MX2023003365A - Linfocitos t modificados por ingenieria genetica con disrupcion de regnasa-1 y/o tgfbrii tienen una funcionalidad y una persistencia mejoradas. - Google Patents

Linfocitos t modificados por ingenieria genetica con disrupcion de regnasa-1 y/o tgfbrii tienen una funcionalidad y una persistencia mejoradas.

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Publication number
MX2023003365A
MX2023003365A MX2023003365A MX2023003365A MX2023003365A MX 2023003365 A MX2023003365 A MX 2023003365A MX 2023003365 A MX2023003365 A MX 2023003365A MX 2023003365 A MX2023003365 A MX 2023003365A MX 2023003365 A MX2023003365 A MX 2023003365A
Authority
MX
Mexico
Prior art keywords
cells
genetically engineered
tgfbrii
persistence
disrupted
Prior art date
Application number
MX2023003365A
Other languages
English (en)
Inventor
Demetrios Kalaitzidis
Mary- Lee Dequeant
Mohammed Ghonime
Original Assignee
Crispr Therapeutics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crispr Therapeutics Ag filed Critical Crispr Therapeutics Ag
Publication of MX2023003365A publication Critical patent/MX2023003365A/es

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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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Abstract

Una población de linfocitos T modificados por ingeniería genética, que comprenden un gen Reg1 alterado y/o un gen TGFBRII alterado; dichos linfocitos T modificados por ingeniería genética pueden comprender modificaciones genéticas adicionales, por ejemplo, un gen CD70 alterado; la población de linfocitos T modificados por ingeniería genética presenta una o más de las siguientes características: (a) actividad de crecimiento celular mejorada; (b) persistencia potenciada; y (c) agotamiento de linfocitos T reducido, (d) actividad de citotoxicidad potenciada, (e) resistencia a efectos inhibidores inducidos por TGF-b y (f) resistencia a efectos inhibidores de fibroblastos y/o factores inhibidores secretados por los mismos, en comparación con linfocitos T homólogos sin modificar.
MX2023003365A 2020-09-23 2021-09-23 Linfocitos t modificados por ingenieria genetica con disrupcion de regnasa-1 y/o tgfbrii tienen una funcionalidad y una persistencia mejoradas. MX2023003365A (es)

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