ZA200103769B - HIV Replication inhibiting pyrimidines. - Google Patents
HIV Replication inhibiting pyrimidines. Download PDFInfo
- Publication number
- ZA200103769B ZA200103769B ZA200103769A ZA200103769A ZA200103769B ZA 200103769 B ZA200103769 B ZA 200103769B ZA 200103769 A ZA200103769 A ZA 200103769A ZA 200103769 A ZA200103769 A ZA 200103769A ZA 200103769 B ZA200103769 B ZA 200103769B
- Authority
- ZA
- South Africa
- Prior art keywords
- compound
- amino
- cyano
- formula
- substituted
- Prior art date
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- 150000003230 pyrimidines Chemical class 0.000 title description 5
- 230000010076 replication Effects 0.000 title description 5
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- 238000000034 method Methods 0.000 claims description 37
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- 241000725303 Human immunodeficiency virus Species 0.000 claims description 29
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- 238000011282 treatment Methods 0.000 claims description 24
- 125000001424 substituent group Chemical group 0.000 claims description 23
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10779298P | 1998-11-10 | 1998-11-10 | |
| US14396299P | 1999-07-15 | 1999-07-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200103769B true ZA200103769B (en) | 2002-08-12 |
Family
ID=26805159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200103769A ZA200103769B (en) | 1998-11-10 | 2001-05-09 | HIV Replication inhibiting pyrimidines. |
Country Status (41)
Families Citing this family (129)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK287270B6 (sk) * | 1998-11-10 | 2010-05-07 | Janssen Pharmaceutica N. V. | Derivát pyrimidínu |
| GB9914258D0 (en) * | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
| DE19945982A1 (de) * | 1999-09-24 | 2001-03-29 | Knoll Ag | Geschwindigkeitsbestimmte Partikel |
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| KR100643419B1 (ko) * | 1998-03-27 | 2006-11-10 | 얀센 파마슈티카 엔.브이. | Ｈｉｖ를 억제하는 피리미딘 유도체 |
| EA002973B1 (ru) * | 1998-03-27 | 2002-12-26 | Янссен Фармацевтика Н.В. | Производные пиримидина в качестве ингибиторов репликации вируса иммунодефицита человека |
| EP0945442A1 (en) * | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituted pyrimidine derivatives |
| SK287270B6 (sk) * | 1998-11-10 | 2010-05-07 | Janssen Pharmaceutica N. V. | Derivát pyrimidínu |
| AU782948B2 (en) * | 2000-05-08 | 2005-09-15 | Janssen Pharmaceutica N.V. | Prodrugs of HIV replication inhibiting pyrimidines |
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1999
- 1999-09-24 SK SK5012-2009A patent/SK287270B6/sk not_active IP Right Cessation
- 1999-09-24 HR HRP20080359AA patent/HRP20080359B1/hr not_active IP Right Cessation
- 1999-09-24 CN CNB998119180A patent/CN1214013C/zh not_active Expired - Lifetime
- 1999-09-24 KR KR1020017003576A patent/KR100658489B1/ko not_active Expired - Lifetime
- 1999-09-24 UA UA2001042857A patent/UA70966C2/uk unknown
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- 1999-09-24 EA EA200100536A patent/EA004049B1/ru active IP Right Revival
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- 1999-09-24 TR TR2001/01306T patent/TR200101306T2/xx unknown
- 1999-09-24 WO PCT/EP1999/007417 patent/WO2000027825A1/en not_active Ceased
- 1999-09-24 HU HU1100091A patent/HU230394B1/hu unknown
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- 1999-11-01 AT AT99203590T patent/ATE233740T1/de active
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- 1999-11-01 SI SI9930275T patent/SI1002795T1/xx unknown
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- 1999-11-01 DE DE69905683T patent/DE69905683T2/de not_active Expired - Lifetime
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- 1999-11-01 AT AT02018455T patent/ATE455107T1/de not_active IP Right Cessation
- 1999-11-01 DE DE122009000003C patent/DE122009000003I1/de active Pending
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- 1999-12-23 TW TW088119614A patent/TWI238161B/zh not_active IP Right Cessation
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2001
- 2001-04-04 NO NO20011696A patent/NO318801B1/no not_active IP Right Cessation
- 2001-04-06 BG BG105418A patent/BG65103B1/bg unknown
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2003
- 2003-02-14 HK HK03101063.7A patent/HK1048817B/en not_active IP Right Cessation
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2005
- 2005-07-28 IL IL169949A patent/IL169949A/en not_active IP Right Cessation
- 2005-08-16 US US11/204,513 patent/US20050288278A1/en not_active Abandoned
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2007
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2008
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2009
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- 2009-01-22 FR FR09C0004C patent/FR09C0004I2/fr active Active
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2011
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2021
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