CN1269958C - 用于gnn的锌指结合结构域 - Google Patents
用于gnn的锌指结合结构域 Download PDFInfo
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- CN1269958C CN1269958C CNB998143405A CN99814340A CN1269958C CN 1269958 C CN1269958 C CN 1269958C CN B998143405 A CNB998143405 A CN B998143405A CN 99814340 A CN99814340 A CN 99814340A CN 1269958 C CN1269958 C CN 1269958C
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- artificial sequence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
靶特异性 | 氨基酸位置-1 1 2 3 4 5 6 | SEQ ID NO: |
GAA | Q S S N L V R | 1 |
GAC | D P G N L V R | 2 |
GAG | R S D N L V R | 3 |
GAT | T S G N L V R | 4 |
GCA | Q S G D L R R | 5 |
GCC | D C R D L A R | 6 |
GCG | R S D D L V K | 7 |
GCT | T S G E L V R | 8 |
GGA | Q R A H L E R | 9 |
GGC | D P G H L V R | 10 |
GGG | R S D K L V R | 11 |
GGT | T S G H L V R | 12 |
GTA | Q S S S L V R | 13 |
GTC | D P G A L V R | 14 |
GTG | R S D E L V R | 15 |
GTT | T S G S L V R | 16 |
Claims (20)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/173,941 US6140081A (en) | 1998-10-16 | 1998-10-16 | Zinc finger binding domains for GNN |
US09/173,941 | 1998-10-16 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2006100958196A Division CN1896099A (zh) | 1998-10-16 | 1999-10-14 | 用于gnn的锌指结合结构域 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1330713A CN1330713A (zh) | 2002-01-09 |
CN1269958C true CN1269958C (zh) | 2006-08-16 |
Family
ID=22634148
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2006100958196A Pending CN1896099A (zh) | 1998-10-16 | 1999-10-14 | 用于gnn的锌指结合结构域 |
CNB998143405A Expired - Fee Related CN1269958C (zh) | 1998-10-16 | 1999-10-14 | 用于gnn的锌指结合结构域 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2006100958196A Pending CN1896099A (zh) | 1998-10-16 | 1999-10-14 | 用于gnn的锌指结合结构域 |
Country Status (17)
Country | Link |
---|---|
US (5) | US6140081A (zh) |
EP (2) | EP1715040B1 (zh) |
JP (2) | JP2002527097A (zh) |
KR (1) | KR100659922B1 (zh) |
CN (2) | CN1896099A (zh) |
AT (2) | ATE323720T1 (zh) |
AU (1) | AU765630B2 (zh) |
BR (1) | BR9914599A (zh) |
CA (1) | CA2347025C (zh) |
DE (1) | DE69930950T2 (zh) |
DK (1) | DK1121381T3 (zh) |
ES (1) | ES2263290T3 (zh) |
IL (3) | IL142440A0 (zh) |
MX (1) | MXPA01003755A (zh) |
NZ (4) | NZ511523A (zh) |
WO (1) | WO2000023464A2 (zh) |
ZA (1) | ZA200102908B (zh) |
Families Citing this family (405)
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US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
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