CN1214013C - 抑制hiv复制的嘧啶类 - Google Patents

抑制hiv复制的嘧啶类 Download PDF

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Publication number
CN1214013C
CN1214013C CNB998119180A CN99811918A CN1214013C CN 1214013 C CN1214013 C CN 1214013C CN B998119180 A CNB998119180 A CN B998119180A CN 99811918 A CN99811918 A CN 99811918A CN 1214013 C CN1214013 C CN 1214013C
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CN
China
Prior art keywords
amino
alkyl
compound
group
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CNB998119180A
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English (en)
Chinese (zh)
Other versions
CN1322198A (zh
Inventor
B·德科尔特
M·R·德容格
J·赫雷斯
C·Y·霍
P·A·J·杨森
R·W·卡瓦斯
L·M·H·科伊曼斯
M·J·库克拉
D·W·卢多维茨
K·J·A·范阿肯
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26805159&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1214013(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of CN1322198A publication Critical patent/CN1322198A/zh
Application granted granted Critical
Publication of CN1214013C publication Critical patent/CN1214013C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CNB998119180A 1998-11-10 1999-09-24 抑制hiv复制的嘧啶类 Expired - Lifetime CN1214013C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10779298P 1998-11-10 1998-11-10
US60/107,792 1998-11-10
US14396299P 1999-07-15 1999-07-15
US60/143,962 1999-07-15

Publications (2)

Publication Number Publication Date
CN1322198A CN1322198A (zh) 2001-11-14
CN1214013C true CN1214013C (zh) 2005-08-10

Family

ID=26805159

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998119180A Expired - Lifetime CN1214013C (zh) 1998-11-10 1999-09-24 抑制hiv复制的嘧啶类

Country Status (41)

Country Link
US (5) US6878717B2 (https=)
EP (2) EP1270560B1 (https=)
JP (1) JP3635238B2 (https=)
KR (1) KR100658489B1 (https=)
CN (1) CN1214013C (https=)
AP (1) AP1683A (https=)
AR (1) AR024227A1 (https=)
AT (2) ATE233740T1 (https=)
AU (2) AU762523C (https=)
BG (1) BG65103B1 (https=)
BR (1) BRPI9915552B8 (https=)
CA (1) CA2350801C (https=)
CY (1) CY2008021I1 (https=)
CZ (1) CZ301367B6 (https=)
DE (3) DE69905683T2 (https=)
DK (1) DK1002795T3 (https=)
EA (1) EA004049B1 (https=)
EE (1) EE05086B1 (https=)
ES (2) ES2193664T3 (https=)
FR (1) FR09C0004I2 (https=)
HK (1) HK1048817B (https=)
HR (2) HRP20080359B1 (https=)
HU (2) HU227453B1 (https=)
ID (1) ID28376A (https=)
IL (2) IL143023A0 (https=)
LT (1) LTC1002795I2 (https=)
LU (1) LU91528I2 (https=)
MY (1) MY121108A (https=)
NL (1) NL300373I2 (https=)
NO (3) NO318801B1 (https=)
NZ (1) NZ511116A (https=)
OA (1) OA11674A (https=)
PL (1) PL204427B1 (https=)
PT (1) PT1002795E (https=)
SI (1) SI1002795T1 (https=)
SK (2) SK287270B6 (https=)
TR (1) TR200101306T2 (https=)
TW (1) TWI238161B (https=)
UA (1) UA70966C2 (https=)
WO (1) WO2000027825A1 (https=)
ZA (1) ZA200103769B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110066273A (zh) * 2019-06-05 2019-07-30 山东大学 一种含三氮唑环的单芳基嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用

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* Cited by examiner, † Cited by third party
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