MX2022002763A - Linfocitos t modificados por ingenieria genetica que tienen persistencia mejorada en cultivo. - Google Patents

Linfocitos t modificados por ingenieria genetica que tienen persistencia mejorada en cultivo.

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Publication number
MX2022002763A
MX2022002763A MX2022002763A MX2022002763A MX2022002763A MX 2022002763 A MX2022002763 A MX 2022002763A MX 2022002763 A MX2022002763 A MX 2022002763A MX 2022002763 A MX2022002763 A MX 2022002763A MX 2022002763 A MX2022002763 A MX 2022002763A
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Mexico
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cells
genetically engineered
culture
cell
gene involved
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MX2022002763A
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English (en)
Inventor
Jonathan Alexander Terrett
Demetrios Kalaitzidis
Hanspeter Waldner
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Crispr Therapeutics Ag
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Publication of MX2022002763A publication Critical patent/MX2022002763A/es

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    • C12N5/0636—T lymphocytes
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    • C12N2510/00—Genetically modified cells

Abstract

Un banco de linfocitos T que comprende linfocitos T modificados por ingeniería genética que tienen una o más de las siguientes características en comparación con los homólogos de linfocitos T no modificados por ingeniería: (a) capacidad de expansión potenciada en cultivo, (b) capacidad de proliferación potenciada, (c) apoptosis reducida y (d) frecuencias de activación potenciadas. Tales linfocitos T modificados por ingeniería genética pueden comprender (i) un gen mutado implicado en la autorrenovación celular; (ii) un gen inactivado implicado en la apoptosis; (iii) un gen inactivado implicado en la regulación del agotamiento de linfocitos T; o (iv) una combinación de uno cualquiera de (i)-(iii).
MX2022002763A 2019-09-06 2020-09-04 Linfocitos t modificados por ingenieria genetica que tienen persistencia mejorada en cultivo. MX2022002763A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962897016P 2019-09-06 2019-09-06
US201962927764P 2019-10-30 2019-10-30
US202063034646P 2020-06-04 2020-06-04
PCT/IB2020/058280 WO2021044378A1 (en) 2019-09-06 2020-09-04 Genetically engineered t cells having improved persistence in culture

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MX2022002763A true MX2022002763A (es) 2022-04-06

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MX2022002763A MX2022002763A (es) 2019-09-06 2020-09-04 Linfocitos t modificados por ingenieria genetica que tienen persistencia mejorada en cultivo.

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US (1) US20210079347A1 (es)
EP (1) EP4025689A1 (es)
JP (1) JP2022547865A (es)
KR (1) KR20220051401A (es)
CN (1) CN114729325A (es)
AU (1) AU2020343516A1 (es)
BR (1) BR112022003891A2 (es)
CA (1) CA3150151A1 (es)
CO (1) CO2022002355A2 (es)
IL (1) IL290795A (es)
MX (1) MX2022002763A (es)
WO (1) WO2021044378A1 (es)

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CN114729325A (zh) 2022-07-08
WO2021044378A1 (en) 2021-03-11
CO2022002355A2 (es) 2022-04-08
JP2022547865A (ja) 2022-11-16
AU2020343516A1 (en) 2022-03-10
EP4025689A1 (en) 2022-07-13
BR112022003891A2 (pt) 2022-05-31
IL290795A (en) 2022-04-01
KR20220051401A (ko) 2022-04-26
CA3150151A1 (en) 2021-03-11
US20210079347A1 (en) 2021-03-18

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