MX2020009896A - Celulas efectoras inmunitarias modificadas y usos de las mismas. - Google Patents

Celulas efectoras inmunitarias modificadas y usos de las mismas.

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Publication number
MX2020009896A
MX2020009896A MX2020009896A MX2020009896A MX2020009896A MX 2020009896 A MX2020009896 A MX 2020009896A MX 2020009896 A MX2020009896 A MX 2020009896A MX 2020009896 A MX2020009896 A MX 2020009896A MX 2020009896 A MX2020009896 A MX 2020009896A
Authority
MX
Mexico
Prior art keywords
effector cells
immune effector
engineered immune
derivative
compositions
Prior art date
Application number
MX2020009896A
Other languages
English (en)
Inventor
Bahram Valamehr
Ryan Bjordahl
Jode Goodridge
Tom Tong Lee
Original Assignee
Fate Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2018/067289 external-priority patent/WO2019126748A1/en
Application filed by Fate Therapeutics Inc filed Critical Fate Therapeutics Inc
Publication of MX2020009896A publication Critical patent/MX2020009896A/es

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Abstract

Se proporcionan métodos y composiciones para obtener células efectoras derivadas funcionalmente potenciadas obtenidas de la diferenciación dirigida de las iPSC genéticamente modificadas. Las células derivadas proporcionadas en la presente tienen una edición del genoma estable y funcional que ofrece efectos terapéuticos potenciados o mejorados. También se proporcionan composiciones terapéuticas y el uso de estas que comprende las células efectoras derivadas funcionalmente potenciadas solas, o con anticuerpos o inhibidores de punto de regulación en terapias combinadas.
MX2020009896A 2018-03-29 2019-03-28 Celulas efectoras inmunitarias modificadas y usos de las mismas. MX2020009896A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862649781P 2018-03-29 2018-03-29
US201862774052P 2018-11-30 2018-11-30
PCT/US2018/067289 WO2019126748A1 (en) 2017-12-22 2018-12-21 Enhanced immune effector cells and use thereof
PCT/US2019/024686 WO2019191495A1 (en) 2018-03-29 2019-03-28 Engineered immune effector cells and use thereof

Publications (1)

Publication Number Publication Date
MX2020009896A true MX2020009896A (es) 2020-10-12

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MX2020009896A MX2020009896A (es) 2018-03-29 2019-03-28 Celulas efectoras inmunitarias modificadas y usos de las mismas.

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US (1) US20210024959A1 (es)
EP (1) EP3775228A4 (es)
JP (1) JP2021519061A (es)
KR (1) KR20200127250A (es)
CN (1) CN111954715A (es)
AU (1) AU2019243315A1 (es)
BR (1) BR112020019205A2 (es)
CA (1) CA3093020A1 (es)
IL (1) IL277611A (es)
MX (1) MX2020009896A (es)
SG (1) SG11202008977UA (es)
WO (1) WO2019191495A1 (es)

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IL309585A (en) 2017-12-22 2024-02-01 Fate Therapeutics Inc Enhanced effector training cells and their use
CN110628821B (zh) * 2018-06-25 2022-02-18 首都医科大学宣武医院 一种细胞模型及其制备方法、应用
JP2023517041A (ja) 2020-03-06 2023-04-21 メタゲノミ，インコーポレイテッド クラスｉｉのｖ型ｃｒｉｓｐｒ系
EP4132545A4 (en) * 2020-04-09 2024-05-22 Wallkill Biopharma Inc TREATMENT OF AUTOIMMUNE DISEASES WITH GENETICALLY MODIFIED CELLS
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CN114107211A (zh) * 2020-12-04 2022-03-01 未来智人再生医学研究院(广州)有限公司 一种多能干细胞及其衍生物
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CN114657133A (zh) * 2020-12-22 2022-06-24 未来智人再生医学研究院(广州)有限公司 一种表达靶向IL-4 Rα的shRNA和/或shRNA-miR的多能干细胞
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