CL2003002336A1 - Procedimiento de preparacion del acido (e)-(6-{2[4-(4-fluorofenil)-6-isopropil-2-[n-metil-n-metilsulfonil-amino]pirimidina-5-il]vinilo}-(4r,6s)-diol-4-il)-acetico o su sal, los intermediarios que se usan y la preparacion de uno de ellos. - Google Patents

Procedimiento de preparacion del acido (e)-(6-{2[4-(4-fluorofenil)-6-isopropil-2-[n-metil-n-metilsulfonil-amino]pirimidina-5-il]vinilo}-(4r,6s)-diol-4-il)-acetico o su sal, los intermediarios que se usan y la preparacion de uno de ellos.

Info

Publication number
CL2003002336A1
CL2003002336A1 CL200302336A CL2003002336A CL2003002336A1 CL 2003002336 A1 CL2003002336 A1 CL 2003002336A1 CL 200302336 A CL200302336 A CL 200302336A CL 2003002336 A CL2003002336 A CL 2003002336A CL 2003002336 A1 CL2003002336 A1 CL 2003002336A1
Authority
CL
Chile
Prior art keywords
isopropil
methylsulphonyl
fluorophenyl
pyrimidine
diol
Prior art date
Application number
CL200302336A
Other languages
English (en)
Inventor
Haruo Kabaki Mikio Taylo Koike
Original Assignee
Astrazeneca Ab And Shionogi &
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10847843&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2003002336(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab And Shionogi & filed Critical Astrazeneca Ab And Shionogi &
Publication of CL2003002336A1 publication Critical patent/CL2003002336A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
CL200302336A 1999-02-17 2003-11-12 Procedimiento de preparacion del acido (e)-(6-{2[4-(4-fluorofenil)-6-isopropil-2-[n-metil-n-metilsulfonil-amino]pirimidina-5-il]vinilo}-(4r,6s)-diol-4-il)-acetico o su sal, los intermediarios que se usan y la preparacion de uno de ellos. CL2003002336A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9903472.0A GB9903472D0 (en) 1999-02-17 1999-02-17 Chemical process
PCT/GB2000/000481 WO2000049014A1 (en) 1999-02-17 2000-02-15 Process for the production of tert-butyl (e)-(6-[2- [4-(4-fluorophenyl) -6-isopropyl-2-[ methyl (methylsulfonyl) amino] pyrimidin-5-yl] vinyl](4r, 6s)-2,2-dimethyl [1,3]dioxan-4-yl) acetate

Publications (1)

Publication Number Publication Date
CL2003002336A1 true CL2003002336A1 (es) 2005-01-14

Family

ID=10847843

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200302336A CL2003002336A1 (es) 1999-02-17 2003-11-12 Procedimiento de preparacion del acido (e)-(6-{2[4-(4-fluorofenil)-6-isopropil-2-[n-metil-n-metilsulfonil-amino]pirimidina-5-il]vinilo}-(4r,6s)-diol-4-il)-acetico o su sal, los intermediarios que se usan y la preparacion de uno de ellos.

Country Status (34)

Country Link
US (2) US6844437B1 (es)
EP (1) EP1155015B1 (es)
JP (3) JP2003518474A (es)
KR (1) KR100648160B1 (es)
CN (1) CN1145625C (es)
AR (1) AR022600A1 (es)
AT (1) ATE415398T1 (es)
AU (1) AU760145B2 (es)
BR (1) BRPI0008301B8 (es)
CA (1) CA2362594C (es)
CL (1) CL2003002336A1 (es)
CY (1) CY1108733T1 (es)
CZ (1) CZ299844B6 (es)
DE (1) DE60040905D1 (es)
DK (1) DK1155015T3 (es)
EE (2) EE05150B1 (es)
ES (1) ES2316349T3 (es)
GB (1) GB9903472D0 (es)
HK (1) HK1041265B (es)
HU (1) HU229835B1 (es)
IL (2) IL144793A0 (es)
IS (1) IS2711B (es)
MX (1) MXPA01008235A (es)
NO (1) NO320739B1 (es)
NZ (1) NZ513261A (es)
PL (1) PL218518B1 (es)
PT (1) PT1155015E (es)
RU (1) RU2243969C2 (es)
SI (1) SI1155015T1 (es)
SK (1) SK286988B6 (es)
TR (2) TR200102360T2 (es)
TW (1) TWI285202B (es)
WO (1) WO2000049014A1 (es)
ZA (1) ZA200106370B (es)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9902202D0 (sv) * 1999-06-10 1999-06-10 Astra Ab Production of aggregates
GB0003305D0 (en) * 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
DK1417180T3 (da) * 2001-07-13 2007-04-10 Astrazeneca Uk Ltd Fremstilling af aminopyrimidinforbindelser
PL370407A1 (en) * 2001-08-16 2005-05-30 Teva Pharmaceutical Industries Ltd. Processes for preparing calcium salt forms of statins
EP1323717A1 (en) * 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
EP1375493A1 (en) 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
GB0218781D0 (en) * 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
CA2509344C (en) 2002-12-16 2011-10-04 Astrazeneca Uk Limited Process for the preparation of pyrimidine compounds
GB0312896D0 (en) * 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
CA2657076A1 (en) 2003-08-28 2005-03-17 Teva Pharmaceutical Industries Ltd. Process for the preparation of rosuvastatin calcium
UY28501A1 (es) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0321827D0 (en) * 2003-09-18 2003-10-15 Astrazeneca Uk Ltd Chemical compounds
GB0322552D0 (en) 2003-09-26 2003-10-29 Astrazeneca Uk Ltd Therapeutic treatment
GB0324791D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
CA2546701C (en) * 2003-11-24 2010-07-27 Teva Pharmaceutical Industries Ltd. Crystalline ammonium salts of rosuvastatin
ATE507209T1 (de) 2003-12-02 2011-05-15 Teva Pharma Referenzstandard zur charakterisierung von rosuvastatin
US7241800B2 (en) 2004-03-17 2007-07-10 Mai De Ltd. Anhydrous amorphous form of fluvastatin sodium
GB0406757D0 (en) 2004-03-26 2004-04-28 Avecia Ltd Process and compounds
JP2007508379A (ja) 2004-07-13 2007-04-05 テバ ファーマシューティカル インダストリーズ リミティド Ｔｅｍｐｏ媒介型酸化段階を包含するロスバスタチンの調製方法
GB0427491D0 (en) 2004-12-16 2005-01-19 Avecia Ltd Process and compounds
GB0428328D0 (en) 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
CN100351240C (zh) * 2005-01-19 2007-11-28 安徽省庆云医药化工有限公司 瑞舒伐他汀钙的合成方法
TWI353981B (en) 2005-02-22 2011-12-11 Teva Pharma Preparation of rosuvastatin
EP1863773A1 (en) * 2005-03-22 2007-12-12 Unichem Laboratories Limited Process for preparation of rosuvastatin
EP1869005A1 (en) * 2005-04-04 2007-12-26 Unichem Laboratories Limited Process for preparation of calcium salt of rosuvastatin
HU227120B1 (hu) * 2005-05-26 2010-07-28 Richter Gedeon Nyrt Eljárás rosuvastatin kalciumsójának elõállítására új intermediereken keresztül
JP5146965B2 (ja) * 2005-06-24 2013-02-20 レツク・フアーマシユーテイカルズ・デー・デー 不純物を含まない非晶質ロスバスタチンカルシウムの調製方法
SI1915349T1 (sl) 2005-06-24 2016-05-31 Lek Pharmaceuticals D.D. Postopek za pripravo čistega amorfnega rosuvastatin kalcija
GB0514078D0 (en) * 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process
EP1912953B1 (en) * 2005-07-28 2016-08-17 LEK Pharmaceuticals d.d. Process for the synthesis of rosuvastatin calcium
US7868169B2 (en) 2005-08-16 2011-01-11 Teva Pharmaceutical Industries, Ltd. Crystalline rosuvastatin intermediate
CN100352821C (zh) * 2005-08-22 2007-12-05 鲁南制药集团股份有限公司 一种瑞舒伐他汀钙中间体的制备方法
CN100436428C (zh) * 2005-08-22 2008-11-26 鲁南制药集团股份有限公司 瑞舒伐他汀及其盐的制备方法
WO2007125547A2 (en) * 2006-05-03 2007-11-08 Manne Satyanarayana Reddy Novel process for statins and its pharmaceutically acceptable salts thereof
HUE028475T2 (en) 2006-10-09 2016-12-28 Msn Laboratories Private Ltd A novel process for the preparation of statins and their pharmaceutically acceptable salts
WO2008053334A2 (en) 2006-10-31 2008-05-08 Aurobindo Pharma Limited An improved process for preparing rosuvastatin calcium
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process
US8212034B2 (en) 2006-12-13 2012-07-03 Aurobindo Pharma Ltd. Process for preparing rosuvastatin calcium
EP2125754B1 (en) 2007-02-08 2012-04-11 Aurobindo Pharma Limited Process for preparation of rosuvastatin calcium
ES2415206T3 (es) 2007-04-18 2013-07-24 Teva Pharmaceutical Industries, Ltd. Un proceso para preparar productos intermedios de inhibidores de la HMG-CoA reductasa
EP2178890A1 (en) 2007-07-12 2010-04-28 Teva Pharmaceutical Industries Ltd. Purification of rosuvastatin intermediate by thin film evaporation and chemical method
WO2009027081A2 (en) 2007-08-28 2009-03-05 Ratiopharm Gmbh Process for preparing pentanoic diacid derivatives
CN101376647B (zh) * 2007-08-31 2010-12-08 中山奕安泰医药科技有限公司 一种用于合成瑞舒伐他汀中间体及瑞舒伐他汀的合成方法
WO2009143776A1 (zh) 2008-05-27 2009-12-03 常州制药厂有限公司 瑞舒伐他汀钙盐的制备方法及其中间体
EP2309992B1 (en) 2008-06-27 2017-10-25 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising a statin
EP2138165A1 (en) 2008-06-27 2009-12-30 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising a statin
RU2011112541A (ru) * 2008-09-09 2012-10-20 Биокон Лимитед (In) Способ получения кальциевой соли (3r,5s,6e)6-{2-[4-(4фторфенил)-6-изопропил-2-(метансульфонилметиламино)-пиримидин-5-ил]-винил}-2,2-диметил-[1,3]-диоксан-4-ил)-уксусной кислоты(ацетонид розувастатина кальция)
WO2010038124A1 (en) * 2008-09-30 2010-04-08 Aurobindo Pharma Limited An improved process for preparing pyrimidine propenaldehyde
WO2010047296A1 (ja) * 2008-10-20 2010-04-29 株式会社カネカ 新規ピリミジン誘導体およびＨＭＧ－ＣｏＡ還元酵素阻害剤中間体の製造方法
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2373609B1 (en) 2008-12-19 2013-10-16 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
WO2010077062A2 (en) * 2008-12-29 2010-07-08 Hanmi Pharm. Co., Ltd. Preparation method of statin compound and benzothiazolyl sulfone compound used therein
WO2010081861A1 (en) 2009-01-14 2010-07-22 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of rosuvastatin
US8487105B2 (en) 2009-01-19 2013-07-16 Msn Laboratories Limited Process for preparing pitavastatin, intermediates and pharmaceuctically acceptable salts thereof
KR101157314B1 (ko) * 2009-06-05 2012-06-15 주식회사종근당 로수바스타틴의 신규한 제조방법, 이 제조에 유용한 중간체 화합물 및 그의 제조방법
US8987444B2 (en) 2010-01-18 2015-03-24 Msn Laboratories Private Limited Process for the preparation of amide intermediates and their use thereof
WO2011104725A2 (en) 2010-02-23 2011-09-01 Cadila Healthcare Limited Hmg-coa reductase inhibitors and process for the preparation thereof
WO2012011129A2 (en) * 2010-07-22 2012-01-26 Msn Laboratories Limited Novel polymorph of bis[(e)-7-[4-(4-fluorophenyl)-6-iso-propyl-2-[methyl (methylsulfonyl)amino]pyrimidin-5-yl](3r,5s)-3,5-dihydroxyhept-6-enoic acid] calcium salt
WO2012073256A1 (en) 2010-11-29 2012-06-07 Cadila Healthcare Limited Salts of rosuvastatin
WO2012098050A1 (en) 2011-01-18 2012-07-26 Dsm Sinochem Pharmaceuticals Netherlands B.V. Methyltetrazole sulfides and sulfones
WO2012098048A1 (en) 2011-01-18 2012-07-26 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of diol sulfones
SI2665723T1 (sl) * 2011-01-18 2015-11-30 Dsm Sinochem Pharmaceuticals Netherlands B.V. Postopek priprave statinov v prisotnosti baze
WO2012172564A1 (en) * 2011-05-25 2012-12-20 Dr. Reddy's Laboratories Limited Process for preparation of rosuvastatin calcium
EP2788342B1 (en) 2011-12-09 2018-01-24 DSM Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of a statin precursor
CN103987705B (zh) 2011-12-09 2015-09-30 中化帝斯曼制药有限公司荷兰公司 制备他汀含硫前体的方法
KR20130087153A (ko) * 2012-01-27 2013-08-06 코오롱생명과학 주식회사 로수바스타틴의 제조방법 및 이에 사용되는 중간체 화합물
CN103232398B (zh) * 2012-04-28 2016-04-06 上海科州药物研发有限公司 一种瑞舒伐他汀氨基酸盐及其制备方法和应用
KR101292743B1 (ko) * 2012-05-17 2013-08-02 (주) 에프엔지리서치 신규한 스타틴 중간체 및 이를 이용한 피타바스타틴, 로수바스타틴, 세리바스타틴 및 플루바스타틴의 제조 방법
CN103864697A (zh) * 2012-12-11 2014-06-18 润泽制药(苏州)有限公司 瑞舒伐中间体主链醇的制备方法
WO2014108795A2 (en) 2013-01-10 2014-07-17 Aurobindo Pharma Limited An improved process for the preparation of chiral diol sulfones and statins
CN103420919B (zh) * 2013-08-22 2015-07-08 南京欧信医药技术有限公司 一种嘧啶类衍生物的合成方法
WO2015037018A1 (en) * 2013-09-14 2015-03-19 Ind-Swift Laboratories Limited Process for the preparation of rosuvastatin via novel intermediates
WO2015131405A1 (zh) * 2014-03-07 2015-09-11 凯莱英医药集团（天津）股份有限公司 用于制备瑞舒伐他汀钙的中间体化合物以及由其制备瑞舒伐他汀钙的方法
CN103936680B (zh) * 2014-04-18 2016-08-24 润泽制药(苏州)有限公司 瑞舒伐他汀钙已知杂质的制备方法
CN104788387A (zh) * 2015-04-17 2015-07-22 浙江海森药业有限公司 高纯度瑞舒伐他汀钙的制备方法
KR20160126700A (ko) 2015-04-24 2016-11-02 미래파인켐 주식회사 스타틴의 중간체, 이의 제조방법 및 이를 이용한 로수바스타틴의 제조방법
CN105461636A (zh) * 2015-12-30 2016-04-06 安徽美诺华药物化学有限公司 一种瑞舒伐他汀甲酯的合成方法
CN106478518A (zh) * 2016-09-27 2017-03-08 南通常佑药业科技有限公司 一种庚烯酸环戊酯衍生物的制备方法
KR101953575B1 (ko) 2016-10-24 2019-05-24 한양대학교 에리카산학협력단 스타틴계 고지혈증 치료제 합성을 위한 새로운 중간체 합성 및 이를 이용한 로수바스타틴 합성 공정 개발
CN108997324A (zh) * 2018-08-21 2018-12-14 南京欧信医药技术有限公司 瑞舒伐他汀钙中间体的制备方法
CN109651259B (zh) * 2018-12-29 2020-05-19 浙江永太科技股份有限公司 一种瑞舒伐他汀钙关键中间体的纯化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3741509A1 (de) * 1987-12-08 1989-06-22 Hoechst Ag Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
JP2648897B2 (ja) 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
FR2741620B1 (fr) 1995-11-28 1997-12-26 Oreal Procede de preparation de composes a groupement beta-hydroxy -delta-lactone analogues de la (+) compactine et de la (+) mevinoline

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HK1041265A1 (en) 2002-07-05
PL218518B1 (pl) 2014-12-31
AU760145B2 (en) 2003-05-08
KR20010102207A (ko) 2001-11-15
BR0008301B1 (pt) 2013-01-22
DE60040905D1 (de) 2009-01-08
ES2316349T3 (es) 2009-04-16
ZA200106370B (en) 2002-11-04
NO20013994L (no) 2001-10-16
JP2007291113A (ja) 2007-11-08
IS2709B3 (is) 2011-01-15
CZ20012930A3 (cs) 2001-11-14
EP1155015A1 (en) 2001-11-21
SI1155015T1 (sl) 2009-04-30
ATE415398T1 (de) 2008-12-15
HUP0200301A2 (en) 2002-08-28
JP4130844B2 (ja) 2008-08-06
PT1155015E (pt) 2009-01-27
CZ299844B6 (cs) 2008-12-10
PL350185A1 (en) 2002-11-18
SK11832001A3 (sk) 2002-01-07
EE200100430A (et) 2002-12-16
CA2362594A1 (en) 2000-08-24
RU2243969C2 (ru) 2005-01-10
BRPI0008301B8 (pt) 2021-05-25
EE200900043A (et) 2010-02-15
CN1145625C (zh) 2004-04-14
MXPA01008235A (es) 2002-04-24
JP2008255114A (ja) 2008-10-23
IL144793A0 (en) 2002-06-30
CN1340052A (zh) 2002-03-13
AR022600A1 (es) 2002-09-04
US20040049036A1 (en) 2004-03-11
TWI285202B (en) 2007-08-11
NZ513261A (en) 2003-10-31
IS2711B (is) 2011-01-15
US6844437B1 (en) 2005-01-18
CA2362594C (en) 2009-06-02
HUP0200301A3 (en) 2004-03-29
AU2557300A (en) 2000-09-04
DK1155015T3 (da) 2009-03-02
HU229835B1 (en) 2014-09-29
BR0008301A (pt) 2002-01-22
IS6029A (is) 2001-07-31
TR200401874T2 (tr) 2004-10-21
EP1155015B1 (en) 2008-11-26
US6784171B2 (en) 2004-08-31
EE05531B1 (et) 2012-04-16
IL163375A (en) 2008-12-29
SK286988B6 (sk) 2009-08-06
TR200102360T2 (tr) 2001-12-21
JP2003518474A (ja) 2003-06-10
NO320739B1 (no) 2006-01-23
NO20013994D0 (no) 2001-08-16
KR100648160B1 (ko) 2006-11-24
EE05150B1 (et) 2009-04-15
GB9903472D0 (en) 1999-04-07
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HK1041265B (zh) 2009-07-03
WO2000049014A1 (en) 2000-08-24

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