|
US7285416B2
(en)
*
|
2000-01-24 |
2007-10-23 |
Gendaq Limited |
Regulated gene expression in plants
|
|
CA2196419C
(en)
|
1994-08-20 |
2007-08-21 |
Yen Choo |
Improvements in or relating to binding proteins for recognition of dna
|
|
GB9824544D0
(en)
|
1998-11-09 |
1999-01-06 |
Medical Res Council |
Screening system
|
|
US7262055B2
(en)
|
1998-08-25 |
2007-08-28 |
Gendaq Limited |
Regulated gene expression in plants
|
|
US6410248B1
(en)
|
1998-01-30 |
2002-06-25 |
Massachusetts Institute Of Technology |
General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
|
|
AU746454B2
(en)
|
1998-03-02 |
2002-05-02 |
Massachusetts Institute Of Technology |
Poly zinc finger proteins with improved linkers
|
|
DE69932813D1
(de)
|
1998-03-17 |
2006-09-28 |
Gendaq Ltd |
Nukleinsäurebindungsproteine
|
|
US6140081A
(en)
*
|
1998-10-16 |
2000-10-31 |
The Scripps Research Institute |
Zinc finger binding domains for GNN
|
|
US7013219B2
(en)
*
|
1999-01-12 |
2006-03-14 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US7070934B2
(en)
|
1999-01-12 |
2006-07-04 |
Sangamo Biosciences, Inc. |
Ligand-controlled regulation of endogenous gene expression
|
|
US6534261B1
(en)
*
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US6453242B1
(en)
|
1999-01-12 |
2002-09-17 |
Sangamo Biosciences, Inc. |
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
|
|
US6599692B1
(en)
|
1999-09-14 |
2003-07-29 |
Sangamo Bioscience, Inc. |
Functional genomics using zinc finger proteins
|
|
US20030104526A1
(en)
*
|
1999-03-24 |
2003-06-05 |
Qiang Liu |
Position dependent recognition of GNN nucleotide triplets by zinc fingers
|
|
US6794136B1
(en)
*
|
2000-11-20 |
2004-09-21 |
Sangamo Biosciences, Inc. |
Iterative optimization in the design of binding proteins
|
|
US7030215B2
(en)
*
|
1999-03-24 |
2006-04-18 |
Sangamo Biosciences, Inc. |
Position dependent recognition of GNN nucleotide triplets by zinc fingers
|
|
US7329728B1
(en)
*
|
1999-10-25 |
2008-02-12 |
The Scripps Research Institute |
Ligand activated transcriptional regulator proteins
|
|
HK1049515B
(en)
|
1999-12-06 |
2006-01-13 |
Sangamo Biosciences Inc. |
Methods of using randomized libraries of zinc finger proteins for the identification of gene function
|
|
WO2001053480A1
(en)
*
|
2000-01-24 |
2001-07-26 |
Sangamo Biosciences, Inc. |
Nucleic acid binding polypeptides characterized by flexible linkers connected nucleic acid binding modules
|
|
DE60143192D1
(de)
*
|
2000-02-08 |
2010-11-18 |
Sangamo Biosciences Inc |
Zellen zur entdeckung von medikamenten
|
|
ATE353361T1
(de)
*
|
2000-04-28 |
2007-02-15 |
Sangamo Biosciences Inc |
Gezielten modifikation der chromatinstruktur
|
|
EP1276860B1
(de)
|
2000-04-28 |
2007-09-26 |
Sangamo Biosciences Inc. |
Datenbanken von regulatorischen sequenzen, methoden zu ihrer herstellung und verwendung
|
|
WO2001083819A2
(en)
|
2000-04-28 |
2001-11-08 |
Sangamo Biosciences, Inc. |
Methods for designing exogenous regulatory molecules
|
|
WO2001084148A2
(en)
|
2000-04-28 |
2001-11-08 |
Sangamo Biosciences, Inc. |
Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions
|
|
US7923542B2
(en)
|
2000-04-28 |
2011-04-12 |
Sangamo Biosciences, Inc. |
Libraries of regulatory sequences, methods of making and using same
|
|
US7011972B2
(en)
|
2000-07-18 |
2006-03-14 |
The Scripps Research Institute |
Fusion polypeptide comprising two ligand binding domains
|
|
NZ523649A
(en)
*
|
2000-07-18 |
2005-02-25 |
Novartis Ag |
Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches
|
|
EP1303608A2
(de)
*
|
2000-07-21 |
2003-04-23 |
Syngenta Participations AG |
Code zur erkennung von zinkfingerdomänen und dessen verwendungen
|
|
US7067317B2
(en)
*
|
2000-12-07 |
2006-06-27 |
Sangamo Biosciences, Inc. |
Regulation of angiogenesis with zinc finger proteins
|
|
AU2884102A
(en)
*
|
2000-12-07 |
2002-06-18 |
Sangamo Biosciences Inc |
Regulation of angiogenesis with zinc finger proteins
|
|
AU2002225187A1
(en)
*
|
2001-01-22 |
2002-07-30 |
Sangamo Biosciences, Inc. |
Zinc finger polypeptides and their use
|
|
CA2435394C
(en)
*
|
2001-01-22 |
2018-01-09 |
Sangamo Biosciences, Inc. |
Modified zinc finger binding proteins
|
|
JP4309133B2
(ja)
*
|
2001-02-21 |
2009-08-05 |
ノバルティス アクチエンゲゼルシャフト |
ヌクレオチド配列annについての亜鉛フィンガー結合ドメイン
|
|
US7067617B2
(en)
*
|
2001-02-21 |
2006-06-27 |
The Scripps Research Institute |
Zinc finger binding domains for nucleotide sequence ANN
|
|
US20040197892A1
(en)
*
|
2001-04-04 |
2004-10-07 |
Michael Moore |
Composition binding polypeptides
|
|
US7381813B2
(en)
|
2001-05-31 |
2008-06-03 |
Novartis Ag |
Nucleic acids encoding estrogen receptor ligand binding domain variants
|
|
WO2003016496A2
(en)
*
|
2001-08-20 |
2003-02-27 |
The Scripps Research Institute |
Zinc finger binding domains for cnn
|
|
US7262054B2
(en)
*
|
2002-01-22 |
2007-08-28 |
Sangamo Biosciences, Inc. |
Zinc finger proteins for DNA binding and gene regulation in plants
|
|
AU2003251286B2
(en)
*
|
2002-01-23 |
2007-08-16 |
The University Of Utah Research Foundation |
Targeted chromosomal mutagenesis using zinc finger nucleases
|
|
CA2475276A1
(en)
*
|
2002-02-07 |
2003-08-14 |
The Scripps Research Institute |
Zinc finger libraries
|
|
US20030232410A1
(en)
*
|
2002-03-21 |
2003-12-18 |
Monika Liljedahl |
Methods and compositions for using zinc finger endonucleases to enhance homologous recombination
|
|
AU2003274404A1
(en)
*
|
2002-06-11 |
2003-12-22 |
The Scripps Research Institute |
Artificial transcription factors
|
|
US7361635B2
(en)
|
2002-08-29 |
2008-04-22 |
Sangamo Biosciences, Inc. |
Simultaneous modulation of multiple genes
|
|
JP2006502748A
(ja)
*
|
2002-09-05 |
2006-01-26 |
カリフォルニア インスティテュート オブ テクノロジー |
遺伝子ターゲッティングを誘発するキメラヌクレアーゼの使用方法
|
|
EP1579005A4
(de)
*
|
2002-11-15 |
2007-07-25 |
Sangamo Biosciences Inc |
Verfahren und zusammensetzungen zur analyse regulatorischer sequenzen
|
|
US8071285B1
(en)
|
2003-05-14 |
2011-12-06 |
Carl Henry Lawyer |
Zinc finger protein derivatives and methods of using same
|
|
US7888121B2
(en)
|
2003-08-08 |
2011-02-15 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
US11311574B2
(en)
|
2003-08-08 |
2022-04-26 |
Sangamo Therapeutics, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
JP4555292B2
(ja)
|
2003-08-08 |
2010-09-29 |
サンガモ バイオサイエンシズ インコーポレイテッド |
標的化された切断及び組換えの方法及び組成物
|
|
US8409861B2
(en)
|
2003-08-08 |
2013-04-02 |
Sangamo Biosciences, Inc. |
Targeted deletion of cellular DNA sequences
|
|
US20120196370A1
(en)
|
2010-12-03 |
2012-08-02 |
Fyodor Urnov |
Methods and compositions for targeted genomic deletion
|
|
US7407776B2
(en)
|
2003-09-19 |
2008-08-05 |
Sangamo Biosciences, Inc. |
Engineered zinc finger proteins for regulation of gene expression
|
|
US7972854B2
(en)
|
2004-02-05 |
2011-07-05 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
EP1737498A2
(de)
*
|
2004-04-08 |
2007-01-03 |
Sangamo Biosciences Inc. |
Zink-finger-proteine zur behandlung von neuropathischen schmerzen
|
|
JP4903689B2
(ja)
*
|
2004-04-08 |
2012-03-28 |
サンガモ バイオサイエンシズ インコーポレイテッド |
神経障害および神経変性症状を治療するための方法と組成物
|
|
EP1732945B1
(de)
*
|
2004-04-08 |
2014-12-24 |
Sangamo BioSciences, Inc. |
Verfahren und zusammensetzungen zur modulation der kardialen kontraktivität
|
|
EP2292274A1
(de)
|
2004-09-16 |
2011-03-09 |
Sangamo BioSciences, Inc. |
Zusammensetzungen und Methoden zur Protein Herstellung
|
|
EP2166098B1
(de)
|
2004-10-05 |
2013-11-06 |
SunGene GmbH |
Konstitutive Expressionskassetten zur Regulation der Pflanzenexpression
|
|
EP1655364A3
(de)
|
2004-11-05 |
2006-08-02 |
BASF Plant Science GmbH |
Expressionskassetten zur bevorzugten Expression in Pflanzensamen
|
|
EP1662000B1
(de)
|
2004-11-25 |
2011-03-30 |
SunGene GmbH |
Expressionskassetten zur bevorzugten Expression in pflanzlichen Schliesszellen
|
|
EP1666599A3
(de)
|
2004-12-04 |
2006-07-12 |
SunGene GmbH |
Expressionskassetten zur bevorzugten Expression in Mesophyll- und/oder Epidermiszellen in Pflanzen
|
|
EP2163634A1
(de)
|
2004-12-08 |
2010-03-17 |
SunGene GmbH |
Expressionskassetten zur vaskularen, gewebebevorzugten Expression bei Pflanzen
|
|
EP1669456A3
(de)
|
2004-12-11 |
2006-07-12 |
SunGene GmbH |
Expressionskasseten für meristembevorzugte Expression in Pflanzen
|
|
EP1851318A2
(de)
|
2005-02-09 |
2007-11-07 |
BASF Plant Science GmbH |
Expressionskassette zur regulation der expression in einkeimblättrigen pflanzen
|
|
US20090031440A1
(en)
|
2005-02-26 |
2009-01-29 |
Basf Plant Science Gmbh |
Expression Cassettes for Seed-Preferential Expression in Plants
|
|
EP1869075B1
(de)
*
|
2005-02-28 |
2012-04-11 |
Sangamo BioSciences, Inc. |
Antiangiogene methoden und zusammensetzungen
|
|
EP1882037A2
(de)
|
2005-05-10 |
2008-01-30 |
BASF Plant Science GmbH |
Expressionskassetten zur bevorzugten expression in pflanzensamen
|
|
WO2007014275A2
(en)
|
2005-07-26 |
2007-02-01 |
Sangamo Biosciences, Inc. |
Targeted integration and expression of exogenous nucleic acid sequences
|
|
WO2007019062A2
(en)
*
|
2005-08-11 |
2007-02-15 |
The Scripps Research Institute |
Zinc finger binding domains for cnn
|
|
WO2007048127A2
(en)
*
|
2005-10-20 |
2007-04-26 |
The Scripps Research Institute |
Fc labeling for immunostaining and immunotargeting
|
|
EP1963499A4
(de)
*
|
2005-11-28 |
2009-04-08 |
Scripps Research Inst |
Zinkfinger-bindungsdomänen für tnn
|
|
US20070154989A1
(en)
*
|
2006-01-03 |
2007-07-05 |
The Scripps Research Institute |
Zinc finger domains specifically binding agc
|
|
WO2007106603A2
(en)
*
|
2006-01-06 |
2007-09-20 |
The Scripps Research Institute |
Specific labeling of proteins with zinc finger tags and use of zinc-finger-tagged proteins for analysis
|
|
WO2007136685A2
(en)
*
|
2006-05-19 |
2007-11-29 |
Sangamo Biosciences, Inc. |
Methods and compositions for inactivation of dihydrofolate reductase
|
|
JP5266210B2
(ja)
|
2006-05-25 |
2013-08-21 |
サンガモ バイオサイエンシズ インコーポレイテッド |
改変開裂ハーフドメイン
|
|
ES2465996T3
(es)
*
|
2006-05-25 |
2014-06-09 |
Sangamo Biosciences, Inc. |
Métodos y composiciones para la inactivación genética
|
|
KR101439568B1
(ko)
|
2006-08-11 |
2014-09-12 |
다우 아그로사이언시즈 엘엘씨 |
아연 손가락 뉴클레아제-매개 상동 재조합
|
|
WO2008060510A2
(en)
*
|
2006-11-13 |
2008-05-22 |
Sangamo Biosciences, Inc. |
Zinc finger nuclease for targeting the human glucocorticoid receptor locus
|
|
ES2586210T3
(es)
|
2006-12-14 |
2016-10-13 |
Sangamo Biosciences, Inc. |
Proteínas de dedo de zinc no canónicas optimizadas
|
|
CA2675926A1
(en)
|
2007-02-16 |
2008-08-21 |
Basf Plant Science Gmbh |
Nucleic acid sequences for regulation of embryo-specific expression in monocotyledonous plants
|
|
CA2684378C
(en)
|
2007-04-26 |
2016-11-29 |
Sangamo Biosciences, Inc. |
Targeted integration into the ppp1r12c locus
|
|
US7919313B2
(en)
|
2007-07-12 |
2011-04-05 |
Sangamo Biosciences, Inc. |
Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT8) gene expression
|
|
EP2188384B1
(de)
*
|
2007-09-27 |
2015-07-15 |
Sangamo BioSciences, Inc. |
Schnelle in-vivo-identifizierung von biologisch aktiven nukleasen
|
|
US8563314B2
(en)
|
2007-09-27 |
2013-10-22 |
Sangamo Biosciences, Inc. |
Methods and compositions for modulating PD1
|
|
US8399218B2
(en)
|
2007-09-27 |
2013-03-19 |
Dow Agrosciences, Llc |
Engineered zinc finger proteins targeting 5-enolpyruvyl shikimate-3-phosphate synthase genes
|
|
US11235026B2
(en)
|
2007-09-27 |
2022-02-01 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modulating PD1
|
|
AU2008317354B2
(en)
|
2007-10-25 |
2014-04-10 |
Ospedale San Raffaele S.R.L. |
Methods and compositions for targeted integration
|
|
BRPI0820653B1
(pt)
|
2007-12-03 |
2023-05-16 |
Syngenta Participations Ag |
Fitase isolada termotolerante e enzimaticamente suscetível, polinucleotídeo, cassete de expressão, vetor, célula hospedeira microbiana, método para preparar a referida fitase, preparação e ração animal
|
|
AU2009212247A1
(en)
*
|
2008-02-08 |
2009-08-13 |
Sangamo Therapeutics, Inc. |
Treatment of chronic pain with zinc finger proteins
|
|
MX2010011511A
(es)
|
2008-04-21 |
2011-06-09 |
Danziger Innovations Ltd |
Vectores de expresion viral de planta y uso de los mismos para generar variaciones genotipicas en genomas de plantas.
|
|
PL2274430T3
(pl)
|
2008-04-30 |
2017-09-29 |
Sanbio Inc |
Komórki regenerujące nerwy ze zmianami w metylacji DNA
|
|
CA2725773C
(en)
*
|
2008-05-28 |
2017-12-05 |
Sangamo Biosciences, Inc. |
Compositions for linking dna-binding domains and cleavage domains
|
|
EP2294191B1
(de)
|
2008-06-10 |
2016-09-28 |
Sangamo BioSciences, Inc. |
Verfahren und zusammensetzungen zur erzeugung von bax- und bak-mangel-zelllinien
|
|
AU2009283194B2
(en)
|
2008-08-22 |
2014-10-16 |
Sangamo Therapeutics, Inc. |
Methods and compositions for targeted single-stranded cleavage and targeted integration
|
|
CN102264915B
(zh)
|
2008-10-29 |
2014-04-16 |
桑格摩生物科学股份有限公司 |
失活谷氨酰胺合成酶基因表达的方法和组合物
|
|
US20110318830A1
(en)
*
|
2008-11-12 |
2011-12-29 |
The Regents Of The University Of California |
Compositions and methods for re-programming and re-differentiating cells
|
|
US20110023158A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Bovine genome editing with zinc finger nucleases
|
|
US20110023151A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genome editing of abc transporters
|
|
US20110023141A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved with parkinson's disease
|
|
US20110023153A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in alzheimer's disease
|
|
US20110023147A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of prion disorder-related genes in animals
|
|
US20110016541A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genome editing of sensory-related genes in animals
|
|
US20110016543A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in inflammation
|
|
US20110023144A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in amyotrophyic lateral sclerosis disease
|
|
US20110023148A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genome editing of addiction-related genes in animals
|
|
US20110023154A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Silkworm genome editing with zinc finger nucleases
|
|
US20110016539A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genome editing of neurotransmission-related genes in animals
|
|
US20110023139A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in cardiovascular disease
|
|
US20110016546A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Porcine genome editing with zinc finger nucleases
|
|
US20110023145A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in autism spectrum disorders
|
|
US20110023146A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in secretase-associated disorders
|
|
US20110023152A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genome editing of cognition related genes in animals
|
|
AU2009322964B2
(en)
|
2008-12-04 |
2014-10-09 |
Sangamo Therapeutics, Inc. |
Genome editing in rats using zinc-finger nucleases
|
|
US20110023143A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of neurodevelopmental genes in animals
|
|
US20110023156A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Feline genome editing with zinc finger nucleases
|
|
US20110030072A1
(en)
*
|
2008-12-04 |
2011-02-03 |
Sigma-Aldrich Co. |
Genome editing of immunodeficiency genes in animals
|
|
US20110023140A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Rabbit genome editing with zinc finger nucleases
|
|
US20110023150A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genome editing of genes associated with schizophrenia in animals
|
|
US20110016540A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genome editing of genes associated with trinucleotide repeat expansion disorders in animals
|
|
US20110023149A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in tumor suppression in animals
|
|
AR074783A1
(es)
|
2008-12-17 |
2011-02-09 |
Dow Agrosciences Llc |
Metodos y composiciones para expresar uno o mas productos de un acido nucleico exogeno integrado al locus zp15 de una celula vegetal
|
|
AU2010211057B2
(en)
*
|
2009-02-04 |
2014-12-18 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treating neuropathies
|
|
WO2010107493A2
(en)
*
|
2009-03-20 |
2010-09-23 |
Sangamo Biosciences, Inc. |
Modification of cxcr4 using engineered zinc finger proteins
|
|
CA2756833C
(en)
*
|
2009-04-09 |
2019-11-19 |
Sangamo Therapeutics, Inc. |
Targeted integration into stem cells
|
|
US8772008B2
(en)
|
2009-05-18 |
2014-07-08 |
Sangamo Biosciences, Inc. |
Methods and compositions for increasing nuclease activity
|
|
WO2011002503A1
(en)
|
2009-06-30 |
2011-01-06 |
Sangamo Biosciences, Inc. |
Rapid screening of biologically active nucleases and isolation of nuclease-modified cells
|
|
CA2769262C
(en)
*
|
2009-07-28 |
2019-04-30 |
Sangamo Biosciences, Inc. |
Methods and compositions for treating trinucleotide repeat disorders
|
|
ES2550202T3
(es)
*
|
2009-08-03 |
2015-11-05 |
Recombinetics, Inc. |
Métodos y composiciones para la modificación dirigida de genes
|
|
EP3156504B1
(de)
*
|
2009-08-11 |
2018-10-31 |
Sangamo Therapeutics, Inc. |
Für gezielte modifikation homozygote organismen
|
|
WO2011048600A1
(en)
|
2009-10-21 |
2011-04-28 |
Danziger Innovations Ltd. |
Generating genotypic variations in plant genomes by gamete infection
|
|
KR101813981B1
(ko)
|
2009-10-22 |
2018-01-04 |
다우 아그로사이언시즈 엘엘씨 |
지방산 생합성에 포함된 식물 유전자를 표적하는 조작된 징크 핑거 단백질
|
|
US8956828B2
(en)
|
2009-11-10 |
2015-02-17 |
Sangamo Biosciences, Inc. |
Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
|
|
DE112010004582T5
(de)
|
2009-11-27 |
2012-11-29 |
Basf Plant Science Company Gmbh |
Optimierte Endonukleasen und Anwendungen davon
|
|
JP5902631B2
(ja)
|
2010-01-22 |
2016-04-13 |
ダウ アグロサイエンシィズ エルエルシー |
標的化ゲノム変更
|
|
WO2011097036A1
(en)
|
2010-02-08 |
2011-08-11 |
Sangamo Biosciences, Inc. |
Engineered cleavage half-domains
|
|
JP2013518602A
(ja)
|
2010-02-09 |
2013-05-23 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
部分的に一本鎖のドナー分子による標的化ゲノム改変
|
|
US9567573B2
(en)
|
2010-04-26 |
2017-02-14 |
Sangamo Biosciences, Inc. |
Genome editing of a Rosa locus using nucleases
|
|
PL2566972T3
(pl)
|
2010-05-03 |
2020-06-29 |
Sangamo Therapeutics, Inc. |
Kompozycje do wiązania modułów z motywem palca cynkowego
|
|
CA3157027A1
(en)
|
2010-07-21 |
2012-01-26 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modification of a t-cell receptor gene
|
|
EP3511420B1
(de)
|
2010-09-27 |
2021-04-07 |
Sangamo Therapeutics, Inc. |
Zusammensetzungen zur hemmung des eindringens von viren in zellen
|
|
KR101930711B1
(ko)
|
2010-10-12 |
2018-12-19 |
더 칠드런스 호스피탈 오브 필라델피아 |
혈우병 b의 치료를 위한 방법 및 조성물
|
|
US9267123B2
(en)
|
2011-01-05 |
2016-02-23 |
Sangamo Biosciences, Inc. |
Methods and compositions for gene correction
|
|
MX2013010197A
(es)
|
2011-03-18 |
2013-09-26 |
Basf Plant Science Co Gmbh |
Promotores para regular la expresion en plantas.
|
|
WO2012139045A1
(en)
|
2011-04-08 |
2012-10-11 |
Gilead Biologics, Inc. |
Methods and compositions for normalization of tumor vasculature by inhibition of loxl2
|
|
US9161995B2
(en)
|
2011-07-25 |
2015-10-20 |
Sangamo Biosciences, Inc. |
Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (CFTR) gene
|
|
US9150847B2
(en)
|
2011-09-21 |
2015-10-06 |
Sangamo Biosciences, Inc. |
Methods and compositions for regulation of transgene expression
|
|
WO2013059507A1
(en)
|
2011-10-20 |
2013-04-25 |
University Of Iowa Research Foundation |
N-demethyase genes and uses thereof
|
|
US8895264B2
(en)
|
2011-10-27 |
2014-11-25 |
Sangamo Biosciences, Inc. |
Methods and compositions for modification of the HPRT locus
|
|
EP4218727A3
(de)
|
2012-01-27 |
2023-08-30 |
SanBio, Inc. |
Verfahren und zusammensetzungen zur modulation der angiogenese und vaskulogenese
|
|
NZ629427A
(en)
|
2012-02-29 |
2016-04-29 |
Sangamo Biosciences Inc |
Methods and compositions for treating huntington’s disease
|
|
WO2013158309A2
(en)
|
2012-04-18 |
2013-10-24 |
The Board Of Trustees Of The Leland Stanford Junior University |
Non-disruptive gene targeting
|
|
WO2013163628A2
(en)
|
2012-04-27 |
2013-10-31 |
Duke University |
Genetic correction of mutated genes
|
|
JP6352250B2
(ja)
|
2012-05-02 |
2018-07-04 |
ダウ アグロサイエンシィズ エルエルシー |
リンゴ酸デヒドロゲナーゼの標的改変
|
|
JP6559063B2
(ja)
|
2012-05-07 |
2019-08-14 |
サンガモ セラピューティクス, インコーポレイテッド |
導入遺伝子のヌクレアーゼ媒介標的化組み込みのための方法および組成物
|
|
US11120889B2
(en)
|
2012-05-09 |
2021-09-14 |
Georgia Tech Research Corporation |
Method for synthesizing a nuclease with reduced off-site cleavage
|
|
EP2861740A1
(de)
|
2012-06-15 |
2015-04-22 |
University of Iowa Research Foundation |
Koffeinreaktive promotoren und regulatorische gene
|
|
EP2872154B1
(de)
|
2012-07-11 |
2017-05-31 |
Sangamo BioSciences, Inc. |
Verfahren und zusammensetzungen zur freisetzung von biologischen wirkstoffen
|
|
CA2875618C
(en)
|
2012-07-11 |
2021-04-27 |
Sangamo Biosciences, Inc. |
Methods and compositions for the treatment of lysosomal storage diseases
|
|
US10648001B2
(en)
|
2012-07-11 |
2020-05-12 |
Sangamo Therapeutics, Inc. |
Method of treating mucopolysaccharidosis type I or II
|
|
DK2890780T3
(da)
|
2012-08-29 |
2020-09-21 |
Sangamo Therapeutics Inc |
Fremgangsmåder og sammensætninger til behandling af en genetisk tilstand
|
|
KR102201867B1
(ko)
|
2012-09-04 |
2021-01-12 |
더 스크립스 리서치 인스티튜트 |
표적화된 바인딩 특이도를 갖는 키메라 폴리펩타이드들
|
|
UA118090C2
(uk)
|
2012-09-07 |
2018-11-26 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив
|
|
HK1217732A1
(zh)
|
2012-09-07 |
2017-01-20 |
美国陶氏益农公司 |
Fad3性能基因座及相應的能夠誘導靶向斷裂的靶位點特異性結合蛋白
|
|
UA119135C2
(uk)
|
2012-09-07 |
2019-05-10 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб отримання трансгенної рослини
|
|
EP3763810A3
(de)
|
2012-10-10 |
2021-07-14 |
Sangamo Therapeutics, Inc. |
T-zell-modifizierende verbindungen und verwendungen davon
|
|
US9255250B2
(en)
|
2012-12-05 |
2016-02-09 |
Sangamo Bioscience, Inc. |
Isolated mouse or human cell having an exogenous transgene in an endogenous albumin gene
|
|
US20140173783A1
(en)
|
2012-12-13 |
2014-06-19 |
Dow Agrosciences Llc |
Precision gene targeting to a particular locus in maize
|
|
EP2958996B1
(de)
|
2013-02-25 |
2019-10-16 |
Sangamo Therapeutics, Inc. |
Verfahren und zusammensetzungen zur verbesserung einer nuklease-vermittelten genunterbrechung
|
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
|
EP2975942B1
(de)
|
2013-03-21 |
2018-08-08 |
Sangamo Therapeutics, Inc. |
Gezielte disruption von t-zell rezeptorgenen mit manipulierten zinkfinger-proteinnukleasen
|
|
RU2723130C2
(ru)
|
2013-04-05 |
2020-06-08 |
ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи |
Способы и композиции для встраивания экзогенной последовательности в геном растений
|
|
CA2910427C
(en)
|
2013-05-10 |
2024-02-20 |
Sangamo Biosciences, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
|
WO2014186435A2
(en)
|
2013-05-14 |
2014-11-20 |
University Of Georgia Research Foundation, Inc. |
Compositions and methods for reducing neointima formation
|
|
EP3730615A3
(de)
|
2013-05-15 |
2020-12-09 |
Sangamo Therapeutics, Inc. |
Verfahren und zusammensetzungen zur behandlung eines genetischen leidens
|
|
CA2920899C
(en)
|
2013-08-28 |
2023-02-28 |
Sangamo Biosciences, Inc. |
Compositions for linking dna-binding domains and cleavage domains
|
|
CN110713995B
(zh)
|
2013-10-17 |
2023-08-01 |
桑格摩生物科学股份有限公司 |
用于核酸酶介导的基因组工程改造的递送方法和组合物
|
|
CA2926078C
(en)
|
2013-10-17 |
2021-11-16 |
Sangamo Biosciences, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
|
|
BR102014027442B1
(pt)
|
2013-11-04 |
2022-09-27 |
Dow Agrosciences Llc |
Molécula de ácido nucleico recombinante, uso de uma planta de milho, parte de planta de milho ou célula de planta de milho compreendendo a mesma e método para produzir uma célula vegetal transgênica compreendendo um dna de interesse
|
|
UY35814A
(es)
|
2013-11-04 |
2015-05-29 |
Dow Agrosciences Llc |
?lugares óptimos para la soja?.
|
|
MX358066B
(es)
|
2013-11-04 |
2018-08-03 |
Dow Agrosciences Llc |
Óptimos loci de soya.
|
|
KR102269769B1
(ko)
|
2013-11-04 |
2021-06-28 |
코르테바 애그리사이언스 엘엘씨 |
최적 메이즈 유전자좌
|
|
AU2014346424B2
(en)
|
2013-11-11 |
2020-09-17 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treating Huntington's Disease
|
|
HUE056436T2
(hu)
|
2013-11-13 |
2022-02-28 |
Childrens Medical Center |
Nukleáz közvetítette génexpresszió-szabályozás
|
|
US9932607B2
(en)
|
2013-11-15 |
2018-04-03 |
The Board Of Trustees Of The Leland Stanford Junior University |
Site-specific integration of transgenes into human cells
|
|
ES2813367T3
(es)
|
2013-12-09 |
2021-03-23 |
Sangamo Therapeutics Inc |
Métodos y composiciones para ingeniería genómica
|
|
US10774338B2
(en)
|
2014-01-16 |
2020-09-15 |
The Regents Of The University Of California |
Generation of heritable chimeric plant traits
|
|
HUE051232T2
(hu)
|
2014-02-03 |
2021-03-01 |
Sangamo Therapeutics Inc |
Béta-talasszémia kezelésére szolgáló eljárások és készítmények
|
|
AU2015218576B2
(en)
|
2014-02-24 |
2020-02-27 |
Sangamo Therapeutics, Inc. |
Methods and compositions for nuclease-mediated targeted integration
|
|
TW201538518A
(zh)
|
2014-02-28 |
2015-10-16 |
Dow Agrosciences Llc |
藉由嵌合基因調控元件所賦予之根部特異性表現
|
|
JP6594891B2
(ja)
|
2014-03-18 |
2019-10-23 |
サンガモ セラピューティクス, インコーポレイテッド |
ジンクフィンガータンパク質発現を調節するための方法および組成物
|
|
MX392639B
(es)
|
2014-03-21 |
2025-03-24 |
Univ Leland Stanford Junior |
Vectores virales recombinantes para la integración de transgenes
|
|
WO2015153889A2
(en)
|
2014-04-02 |
2015-10-08 |
University Of Florida Research Foundation, Incorporated |
Materials and methods for the treatment of latent viral infection
|
|
US9522936B2
(en)
|
2014-04-24 |
2016-12-20 |
Sangamo Biosciences, Inc. |
Engineered transcription activator like effector (TALE) proteins
|
|
CN106413760B
(zh)
|
2014-05-08 |
2020-01-14 |
桑格摩生物科学股份有限公司 |
用于治疗亨廷顿病的方法和组合物
|
|
US11918695B2
(en)
|
2014-05-09 |
2024-03-05 |
Yale University |
Topical formulation of hyperbranched polymer-coated particles
|
|
EP3139909B1
(de)
|
2014-05-09 |
2025-01-01 |
Yale University |
Mit hyperverzweigtem polyglycerin beschichtete partikeln
|
|
WO2015175642A2
(en)
|
2014-05-13 |
2015-11-19 |
Sangamo Biosciences, Inc. |
Methods and compositions for prevention or treatment of a disease
|
|
EP3151846A4
(de)
|
2014-06-05 |
2017-12-27 |
Sangamo BioSciences, Inc. |
Verfahren und zusammensetzungen zur nukleasekonstruktion
|
|
EP3166964A1
(de)
|
2014-07-08 |
2017-05-17 |
Vib Vzw |
Mittel und verfahren zur steigerung des pflanzenertrags
|
|
FI3169778T3
(fi)
|
2014-07-14 |
2023-12-13 |
Univ Washington State |
Ituradan soluja ablatoiva nanos-geeninpoisto
|
|
AU2015289644A1
(en)
|
2014-07-15 |
2017-02-02 |
Juno Therapeutics, Inc. |
Engineered cells for adoptive cell therapy
|
|
US11278572B2
(en)
|
2014-07-18 |
2022-03-22 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Reducing CXCR4 expression and/or function to enhance engraftment of hematopoietic stem cells
|
|
US9757420B2
(en)
|
2014-07-25 |
2017-09-12 |
Sangamo Therapeutics, Inc. |
Gene editing for HIV gene therapy
|
|
US9816074B2
(en)
|
2014-07-25 |
2017-11-14 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
|
|
US9616090B2
(en)
|
2014-07-30 |
2017-04-11 |
Sangamo Biosciences, Inc. |
Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
|
|
HUE055583T2
(hu)
|
2014-09-16 |
2021-12-28 |
Sangamo Therapeutics Inc |
Eljárások és készítmények nukleáz által közvetített genommódosításhoz és -javításhoz hematopoetikus õssejtekben
|
|
US10889834B2
(en)
|
2014-12-15 |
2021-01-12 |
Sangamo Therapeutics, Inc. |
Methods and compositions for enhancing targeted transgene integration
|
|
HK1246690A1
(zh)
|
2015-01-21 |
2018-09-14 |
Sangamo Therapeutics, Inc. |
用於鉴定高度特异性核酸酶的方法和组合物
|
|
WO2016123100A1
(en)
|
2015-01-26 |
2016-08-04 |
Fate Therapeutics, Inc. |
Methods and compositions for inducing hematopoietic cell differentiation
|
|
JP6929791B2
(ja)
|
2015-02-09 |
2021-09-01 |
デューク ユニバーシティ |
エピゲノム編集のための組成物および方法
|
|
WO2016159110A1
(ja)
*
|
2015-03-31 |
2016-10-06 |
国立研究開発法人農業生物資源研究所 |
バイナリー遺伝子発現システム
|
|
WO2016161446A1
(en)
|
2015-04-03 |
2016-10-06 |
Dana-Farber Cancer Institute, Inc. |
Composition and methods of genome editing of b-cells
|
|
BR112017021703B1
(pt)
|
2015-04-15 |
2023-11-28 |
Corteva Agriscience Llc |
Promotor de planta para expressão de transgene
|
|
EP3283633A2
(de)
|
2015-04-15 |
2018-02-21 |
Dow AgroSciences LLC |
Pflanzenpromoter zur transgenen expression
|
|
CN108026566A
(zh)
|
2015-05-04 |
2018-05-11 |
特拉维夫大学拉莫特有限公司 |
用于使dna片段化的方法和试剂盒
|
|
US10179918B2
(en)
|
2015-05-07 |
2019-01-15 |
Sangamo Therapeutics, Inc. |
Methods and compositions for increasing transgene activity
|
|
JP6873917B2
(ja)
|
2015-05-12 |
2021-05-19 |
サンガモ セラピューティクス, インコーポレイテッド |
ヌクレアーゼ介在性遺伝子発現調節
|
|
MA43344A
(fr)
|
2015-05-29 |
2018-04-11 |
Juno Therapeutics Inc |
Composition et procédés de régulation des interactions inhibitrices dans les cellules génétiquement modifiées
|
|
US9957501B2
(en)
|
2015-06-18 |
2018-05-01 |
Sangamo Therapeutics, Inc. |
Nuclease-mediated regulation of gene expression
|
|
CN108024544B
(zh)
|
2015-07-13 |
2022-04-29 |
桑格摩生物治疗股份有限公司 |
用于核酸酶介导的基因组工程化的递送方法及组合物
|
|
MA42895A
(fr)
|
2015-07-15 |
2018-05-23 |
Juno Therapeutics Inc |
Cellules modifiées pour thérapie cellulaire adoptive
|
|
RU2018107842A
(ru)
|
2015-08-06 |
2019-09-09 |
Дзе Кьюрейторз Оф Дзе Юниверсити Оф Миссури |
Устойчивые к патогенам животные, имеющие модифицированные гены cd163
|
|
TW201718862A
(zh)
|
2015-09-22 |
2017-06-01 |
Dow Agrosciences Llc |
用於轉殖基因表現之植物啟動子及3’utr
|
|
TW201718861A
(zh)
|
2015-09-22 |
2017-06-01 |
道禮責任有限公司 |
用於轉殖基因表現之植物啟動子及3’utr
|
|
LT3352776T
(lt)
|
2015-09-23 |
2025-07-10 |
Sangamo Therapeutics, Inc. |
Htt represoriai ir jų panaudojimas
|
|
EP4089175A1
(de)
|
2015-10-13 |
2022-11-16 |
Duke University |
Genom-engineering mit typ-i-crispr-systemen in eukaryotischen zellen
|
|
CN108473997B
(zh)
|
2015-10-22 |
2022-04-12 |
美国陶氏益农公司 |
用于转基因表达的植物启动子
|
|
CN108368520B
(zh)
|
2015-11-04 |
2023-01-17 |
菲特治疗公司 |
多能细胞的基因组工程改造
|
|
WO2017078807A1
(en)
|
2015-11-04 |
2017-05-11 |
Fate Therapeutics, Inc. |
Methods and compositions for inducing hematopoietic cell differentiation
|
|
US20170121726A1
(en)
|
2015-11-04 |
2017-05-04 |
Dow Agrosciences Llc |
Plant promoter for transgene expression
|
|
US10639383B2
(en)
|
2015-11-23 |
2020-05-05 |
Sangamo Therapeutics, Inc. |
Methods and compositions for engineering immunity
|
|
WO2017095967A2
(en)
|
2015-11-30 |
2017-06-08 |
Duke University |
Therapeutic targets for the correction of the human dystrophin gene by gene editing and methods of use
|
|
AU2016374253B2
(en)
|
2015-12-18 |
2021-10-21 |
Sangamo Therapeutics, Inc. |
Targeted disruption of the MHC cell receptor
|
|
ES2983043T3
(es)
|
2015-12-18 |
2024-10-21 |
Sangamo Therapeutics Inc |
Alteración dirigida del receptor de células T
|
|
AU2017207818B2
(en)
|
2016-01-15 |
2024-03-28 |
Regents Of The University Of Minnesota |
Methods and compositions for the treatment of neurologic disease
|
|
CN109069568B
(zh)
|
2016-02-02 |
2023-07-07 |
桑格摩生物治疗股份有限公司 |
用于连接dna结合结构域和切割结构域的组合物
|
|
CA3014795A1
(en)
|
2016-02-16 |
2017-08-24 |
Yale University |
Compositions and methods for treatment of cystic fibrosis
|
|
EP3416976A2
(de)
|
2016-02-16 |
2018-12-26 |
Yale University |
Zusammensetzungen zur verbesserung von gezielter geneditierung und verfahren zur verwendung davon
|
|
AU2017238512B2
(en)
|
2016-03-23 |
2022-12-08 |
Dana-Farber Cancer Institute, Inc. |
Methods for enhancing the efficiency of gene editing
|
|
WO2017173453A1
(en)
|
2016-04-01 |
2017-10-05 |
The Brigham And Women's Hospital, Inc. |
Stimuli-responsive nanoparticles for biomedical applications
|
|
EP3443081A4
(de)
|
2016-04-13 |
2019-10-30 |
Duke University |
Crispr/cas9-basierte repressoren zur in-vivo-ausschaltung von gen-targets und verfahren zur verwendung
|
|
US11514331B2
(en)
|
2016-04-27 |
2022-11-29 |
Massachusetts Institute Of Technology |
Sequence-controlled polymer random access memory storage
|
|
US11410746B2
(en)
|
2016-04-27 |
2022-08-09 |
Massachusetts Institute Of Technology |
Stable nanoscale nucleic acid assemblies and methods thereof
|
|
EP3475706B1
(de)
|
2016-06-27 |
2021-08-11 |
Juno Therapeutics, Inc. |
Mhc-e-beschränkte epitopen, bindungsmoleküle, und zugehörige verfahren und verwendungen
|
|
US20200182884A1
(en)
|
2016-06-27 |
2020-06-11 |
Juno Therapeutics, Inc. |
Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
|
|
EP3484870B1
(de)
|
2016-07-13 |
2022-11-16 |
Vertex Pharmaceuticals Incorporated |
Verfahren, zusammensetzungen und kits zur erhöhung der genomeditierungseffizienz
|
|
EP4275747A3
(de)
|
2016-07-19 |
2024-01-24 |
Duke University |
Therapeutische anwendungen von cpf1-basierter genomeditierung
|
|
EP3490556A4
(de)
|
2016-07-27 |
2020-04-15 |
Case Western Reserve University |
Verbindungen und verfahren zur förderung der myelinisierung
|
|
WO2018029034A1
(en)
|
2016-08-09 |
2018-02-15 |
Vib Vzw |
Cellulose synthase inhibitors and mutant plants
|
|
BR112019003100A2
(pt)
|
2016-08-24 |
2019-07-09 |
Sangamo Therapeutics, Inc. |
regulação da expressão gênica usando nucleases manipuladas
|
|
IL300783B2
(en)
|
2016-08-24 |
2026-03-01 |
Sangamo Therapeutics Inc |
Engineered nucleases with target-specific zinc fingers
|
|
WO2018049009A2
(en)
|
2016-09-07 |
2018-03-15 |
Sangamo Therapeutics, Inc. |
Modulation of liver genes
|
|
US10400246B2
(en)
|
2016-10-03 |
2019-09-03 |
Dow Agrosciences Llc |
Plant promoter for transgene expression
|
|
WO2018067265A1
(en)
|
2016-10-03 |
2018-04-12 |
Dow Agrosciences Llc |
Plant promoter for transgene expression
|
|
EP3519433A1
(de)
|
2016-10-03 |
2019-08-07 |
Juno Therapeutics, Inc. |
Hpv-spezifische bindungsmoleküle
|
|
EP3523422B1
(de)
|
2016-10-05 |
2024-12-25 |
FUJIFILM Cellular Dynamics, Inc. |
Erzeugung reifer linien aus induzierten pluripotenten stammzellen mit mecp2-unterbrechung
|
|
ES2939646T3
(es)
|
2016-10-13 |
2023-04-25 |
Juno Therapeutics Inc |
Métodos y composiciones de inmunoterapia que comprenden moduladores de la vía metabólica del triptófano
|
|
CN110022904B
(zh)
|
2016-10-20 |
2024-04-19 |
桑格摩生物治疗股份有限公司 |
用于治疗法布里病的方法和组合物
|
|
US11766400B2
(en)
|
2016-10-24 |
2023-09-26 |
Yale University |
Biodegradable contraceptive implants
|
|
US11020492B2
(en)
|
2016-10-31 |
2021-06-01 |
Sangamo Therapeutics, Inc. |
Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
|
|
EP3548616A4
(de)
|
2016-12-01 |
2020-05-13 |
Sangamo Therapeutics, Inc. |
Tau-modulatoren und verfahren und zusammensetzungen zur abgabe davon
|
|
AU2017367695A1
(en)
|
2016-12-02 |
2019-06-13 |
Juno Therapeutics, Inc. |
Engineered B cells and related compositions and methods
|
|
MA46998A
(fr)
|
2016-12-05 |
2019-10-09 |
Juno Therapeutics Inc |
Production de cellules modifiées pour une thérapie cellulaire adoptive
|
|
CA3046199A1
(en)
|
2016-12-08 |
2018-06-14 |
Case Western Reserve University |
Methods and compositions for enhancing functional myelin production
|
|
WO2018112470A1
(en)
|
2016-12-16 |
2018-06-21 |
The Brigham And Women's Hospital, Inc. |
Co-delivery of nucleic acids for simultaneous suppression and expression of target genes
|
|
CN119351474A
(zh)
|
2017-02-22 |
2025-01-24 |
克里斯珀医疗股份公司 |
用于基因编辑的组合物和方法
|
|
US20200113821A1
(en)
|
2017-04-04 |
2020-04-16 |
Yale University |
Compositions and methods for in utero delivery
|
|
KR20190140950A
(ko)
|
2017-04-20 |
2019-12-20 |
오레곤 헬스 앤드 사이언스 유니버시티 |
인간 유전자 교정
|
|
ES2981244T3
(es)
|
2017-04-28 |
2024-10-07 |
Acuitas Therapeutics Inc |
Novedosas formulaciones de nanopartículas de lípidos de carbonilo y lípidos para la administración de ácidos nucleicos
|
|
US11655275B2
(en)
|
2017-05-03 |
2023-05-23 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modification of a cystic fibrosis transmembrane conductance regulator (CFTR) gene
|
|
KR20200026874A
(ko)
|
2017-06-06 |
2020-03-11 |
지머젠 인코포레이티드 |
대장균 개량을 위한 htp 게놈 공학 플랫폼
|
|
US11512287B2
(en)
|
2017-06-16 |
2022-11-29 |
Sangamo Therapeutics, Inc. |
Targeted disruption of T cell and/or HLA receptors
|
|
CN111278276B
(zh)
|
2017-06-28 |
2023-05-26 |
美国陶氏益农公司 |
用于转基因表达的植物启动子
|
|
CA3071683A1
(en)
|
2017-08-08 |
2019-02-14 |
Sangamo Therapeutics, Inc. |
Chimeric antigen receptor mediated cell targeting
|
|
EP3692063A1
(de)
|
2017-10-03 |
2020-08-12 |
Juno Therapeutics, Inc. |
Hpv-spezifische bindungsmoleküle
|
|
US11225670B2
(en)
|
2017-10-30 |
2022-01-18 |
Corteva Agriscience Llc |
Plant promoter for transgene expression
|
|
WO2019089982A1
(en)
|
2017-11-01 |
2019-05-09 |
Juno Therapeutics, Inc. |
Method of assessing activity of recombinant antigen receptors
|
|
BR112020008568A2
(pt)
|
2017-11-09 |
2020-10-06 |
Sangamo Therapeutics, Inc. |
modificação genética de gene de proteína contendo sh2 indutível por citoquina (cish)
|
|
WO2019094928A1
(en)
|
2017-11-10 |
2019-05-16 |
Massachusetts Institute Of Technology |
Microbial production of pure single stranded nucleic acids
|
|
WO2019100053A1
(en)
|
2017-11-20 |
2019-05-23 |
University Of Georgia Research Foundation, Inc. |
Compositions and methods for modulating hif-2α to improve muscle generation and repair
|
|
JP7401432B2
(ja)
|
2017-12-01 |
2023-12-19 |
エンコーデッド セラピューティクス, インコーポレイテッド |
操作されたdna結合タンパク質
|
|
EP3728587A4
(de)
|
2017-12-18 |
2022-01-26 |
Syngenta Participations Ag |
Stellen zur gezielten insertion im maisgenom
|
|
KR20250048610A
(ko)
|
2017-12-22 |
2025-04-09 |
페이트 세러퓨틱스, 인코포레이티드 |
향상된 면역 효과기 세포 및 이의 용도
|
|
AU2019209292B2
(en)
|
2018-01-17 |
2023-10-05 |
Vertex Pharmaceuticals Incorporated |
Quinoxalinone compounds, compositions, methods, and kits for increasing genome editing efficiency
|
|
JP7391854B2
(ja)
|
2018-01-17 |
2023-12-05 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Dna-pk阻害剤
|
|
BR112020014140A2
(pt)
|
2018-01-17 |
2020-12-01 |
Vertex Pharmaceuticals Incorporated |
inibidores de dna-pk
|
|
US12509492B2
(en)
|
2018-01-19 |
2025-12-30 |
Duke University |
Genome engineering with CRISPR-Cas systems in eukaryotes
|
|
CN111954540A
(zh)
|
2018-02-08 |
2020-11-17 |
桑格摩生物治疗股份有限公司 |
工程化靶标特异性核酸酶
|
|
WO2019191495A1
(en)
|
2018-03-29 |
2019-10-03 |
Fate Therapeutics, Inc. |
Engineered immune effector cells and use thereof
|
|
AU2019247199A1
(en)
|
2018-04-05 |
2020-10-15 |
Editas Medicine, Inc. |
T cells expressing a recombinant receptor, related polynucleotides and methods
|
|
EP3775238A1
(de)
|
2018-04-05 |
2021-02-17 |
Juno Therapeutics, Inc. |
Verfahren zur herstellung von zellen, die einen rekombinanten rezeptor exprimieren, und verwandte zusammensetzungen
|
|
CN112566698A
(zh)
|
2018-04-05 |
2021-03-26 |
朱诺治疗学股份有限公司 |
T细胞受体和表达该t细胞受体的工程化细胞
|
|
US11421007B2
(en)
|
2018-04-18 |
2022-08-23 |
Sangamo Therapeutics, Inc. |
Zinc finger protein compositions for modulation of huntingtin (Htt)
|
|
EP3790629A1
(de)
|
2018-05-11 |
2021-03-17 |
CRISPR Therapeutics AG |
Verfahren und zusammensetzungen zur behandlung von krebs
|
|
US11690921B2
(en)
|
2018-05-18 |
2023-07-04 |
Sangamo Therapeutics, Inc. |
Delivery of target specific nucleases
|
|
GB201809273D0
(en)
|
2018-06-06 |
2018-07-25 |
Vib Vzw |
Novel mutant plant cinnamoyl-coa reductase proteins
|
|
CA3102975A1
(en)
|
2018-06-07 |
2019-12-12 |
The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) |
Methods of regenerating and transforming cannabis
|
|
US11827892B2
(en)
|
2018-06-07 |
2023-11-28 |
The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) |
Nucleic acid constructs and methods of using same
|
|
WO2020028617A1
(en)
|
2018-08-01 |
2020-02-06 |
University Of Georgia Research Foundation, Inc. |
Compositions and methods for improving embryo development
|
|
EP3841204A4
(de)
|
2018-08-23 |
2022-05-18 |
Sangamo Therapeutics, Inc. |
Modifizierte zielspezifische basiseditoren
|
|
EP3844287B1
(de)
|
2018-08-31 |
2024-05-22 |
Yale University |
Zusammensetzungen und verfahren zur verbesserung der oligonukleotidbasierten geneditierung
|
|
WO2020047353A1
(en)
|
2018-08-31 |
2020-03-05 |
Yale University |
Compositions and methods for enhancing triplex and nuclease-based gene editing
|
|
AU2019344927A1
(en)
|
2018-09-18 |
2021-04-01 |
Sangamo Therapeutics, Inc. |
Programmed cell death 1 (PD1) specific nucleases
|
|
IL281615B2
(en)
|
2018-09-21 |
2026-01-01 |
Acuitas Therapeutics Inc |
Systems and methods for producing lipid nanoparticles and liposomes
|
|
CN113226333A
(zh)
|
2018-10-02 |
2021-08-06 |
桑格摩生物治疗股份有限公司 |
用于调控Tau蛋白的方法和组合物
|
|
US12583816B2
(en)
|
2018-10-18 |
2026-03-24 |
Acuitas Therapeutics, Inc. |
Lipids for lipid nanoparticle delivery of active agents
|
|
WO2020095248A1
(en)
|
2018-11-07 |
2020-05-14 |
Crispr Therapeutics Ag |
Anti-ptk7 immune cell cancer therapy
|
|
US20220226375A1
(en)
|
2018-11-07 |
2022-07-21 |
Crispr Therapeutics Ag |
Anti-cd33 immune cell cancer therapy
|
|
WO2020095249A1
(en)
|
2018-11-07 |
2020-05-14 |
Crispr Therapeutics Ag |
Anti-liv1 immune cell cancer therapy
|
|
WO2020112195A1
(en)
|
2018-11-30 |
2020-06-04 |
Yale University |
Compositions, technologies and methods of using plerixafor to enhance gene editing
|
|
SG11202105480WA
(en)
|
2018-12-02 |
2021-06-29 |
Fate Therapeutics Inc |
IMMUNOTHERAPIES USING ENHANCED iPSC DERIVED EFFECTOR CELLS
|
|
CA3121781A1
(en)
|
2018-12-05 |
2020-06-11 |
Vertex Pharmaceuticals Incorporated |
Gene-editing systems for editing a cystic fibrosis transmembrane regulator (cftr) gene
|
|
GB201820109D0
(en)
|
2018-12-11 |
2019-01-23 |
Vib Vzw |
Plants with a lignin trait and udp-glycosyltransferase mutation
|
|
JP7523449B2
(ja)
|
2019-01-11 |
2024-07-26 |
アクイタス セラピューティクス インコーポレイテッド |
活性剤の脂質ナノ粒子送達のための脂質
|
|
US12156877B1
(en)
|
2019-01-15 |
2024-12-03 |
The Regents Of The University Of California |
Methods of treating conditions related to a thiamine deficiency, a thiamine-dependent enzyme, or an associated cofactor
|
|
WO2020154595A1
(en)
|
2019-01-24 |
2020-07-30 |
Massachusetts Institute Of Technology |
Nucleic acid nanostructure platform for antigen presentation and vaccine formulations formed therefrom
|
|
US11857641B2
(en)
|
2019-02-06 |
2024-01-02 |
Sangamo Therapeutics, Inc. |
Method for the treatment of mucopolysaccharidosis type I
|
|
CN114174327A
(zh)
|
2019-03-08 |
2022-03-11 |
黑曜石疗法公司 |
用于可调整调控的cd40l组合物和方法
|
|
US20200316116A1
(en)
|
2019-04-02 |
2020-10-08 |
Sangamo Therapeutics, Inc. |
Method for the treatment of beta-thalassemia
|
|
PH12021552554A1
(en)
|
2019-04-23 |
2022-07-04 |
Sangamo Therapeutics Inc |
Modulators of chromosome 9 open reading frame 72 gene expression and uses thereof
|
|
MX2021013223A
(es)
|
2019-05-01 |
2022-02-17 |
Juno Therapeutics Inc |
Celulas que expresan un receptor quimerico de un locus cd247 modificado, polinucleotidos relacionados y metodos.
|
|
AU2020265741A1
(en)
|
2019-05-01 |
2021-11-25 |
Editas Medicine, Inc. |
Cells expressing a recombinant receptor from a modified TGFBR2 Locus, related polynucleotides and methods
|
|
WO2020243651A1
(en)
|
2019-05-29 |
2020-12-03 |
Encoded Therapeutics, Inc. |
Compositions and methods for selective gene regulation
|
|
US11905532B2
(en)
|
2019-06-25 |
2024-02-20 |
Massachusetts Institute Of Technology |
Compositions and methods for molecular memory storage and retrieval
|
|
KR20220026586A
(ko)
|
2019-06-27 |
2022-03-04 |
크리스퍼 테라퓨틱스 아게 |
암 치료를 위한 키메라 항원 수용체 t세포 및 nk세포 억제제의 용도
|
|
CA3146967A1
(en)
|
2019-07-17 |
2021-01-21 |
Fate Therapeutics, Inc. |
Immune effector cell engineering and use thereof
|
|
WO2021022223A1
(en)
|
2019-08-01 |
2021-02-04 |
Sana Biotechnology, Inc. |
Dux4 expressing cells and uses thereof
|
|
JP7728747B2
(ja)
|
2019-08-23 |
2025-08-25 |
サナ バイオテクノロジー,インコーポレイテッド |
Cd24発現細胞およびそれらの用途
|
|
US12485180B2
(en)
|
2019-08-30 |
2025-12-02 |
Yale University |
Compositions and methods for delivery of nucleic acids to cells
|
|
MX2022002763A
(es)
|
2019-09-06 |
2022-04-06 |
Crispr Therapeutics Ag |
Linfocitos t modificados por ingenieria genetica que tienen persistencia mejorada en cultivo.
|
|
US20230002459A1
(en)
|
2019-10-02 |
2023-01-05 |
Sangamo Therapeutics, Inc. |
Zinc Finger Protein Transcription Factors for Treatment of Prion Disease
|
|
US20230048224A1
(en)
|
2019-11-01 |
2023-02-16 |
Sangamo Therapeutics, Inc. |
Zinc finger nuclease variants for treating or preventing lysosomal storage diseases
|
|
TW202132565A
(zh)
|
2019-11-01 |
2021-09-01 |
美商聖加莫治療股份有限公司 |
Gin重組酶變異體
|
|
MX2022008415A
(es)
|
2020-01-08 |
2022-08-08 |
Obsidian Therapeutics Inc |
Composiciones y metodos para la regulacion ajustable de la transcripcion.
|
|
WO2021155065A1
(en)
|
2020-01-28 |
2021-08-05 |
The Broad Institute, Inc. |
Base editors, compositions, and methods for modifying the mitochondrial genome
|
|
BR112022019060A2
(pt)
|
2020-03-25 |
2022-11-29 |
Sana Biotechnology Inc |
Células neurais hipoimunogênicas para o tratamento de distúrbios e condições neurológicas
|
|
US12534744B2
(en)
|
2020-05-06 |
2026-01-27 |
Cellectis S.A. |
Methods to genetically modify cells for delivery of therapeutic proteins
|
|
CN115803435A
(zh)
|
2020-05-06 |
2023-03-14 |
塞勒克提斯公司 |
用于在细胞基因组中靶向插入外源序列的方法
|
|
KR20230022868A
(ko)
|
2020-05-13 |
2023-02-16 |
주노 쎄러퓨티크스 인코퍼레이티드 |
재조합 수용체를 발현하는 공여자-배치 세포의 제조 방법
|
|
US20230190871A1
(en)
|
2020-05-20 |
2023-06-22 |
Sana Biotechnology, Inc. |
Methods and compositions for treatment of viral infections
|
|
WO2021247836A1
(en)
|
2020-06-03 |
2021-12-09 |
Board Of Regents, The University Of Texas System |
Methods for targeting shp-2 to overcome resistance
|
|
MX2022015863A
(es)
|
2020-06-19 |
2023-03-23 |
Fate Therapeutics Inc |
Combinación de tipos de células efectoras derivadas de células madre pluripotentes inducidas (ipsc) para uso en inmunoterapia.
|
|
WO2021260186A1
(en)
|
2020-06-26 |
2021-12-30 |
Juno Therapeutics Gmbh |
Engineered t cells conditionally expressing a recombinant receptor, related polynucleotides and methods
|
|
JP7798855B2
(ja)
|
2020-07-16 |
2026-01-14 |
アクイタス セラピューティクス インコーポレイテッド |
脂質ナノ粒子に使用するためのカチオン性脂質
|
|
IL300516A
(en)
|
2020-08-13 |
2023-04-01 |
Sana Biotechnology Inc |
Methods for treating susceptible patients with hypoimmunogenic cells, and related methods and compounds
|
|
EP4501951A3
(de)
|
2020-08-25 |
2025-04-30 |
Kite Pharma, Inc. |
T-zellen mit verbesserter funktionalität
|
|
IL301014A
(en)
|
2020-08-31 |
2023-05-01 |
Univ Yale |
Compositions and methods for delivery of nucleic acids to cells
|
|
AU2021347907A1
(en)
|
2020-09-23 |
2023-04-20 |
Crispr Therapeutics Ag |
Genetically engineered t cells with regnase-1 and/or tgfbrii disruption have improved functionality and persistence
|
|
KR20230074519A
(ko)
|
2020-09-25 |
2023-05-30 |
상가모 테라퓨틱스, 인코포레이티드 |
핵염기 편집을 위한 아연 핑거 융합 단백질
|
|
WO2022098787A1
(en)
|
2020-11-04 |
2022-05-12 |
Juno Therapeutics, Inc. |
Cells expressing a chimeric receptor from a modified invariant cd3 immunoglobulin superfamily chain locus and related polynucleotides and methods
|
|
US20240000051A1
(en)
|
2020-11-16 |
2024-01-04 |
Pig Improvement Company Uk Limited |
Influenza a-resistant animals having edited anp32 genes
|
|
TW202237827A
(zh)
|
2020-12-03 |
2022-10-01 |
美商世紀治療股份有限公司 |
經基因工程改造之細胞及其用途
|
|
US11661459B2
(en)
|
2020-12-03 |
2023-05-30 |
Century Therapeutics, Inc. |
Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
|
|
WO2022137181A1
(en)
|
2020-12-23 |
2022-06-30 |
Crispr Therapeutics Ag |
Co-use of lenalidomide with car-t cells
|
|
CA3200509A1
(en)
|
2020-12-31 |
2022-07-07 |
Sonja SCHREPFER |
Methods and compositions for modulating car-t activity
|
|
EP4277989A2
(de)
|
2021-01-12 |
2023-11-22 |
March Therapeutics, Inc. |
Kontextabhängige doppelsträngige dna-spezifische deaminasen und verwendungen davon
|
|
KR20230147644A
(ko)
*
|
2021-02-04 |
2023-10-23 |
뉴욕 유니버시티 |
천연 기능을 징발하기 위한 내인성 전사 인자에 조작된 징크 핑거의 원활한 통합
|
|
EP4305153A1
(de)
|
2021-03-09 |
2024-01-17 |
CRISPR Therapeutics AG |
Genetisch veränderte t-zellen mit ptpn2-knockout mit verbesserter funktionalität und antitumoraktivität
|
|
KR20230158573A
(ko)
|
2021-03-22 |
2023-11-20 |
주노 쎄러퓨티크스 인코퍼레이티드 |
바이러스 벡터 입자의 효력을 평가하는 방법
|
|
US20220333074A1
(en)
|
2021-04-07 |
2022-10-20 |
Century Therapeutics, Inc. |
Compositions and Methods for Generating Alpha-Beta T Cells from Induced Pluripotent Stem Cells
|
|
CA3214045A1
(en)
|
2021-04-07 |
2022-10-13 |
Century Therapeutics, Inc. |
Compositions and methods for generating gamma-delta t cells from induced pluripotent stem cells
|
|
WO2022216524A1
(en)
|
2021-04-07 |
2022-10-13 |
Century Therapeutics, Inc. |
Combined artificial cell death/reporter system polypeptide for chimeric antigen receptor cell and uses thereof
|
|
EP4334438A1
(de)
|
2021-05-05 |
2024-03-13 |
Fujifilm Cellular Dynamics, Inc. |
Verfahren und zusammensetzungen für mikroglia aus ipsc
|
|
WO2022251443A1
(en)
|
2021-05-26 |
2022-12-01 |
FUJIFILM Cellular Dynamics, Inc. |
Methods to prevent rapid silencing of genes in pluripotent stem cells
|
|
BR112023024434A2
(pt)
|
2021-05-27 |
2024-02-20 |
Sana Biotechnology Inc |
Células hipoimunogênicas que compreendem hla-e ou hla-g geneticamente modificadas
|
|
CN113429487B
(zh)
*
|
2021-06-21 |
2022-04-22 |
山东大学 |
一种能在水环境中去除抗生素耐药基因的人工合成蛋白
|
|
EP4370544A2
(de)
|
2021-07-14 |
2024-05-22 |
Sana Biotechnology, Inc. |
Veränderte expression von y-chromosom-gebundenen antigenen in hypoimmunogenen zellen
|
|
EP4377459A2
(de)
|
2021-07-30 |
2024-06-05 |
Tune Therapeutics, Inc. |
Zusammensetzungen und verfahren zur modulation der expression von frataxin (fxn)
|
|
WO2023010135A1
(en)
|
2021-07-30 |
2023-02-02 |
Tune Therapeutics, Inc. |
Compositions and methods for modulating expression of methyl-cpg binding protein 2 (mecp2)
|
|
AU2022325955A1
(en)
|
2021-08-11 |
2024-02-08 |
Sana Biotechnology, Inc. |
Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions
|
|
JP2024531234A
(ja)
|
2021-08-11 |
2024-08-29 |
サナ バイオテクノロジー,インコーポレイテッド |
同種異系細胞療法のための遺伝子改変された初代細胞
|
|
MX2024001443A
(es)
|
2021-08-11 |
2024-05-15 |
Sana Biotechnology Inc |
Sistemas inducibles para alterar la expresión génica en células hipoinmunógenas.
|
|
WO2023019226A1
(en)
|
2021-08-11 |
2023-02-16 |
Sana Biotechnology, Inc. |
Genetically modified cells for allogeneic cell therapy
|
|
JP2024534771A
(ja)
|
2021-08-11 |
2024-09-26 |
サナ バイオテクノロジー,インコーポレイテッド |
補体媒介性炎症反応を低減するための同種異系細胞療法のための遺伝子改変細胞
|
|
KR20240055838A
(ko)
|
2021-09-10 |
2024-04-29 |
후지필름 셀룰러 다이내믹스, 인코포레이티드 |
유도된 만능 줄기 세포 유래된 세포의 조성물 및 이의 사용 방법
|
|
US20230128917A1
(en)
|
2021-09-14 |
2023-04-27 |
Crispr Therapeutics Ag |
Genetically engineered immune cells having a disrupted cd83 gene
|
|
WO2023070043A1
(en)
|
2021-10-20 |
2023-04-27 |
Yale University |
Compositions and methods for targeted editing and evolution of repetitive genetic elements
|
|
AU2022371442A1
(en)
|
2021-10-21 |
2024-04-18 |
Vertex Pharmaceuticals Incorporated |
Hypoimmune cells
|
|
US20250313861A1
(en)
|
2021-10-22 |
2025-10-09 |
Sana Biotechnology, Inc. |
Methods of engineering allogeneic t cells with a transgene in a tcr locus and associated compositions and methods
|
|
US20240409934A1
(en)
|
2021-10-25 |
2024-12-12 |
Board Of Regents, The University Of Texas System |
Foxo1-targeted therapy for the treatment of cancer
|
|
CA3235390A1
(en)
|
2021-10-29 |
2023-05-04 |
Deepika Rajesh |
Dopaminergic neurons comprising mutations and methods of use thereof
|
|
EP4426832A1
(de)
|
2021-11-03 |
2024-09-11 |
The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone |
Genaue genomeditierung mit retrons
|
|
WO2023081900A1
(en)
|
2021-11-08 |
2023-05-11 |
Juno Therapeutics, Inc. |
Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods
|
|
WO2023105244A1
(en)
|
2021-12-10 |
2023-06-15 |
Pig Improvement Company Uk Limited |
Editing tmprss2/4 for disease resistance in livestock
|
|
WO2023111913A1
(en)
|
2021-12-15 |
2023-06-22 |
Crispr Therapeutics Ag |
Engineered anti-liv1 cell with regnase-1 and/or tgfbrii disruption
|
|
CA3242402A1
(en)
|
2021-12-16 |
2023-06-22 |
Acuitas Therapeutics, Inc. |
Lipids for use in lipid nanoparticle formulations
|
|
WO2023119201A2
(en)
|
2021-12-22 |
2023-06-29 |
Crispr Therapeutics Ag |
Genetically engineered t cells with disrupted casitas b-lineage lymphoma proto-oncogene-b (cblb) and uses thereof
|
|
US20250361528A1
(en)
|
2021-12-22 |
2025-11-27 |
Sangamo Therapeutics, Inc. |
Novel zinc finger fusion proteins for nucleobase editing
|
|
MX2024007528A
(es)
|
2021-12-23 |
2024-08-30 |
Sana Biotechnology Inc |
Linfocitos t del receptor de antígeno quimérico (car) para el tratamiento de enfermedades autoinmunitarias y métodos asociados.
|
|
WO2023129937A1
(en)
|
2021-12-29 |
2023-07-06 |
Century Therapeutics, Inc. |
Genetically engineered cells having anti-cd19 / anti-cd22 chimeric antigen receptors, and uses thereof
|
|
WO2023131616A1
(en)
|
2022-01-05 |
2023-07-13 |
Vib Vzw |
Means and methods to increase abiotic stress tolerance in plants
|
|
WO2023131637A1
(en)
|
2022-01-06 |
2023-07-13 |
Vib Vzw |
Improved silage grasses
|
|
CA3247927A1
(en)
|
2022-01-14 |
2023-07-20 |
Tune Therapeutics, Inc. |
Compositions, systems and methods for programming T-lymphocyte phenotypes by targeted gene repression
|
|
US20250134999A1
(en)
|
2022-01-14 |
2025-05-01 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for programming t cell phenotypes through targeted gene activation
|
|
WO2023141602A2
(en)
|
2022-01-21 |
2023-07-27 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
|
WO2023144199A1
(en)
|
2022-01-26 |
2023-08-03 |
Vib Vzw |
Plants having reduced levels of bitter taste metabolites
|
|
US20250302953A1
(en)
|
2022-02-14 |
2025-10-02 |
Sana Biotechnology, Inc. |
Methods of treating patients exhibiting a prior failed therapy with hypoimmunogenic cells
|
|
JP2025508720A
(ja)
|
2022-02-17 |
2025-04-10 |
サナ バイオテクノロジー,インコーポレイテッド |
遺伝子操作されたcd47タンパク質及びその使用関連出願の相互参照
|
|
TW202340457A
(zh)
|
2022-02-28 |
2023-10-16 |
美商凱特製藥公司 |
同種異體治療細胞
|
|
US12037616B2
(en)
|
2022-03-01 |
2024-07-16 |
Crispr Therapeutics Ag |
Methods and compositions for treating angiopoietin-like 3 (ANGPTL3) related conditions
|
|
US20250101382A1
(en)
|
2022-03-11 |
2025-03-27 |
Sana Biotechnology, Inc. |
Genetically modified cells and compositions and uses thereof
|
|
TW202403046A
(zh)
|
2022-03-21 |
2024-01-16 |
瑞士商Crispr治療公司 |
用於治療脂蛋白相關的疾病之方法及組成物
|
|
TW202346575A
(zh)
|
2022-03-23 |
2023-12-01 |
瑞士商Crispr治療公司 |
具有regnase-1及/或tgfbrii破壞的抗cd83 car-t細胞
|
|
WO2023180968A1
(en)
|
2022-03-23 |
2023-09-28 |
Crispr Therapeutics Ag |
Anti-cd19 car-t cells with multiple gene edits and therapeutic uses thereof
|
|
US20230302423A1
(en)
|
2022-03-28 |
2023-09-28 |
Massachusetts Institute Of Technology |
Rna scaffolded wireframe origami and methods thereof
|
|
KR20250005097A
(ko)
|
2022-04-08 |
2025-01-09 |
페이트 세러퓨틱스, 인코포레이티드 |
고형 종양 표적화 골격을 갖는 세포 및 이의 용도
|
|
JP7707304B2
(ja)
|
2022-04-08 |
2025-07-14 |
フェイト セラピューティクス,インコーポレイティド |
腫瘍標的化のためのキメラ抗原受容体
|
|
CA3255335A1
(en)
|
2022-05-27 |
2023-11-30 |
President And Fellows Of Harvard College |
IMPROVED MITOCHONDRIAL BASIS EDITORS AND MITOCHONDRIAL DNA EDITING METHODS
|
|
WO2023240147A1
(en)
|
2022-06-08 |
2023-12-14 |
Century Therapeutics, Inc. |
Genetically engineered cells expressing cd16 variants and nkg2d and uses thereof
|
|
US20250090582A1
(en)
|
2022-06-08 |
2025-03-20 |
Century Therapeutics, Inc. |
Genetically engineered cells having anti-cd133 / anti-egfr chimeric antigen receptors, and uses thereof
|
|
CA3257650A1
(en)
|
2022-06-08 |
2023-12-14 |
Century Therapeutics, Inc. |
Immunoeffector cells derived from genetically modified, multipotential stem cells with membrane IL-12 and their uses
|
|
EP4540387A2
(de)
|
2022-06-17 |
2025-04-23 |
CRISPR Therapeutics AG |
Auf lipidnanopartikeln (lnps) basierende okulare freisetzung
|
|
US20250381304A1
(en)
|
2022-06-21 |
2025-12-18 |
Crispr Therapeutics Ag |
Methods and compositions for in vivo editing of stem cells
|
|
WO2023248145A1
(en)
|
2022-06-21 |
2023-12-28 |
Crispr Therapeutics Ag |
Compositions and methods for treating human immunodeficiency virus
|
|
KR20250044484A
(ko)
|
2022-06-24 |
2025-03-31 |
튠 쎄라퓨틱스, 인코포레이티드 |
표적 유전자 억제를 통해 저밀도 지단백질을 감소시키기 위한 조성물, 시스템, 및 방법
|
|
WO2024006911A1
(en)
|
2022-06-29 |
2024-01-04 |
FUJIFILM Holdings America Corporation |
Ipsc-derived astrocytes and methods of use thereof
|
|
WO2024003786A1
(en)
|
2022-06-29 |
2024-01-04 |
Crispr Therapeutics Ag |
Chimeric antigen receptor targeting gpc-3 and immune cells expressing such for therapeutic uses
|
|
EP4554967A2
(de)
|
2022-07-12 |
2025-05-21 |
Tune Therapeutics, Inc. |
Zusammensetzungen, systeme und verfahren zur gezielten transkriptionsaktivierung
|
|
WO2024013514A2
(en)
|
2022-07-15 |
2024-01-18 |
Pig Improvement Company Uk Limited |
Gene edited livestock animals having coronavirus resistance
|
|
AU2023311477A1
(en)
|
2022-07-22 |
2025-01-30 |
The Johns Hopkins University |
Dendrimer-enabled targeted intracellular crispr/cas system delivery and gene editing
|
|
WO2024023801A2
(en)
|
2022-07-29 |
2024-02-01 |
Crispr Therapeutics Ag |
Genetically engineered immune cells having disrupted transporter associated with antigen processing-1 (tap-1) gene
|
|
WO2024023804A2
(en)
|
2022-07-29 |
2024-02-01 |
Crispr Therapeutics Ag |
Genetically engineered immune cells having disrupted transporter associated with antigen processing binding protein (tapbp) gene
|
|
WO2024023802A2
(en)
|
2022-07-29 |
2024-02-01 |
Crispr Therapeutics Ag |
Genetically engineered immune cells having disrupted transporter associated with antigen processing-2 (tap-2) gene
|
|
CN120435557A
(zh)
|
2022-08-19 |
2025-08-05 |
图恩疗法股份有限公司 |
通过靶向基因阻遏调节乙型肝炎病毒的组合物、系统和方法
|
|
WO2024044723A1
(en)
|
2022-08-25 |
2024-02-29 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
|
WO2024064642A2
(en)
|
2022-09-19 |
2024-03-28 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for modulating t cell function
|
|
WO2024062388A2
(en)
|
2022-09-20 |
2024-03-28 |
Crispr Therapeutics Ag |
Genetically engineered immune cells expressing chimeric antigen receptor targeting cd20
|
|
JP2025536260A
(ja)
|
2022-10-11 |
2025-11-05 |
イェール ユニバーシティー |
細胞透過性抗体の組成物および使用方法
|
|
EP4615960A1
(de)
|
2022-11-09 |
2025-09-17 |
C3S2 GmbH |
Verfahren zur herstellung von manipulierten immunzellen
|
|
WO2024102838A1
(en)
|
2022-11-09 |
2024-05-16 |
Century Therapeutics, Inc. |
Engineered interleukin-7 receptors and uses thereof
|
|
AU2023375625A1
(en)
|
2022-11-10 |
2025-05-15 |
Century Therapeutics, Inc. |
Genetically engineered cells having anti-nectin4 chimeric antigen receptors, and uses thereof
|
|
AU2023406926A1
(en)
|
2022-12-01 |
2025-06-26 |
Yale University |
Stimuli-responsive traceless engineering platform for intracellular payload delivery
|
|
US20240269189A1
(en)
|
2022-12-19 |
2024-08-15 |
FUJIFILM Holdings America Corporation |
Extracellular vesicle-enriched secretome composition derived from induced pluripotent stem cell derived-microglia and methods of use thereof
|
|
AU2023412431A1
(en)
|
2022-12-23 |
2025-08-07 |
Epigenic Therapeutics Pte. Ltd. |
Complex and use thereof
|
|
TW202440931A
(zh)
|
2022-12-23 |
2024-10-16 |
大陸商益杰立科(上海)生物科技有限公司 |
融合物及其用途
|
|
WO2024151541A1
(en)
|
2023-01-09 |
2024-07-18 |
Sana Biotechnology, Inc. |
Type-1 diabetes autoimmune mouse
|
|
WO2024163683A2
(en)
|
2023-02-01 |
2024-08-08 |
Tune Therapeutics, Inc. |
Systems, compositions, and methods for modulating expression of methyl-cpg binding protein 2 (mecp2) and x-inactive specific transcript (xist)
|
|
WO2024163678A2
(en)
|
2023-02-01 |
2024-08-08 |
Tune Therapeutics, Inc. |
Fusion proteins and systems for targeted activation of frataxin (fxn) and related methods
|
|
CN121002052A
(zh)
|
2023-02-03 |
2025-11-21 |
C3S2 有限公司 |
用于非病毒生产工程化免疫细胞的方法
|
|
CN120712355A
(zh)
|
2023-02-15 |
2025-09-26 |
阿伯生物技术公司 |
用于抑制抑微管装配蛋白2(stmn2)转录物中的异常剪接的基因编辑方法
|
|
WO2024192108A1
(en)
|
2023-03-14 |
2024-09-19 |
Evolveimmune Therapeutics, Inc. |
Genetically modified car t cells and methods of making and using the same
|
|
TW202444898A
(zh)
|
2023-04-21 |
2024-11-16 |
美商凱特製藥公司 |
免疫排斥之風險降低的同種異體治療性細胞
|
|
AU2024264889A1
(en)
|
2023-05-03 |
2025-11-13 |
Sana Biotechnology, Inc. |
Methods of dosing and administration of engineered islet cells
|
|
CN121604968A
(zh)
|
2023-05-22 |
2026-03-03 |
萨那生物科技公司 |
递送胰岛细胞的方法及相关方法
|
|
TW202515898A
(zh)
|
2023-06-30 |
2025-04-16 |
日商武田藥品工業股份有限公司 |
Htt抑制物及其用途
|
|
WO2025019742A1
(en)
|
2023-07-19 |
2025-01-23 |
Omega Therapeutics, Inc. |
Methods and compositions for modulating ctnnb1 expression
|
|
US20250027087A1
(en)
|
2023-07-21 |
2025-01-23 |
Crispr Therapeutics Ag |
Modulating expression of alas1 (5'-aminolevulinate synthase 1) gene
|
|
WO2025029835A1
(en)
|
2023-07-31 |
2025-02-06 |
Tune Therapeutics, Inc. |
Compositions and methods for modulating il-2 gene expression
|
|
WO2025029840A1
(en)
|
2023-07-31 |
2025-02-06 |
Tune Therapeutics, Inc. |
Compositions and methods for multiplexed activation and repression of t cell gene expression
|
|
WO2025038494A1
(en)
|
2023-08-11 |
2025-02-20 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for lymphoid cell differentiation using targeted gene activation
|
|
WO2025049959A2
(en)
|
2023-09-01 |
2025-03-06 |
Renagade Therapeutics Management Inc. |
Gene editing systems, compositions, and methods for treatment of vexas syndrome
|
|
WO2025059073A1
(en)
|
2023-09-11 |
2025-03-20 |
Tune Therapeutics, Inc. |
Epigenetic editing methods and systems for differentiating stem cells
|
|
WO2025101938A2
(en)
|
2023-11-10 |
2025-05-15 |
Century Therapeutics, Inc. |
Genetically engineered cells having multi-transmembrane domain chimeric antigen receptors utilizing g protein-coupled receptor scaffolds, and uses thereof
|
|
WO2025106626A1
(en)
|
2023-11-15 |
2025-05-22 |
Century Therapeutics, Inc. |
Genetically engineered cells expressing c-x-c chemokine receptor type 4, and uses thereof
|
|
WO2025174765A1
(en)
|
2024-02-12 |
2025-08-21 |
Renagade Therapeutics Management Inc. |
Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents
|
|
WO2025186726A1
(en)
|
2024-03-05 |
2025-09-12 |
Crispr Therapeutics Ag |
Modulating expression of agt (angiotensinogen) gene
|
|
WO2025207798A1
(en)
|
2024-03-26 |
2025-10-02 |
Century Therapeutics, Inc. |
Genetically engineered cells having anti-cd123 chimeric antigen receptors, and uses thereof
|
|
WO2025207795A1
(en)
|
2024-03-26 |
2025-10-02 |
Juno Therapeutics, Inc. |
Genetically engineered cells having anti-cd33 / anti-cd123 chimeric antigen receptors, and uses thereof
|
|
WO2025226122A1
(ko)
*
|
2024-04-25 |
2025-10-30 |
(주)셀트리온 |
글루타민 합성효소 유전자를 불활성화시키는 방법 및 이를 이용한 목적 단백질의 생산 방법
|
|
WO2025224715A1
(en)
|
2024-04-26 |
2025-10-30 |
King Abdullah Univeristy Of Science And Technology |
Methods for improving precise genome modification and reducing unwanted mutations by crispr-cas editing
|
|
TW202605143A
(zh)
|
2024-05-10 |
2026-02-01 |
美商奇諾治療有限公司 |
表現cd19嵌合抗原受體(car)之基因工程化t細胞及其用於同種異體細胞療法之用途
|
|
WO2025260068A1
(en)
|
2024-06-14 |
2025-12-18 |
Tune Therapeutics, Inc. |
Lipid nanoparticle formulation for delivery of nucleic acids to cells
|
|
WO2026006832A1
(en)
|
2024-06-28 |
2026-01-02 |
University Of Connecticut |
Gene modulation for treating cancer
|
|
WO2026015647A1
(en)
|
2024-07-09 |
2026-01-15 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for cell differentiation using targeted gene activation of dll4 and/or vcam1
|
|
WO2026064753A1
(en)
|
2024-09-23 |
2026-03-26 |
Tune Therapeutics, Inc. |
Dna methyltransferase-like protein (dnmt3l) or dna methyltransferase 3a (dnmt3a) repressor systems for epigenetic editing
|