CN1278794A - 用作蛋白酪氨酸激酶和蛋白丝氨酸/苏氨酸激酶抑制剂的取代的2－羟基吲哚衍生物 - Google Patents

用作蛋白酪氨酸激酶和蛋白丝氨酸/苏氨酸激酶抑制剂的取代的2－羟基吲哚衍生物 Download PDF

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CN1278794A
CN1278794A CN98810937A CN98810937A CN1278794A CN 1278794 A CN1278794 A CN 1278794A CN 98810937 A CN98810937 A CN 98810937A CN 98810937 A CN98810937 A CN 98810937A CN 1278794 A CN1278794 A CN 1278794A
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aliphatic group
amino
het
group
aryl
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CN98810937A
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Chinese (zh)
Inventor
S·T·戴维斯
S·H·迪克森
S·V·弗尔耶
P·A·哈尔里斯
R·N·亨特尔三世
L·F·库伊珀
K·E·拉基
M·J·鲁兹奥
J·M·维尔
D·H·瓦尔克
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Glaxo Group Ltd
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Glaxo Group Ltd
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Indole Compounds (AREA)
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CN98810937A 1997-09-05 1998-09-03 用作蛋白酪氨酸激酶和蛋白丝氨酸/苏氨酸激酶抑制剂的取代的2－羟基吲哚衍生物 Pending CN1278794A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9718913.8A GB9718913D0 (en) 1997-09-05 1997-09-05 Substituted oxindole derivatives
GB9718913.8 1997-09-05

Publications (1)

Publication Number Publication Date
CN1278794A true CN1278794A (zh) 2001-01-03

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CN98810937A Pending CN1278794A (zh) 1997-09-05 1998-09-03 用作蛋白酪氨酸激酶和蛋白丝氨酸/苏氨酸激酶抑制剂的取代的2－羟基吲哚衍生物

Country Status (23)

Country Link
US (4) US6387919B1 (https=)
EP (1) EP1009738B1 (https=)
JP (1) JP2001517652A (https=)
KR (1) KR20010023695A (https=)
CN (1) CN1278794A (https=)
AR (1) AR015432A1 (https=)
AT (1) ATE267170T1 (https=)
AU (1) AU747506B2 (https=)
BR (1) BR9812048A (https=)
CA (1) CA2302572A1 (https=)
CO (1) CO4960633A1 (https=)
DE (1) DE69824014T2 (https=)
EE (1) EE200000117A (https=)
ES (1) ES2221211T3 (https=)
GB (1) GB9718913D0 (https=)
HU (1) HUP0004490A3 (https=)
MA (1) MA26542A1 (https=)
PE (1) PE107699A1 (https=)
PL (1) PL338991A1 (https=)
TR (1) TR200001174T2 (https=)
TW (1) TW520358B (https=)
WO (1) WO1999015500A1 (https=)
ZA (1) ZA988078B (https=)

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CN100338036C (zh) * 1998-04-15 2007-09-19 贝林格尔英格海姆法玛两合公司 对激酶及细胞周期蛋白复合物具有抑制作用的取代的吲哚满酮
CN100351235C (zh) * 2002-07-24 2007-11-28 贝林格尔英格海姆法玛两合公司 2－吲哚满酮－单乙磺酸盐及其制备药物组合物的用途
CN102231984A (zh) * 2008-10-01 2011-11-02 北卡罗来纳大学查珀尔希尔分校 使用选择性细胞周期蛋白依赖性激酶4/6抑制剂对抗化疗化合物的造血防护
CN102712658A (zh) * 2009-10-29 2012-10-03 帕劳制药股份有限公司 作为jak3激酶抑制剂的含氮杂芳基衍生物
CN103946223A (zh) * 2011-11-22 2014-07-23 默克专利股份公司 3-氰基芳基-1H-吡咯并[2,3-b]吡啶衍生物
CN102007125B (zh) * 2008-01-15 2016-05-25 安姆根有限公司 稠合杂环衍生物及使用方法
CN103342701B (zh) * 2007-02-13 2016-09-21 Ab科学有限公司 作为激酶抑制剂的2-氨基噻唑化合物多晶型及其制备方法
US9464092B2 (en) 2013-03-15 2016-10-11 G1 Therapeutics, Inc. Transient protection of normal cells during chemotherapy
US9616062B2 (en) 2009-05-13 2017-04-11 The University Of North Carolina At Chapel Hill Cyclin dependent kinase inhibitors and methods of use
CN106977508A (zh) * 2017-05-05 2017-07-25 遵义医学院 具有靛红结构的吡唑衍生物用于防治肿瘤的药物及其制法
US9717735B2 (en) 2014-04-17 2017-08-01 G1 Therapeutics, Inc. Tricyclic lactams for use in HSPC-sparing treatments for RB-positive abnormal cellular proliferation
US9808461B2 (en) 2010-11-17 2017-11-07 The University Of North Carolina At Chapel Hill Protection of renal tissues from ischemia through inhibition of the proliferative kinases CDK4 and CDK6
CN108137595A (zh) * 2015-06-18 2018-06-08 左坚 预防和治疗听力损失的方法和组合物
US10231969B2 (en) 2014-09-12 2019-03-19 GI Therapeutics, Inc. Anti-neoplastic combinations and dosing regimens using CDK4/6 inhibitor compounds to treat RB-positive tumors
US10413547B2 (en) 2014-09-12 2019-09-17 G1 Therapeutics, Inc. Treatment of Rb-negative tumors using topoisomerase with cyclin dependent kinase 4/6 inhibitors
US10709711B2 (en) 2013-03-15 2020-07-14 G1 Therapeutics, Inc. Highly active anti-neoplastic and anti-proliferative agents
CN117700397A (zh) * 2022-11-02 2024-03-15 徐诺药业(南京)有限公司 2-氧代吲哚啉类衍生物及其制备方法和应用

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US6407132B1 (en) * 1997-07-25 2002-06-18 James Black Foundation Limited Substituted imidazole derivatives and their use as histamine H3 receptor ligands
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6319918B1 (en) 1998-06-04 2001-11-20 Boehringer Ingelheim Pharma Kg Substituted indolinones with kinase inhibitory activity
DE19824922A1 (de) * 1998-06-04 1999-12-09 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
EP1149093A1 (en) 1998-12-17 2001-10-31 F. Hoffmann-La Roche Ag 4-aryloxindoles as inhibitors of jnk protein kinases
US6153634A (en) 1998-12-17 2000-11-28 Hoffmann-La Roche Inc. 4,5-azolo-oxindoles
PT1149106E (pt) * 1998-12-17 2003-06-30 Hoffmann La Roche 4,5-azolo-oxindois
CN1158283C (zh) * 1998-12-17 2004-07-21 霍夫曼-拉罗奇有限公司 作为蛋白激酶抑制剂的4-和5-吡嗪基羟吲哚
BR9916327A (pt) * 1998-12-17 2001-09-18 Hoffmann La Roche Oxindóis de 4-alquenila (e alquinila) como inibidores de cinases dependentes de ciclina, em particular, cdk2
JP4865129B2 (ja) 1999-01-13 2012-02-01 ザ・リサーチ・ファウンデーション・オブ・ステイト・ユニバーシティ・オブ・ニューヨーク タンパク質キナーゼ阻害剤を設計するための新規の方法
US6492398B1 (en) * 1999-03-04 2002-12-10 Smithkline Beechman Corporation Thiazoloindolinone compounds
GB9904932D0 (en) * 1999-03-04 1999-04-28 Glaxo Group Ltd Composition and method for preventing/reducing the severity of side effects of chemotherapy and/or radiation therapy
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
GB9904930D0 (en) * 1999-03-04 1999-04-28 Glaxo Group Ltd Thiazoloindolinone compounds
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