TR200101745T2 - 4,5-Azolo-oksindoller - Google Patents

4,5-Azolo-oksindoller

Info

Publication number
TR200101745T2
TR200101745T2 TR2001/01745T TR200101745T TR200101745T2 TR 200101745 T2 TR200101745 T2 TR 200101745T2 TR 2001/01745 T TR2001/01745 T TR 2001/01745T TR 200101745 T TR200101745 T TR 200101745T TR 200101745 T2 TR200101745 T2 TR 200101745T2
Authority
TR
Turkey
Prior art keywords
oxindoles
novel
formula
azolo
cdks
Prior art date
Application number
TR2001/01745T
Other languages
English (en)
Inventor
Luk Kin-Chun
Michoud Christophe
Gregory Mischke Steven
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of TR200101745T2 publication Critical patent/TR200101745T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/04—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups one >CH- group, e.g. cyanines, isocyanines, pseudocyanines

Abstract

Içinde yer alan R1,R2,Y, ve Z'nin anlamlar tanimlarda belirtilen formül (I)'e sahip olan yeni 4,5-azolo-oksindoller,siklin'e-bagimli kinazlari(CDK'ler), özellikle CDK2'yi engellerler ve hücre çogalmasi ile ilgili bozukluklarin özellikle kanserin tedavi yada kontrolünde faydalidirlar.(Formül1)
TR2001/01745T 1998-12-17 1999-12-10 4,5-Azolo-oksindoller TR200101745T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11261198P 1998-12-17 1998-12-17

Publications (1)

Publication Number Publication Date
TR200101745T2 true TR200101745T2 (tr) 2002-05-21

Family

ID=22344875

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01745T TR200101745T2 (tr) 1998-12-17 1999-12-10 4,5-Azolo-oksindoller

Country Status (18)

Country Link
EP (1) EP1149106B1 (tr)
JP (1) JP2002532502A (tr)
KR (2) KR100723854B1 (tr)
CN (1) CN1159315C (tr)
AR (1) AR021693A1 (tr)
AT (1) ATE234839T1 (tr)
AU (1) AU770060B2 (tr)
BR (1) BR9916216A (tr)
CA (1) CA2354852C (tr)
DE (1) DE69906149T2 (tr)
DK (1) DK1149106T3 (tr)
ES (1) ES2192878T3 (tr)
PE (1) PE20001329A1 (tr)
PT (1) PT1149106E (tr)
TR (1) TR200101745T2 (tr)
UY (1) UY25855A1 (tr)
WO (1) WO2000035920A2 (tr)
ZA (1) ZA200104269B (tr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
EP1680401A2 (en) 2003-10-24 2006-07-19 Schering Aktiengesellschaft Indolinone derivatives and their use in treating disease-states such as cancer
KR20070113286A (ko) * 2005-04-14 2007-11-28 에프. 호프만-라 로슈 아게 아미노피라졸 유도체, 이의 제조 및 약학 제제로서의 용도
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
US9777320B2 (en) 2010-08-25 2017-10-03 Pacific Biosciences Of California, Inc. Molecular adaptors for dye conjugates
US9315864B2 (en) 2012-05-18 2016-04-19 Pacific Biosciences Of California, Inc. Heteroarylcyanine dyes with sulfonic acid substituents
EP2850086B1 (en) * 2012-05-18 2023-07-05 Pacific Biosciences Of California, Inc. Heteroarylcyanine dyes
KR101668074B1 (ko) 2015-02-12 2016-10-21 전북대학교산학협력단 Ｐｋｒ 저해제를 유효성분으로 포함하는 기관지 천식의 예방 또는 치료용 조성물

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0984930B1 (en) * 1997-05-07 2005-04-06 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives

Also Published As

Publication number Publication date
WO2000035920A2 (en) 2000-06-22
KR20060109360A (ko) 2006-10-19
EP1149106B1 (en) 2003-03-19
AU3037200A (en) 2000-07-03
UY25855A1 (es) 2001-08-27
EP1149106A2 (en) 2001-10-31
BR9916216A (pt) 2001-09-11
PE20001329A1 (es) 2000-12-11
DE69906149D1 (de) 2003-04-24
KR100685192B1 (ko) 2007-02-22
KR100723854B1 (ko) 2007-05-31
ATE234839T1 (de) 2003-04-15
AU770060B2 (en) 2004-02-12
ZA200104269B (en) 2002-08-26
DK1149106T3 (da) 2003-07-14
AR021693A1 (es) 2002-07-31
WO2000035920A3 (en) 2000-11-23
PT1149106E (pt) 2003-06-30
ES2192878T3 (es) 2003-10-16
KR20010080768A (ko) 2001-08-22
CA2354852C (en) 2008-09-23
JP2002532502A (ja) 2002-10-02
CN1330654A (zh) 2002-01-09
CA2354852A1 (en) 2000-06-22
CN1159315C (zh) 2004-07-28
DE69906149T2 (de) 2003-12-18

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