BR112023024434A2 - Células hipoimunogênicas que compreendem hla-e ou hla-g geneticamente modificadas - Google Patents

Células hipoimunogênicas que compreendem hla-e ou hla-g geneticamente modificadas

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Publication number
BR112023024434A2
BR112023024434A2 BR112023024434A BR112023024434A BR112023024434A2 BR 112023024434 A2 BR112023024434 A2 BR 112023024434A2 BR 112023024434 A BR112023024434 A BR 112023024434A BR 112023024434 A BR112023024434 A BR 112023024434A BR 112023024434 A2 BR112023024434 A2 BR 112023024434A2
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Brazil
Prior art keywords
hla
cells
hypoimmunogenic
genetically modified
human leukocyte
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BR112023024434A
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English (en)
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Edward Rebar
Sonja Schrepfer
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Sana Biotechnology Inc
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Publication date
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Publication of BR112023024434A2 publication Critical patent/BR112023024434A2/pt

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/4613—Natural-killer cells [NK or NK-T]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61K39/4643—Vertebrate antigens
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    • A—HUMAN NECESSITIES
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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Abstract

células hipoimunogênicas que compreendem hla-e ou hla-g geneticamente modificadas. são divulgadas neste documento células geneticamente modificadas e/ou células hipoimunogênicas, incluindo células-tronco hipoimunogênicas, células hipoimunogênicas diferenciadas das mesmas e células car-t hipoimunogênicas e métodos relacionados de seu uso e geração compreendendo um ou mais receptores exógenos selecionados do grupo que consiste em proteína variante de um antígeno leucocitário humano e (hla-e), uma proteína variante do antígeno leucocitário humano g (hla-g) e uma proteína pd-l1 exógena. são fornecidas no presente pedido células que exibem ainda expressão reduzida de antígenos leucocitários humanos de mhc i e mhc ii e de receptores de células t.
BR112023024434A 2021-05-27 2022-05-25 Células hipoimunogênicas que compreendem hla-e ou hla-g geneticamente modificadas BR112023024434A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163194106P 2021-05-27 2021-05-27
US202163255912P 2021-10-14 2021-10-14
PCT/US2022/030934 WO2022251367A1 (en) 2021-05-27 2022-05-25 Hypoimmunogenic cells comprising engineered hla-e or hla-g

Publications (1)

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BR112023024434A2 true BR112023024434A2 (pt) 2024-02-20

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EP (1) EP4347797A1 (pt)
JP (1) JP2024521619A (pt)
KR (1) KR20240013135A (pt)
AU (1) AU2022283291A1 (pt)
BR (1) BR112023024434A2 (pt)
CA (1) CA3216346A1 (pt)
IL (1) IL308097A (pt)
MX (1) MX2023014017A (pt)
WO (1) WO2022251367A1 (pt)

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WO2023069790A1 (en) * 2021-10-22 2023-04-27 Sana Biotechnology, Inc. Methods of engineering allogeneic t cells with a transgene in a tcr locus and associated compositions and methods

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