DK1155015T3 - Fremgangsmåde til fremstilling af tert-butyl-(E)-(6{2-[4-4(4-flourphenyl)-6-isopropyl-2-[methyld(methylsulfonyl)amino]pyrimidin-5-yl]vinyl}-(4R,6S)-2,2-dimethyl[1,3]dioxan-4-yl)acetat - Google Patents

Fremgangsmåde til fremstilling af tert-butyl-(E)-(6{2-[4-4(4-flourphenyl)-6-isopropyl-2-[methyld(methylsulfonyl)amino]pyrimidin-5-yl]vinyl}-(4R,6S)-2,2-dimethyl[1,3]dioxan-4-yl)acetat

Info

Publication number
DK1155015T3
DK1155015T3 DK00903810T DK00903810T DK1155015T3 DK 1155015 T3 DK1155015 T3 DK 1155015T3 DK 00903810 T DK00903810 T DK 00903810T DK 00903810 T DK00903810 T DK 00903810T DK 1155015 T3 DK1155015 T3 DK 1155015T3
Authority
DK
Denmark
Prior art keywords
dioxan
methylsulfonyl
pyrimidin
fluorophenyl
tert
Prior art date
Application number
DK00903810T
Other languages
English (en)
Inventor
Haruo Koike
Mikio Kabaki
Nigel Philip Taylor
Louis Joseph Diorazio
Original Assignee
Astrazeneca Ab
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10847843&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1155015(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab, Shionogi & Co filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK1155015T3 publication Critical patent/DK1155015T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK00903810T 1999-02-17 2000-02-15 Fremgangsmåde til fremstilling af tert-butyl-(E)-(6{2-[4-4(4-flourphenyl)-6-isopropyl-2-[methyld(methylsulfonyl)amino]pyrimidin-5-yl]vinyl}-(4R,6S)-2,2-dimethyl[1,3]dioxan-4-yl)acetat DK1155015T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9903472.0A GB9903472D0 (en) 1999-02-17 1999-02-17 Chemical process
PCT/GB2000/000481 WO2000049014A1 (en) 1999-02-17 2000-02-15 Process for the production of tert-butyl (e)-(6-[2- [4-(4-fluorophenyl) -6-isopropyl-2-[ methyl (methylsulfonyl) amino] pyrimidin-5-yl] vinyl](4r, 6s)-2,2-dimethyl [1,3]dioxan-4-yl) acetate

Publications (1)

Publication Number Publication Date
DK1155015T3 true DK1155015T3 (da) 2009-03-02

Family

ID=10847843

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00903810T DK1155015T3 (da) 1999-02-17 2000-02-15 Fremgangsmåde til fremstilling af tert-butyl-(E)-(6{2-[4-4(4-flourphenyl)-6-isopropyl-2-[methyld(methylsulfonyl)amino]pyrimidin-5-yl]vinyl}-(4R,6S)-2,2-dimethyl[1,3]dioxan-4-yl)acetat

Country Status (34)

Country Link
US (2) US6844437B1 (da)
EP (1) EP1155015B1 (da)
JP (3) JP2003518474A (da)
KR (1) KR100648160B1 (da)
CN (1) CN1145625C (da)
AR (1) AR022600A1 (da)
AT (1) ATE415398T1 (da)
AU (1) AU760145B2 (da)
BR (1) BRPI0008301B8 (da)
CA (1) CA2362594C (da)
CL (1) CL2003002336A1 (da)
CY (1) CY1108733T1 (da)
CZ (1) CZ299844B6 (da)
DE (1) DE60040905D1 (da)
DK (1) DK1155015T3 (da)
EE (2) EE05531B1 (da)
ES (1) ES2316349T3 (da)
GB (1) GB9903472D0 (da)
HK (1) HK1041265B (da)
HU (1) HU229835B1 (da)
IL (2) IL144793A0 (da)
IS (1) IS2711B (da)
MX (1) MXPA01008235A (da)
NO (1) NO320739B1 (da)
NZ (1) NZ513261A (da)
PL (1) PL218518B1 (da)
PT (1) PT1155015E (da)
RU (1) RU2243969C2 (da)
SI (1) SI1155015T1 (da)
SK (1) SK286988B6 (da)
TR (2) TR200401874T2 (da)
TW (1) TWI285202B (da)
WO (1) WO2000049014A1 (da)
ZA (1) ZA200106370B (da)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9902202D0 (sv) * 1999-06-10 1999-06-10 Astra Ab Production of aggregates
GB0003305D0 (en) * 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
GB0011120D0 (en) * 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
PL366831A1 (en) 2001-07-13 2005-02-07 Astrazeneca Uk Limited Preparation of aminopyrimidine compounds
TR200302281T2 (tr) * 2001-08-16 2004-09-21 Teva Pharmaceutical Industries Ltd. Statinlerin kalsiyum tuzu formlarını hazırlamak için işlemler
EP1323717A1 (en) * 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
EP1375493A1 (en) 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
EP1578731B1 (en) 2002-12-16 2009-11-11 AstraZeneca UK Limited Process for the preparation of pyrimidine compounds
GB0312896D0 (en) * 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
EP1562912A2 (en) 2003-08-28 2005-08-17 Teva Pharmaceutical Industries Limited Process for preparation of rosuvastatin calcium
UY28501A1 (es) * 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0321827D0 (en) * 2003-09-18 2003-10-15 Astrazeneca Uk Ltd Chemical compounds
GB0322552D0 (en) 2003-09-26 2003-10-29 Astrazeneca Uk Ltd Therapeutic treatment
GB0324791D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
CA2546701C (en) * 2003-11-24 2010-07-27 Teva Pharmaceutical Industries Ltd. Crystalline ammonium salts of rosuvastatin
WO2005056534A1 (en) 2003-12-02 2005-06-23 Teva Pharmaceutical Industries Ltd. Reference standard for characterization of rosuvastatin
US7241800B2 (en) 2004-03-17 2007-07-10 Mai De Ltd. Anhydrous amorphous form of fluvastatin sodium
GB0406757D0 (en) 2004-03-26 2004-04-28 Avecia Ltd Process and compounds
US7179916B2 (en) 2004-07-13 2007-02-20 Teva Pharmaceutical Industries Ltd. Process for the preparation of rosuvastatin
GB0427491D0 (en) 2004-12-16 2005-01-19 Avecia Ltd Process and compounds
GB0428328D0 (en) * 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
CN100351240C (zh) * 2005-01-19 2007-11-28 安徽省庆云医药化工有限公司 瑞舒伐他汀钙的合成方法
EP1851206B1 (en) 2005-02-22 2012-08-15 Teva Pharmaceutical Industries, Ltd. Rosuvastatin and salts thereof free of rosuvastatin alkylether and a process for the preparation thereof
US20090124803A1 (en) * 2005-03-22 2009-05-14 Pandurang Balwant Deshpande Process for preparation of rosuvastatin
EP1869005A1 (en) * 2005-04-04 2007-12-26 Unichem Laboratories Limited Process for preparation of calcium salt of rosuvastatin
HU227120B1 (hu) * 2005-05-26 2010-07-28 Richter Gedeon Nyrt Eljárás rosuvastatin kalciumsójának elõállítására új intermediereken keresztül
ES2564807T5 (es) 2005-06-24 2019-02-26 Lek Pharmaceuticals Proceso para preparación de rosuvastatina de calcio amorfa pura
US9150518B2 (en) * 2005-06-24 2015-10-06 Lek Pharmaceuticals, D.D. Process for preparing amorphous rosuvastatin calcium of impurities
GB0514078D0 (en) * 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process
WO2007017117A1 (en) * 2005-07-28 2007-02-15 Lek Pharmaceuticals D.D. Process for the synthesis of rosuvastatin calcium
US7868169B2 (en) 2005-08-16 2011-01-11 Teva Pharmaceutical Industries, Ltd. Crystalline rosuvastatin intermediate
CN100436428C (zh) * 2005-08-22 2008-11-26 鲁南制药集团股份有限公司 瑞舒伐他汀及其盐的制备方法
CN100352821C (zh) * 2005-08-22 2007-12-05 鲁南制药集团股份有限公司 一种瑞舒伐他汀钙中间体的制备方法
ES2564250T3 (es) * 2006-05-03 2016-03-21 Msn Laboratories Private Limited Nuevo proceso para estatinas y sus sales farmacéuticamente aceptables de las mismas
WO2008044243A2 (en) 2006-10-09 2008-04-17 Manne Satyanarayana Reddy Novel process for the preparation of statins and their pharmaceutically acceptable salts thereof
US8318933B2 (en) 2006-10-31 2012-11-27 Aurobindo Pharma Ltd Process for preparing rosuvastatin calcium
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process
WO2008072078A1 (en) 2006-12-13 2008-06-19 Aurobindo Pharma Limited An improved process for preparing rosuvastatin caclium
US8212035B2 (en) 2007-02-08 2012-07-03 Aurobindo Pharma Ltd. Process for preparation of rosuvastatin calcium field of the invention
KR20090033183A (ko) 2007-04-18 2009-04-01 테바 파마슈티컬 인더스트리즈 리미티드 로수바스타틴 중간체 및 로수바스타틴의 제조 방법
WO2009009152A1 (en) 2007-07-12 2009-01-15 Teva Pharmaceutical Industries Ltd. Rosuvastatin intermediates and their preparation
WO2009027081A2 (en) 2007-08-28 2009-03-05 Ratiopharm Gmbh Process for preparing pentanoic diacid derivatives
CN101376647B (zh) * 2007-08-31 2010-12-08 中山奕安泰医药科技有限公司 一种用于合成瑞舒伐他汀中间体及瑞舒伐他汀的合成方法
WO2009143776A1 (zh) 2008-05-27 2009-12-03 常州制药厂有限公司 瑞舒伐他汀钙盐的制备方法及其中间体
EP2138165A1 (en) 2008-06-27 2009-12-30 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising a statin
ES2657416T3 (es) 2008-06-27 2018-03-05 Krka, Torvarna Zdravil, D.D., Novo Mesto Composición farmacéutica que comprende una estatina
RU2011112541A (ru) * 2008-09-09 2012-10-20 Биокон Лимитед (In) Способ получения кальциевой соли (3r,5s,6e)6-{2-[4-(4фторфенил)-6-изопропил-2-(метансульфонилметиламино)-пиримидин-5-ил]-винил}-2,2-диметил-[1,3]-диоксан-4-ил)-уксусной кислоты(ацетонид розувастатина кальция)
EP2350025A1 (en) * 2008-09-30 2011-08-03 Aurobindo Pharma Limited An improved process for preparing pyrimidine propenaldehyde
CN102186869A (zh) * 2008-10-20 2011-09-14 株式会社钟化 新嘧啶衍生物及HMG-CoA还原酶抑制剂中间体的制造方法
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
SI2373609T1 (sl) 2008-12-19 2013-12-31 Krka, D.D., Novo Mesto Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov
WO2010077062A2 (en) * 2008-12-29 2010-07-08 Hanmi Pharm. Co., Ltd. Preparation method of statin compound and benzothiazolyl sulfone compound used therein
EP2752407B1 (en) 2009-01-14 2015-09-23 Krka Tovarna Zdravil, D.D., Novo Mesto Crystalline rosuvastatin calcium trihydrate
EP2387561A4 (en) 2009-01-19 2012-07-25 Msn Lab Ltd IMPROVED PROCESS FOR THE PREPARATION OF HIGH-PURITY (3R, 5S) -7-β-CYCLOPROPYL-4- (4-FLUOROPHENYL) QUINOLIN-3-YL-3,5-DIHYDROXY-6 (E) -HEPTENOIC ACID, INCLUDING ITS PHARMACEUTICALLY ACCEPTABLE SALTS
KR101157314B1 (ko) 2009-06-05 2012-06-15 주식회사종근당 로수바스타틴의 신규한 제조방법, 이 제조에 유용한 중간체 화합물 및 그의 제조방법
EP2526099B1 (en) 2010-01-18 2016-03-30 MSN Laboratories Limited Improved process for the preparation of amide intermediates and their use thereof
WO2011104725A2 (en) 2010-02-23 2011-09-01 Cadila Healthcare Limited Hmg-coa reductase inhibitors and process for the preparation thereof
WO2012011129A2 (en) * 2010-07-22 2012-01-26 Msn Laboratories Limited Novel polymorph of bis[(e)-7-[4-(4-fluorophenyl)-6-iso-propyl-2-[methyl (methylsulfonyl)amino]pyrimidin-5-yl](3r,5s)-3,5-dihydroxyhept-6-enoic acid] calcium salt
WO2012073256A1 (en) 2010-11-29 2012-06-07 Cadila Healthcare Limited Salts of rosuvastatin
EP2665721B1 (en) 2011-01-18 2015-07-08 DSM Sinochem Pharmaceuticals Netherlands B.V. Methyltetrazole sulfides and sulfones
US9126975B2 (en) * 2011-01-18 2015-09-08 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of statins in the presence of base
CN103328470A (zh) 2011-01-18 2013-09-25 中化帝斯曼制药有限公司荷兰公司 制备二醇砜的方法
WO2012172564A1 (en) * 2011-05-25 2012-12-20 Dr. Reddy's Laboratories Limited Process for preparation of rosuvastatin calcium
MX359424B (es) 2011-12-09 2018-09-12 Dsm Sinochem Pharm Nl Bv Proceso para la preparación de un precursor de estatina.
CN103987705B (zh) 2011-12-09 2015-09-30 中化帝斯曼制药有限公司荷兰公司 制备他汀含硫前体的方法
KR20130087153A (ko) * 2012-01-27 2013-08-06 코오롱생명과학 주식회사 로수바스타틴의 제조방법 및 이에 사용되는 중간체 화합물
CN103232398B (zh) * 2012-04-28 2016-04-06 上海科州药物研发有限公司 一种瑞舒伐他汀氨基酸盐及其制备方法和应用
KR101292743B1 (ko) * 2012-05-17 2013-08-02 (주) 에프엔지리서치 신규한 스타틴 중간체 및 이를 이용한 피타바스타틴, 로수바스타틴, 세리바스타틴 및 플루바스타틴의 제조 방법
CN103864697A (zh) * 2012-12-11 2014-06-18 润泽制药(苏州)有限公司 瑞舒伐中间体主链醇的制备方法
WO2014108795A2 (en) 2013-01-10 2014-07-17 Aurobindo Pharma Limited An improved process for the preparation of chiral diol sulfones and statins
CN103420919B (zh) * 2013-08-22 2015-07-08 南京欧信医药技术有限公司 一种嘧啶类衍生物的合成方法
WO2015037018A1 (en) * 2013-09-14 2015-03-19 Ind-Swift Laboratories Limited Process for the preparation of rosuvastatin via novel intermediates
JP6240346B2 (ja) * 2014-03-07 2017-11-29 ▲凱▼菜英医▲薬▼集▲団▼（天津）股▲フン▼有限公司 ロスバスタチンカルシウムを製造するための中間体化合物、及びそれを用いてロスバスタチンカルシウムを製造する方法
CN103936680B (zh) * 2014-04-18 2016-08-24 润泽制药(苏州)有限公司 瑞舒伐他汀钙已知杂质的制备方法
CN104788387A (zh) * 2015-04-17 2015-07-22 浙江海森药业有限公司 高纯度瑞舒伐他汀钙的制备方法
KR20160126700A (ko) 2015-04-24 2016-11-02 미래파인켐 주식회사 스타틴의 중간체, 이의 제조방법 및 이를 이용한 로수바스타틴의 제조방법
CN105461636A (zh) * 2015-12-30 2016-04-06 安徽美诺华药物化学有限公司 一种瑞舒伐他汀甲酯的合成方法
CN106478518A (zh) * 2016-09-27 2017-03-08 南通常佑药业科技有限公司 一种庚烯酸环戊酯衍生物的制备方法
KR101953575B1 (ko) 2016-10-24 2019-05-24 한양대학교 에리카산학협력단 스타틴계 고지혈증 치료제 합성을 위한 새로운 중간체 합성 및 이를 이용한 로수바스타틴 합성 공정 개발
CN108997324A (zh) * 2018-08-21 2018-12-14 南京欧信医药技术有限公司 瑞舒伐他汀钙中间体的制备方法
CN109651259B (zh) * 2018-12-29 2020-05-19 浙江永太科技股份有限公司 一种瑞舒伐他汀钙关键中间体的纯化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3741509A1 (de) * 1987-12-08 1989-06-22 Hoechst Ag Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
JP2648897B2 (ja) * 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
FR2741620B1 (fr) * 1995-11-28 1997-12-26 Oreal Procede de preparation de composes a groupement beta-hydroxy -delta-lactone analogues de la (+) compactine et de la (+) mevinoline

Also Published As

Publication number Publication date
US20040049036A1 (en) 2004-03-11
JP2003518474A (ja) 2003-06-10
CA2362594C (en) 2009-06-02
HUP0200301A3 (en) 2004-03-29
PL218518B1 (pl) 2014-12-31
SK286988B6 (sk) 2009-08-06
GB9903472D0 (en) 1999-04-07
AU2557300A (en) 2000-09-04
EE05150B1 (et) 2009-04-15
HUP0200301A2 (en) 2002-08-28
SK11832001A3 (sk) 2002-01-07
TR200401874T2 (tr) 2004-10-21
EE200100430A (et) 2002-12-16
IS6029A (is) 2001-07-31
ZA200106370B (en) 2002-11-04
BR0008301B1 (pt) 2013-01-22
DE60040905D1 (de) 2009-01-08
MXPA01008235A (es) 2002-04-24
EE05531B1 (et) 2012-04-16
NZ513261A (en) 2003-10-31
CY1108733T1 (el) 2014-04-09
AU760145B2 (en) 2003-05-08
IL144793A0 (en) 2002-06-30
AR022600A1 (es) 2002-09-04
EE200900043A (et) 2010-02-15
NO320739B1 (no) 2006-01-23
HK1041265A1 (en) 2002-07-05
CA2362594A1 (en) 2000-08-24
JP2008255114A (ja) 2008-10-23
WO2000049014A1 (en) 2000-08-24
KR100648160B1 (ko) 2006-11-24
CN1145625C (zh) 2004-04-14
RU2243969C2 (ru) 2005-01-10
US6844437B1 (en) 2005-01-18
KR20010102207A (ko) 2001-11-15
JP4130844B2 (ja) 2008-08-06
PT1155015E (pt) 2009-01-27
IL163375A (en) 2008-12-29
HU229835B1 (en) 2014-09-29
SI1155015T1 (sl) 2009-04-30
JP2007291113A (ja) 2007-11-08
IS2709B3 (is) 2011-01-15
EP1155015A1 (en) 2001-11-21
TR200102360T2 (tr) 2001-12-21
CZ299844B6 (cs) 2008-12-10
NO20013994D0 (no) 2001-08-16
EP1155015B1 (en) 2008-11-26
BRPI0008301B8 (pt) 2021-05-25
ATE415398T1 (de) 2008-12-15
HK1041265B (zh) 2009-07-03
NO20013994L (no) 2001-10-16
CZ20012930A3 (cs) 2001-11-14
ES2316349T3 (es) 2009-04-16
PL350185A1 (en) 2002-11-18
BR0008301A (pt) 2002-01-22
CN1340052A (zh) 2002-03-13
US6784171B2 (en) 2004-08-31
IS2711B (is) 2011-01-15
TWI285202B (en) 2007-08-11
CL2003002336A1 (es) 2005-01-14

Similar Documents

Publication Publication Date Title
DK1155015T3 (da) Fremgangsmåde til fremstilling af tert-butyl-(E)-(6{2-[4-4(4-flourphenyl)-6-isopropyl-2-[methyld(methylsulfonyl)amino]pyrimidin-5-yl]vinyl}-(4R,6S)-2,2-dimethyl[1,3]dioxan-4-yl)acetat
DK1897546T3 (da) Kombinerede sammensætninger omfattende (E)-7-[4-(4-fluorphenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3r,5s]-3,5-dihydroxyhept-6-enoinsyre
MEP33808A (en) Pharmaceutical compositions comprising a hmg reductase inhibitor
IL158588A0 (en) Optical resolution of (1-benzyl-4-methylpiperidin-3-yl) - methylamine and the use thereof for the preparation of pyrrolo 2,3-pyrimidine derivatives as protein kinase inhibitors
CA2429263A1 (en) Use of rosuvastatin (zd-4522) in the treatment of heterozygous familial hypercholesterolemia
DK1682536T3 (da) Fremgangsmåde til fremstilling af calciumsaltet af rosuvastatin (e)-7-[4-(4-fluorphenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl](3r,5s)-3,5-dihydroxyhept-6-ensyre og krystallinske mellemprodukter deraf
DK2050445T4 (da) Farmaceutisk sammensætning af phenofibrat med forøget biotilgængelighed samt fremgangsmåde til dens fremstilling
HUP0104828A3 (en) Crystalline bis[(e)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl-(methylsulfonyl)amino]pyrimidin-5-yl](3r,5s)-1,5-dihydroxyhept-6-enoic acid]calcium salt, pharmaceutical composition containing it and process for its preparation
DK1005475T3 (da) Fremgangsmåde til fremstilling af Glufosinat samt mellemprodukter dertil
DE60100750D1 (de) NEUE KRISTALLINE FORM VON N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-d]-PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMINSÄURE UND VERFAHREN FÜR IHRE HERSTELLUNG
IS6009A (is) Lyfjablöndur sem samanstanda af (E)-7-[4-(4 flúorófenýl)-6-ísóprópýl-2-[metýl(metýlsúlfónýl) amínó]pýrimidín-5-ýl](3R,5S)-3,5-díhýdroxýhept-6-enósýruog lata, vaka eða hvarfefni af P450 ísóensími 3A4
AU2002215222A1 (en) Pyrimidine compounds or salts thereof, herbicides containing the compounds or the salts, methods for control of weeds by applying the same
DK0840735T3 (da) Spaltning af 1-azabicyclo[2.2.2]octan-3-amin, 2-(diphenylmethyl)-N-2-methoxy-5-(1methylethyl)phenyl]methyl]
AU2992800A (en) Process for the preparation of 6-(perfluoroalkyl)uracil compounds
DE69711265D1 (de) Verfahren zur Herstellung von 5-(Alkoxymethyl)-2,3-Pyridindicarbonsäureimidverbindungen
DE59607662D1 (de) Verfahren zur Herstellung von 2-(Alkoxymethyl)acrolein
DE59709211D1 (de) Verfahren zur Herstellung von 4,6-Dihydroxypyrimidin