ES2192878T3 - 4,5-azolo-oxindoles. - Google Patents

4,5-azolo-oxindoles.

Info

Publication number
ES2192878T3
ES2192878T3 ES99964543T ES99964543T ES2192878T3 ES 2192878 T3 ES2192878 T3 ES 2192878T3 ES 99964543 T ES99964543 T ES 99964543T ES 99964543 T ES99964543 T ES 99964543T ES 2192878 T3 ES2192878 T3 ES 2192878T3
Authority
ES
Spain
Prior art keywords
compounds
treatment
control
azolo
directed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99964543T
Other languages
English (en)
Inventor
Kin-Chun Luk
Christophe Michoud
Steven Gregory Mischke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2192878T3 publication Critical patent/ES2192878T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/04—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups one >CH- group, e.g. cyanines, isocyanines, pseudocyanines

Abstract

La presente invención está dirigida a nuevos 4, 5-azolo-oxindoles los cuales inhiban las quinasas dependientes de ciclina (CDKs) en particular CDK2. Estos compuestos y sus sales farmacéuticamente aceptables, y los profármacos de dichos compuestos, son agentes antiproliferativos útiles en el tratamiento o control de los desórdenes proliferativos celulares, en particular, del cáncer. La invención está también dirigida a las composiciones farmacéuticas conteniendo tales compuestos, y al uso de estos compuestos en la preparación de medicamentos para el tratamiento y/o prevención del cáncer, particularmente para el tratamiento o control de tumores sólidos. Los compuestos de la invención son especialmente útiles en el tratamiento o control de los tumores de colon y mama.
ES99964543T 1998-12-17 1999-12-10 4,5-azolo-oxindoles. Expired - Lifetime ES2192878T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11261198P 1998-12-17 1998-12-17

Publications (1)

Publication Number Publication Date
ES2192878T3 true ES2192878T3 (es) 2003-10-16

Family

ID=22344875

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99964543T Expired - Lifetime ES2192878T3 (es) 1998-12-17 1999-12-10 4,5-azolo-oxindoles.

Country Status (18)

Country Link
EP (1) EP1149106B1 (es)
JP (1) JP2002532502A (es)
KR (2) KR100685192B1 (es)
CN (1) CN1159315C (es)
AR (1) AR021693A1 (es)
AT (1) ATE234839T1 (es)
AU (1) AU770060B2 (es)
BR (1) BR9916216A (es)
CA (1) CA2354852C (es)
DE (1) DE69906149T2 (es)
DK (1) DK1149106T3 (es)
ES (1) ES2192878T3 (es)
PE (1) PE20001329A1 (es)
PT (1) PT1149106E (es)
TR (1) TR200101745T2 (es)
UY (1) UY25855A1 (es)
WO (1) WO2000035920A2 (es)
ZA (1) ZA200104269B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
EP1680401A2 (en) 2003-10-24 2006-07-19 Schering Aktiengesellschaft Indolinone derivatives and their use in treating disease-states such as cancer
MX2007012477A (es) 2005-04-14 2007-11-08 Hoffmann La Roche Derivados de aminopirazol, su fabricacion y uso como agentes farmaceuticos.
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
WO2012027623A2 (en) 2010-08-25 2012-03-01 Pacific Biosciences Of California, Inc. Cyanine dyes
US9315864B2 (en) 2012-05-18 2016-04-19 Pacific Biosciences Of California, Inc. Heteroarylcyanine dyes with sulfonic acid substituents
WO2013173844A1 (en) 2012-05-18 2013-11-21 Pacific Biosciences Of California, Inc. Heteroarylcyanine dyes
KR101668074B1 (ko) * 2015-02-12 2016-10-21 전북대학교산학협력단 Ｐｋｒ 저해제를 유효성분으로 포함하는 기관지 천식의 예방 또는 치료용 조성물

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2289102A1 (en) * 1997-05-07 1998-11-12 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives

Also Published As

Publication number Publication date
DE69906149T2 (de) 2003-12-18
PT1149106E (pt) 2003-06-30
DE69906149D1 (de) 2003-04-24
CN1159315C (zh) 2004-07-28
EP1149106B1 (en) 2003-03-19
KR20060109360A (ko) 2006-10-19
WO2000035920A3 (en) 2000-11-23
CA2354852A1 (en) 2000-06-22
DK1149106T3 (da) 2003-07-14
JP2002532502A (ja) 2002-10-02
AU770060B2 (en) 2004-02-12
EP1149106A2 (en) 2001-10-31
AU3037200A (en) 2000-07-03
ATE234839T1 (de) 2003-04-15
PE20001329A1 (es) 2000-12-11
ZA200104269B (en) 2002-08-26
WO2000035920A2 (en) 2000-06-22
CA2354852C (en) 2008-09-23
KR20010080768A (ko) 2001-08-22
KR100723854B1 (ko) 2007-05-31
BR9916216A (pt) 2001-09-11
CN1330654A (zh) 2002-01-09
AR021693A1 (es) 2002-07-31
TR200101745T2 (tr) 2002-05-21
UY25855A1 (es) 2001-08-27
KR100685192B1 (ko) 2007-02-22

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