci Licensing, Inc. | System and method for determining a fill status of a canister of fluid in a reduced pressure treatment system |
US7862339B2 (en) | 2006-09-21 | 2011-01-04 | Tyco Healthcare Group Lp | Negative wound pressure therapy test system |
ES2340085T5 (es) | 2006-09-28 | 2014-04-16 | Smith & Nephew, Inc. | Sistema portátil de terapia de heridas |
DE102006047041A1 (de) | 2006-10-02 | 2008-04-10 | Birgit Riesinger | Flächenhafter Absorptionskörper |
US8308714B2 (en) | 2006-10-13 | 2012-11-13 | Bluesky Medical Group Inc. | Control circuit and method for negative pressure wound treatment apparatus |
CN101547712B (zh) | 2006-10-13 | 2012-05-30 | 凯希特许有限公司 | 用于对低严重性伤口提供治疗的、具有手动启动泵的减压输送系统 |
JP5548454B2 (ja) | 2006-10-17 | 2014-07-16 | ブルースカイ・メディカル・グループ・インコーポレーテッド | 補助動力陰圧創傷治療装置および方法 |
US20080167592A1 (en) | 2006-10-26 | 2008-07-10 | Greer Steven E | Preventing or treating wounds with a collodion barrier incorporating active agents |
US8186978B2 (en) | 2006-10-31 | 2012-05-29 | Humphrey Products Company | Pump with linear actuator |
KR100819609B1 (ko) | 2006-12-08 | 2008-04-04 | 엘지전자 주식회사 | 리니어 압축기 |
US8377016B2 (en) | 2007-01-10 | 2013-02-19 | Wake Forest University Health Sciences | Apparatus and method for wound treatment employing periodic sub-atmospheric pressure |
US7829819B2 (en) | 2007-02-08 | 2010-11-09 | Automotive Components Holdings, Llc | Attaching a component to an internal surface of a tank formed of polymer |
CA2925998C (en) | 2007-02-09 | 2018-08-21 | Kci Licensing, Inc. | Apparatus and method for administering reduced pressure treatment to a tissue site |
US8267908B2 (en) | 2007-02-09 | 2012-09-18 | Kci Licensing, Inc. | Delivery tube, system, and method for storing liquid from a tissue site |
US7880050B2 (en) | 2007-02-09 | 2011-02-01 | Kci Licensing, Inc. | Breathable interface system for topical reduced pressure |
EP2974754B1 (en) | 2007-02-09 | 2018-11-21 | KCI Licensing, Inc. | System for managing reduced pressure at a tissue site |
TWM320097U (en) | 2007-02-13 | 2007-10-01 | Mustek Systems Inc | High stability planar spring utilized in a voice coil motor |
JP4808811B2 (ja) | 2007-02-20 | 2011-11-02 | ケーシーアイ ライセンシング インコーポレイテッド | 減圧治療システムにおいてキャニスタ係合外れ状態からリークを識別するシステム及び方法 |
JP5224209B2 (ja) | 2007-03-02 | 2013-07-03 | 孝仁 今川 | 二次元共鳴振動モーター |
CA2581698A1 (en) | 2007-03-14 | 2008-09-14 | Canica Design Inc. | Viscera protector |
DE102007014709A1 (de) | 2007-03-23 | 2008-09-25 | Carl Freudenberg Kg | Membranpumpe zur Förderung eines Fluids |
USD565177S1 (en) | 2007-04-01 | 2008-03-25 | Kci Licensing, Inc. | Reduced pressure treatment apparatus |
US7785247B2 (en) | 2007-04-20 | 2010-08-31 | Medical Engineering Co., LLC | Physiologic pulsatile pump |
EP2216057A3 (en) | 2007-05-07 | 2012-05-30 | Carmeli Adahan | Suction system |
GB0710846D0 (en) | 2007-06-06 | 2007-07-18 | Bristol Myers Squibb Co | A wound dressing |
SE531259C2 (sv) | 2007-06-27 | 2009-02-03 | Moelnlycke Health Care Ab | Anordning för behandling av sår med reducerat tryck |
GB0712759D0 (en) | 2007-07-02 | 2007-08-08 | Smith & Nephew | Measuring pressure |
GB0712760D0 (en) | 2007-07-02 | 2007-08-08 | Smith & Nephew | Status indication |
GB0715259D0 (en) | 2007-08-06 | 2007-09-12 | Smith & Nephew | Canister status determination |
US7790946B2 (en) | 2007-07-06 | 2010-09-07 | Tyco Healthcare Group Lp | Subatmospheric pressure wound therapy dressing |
JP5394383B2 (ja) | 2007-08-21 | 2014-01-22 | ケーシーアイ ライセンシング インコーポレイテッド | ガスケットを用いた減圧システム及び方法 |
CN101377192B (zh) | 2007-08-30 | 2012-06-13 | 研能科技股份有限公司 | 流体输送装置 |
US8246590B2 (en) | 2007-10-11 | 2012-08-21 | Spiracur, Inc. | Closed incision negative pressure wound therapy device and methods of use |
TWI340653B (en) | 2007-11-09 | 2011-04-21 | Ind Tech Res Inst | Detachable pump and the negative pressure wound therapy system using the same |
WO2009062327A1 (de) | 2007-11-13 | 2009-05-22 | Medela Holding Ag | Wunddrainageauflage |
US8234393B2 (en) * | 2007-11-16 | 2012-07-31 | Red Hat, Inc. | Generic network protocol scripting |
DE102007055565B3 (de) | 2007-11-20 | 2009-04-16 | Aloys F. Dornbracht Gmbh & Co. Kg | Vorrichtung zur Unterputzbefestigung von sanitären Elementen |
CA2705896C (en) | 2007-11-21 | 2019-01-08 | Smith & Nephew Plc | Wound dressing |
EP3000448B2 (en) | 2007-11-21 | 2022-03-09 | Smith & Nephew PLC | Wound dressing |
ES2555204T3 (es) | 2007-11-21 | 2015-12-29 | T.J. Smith & Nephew Limited | Dispositivo de succión y venda |
GB0722820D0 (en) | 2007-11-21 | 2008-01-02 | Smith & Nephew | Vacuum assisted wound dressing |
GB0723875D0 (en) | 2007-12-06 | 2008-01-16 | Smith & Nephew | Wound management |
US20090157024A1 (en) | 2007-12-14 | 2009-06-18 | Kimberly-Clark Worldwide, Inc. | Hydration Test Devices |
SE531853C2 (sv) | 2007-12-18 | 2009-08-25 | Moelnlycke Health Care Ab | Transparent filmförband för skydd av hud omgivande ett sår |
GB0724564D0 (en) | 2007-12-18 | 2008-01-30 | Smith & Nephew | Portable wound therapy apparatus and method |
EP2244748B1 (en) | 2008-02-27 | 2018-04-11 | KCI Licensing, Inc. | System and method for healing a wound at a tissue site |
US8449508B2 (en) | 2008-03-05 | 2013-05-28 | Kci Licensing, Inc. | Dressing and method for applying reduced pressure to and collecting and storing fluid from a tissue site |
CN101959480B (zh) | 2008-03-05 | 2013-06-05 | 凯希特许有限公司 | 用于将减压施加到组织部位并收集和存储组织部位的流体的敷料和方法 |
US9033942B2 (en) | 2008-03-07 | 2015-05-19 | Smith & Nephew, Inc. | Wound dressing port and associated wound dressing |
US8021347B2 (en) | 2008-07-21 | 2011-09-20 | Tyco Healthcare Group Lp | Thin film wound dressing |
US8298200B2 (en) | 2009-06-01 | 2012-10-30 | Tyco Healthcare Group Lp | System for providing continual drainage in negative pressure wound therapy |
US20090234306A1 (en) | 2008-03-13 | 2009-09-17 | Tyco Healthcare Group Lp | Vacuum wound therapy wound dressing with variable performance zones |
US8152785B2 (en) | 2008-03-13 | 2012-04-10 | Tyco Healthcare Group Lp | Vacuum port for vacuum wound therapy |
GB0804739D0 (en) | 2008-03-14 | 2008-04-16 | The Technology Partnership Plc | Pump |
US20090240218A1 (en) | 2008-03-20 | 2009-09-24 | Tyco Healthcare Group Lp | Wound Therapy System |
WO2009122479A1 (ja) | 2008-03-31 | 2009-10-08 | パナソニック電工株式会社 | 運動装置 |
EP2265234A4 (en) | 2008-04-04 | 2011-08-31 | 3M Innovative Properties Co | MEDICAL ASSOCIATIONS WITH VALVE AND THESE INCLUDING KITS |
CN102046121A (zh) | 2008-04-04 | 2011-05-04 | 3M创新有限公司 | 具有微型泵的伤口敷料 |
SE533167C2 (sv) | 2008-04-09 | 2010-07-13 | Moelnlycke Health Care Ab | Anordning för att behandla sår och sätt för att tillverka sårdynor |
SE533170C2 (sv) | 2008-04-09 | 2010-07-13 | Moelnlycke Health Care Ab | Anordning för att behandla sår med undertryck |
US7825289B2 (en) | 2008-05-16 | 2010-11-02 | Tyco Healthcare Group Lp | Wound dressing adhesive compression device |
EP2296723B1 (en) | 2008-05-21 | 2018-09-12 | Moris Topaz | Wound healing device |
US8048046B2 (en) | 2008-05-21 | 2011-11-01 | Tyco Healthcare Group Lp | Wound therapy system with housing and canister support |
US8414519B2 (en) | 2008-05-21 | 2013-04-09 | Covidien Lp | Wound therapy system with portable container apparatus |
EP2288321B1 (en) | 2008-05-27 | 2019-10-23 | Smith & Nephew, Inc. | Control unit with pump module for a negative pressure wound therapy device |
JP2011521708A (ja) | 2008-05-27 | 2011-07-28 | カリプト メディカル インコーポレーション | 陰圧式外傷治療具 |
RU2472533C2 (ru) | 2008-05-30 | 2013-01-20 | КейСиАй ЛАЙСЕНЗИНГ, ИНК. | Системы терапии линейных ран пониженным давлением |
DE202008007730U1 (de) | 2008-06-10 | 2008-09-11 | Richter, Siegfried, Dipl.-Ing. (FH) | Elektrischer Schwingantrieb |
US20090312725A1 (en) | 2008-06-13 | 2009-12-17 | Braga Richard M | Negative pressure wound therapy fluid collection canister |
CA2765419C (en) | 2008-06-13 | 2017-10-24 | Premco Medical Systems, Inc. | Wound treatment apparatus and method |
US8257326B2 (en) | 2008-06-30 | 2012-09-04 | Tyco Healthcare Group Lp | Apparatus for enhancing wound healing |
AU2009268997B2 (en) | 2008-07-08 | 2015-04-02 | Smith & Nephew Inc. | Portable negative pressure wound therapy device |
WO2010005910A2 (en) | 2008-07-08 | 2010-01-14 | Monarch Labs Llc | Maggot debridement therapy dressings and methods |
US20100030170A1 (en) | 2008-08-01 | 2010-02-04 | Keith Alan Keller | Absorptive Pad |
US8454990B2 (en) | 2008-08-01 | 2013-06-04 | Milliken & Company | Composite article suitable for use as a wound dressing |
US8460698B2 (en) | 2008-08-01 | 2013-06-11 | Milliken & Company | Composite article suitable for use as a wound dressing |
FR2934652B1 (fr) | 2008-08-01 | 2013-01-11 | Ams R & D Sas | Pompe a membrane ondulante de rendement ameliore. |
US20100036367A1 (en) | 2008-08-05 | 2010-02-11 | Bluesky Medical Group, Inc. | Wound overlay with cuff for wound treatment employing reduced pressure |
AU2009279525B2 (en) | 2008-08-08 | 2015-04-09 | Smith & Nephew Inc. | Wound dressing of continuous fibers |
US8251979B2 (en) | 2009-05-11 | 2012-08-28 | Tyco Healthcare Group Lp | Orientation independent canister for a negative pressure wound therapy device |
EP2323703A4 (en) | 2008-08-28 | 2013-11-20 | Covidien Lp | ENVIRONMENTALLY ACTIVATED COMPOSITIONS, ARTICLES AND METHOD |
US9414968B2 (en) | 2008-09-05 | 2016-08-16 | Smith & Nephew, Inc. | Three-dimensional porous film contact layer with improved wound healing |
BRPI0913554A2 (pt) | 2008-09-18 | 2016-09-13 | Kci Licensing | curativo para aplicação de pressão reduzida em um local de tecido, sistema para aplicar uma pressão reduzida em um local de tecido, método para aplicar pressão reduzida em um local de tecido, método de fabricação de um curativo para aplicar uma pressão reduzida em um local de tecido e curativo de ferida de pressão reduzida |
WO2010036815A2 (en) | 2008-09-26 | 2010-04-01 | Launchpoint Technologies, Inc. | Magnetically-levitated blood pump with optimization method enabling miniaturization |
GB0817796D0 (en) | 2008-09-29 | 2008-11-05 | Convatec Inc | wound dressing |
CA2739837C (en) | 2008-10-06 | 2018-02-20 | Tatuyou, Llc | Transparent breathable polyurethane film for tattoo aftercare and method |
US8158844B2 (en) | 2008-10-08 | 2012-04-17 | Kci Licensing, Inc. | Limited-access, reduced-pressure systems and methods |
US8092436B2 (en) | 2008-10-17 | 2012-01-10 | Sterigear LLC | Bodily fluid drainage assembly |
WO2010048078A1 (en) | 2008-10-24 | 2010-04-29 | 3M Innovative Properties Company | Conformable wound dressing |
US20100106120A1 (en) | 2008-10-24 | 2010-04-29 | 3M Innovative Properties Company | Wound dressing |
WO2010053870A1 (en) | 2008-11-07 | 2010-05-14 | Kci Licensing, Inc. | Reduced-pressure, wound-treatment dressings and systems |
BRPI0915237A2 (pt) | 2008-11-14 | 2016-02-16 | Kci Licensing Inc | sistema para armazenar fluido removido de um local de tecido, aparelho para armazenar o líquido de um local de tecido, método para armazenar o líquido de um local de tecido, e, método para fabricar um aparelho para armazenar o líquido de um local de tecido |
US8563800B2 (en) | 2008-11-18 | 2013-10-22 | Patricia A. Smith | Method of use of a tulip-shaped sacral wound dressing |
MX2011005193A (es) | 2008-11-19 | 2011-06-01 | Kci Licensing Inc | Sistema de soporte multi-estratificado y metodos para el mismo. |
US20100150991A1 (en) | 2008-12-15 | 2010-06-17 | Bernstein Brent H | Combination Wound Therapy |
TWI396525B (zh) | 2008-12-19 | 2013-05-21 | Ind Tech Res Inst | 液體收集裝置 |
GB0900423D0 (en) | 2009-01-12 | 2009-02-11 | Smith & Nephew | Negative pressure device |
US8162907B2 (en) | 2009-01-20 | 2012-04-24 | Tyco Healthcare Group Lp | Method and apparatus for bridging from a dressing in negative pressure wound therapy |
US20100191198A1 (en) | 2009-01-26 | 2010-07-29 | Tyco Healthcare Group Lp | Wound Filler Material with Improved Nonadherency Properties |
US20100191196A1 (en) | 2009-01-26 | 2010-07-29 | Heagle David G | Fibrous Wound Filler Material for Negative Pressure Wound Therapy |
US8212101B2 (en) | 2009-02-03 | 2012-07-03 | Centurion Medical Products Corporation | Window dressing having integral anchor |
US8167869B2 (en) | 2009-02-10 | 2012-05-01 | Tyco Healthcare Group Lp | Wound therapy system with proportional valve mechanism |
US8439860B2 (en) | 2009-02-24 | 2013-05-14 | Neogenix, Llc | Oxygen-producing bandage with releasable oxygen source |
EP2419157A4 (en) | 2009-04-17 | 2018-01-03 | Kalypto Medical, Inc. | Negative pressure wound therapy device |
US20100298866A1 (en) | 2009-05-19 | 2010-11-25 | Tyco Healthcare Group Lp | Wound closure system and method of use |
ES1070675Y (es) | 2009-05-20 | 2010-01-14 | Canada Juan Marquez | Aposito de vacio mejorado aplicable como tratamiento de compresion postoperatoria |
US9421309B2 (en) | 2009-06-02 | 2016-08-23 | Kci Licensing, Inc. | Reduced-pressure treatment systems and methods employing hydrogel reservoir members |
GB2470940A (en) | 2009-06-10 | 2010-12-15 | Systagenix Wound Man Ip Co Bv | Vacuum wound dressing with hydrogel layer |
US20100318043A1 (en) | 2009-06-10 | 2010-12-16 | Tyco Healthcare Group Lp | Negative Pressure Wound Therapy Systems Capable of Vacuum Measurement Independent of Orientation |
SE533841C2 (sv) | 2009-06-15 | 2011-02-01 | Moelnlycke Health Care Ab | Sårförband med hög vätskehanteringskapacitet |
JP6001449B2 (ja) | 2009-06-16 | 2016-10-05 | スリーエム イノベイティブ プロパティズ カンパニー | 自己支持基材を備える柔軟性のある接着性医療用物品 |
US20100324516A1 (en) | 2009-06-18 | 2010-12-23 | Tyco Healthcare Group Lp | Apparatus for Vacuum Bridging and/or Exudate Collection |
TW201101652A (en) | 2009-06-23 | 2011-01-01 | Asia Optical Co Inc | Flat elastic sheet of voice coil motor |
GB2474417A (en) | 2009-07-03 | 2011-04-20 | Isis Innovation | A spring and a spring assembly |
DE102009031992A1 (de) | 2009-07-06 | 2011-01-13 | Paul Hartmann Ag | Vorrichtung zur Unterdrucktherapie von Wunden |
BRPI0902557B1 (pt) | 2009-07-08 | 2020-03-10 | Embraco Indústria De Compressores E Soluções E Refrigeração Ltda. | Compressor linear |
US8444613B2 (en) | 2009-07-14 | 2013-05-21 | Richard Vogel | Pump leak monitor for negative pressure wound therapy |
US8252971B2 (en) | 2009-07-16 | 2012-08-28 | Aalnex, Inc. | Systems and methods for protecting incisions |
US20110034892A1 (en) | 2009-08-10 | 2011-02-10 | John Buan | Passive wound therapy device |
CN101997382B (zh) | 2009-08-19 | 2013-01-09 | 鸿富锦精密工业(深圳)有限公司 | 弹片及音圈马达 |
US8690844B2 (en) | 2009-08-27 | 2014-04-08 | Kci Licensing, Inc. | Re-epithelialization wound dressings and systems |
US8778387B2 (en) | 2009-09-02 | 2014-07-15 | Hyprotek, Inc. | Antimicrobial medical dressings and protecting wounds and catheter sites |
SE0901356A1 (sv) | 2009-10-20 | 2011-04-21 | Moelnlycke Health Care Ab | Artikel för användning vid sårbehandling |
US8529526B2 (en) | 2009-10-20 | 2013-09-10 | Kci Licensing, Inc. | Dressing reduced-pressure indicators, systems, and methods |
US20120238932A1 (en) | 2009-12-03 | 2012-09-20 | Pharmaplast Sae | Wound dressing, and method and production line of producing the wound dressing |
KR20110081532A (ko) | 2010-01-08 | 2011-07-14 | 엘지이노텍 주식회사 | 보이스 코일 모터용 판 스프링 및 이를 갖는 보이스 코일 모터 |
US20110178375A1 (en) | 2010-01-19 | 2011-07-21 | Avery Dennison Corporation | Remote physiological monitoring |
WO2011090986A2 (en) | 2010-01-20 | 2011-07-28 | Kci Licensing, Inc. | Wound-connection pads for fluid instillation and negative pressure wound therapy, and systems and methods |
JP5805669B2 (ja) | 2010-01-29 | 2015-11-04 | ケーシーアイ ライセンシング インク | 流体供給システムを位置付けるためのシステムと方法 |
US8646479B2 (en) | 2010-02-03 | 2014-02-11 | Kci Licensing, Inc. | Singulation of valves |
JP2011169446A (ja) | 2010-02-22 | 2011-09-01 | Mitsumi Electric Co Ltd | 板バネおよびレンズ駆動装置 |
JP2011169443A (ja) | 2010-02-22 | 2011-09-01 | Mitsumi Electric Co Ltd | 板バネおよびレンズ駆動装置 |
US8563798B2 (en) | 2010-03-04 | 2013-10-22 | Kalliope Dontas | Enclosing bandage for providing comfortable wound care and limiting fluid leakage |
CA2789489C (en) | 2010-03-10 | 2015-02-17 | Bsn Medical, Inc. | Water resistant medical bandaging product |
US8721606B2 (en) | 2010-03-11 | 2014-05-13 | Kci Licensing, Inc. | Dressings, systems, and methods for treating a tissue site |
US8814842B2 (en) | 2010-03-16 | 2014-08-26 | Kci Licensing, Inc. | Delivery-and-fluid-storage bridges for use with reduced-pressure systems |
US20110247636A1 (en) | 2010-04-12 | 2011-10-13 | Pollack Larry H | Nipple/Areola Protective Cover |
US8702665B2 (en) | 2010-04-16 | 2014-04-22 | Kci Licensing, Inc. | Reduced-pressure sources, systems, and methods employing a polymeric, porous, hydrophobic material |
US8328858B2 (en) | 2010-04-26 | 2012-12-11 | Solar Light Company, Inc. | Infrared wound healing unit |
GB201006985D0 (en) | 2010-04-27 | 2010-06-09 | Smith & Nephew | Wound dressing |
GB201006983D0 (en) | 2010-04-27 | 2010-06-09 | Smith & Nephew | Wound dressing |
GB201008347D0 (en) | 2010-05-19 | 2010-07-07 | Smith & Nephew | Wound protection |
US9061095B2 (en) | 2010-04-27 | 2015-06-23 | Smith & Nephew Plc | Wound dressing and method of use |
GB201006988D0 (en) | 2010-04-27 | 2010-06-09 | Smith & Nephew | Suction port |
ES2662331T3 (es) | 2010-08-10 | 2018-04-06 | Lifecell Corporation | Matrices tisulares regenerativas |
EP2417947A1 (en) | 2010-08-12 | 2012-02-15 | John Bennett | Integrated contoured negative pressure bandages |
US10751221B2 (en) | 2010-09-14 | 2020-08-25 | Kpr U.S., Llc | Compression sleeve with improved position retention |
GB201015656D0 (en) | 2010-09-20 | 2010-10-27 | Smith & Nephew | Pressure control apparatus |
BR112013008345A2 (pt) | 2010-10-15 | 2016-06-14 | Procter & Gamble | artigo absorvente que tem textura visual superficial |
CA140188S (en) | 2010-10-15 | 2011-11-07 | Smith & Nephew | Medical dressing |
CA140189S (en) | 2010-10-15 | 2011-11-07 | Smith & Nephew | Medical dressing |
US8591493B2 (en) | 2010-10-25 | 2013-11-26 | Entrotech, Inc. | Wound compression dressing |
US8865962B2 (en) | 2010-11-11 | 2014-10-21 | Linda A. Weidemann-Hendrickson | Multipurpose medical wrap |
ES2680634T3 (es) | 2010-12-08 | 2018-09-10 | Convatec Technologies Inc. | Apósitos autosellantes |
TWI465263B (zh) | 2010-12-10 | 2014-12-21 | Ind Tech Res Inst | 醫用敷料及使用該敷料之負壓治療裝置 |
US8637726B2 (en) | 2011-01-02 | 2014-01-28 | Omnitek Partners Llc | Shape and pressure adjustable dressing |
FR2972923B1 (fr) | 2011-03-25 | 2013-08-23 | Urgo Lab | Composition filmogene contenant un filtre solaire, son utilisation pour le traitement des cicatrices |
US9004883B2 (en) | 2011-04-01 | 2015-04-14 | Gm Global Technology Operations, Llc | Low noise high efficiency solenoid pump |
FR2974005B1 (fr) | 2011-04-15 | 2014-05-02 | Urgo Lab | Pansement adhesif mince tres absorbant, ses utilisations pour le traitement des plaies chroniques |
EP3072543B1 (en) | 2011-04-21 | 2020-11-11 | Smith & Nephew plc | Blockage management |
WO2012170744A2 (en) | 2011-06-07 | 2012-12-13 | Spiracur, Inc. | Solutions for bridging and pressure concentration reduction at wound sites |
ES2518890T3 (es) | 2011-07-18 | 2014-11-05 | Laboratoires Urgo | Conjunto de tratamiento de herida con presión negativa |
US8911681B2 (en) | 2011-09-12 | 2014-12-16 | Kimberly-Clark Worldwide, Inc. | Wetness indicator having varied hues |
CA2844663C (en) | 2011-09-14 | 2019-09-24 | Kci Licensing, Inc. | Reduced-pressure systems and methods employing a leak-detection member |
ES2672230T3 (es) | 2011-11-02 | 2018-06-13 | Smith & Nephew Plc | Aparatos de terapia de presión reducida |
US9084845B2 (en) | 2011-11-02 | 2015-07-21 | Smith & Nephew Plc | Reduced pressure therapy apparatuses and methods of using same |
WO2013083800A1 (de) | 2011-12-09 | 2013-06-13 | Birgit Riesinger | Set aus wundauflage und wundfüller |
US9861532B2 (en) | 2011-12-16 | 2018-01-09 | Kci Licensing, Inc. | Releasable medical drapes |
GB2501055B (en) | 2012-02-01 | 2017-08-30 | Banwell Paul | Scar reduction apparatus |
EP3660308B1 (en) | 2012-03-07 | 2021-07-14 | 3M Innovative Properties Company | Two-cavity disc pump |
EP2825220B2 (en) | 2012-03-12 | 2021-03-03 | Smith & Nephew PLC | Reduced pressure apparatus and methods |
CN104168865B (zh) | 2012-03-28 | 2016-10-26 | 凯希特许有限公司 | 协助电子的和临床的零部件分离的减压系统、敷件、和方法 |
WO2014008348A2 (en) | 2012-07-05 | 2014-01-09 | Kci Licensing, Inc. | Systems and methods for supplying reduced pressure using a disc pump with electrostatic actuation |
FR2993465B1 (fr) | 2012-07-23 | 2015-06-26 | Commissariat Energie Atomique | Article destine a venir en contact avec un liquide, notamment pansement. |
CN104487033B (zh) | 2012-07-30 | 2018-06-15 | 凯希特许有限公司 | 用于治疗组织部位的减压吸收性敷件、系统以及制造该敷件的方法 |
EP3406231B1 (en) | 2012-08-01 | 2022-04-13 | Smith & Nephew plc | Wound dressing and method of treatment |
CA3178997A1 (en) | 2012-08-01 | 2014-02-06 | Smith & Nephew Plc | Wound dressing |
DE102013100157A1 (de) | 2013-01-09 | 2014-07-10 | Birgit Riesinger | Flüssigkeitsdurchlässiger Primärverband mit einer Silikonbeschichtung |
GB201317746D0 (en) | 2013-10-08 | 2013-11-20 | Smith & Nephew | PH indicator |
JP6392781B2 (ja) | 2013-01-16 | 2018-09-19 | ケーシーアイ ライセンシング インコーポレイテッド | 陰圧閉鎖療法用の非対称性の吸収性コアを備えるドレッシング |
US10695226B2 (en) | 2013-03-15 | 2020-06-30 | Smith & Nephew Plc | Wound dressing and method of treatment |
AU2014307884B2 (en) | 2013-08-12 | 2019-03-28 | Bsn Medical Gmbh | Wound care article having a substantially polygonal or ellipsoid main surface and at least one recess arranged on one side |
AU2014307890B2 (en) | 2013-08-12 | 2018-04-19 | Bsn Medical Gmbh | Wound care article having super-absorbent fibers and super-absorbent particles |
CN107407270A (zh) | 2013-08-29 | 2017-11-28 | 妮薇尔公司 | 泵、促动器和相关装置以及用于制作的方法 |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1163907A (fr) * | 1956-10-25 | 1958-10-02 | Appareils pour soins cutanés | |
CN1161235A (zh) * | 1997-04-02 | 1997-10-08 | 张凤林 | 疔疮伤口除脓用吸注器 |
DE19844355A1 (de) * | 1998-09-28 | 2000-04-06 | Rainer E Sachse | Wundverband mit integrierter Saugvorrichtung |
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