UA70966C2 - Піримідини, що інгібують реплікацію віл - Google Patents
Піримідини, що інгібують реплікацію вілInfo
- Publication number
- UA70966C2 UA70966C2 UA2001042857A UA01042857A UA70966C2 UA 70966 C2 UA70966 C2 UA 70966C2 UA 2001042857 A UA2001042857 A UA 2001042857A UA 01042857 A UA01042857 A UA 01042857A UA 70966 C2 UA70966 C2 UA 70966C2
- Authority
- UA
- Ukraine
- Prior art keywords
- 6alkyl
- optionally substituted
- amino
- nhc
- halo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Даний винахід стосується застосування сполук формули (І), їх N-оксидів, фармацевтичнo прийнятних солей приєднання, четвертинних амінів та стереохімічно ізомерних форм, де -а1=а2-а3=а4- утворює феніл, піридиніл, піримідиніл, піридазиніл або піразиніл з приєднаною вініловою групою; n дорівнює 0-4; і, де можливо, 5; R1 являє собою водень, арил, форміл, С1-6aлкілкарбоніл, С1-6алкіл, С1-6алкілоксикарбоніл, заміщений С1-6алкіл, або заміщений С1-6алкілоксіС1-6алкілкарбоніл; кожна R2 являє собою, незалежно, гідрокси, гало, заміщений, при потребі, С1-6алкіл, С2-6алкеніл або С1-6алкініл, С3-7циклоалкіл, С1-6алкілокси, С1-6алкілоксикарбоніл, карбоксил, ціано, нітро, аміно, моно- або ді(С1-6алкіл)аміно, полігалометил, полігалометилокси, полігалометилтіо, -S(=O)pR6, -NH-S(=O)pR6, -C(=O)R6, -NHC(=O)H, -C(=O)NHNH2, -NHC(=O)R6, -C(=NH)R6 або 5-членне гетероциклічне кільце; р дорівнює 1 або 2; L являє собою заміщений, при потребі, С1-10алкіл, C2-10алкеніл, С2-10алкініл або С3-7циклоалкіл; або L являє собою -X-R3, де R3 являє собою заміщений, при потребі, феніл, піридиніл, піримідиніл, піразиніл або піридазиніл; Х являє собою -NR1-, -NH-NH-, -N=N-, -О-, -С(=O)-, -СНОН-, -S-, =S(=O)- або -S(=O)2-; Q являє собою водень, С1-6алкіл, гало, полігало-С1-6алкіл або заміщену, при потребі, аміногрупу; Y являє собою гідрокси, гало, С3-7циклоалкіл, заміщений, при потребі, С1-6алкіл, С2-6алкеніл або С2-6алкініл, С1-6 алкілокси, С1-6алкілоксикарбоніл, карбоксил, ціано, нітро, аміно, моно- або ді(С1-6 алкіл)аміно, полігалометил, полігалометилокси, полігалометилтіо, -S(=O)pR6, -NH-S(=O)pR6, -C(=O)R6, -NHC(=O)H, -C(=O)NHNH2, -NHC(=O)R6, -C(=NH)R6 або арил; арил являє собою заміщений, при потребі, феніл; Het являє собою заміщений, при потребі, гетероциклічний радикал; для виробництва ліків, призначених для лікування суб'єктів, що страждають на ВІЛ-інфекції. EMBED ISISServer
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10779298P | 1998-11-10 | 1998-11-10 | |
US14396299P | 1999-07-15 | 1999-07-15 | |
PCT/EP1999/007417 WO2000027825A1 (en) | 1998-11-10 | 1999-09-24 | Hiv replication inhibiting pyrimidines |
Publications (1)
Publication Number | Publication Date |
---|---|
UA70966C2 true UA70966C2 (uk) | 2004-11-15 |
Family
ID=26805159
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA2001042857A UA70966C2 (uk) | 1998-11-10 | 1999-09-24 | Піримідини, що інгібують реплікацію віл |
Country Status (41)
Country | Link |
---|---|
US (5) | US6878717B2 (uk) |
EP (2) | EP1002795B1 (uk) |
JP (1) | JP3635238B2 (uk) |
KR (1) | KR100658489B1 (uk) |
CN (1) | CN1214013C (uk) |
AP (1) | AP1683A (uk) |
AR (1) | AR024227A1 (uk) |
AT (2) | ATE455107T1 (uk) |
AU (2) | AU762523C (uk) |
BG (1) | BG65103B1 (uk) |
BR (1) | BRPI9915552B8 (uk) |
CA (1) | CA2350801C (uk) |
CY (1) | CY2008021I1 (uk) |
CZ (1) | CZ301367B6 (uk) |
DE (3) | DE69941934D1 (uk) |
DK (1) | DK1002795T3 (uk) |
EA (1) | EA004049B1 (uk) |
EE (1) | EE05086B1 (uk) |
ES (2) | ES2193664T3 (uk) |
FR (1) | FR09C0004I2 (uk) |
HK (2) | HK1025330A1 (uk) |
HR (2) | HRP20010161B9 (uk) |
HU (2) | HU230394B1 (uk) |
ID (1) | ID28376A (uk) |
IL (2) | IL143023A0 (uk) |
LT (1) | LTC1002795I2 (uk) |
LU (1) | LU91528I2 (uk) |
MY (1) | MY121108A (uk) |
NL (1) | NL300373I2 (uk) |
NO (3) | NO318801B1 (uk) |
NZ (1) | NZ511116A (uk) |
OA (1) | OA11674A (uk) |
PL (1) | PL204427B1 (uk) |
PT (1) | PT1002795E (uk) |
SI (1) | SI1002795T1 (uk) |
SK (2) | SK287269B6 (uk) |
TR (1) | TR200101306T2 (uk) |
TW (1) | TWI238161B (uk) |
UA (1) | UA70966C2 (uk) |
WO (1) | WO2000027825A1 (uk) |
ZA (1) | ZA200103769B (uk) |
Families Citing this family (126)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
OA11674A (en) * | 1998-11-10 | 2005-01-12 | Janssen Pharmaceutica Nv | HIV Replication inhibiting pyrimidines. |
GB9914258D0 (en) * | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
OA12029A (en) * | 1999-09-24 | 2006-04-28 | Janssen Pharmaceutica Nv | Antiviral compositions. |
DE19945982A1 (de) | 1999-09-24 | 2001-03-29 | Knoll Ag | Geschwindigkeitsbestimmte Partikel |
ES2306671T3 (es) | 1999-10-07 | 2008-11-16 | Amgen Inc. | Inhibidores de triazina quinasa. |
CA2400447C (en) | 2000-02-17 | 2008-04-22 | Amgen Inc. | Kinase inhibitors |
JP4969010B2 (ja) * | 2000-05-08 | 2012-07-04 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Hiv複製阻害性ピリミジンのプロドラッグ |
WO2001085700A2 (en) | 2000-05-08 | 2001-11-15 | Janssen Pharmaceutica N.V. | Hiv replication inhibiting pyrimidines and triazines |
EP1337931A4 (en) * | 2000-11-01 | 2005-05-11 | Snapnames Com Inc | DOMAIN NAME ACQUISITION AND MANAGEMENT SYSTEM AND METHOD |
US6958211B2 (en) | 2001-08-08 | 2005-10-25 | Tibotech Bvba | Methods of assessing HIV integrase inhibitor therapy |
US7638522B2 (en) | 2001-08-13 | 2009-12-29 | Janssen Pharmaceutica N.V. | Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile |
US8101629B2 (en) | 2001-08-13 | 2012-01-24 | Janssen Pharmaceutica N.V. | Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile |
JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
US7115617B2 (en) | 2001-08-22 | 2006-10-03 | Amgen Inc. | Amino-substituted pyrimidinyl derivatives and methods of use |
US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
CA2463989C (en) * | 2001-10-17 | 2012-01-31 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pyrimidine derivatives, pharmaceutical compositions containing these compounds, the use thereof and process for the preparation thereof |
WO2003032994A2 (de) | 2001-10-17 | 2003-04-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 5-substituierte 4-amino-2-phenylamino-pyrimidinderivate und ihre verwendung als beta-amyloid modulatoren |
KR20040048920A (ko) | 2001-11-01 | 2004-06-10 | 얀센 파마슈티카 엔.브이. | 글리코겐 신타아제 키나제 3-베타 저해제(gsk저해제)로서의 헤테로아릴 아민 |
BR0213791A (pt) | 2001-11-01 | 2004-12-07 | Janssen Pharmaceutica Nv | Derivados de amida como inibidores de glicogênio sintase quinase 3-beta |
SE0104140D0 (sv) | 2001-12-07 | 2001-12-07 | Astrazeneca Ab | Novel Compounds |
TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
US7501417B2 (en) | 2002-03-13 | 2009-03-10 | Janssen Pharmaceutica, N.V. | Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase |
PL214279B1 (pl) | 2002-03-13 | 2013-07-31 | Janssen Pharmaceutica Nv | Pochodna sulfonyloaminowa, sposób jej wytwarzania i zastosowanie oraz kompozycja farmaceutyczna i sposób jej wytwarzania |
GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
NZ536294A (en) * | 2002-05-03 | 2005-05-27 | Janssen Pharmaceutica Nv | Polymeric microemulsions of amphiphilic diblock copolymers |
AR039540A1 (es) * | 2002-05-13 | 2005-02-23 | Tibotec Pharm Ltd | Compuestos microbicidas con contenido de pirimidina o triazina |
TW200409629A (en) | 2002-06-27 | 2004-06-16 | Bristol Myers Squibb Co | 2,4-disubstituted-pyridine N-oxides useful as HIV reverse transcriptase inhibitors |
CN1678321A (zh) | 2002-07-29 | 2005-10-05 | 里格尔药品股份有限公司 | 用2,4-嘧啶二胺化合物治疗或者预防自体免疫性疾病的方法 |
US7399856B2 (en) * | 2002-08-09 | 2008-07-15 | Janssen Pharmaceutica N.V. | Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-2pyrimidinyl]amino]benzonitrile |
PT1551372T (pt) | 2002-09-20 | 2018-07-23 | Alpharma Pharmaceuticals Llc | Subunidade de sequestração e composições e métodos relacionados |
US7504410B2 (en) * | 2002-11-28 | 2009-03-17 | Schering Aktiengesellschaft | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents |
ATE374766T1 (de) | 2003-01-14 | 2007-10-15 | Arena Pharm Inc | 1,2,3-trisubstituierte aryl- und heteroarylderivate als modulatoren des metabolismus zur vorbeugung und behandlung von metabolismus-bedingten krankheiten wie diabetes oder hyperglykämie |
CL2004000192A1 (es) | 2003-02-07 | 2005-03-18 | Janssen Pharmaceutica Nv | Uso de compuestos derivados de 2-aminopirimidina para preparar un medicamento para la prevencion de una infeccion por vih relaciones sexuales o un contacto intimo en la pareja. |
ATE402152T1 (de) * | 2003-02-07 | 2008-08-15 | Janssen Pharmaceutica Nv | Hiv-inhibierende1,2,4-triazine |
CL2004000303A1 (es) * | 2003-02-20 | 2005-04-08 | Tibotec Pharm Ltd | Compuestos derivados de pirimidinas y triazinas; proceso de preparacion; composicion farmaceutica; y su uso para inhibir la replicacion del vih. |
DE602004021472D1 (en) * | 2003-02-20 | 2009-07-23 | Smithkline Beecham Corp | Pyrimiidinverbindungen |
CN1822843B (zh) * | 2003-07-17 | 2010-04-28 | 泰博特克药品有限公司 | 制备含有抗病毒药物颗粒的方法 |
US7122542B2 (en) | 2003-07-30 | 2006-10-17 | Rigel Pharmaceuticals, Inc. | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds |
CN100475815C (zh) * | 2003-09-25 | 2009-04-08 | 詹森药业有限公司 | 抑制hiv复制的嘌呤衍生物 |
WO2005086061A2 (en) | 2004-03-02 | 2005-09-15 | Virco Bvba | Estimation of clinical cut-offs |
EP1598343A1 (de) * | 2004-05-19 | 2005-11-23 | Boehringer Ingelheim International GmbH | 2-Arylaminopyrimidine als PLK Inhibitoren |
KR101261305B1 (ko) | 2004-07-28 | 2013-05-08 | 얀센 파마슈티카 엔.브이. | 히스톤 디아세틸라제의 신규한 저해제로의 치환된 인돌릴알킬 아미노 유도체 |
CN101035773B (zh) | 2004-08-10 | 2012-06-06 | 詹森药业有限公司 | 抑制hiv的1,2,4-三嗪-6-酮衍生物 |
ES2380631T3 (es) * | 2004-09-30 | 2012-05-17 | Tibotec Pharmaceuticals | Pirimidinas sustituidas en posición 5 inhibidoras de VIH |
JP5162245B2 (ja) | 2004-09-30 | 2013-03-13 | テイボテク・フアーマシユーチカルズ | Hiv阻害性5−炭素環または複素環置換ピリミジン |
AU2005288864B2 (en) | 2004-09-30 | 2012-08-23 | Janssen Sciences Ireland Uc | HIV inhibiting 5-heterocyclyl pyrimidines |
ES2508766T3 (es) | 2004-10-29 | 2014-10-16 | Janssen R&D Ireland | Derivados de pirimidina bicíclicos que inhiben el VIH |
EP1812069A2 (en) * | 2004-11-08 | 2007-08-01 | Boehringer Ingelheim International GmbH | Method for treating hiv infection through co-administration of tipranavir and etravirine |
DK1814878T3 (da) | 2004-11-24 | 2012-05-07 | Rigel Pharmaceuticals Inc | Spiro-2, 4-pyrimidindiamin-forbindelser og anvendelser deraf |
DK1856135T3 (da) | 2005-01-19 | 2010-04-12 | Rigel Pharmaceuticals Inc | Prodrugs af 2,4-pyrimidindiamin-forbindelser og deres anvendelser |
RU2403245C2 (ru) | 2005-01-27 | 2010-11-10 | Тиботек Фармасьютикалз Лтд. | Ингибирующие вич производные 2-(4-цианофениламино)пиримидина |
PT1853588E (pt) | 2005-02-16 | 2008-08-25 | Astrazeneca Ab | Compostos químicos |
MX2007010051A (es) * | 2005-02-18 | 2007-09-21 | Tibotec Pharm Ltd | Derivados de oxido de 2-(4-cianofenilamino)pirimidina que inhiben el virus de inmunodeficiencia humana. |
CN101133038B (zh) * | 2005-03-04 | 2012-06-27 | 泰博特克药品有限公司 | 抑制hiv的2-(4-氰基苯基)-6-羟氨基嘧啶 |
CA2608009A1 (en) | 2005-05-16 | 2006-11-23 | Astrazeneca Ab | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors |
ME01612B (me) * | 2005-05-26 | 2014-09-20 | Janssen Sciences Ireland Uc | Proces za pripremu 4-[(1,6-dihidro-6-okso-2-pirimidinil)amino benzonitrila |
US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
NZ563454A (en) | 2005-06-08 | 2011-03-31 | Rigel Pharmaceuticals Inc | 2,4-diaminopyrimidine derivatives for inhibition of the JAK pathway |
EA200801025A1 (ru) * | 2005-10-06 | 2008-12-30 | Юниверсити Оф Массачусетс | Композиция и синтез новых реагентов для ингибирования репликации вич |
ES2391783T3 (es) | 2005-10-28 | 2012-11-29 | Astrazeneca Ab | Derivados de 4-(3-aminopirazol)pirimidina para su uso como agentes inhibidores de las tirosina cinasas en el tratamiento del cáncer |
AU2007206950B2 (en) | 2006-01-19 | 2012-02-02 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
AU2007206942B2 (en) | 2006-01-19 | 2012-08-23 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
JP5225104B2 (ja) | 2006-01-19 | 2013-07-03 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 新しい、ヒストンデアセチラーゼのインヒビターとしてのアミノフェニル誘導体 |
US8962643B2 (en) | 2006-02-24 | 2015-02-24 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
MX2008012577A (es) | 2006-03-30 | 2008-10-10 | Tibotec Pharm Ltd | Pirimidinas sustituidas con 5-(hidroximetileno y aminometileno) que inhiben el virus de inmunodeficiencia humana. |
EP2004632B1 (en) | 2006-03-30 | 2014-03-12 | Janssen R&D Ireland | Hiv inhibiting 5-amido substituted pyrimidines |
PE20080068A1 (es) | 2006-05-15 | 2008-03-17 | Boehringer Ingelheim Int | Compuestos derivados de pirimidina como inhibidores de la quinasa aurora |
CA2651665C (en) * | 2006-06-06 | 2010-04-27 | Tibotec Pharmaceuticals Ltd. | Process for preparing spray dried formulations of tmc125 |
US8158156B2 (en) | 2006-06-19 | 2012-04-17 | Alpharma Pharmaceuticals, Llc | Abuse-deterrent multi-layer pharmaceutical composition comprising an opioid antagonist and an opioid agonist |
AU2007322269A1 (en) * | 2006-10-11 | 2008-05-29 | Alpharma Pharmaceuticals, Llc | Pharmaceutical compositions |
JP5464584B2 (ja) * | 2006-12-06 | 2014-04-09 | ヤンセン・アールアンドデイ・アイルランド | 抗hiv化合物の臭化水素酸塩 |
AU2007341228B2 (en) * | 2006-12-29 | 2013-04-18 | Janssen Sciences Ireland Uc | HIV inhibiting 5,6-substituted pyrimidines |
KR20090094073A (ko) * | 2006-12-29 | 2009-09-03 | 티보텍 파마슈티칼즈 리미티드 | Hiv를 억제하는 6-치환된 피리미딘 |
UA99459C2 (en) | 2007-05-04 | 2012-08-27 | Астразенека Аб | 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer |
US8410124B2 (en) | 2007-10-18 | 2013-04-02 | Concert Pharmaceuticals Inc. | Deuterated etravirine |
US20100151014A1 (en) * | 2008-12-16 | 2010-06-17 | Alpharma Pharmaceuticals, Llc | Pharmaceutical composition |
US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
WO2009079521A1 (en) * | 2007-12-17 | 2009-06-25 | Alpharma Pharmaceuticals, Llc | Pharmaceutical composition |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
MX2010012703A (es) | 2008-05-21 | 2010-12-21 | Ariad Pharma Inc | Derivados fosforosos como inhibidores de cinasa. |
US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
US8450335B2 (en) | 2008-06-27 | 2013-05-28 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
US20100137313A1 (en) * | 2008-10-03 | 2010-06-03 | Astrazeneca Ab | Heterocyclic derivatives and methods of use thereof |
US20110071158A1 (en) * | 2009-03-18 | 2011-03-24 | Boehringer Ingelheim International Gmbh | New compounds |
WO2010112411A1 (en) | 2009-03-30 | 2010-10-07 | Tibotec Pharmaceuticals | Co-crystal of etravirine and nicotinamide |
WO2010129053A2 (en) | 2009-05-05 | 2010-11-11 | Dana Farber Cancer Institute | Egfr inhibitors and methods of treating disorders |
WO2010131118A2 (en) * | 2009-05-12 | 2010-11-18 | Pliva Hrvatska D.O.O. | Polymorphs of etravirine and processes for preparation thereof |
UA106972C2 (uk) | 2009-06-22 | 2014-11-10 | Емк'Юр Фармас'Ютікалз Лімітед | Спосіб синтезу діарилпіримідинового ненуклеозидного інгібітора зворотної транскриптази |
WO2011017079A1 (en) | 2009-07-27 | 2011-02-10 | Teva Pharmaceutical Industries Ltd. | Process for the preparation and purification of etravirine and intermediates thereof |
GR1007010B (el) | 2009-10-08 | 2010-10-07 | Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), | Ινσουλινοειδη πεπτιδια |
JP5713367B2 (ja) | 2010-06-04 | 2015-05-07 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Lrrk2モジュレーターとしてのアミノピリミジン誘導体 |
US8598341B2 (en) | 2010-06-28 | 2013-12-03 | Hetero Research Foundation | Process for etravirine intermediate and polymorphs of etravirine |
CN103096716B (zh) | 2010-08-10 | 2016-03-02 | 西建阿维拉米斯研究公司 | Btk抑制剂的苯磺酸盐 |
CA2812061A1 (en) | 2010-09-22 | 2012-03-29 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2012061303A1 (en) | 2010-11-01 | 2012-05-10 | Avila Therapeutics, Inc. | Heteroaryl compounds and uses thereof |
WO2012061299A1 (en) | 2010-11-01 | 2012-05-10 | Avila Therapeutics, Inc. | Heterocyclic compounds and uses thereof |
EP2637502B1 (en) | 2010-11-10 | 2018-01-10 | Celgene CAR LLC | Mutant-selective egfr inhibitors and uses thereof |
CA3017869C (en) | 2010-11-10 | 2021-07-27 | Genentech, Inc. | Pyrazole aminopyrimidine derivatives as lrrk2 modulators |
PT2702045T (pt) | 2011-04-26 | 2018-01-11 | Mylan Laboratories Ltd | Método inovador para a preparação de etravirina |
AU2012250517B2 (en) | 2011-05-04 | 2016-05-19 | Takeda Pharmaceutical Company Limited | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
WO2012170647A1 (en) * | 2011-06-09 | 2012-12-13 | Assia Chemical Industriew Ltd. | Process for the preparation of etravirine and intermediates in the synthesis thereof |
FI3392252T3 (fi) | 2011-08-23 | 2024-01-08 | Libertas Bio Inc | Pyrimidopyridazinoniyhdisteet ja niiden käyttö |
WO2013059572A1 (en) | 2011-10-19 | 2013-04-25 | Assia Chemical Industries Ltd. | Process for the preparation of etravirine and intermediates in the synthesis thereof |
CA2853498A1 (en) | 2011-10-28 | 2013-05-02 | Celgene Avilomics Research, Inc. | Methods of treating a bruton's tyrosine kinase disease or disorder |
US8703786B2 (en) * | 2011-12-07 | 2014-04-22 | Texas Southern University | Etravirine formulations and uses thereof |
SG11201405691WA (en) | 2012-03-15 | 2014-10-30 | Celgene Avilomics Res Inc | Solid forms of an epidermal growth factor receptor kinase inhibitor |
CN104284584B (zh) | 2012-03-15 | 2019-06-04 | 西建卡尔有限责任公司 | 表皮生长因子受体激酶抑制剂的盐 |
JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Egfr発動性がんの細胞増殖阻害用化合物 |
US20150336900A1 (en) * | 2012-10-29 | 2015-11-26 | Biophore India Pharmaceuticals Pvt. Ltd. | Process for the Synthesis of Etravirine and Its Intermediates |
WO2014072419A1 (en) | 2012-11-08 | 2014-05-15 | Universiteit Antwerpen | Novel anti-hiv compounds |
WO2014100748A1 (en) | 2012-12-21 | 2014-06-26 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
KR20150126595A (ko) | 2012-12-21 | 2015-11-12 | 벌릭스 파마 인코포레이티드 | 간 질환 또는 증상의 치료를 위한 용도 및 방법 |
MX2015009952A (es) | 2013-02-08 | 2015-10-05 | Celgene Avilomics Res Inc | Inhibidores de cinasas reguladas por señales extracelulares (erk) y sus usos. |
US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
US9492471B2 (en) | 2013-08-27 | 2016-11-15 | Celgene Avilomics Research, Inc. | Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase |
US9415049B2 (en) | 2013-12-20 | 2016-08-16 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
EP3179858B1 (en) | 2014-08-13 | 2019-05-15 | Celgene Car Llc | Forms and compositions of an erk inhibitor |
CN107405332A (zh) | 2015-01-06 | 2017-11-28 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病症的方法 |
CN104926829A (zh) * | 2015-06-08 | 2015-09-23 | 山东大学 | 一种噻吩并嘧啶类衍生物及其制备方法和应用 |
CA3002551A1 (en) | 2015-06-22 | 2016-12-29 | Arena Pharmaceuticals, Inc. | Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid(com pound 1)for use in s1p1 receptor-associated disorders |
CN118105392A (zh) | 2017-04-28 | 2024-05-31 | 自由生物有限公司 | 治疗特应性皮炎以及提高活性药物成分稳定性的制剂、方法、试剂盒和剂型 |
CN110066273A (zh) * | 2019-06-05 | 2019-07-30 | 山东大学 | 一种含三氮唑环的单芳基嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用 |
KR20220028075A (ko) | 2019-07-03 | 2022-03-08 | 스미토모 다이니폰 파마 온콜로지, 인크. | 티로신 키나제 비-수용체 1 (tnk1) 억제제 및 그의 용도 |
CN111217833B (zh) * | 2020-02-21 | 2021-03-16 | 山东大学 | 噻吩并[2,3-d]嘧啶类HIV-1非核苷类逆转录酶抑制剂及其制备方法和应用 |
CN111875548A (zh) * | 2020-07-16 | 2020-11-03 | 山东大学 | 一种5位芳环取代的二芳基嘧啶类衍生物及其制备方法与应用 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3459731A (en) | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
US4659363A (en) * | 1983-07-25 | 1987-04-21 | Ciba-Geigy Corporation | N-(2-nitrophenyl)-2-aminopyrimidine derivatives, the preparation and use thereof |
US4694009A (en) * | 1984-06-25 | 1987-09-15 | Ciba-Geigy Corporation | Pesticidal compositions |
DE68918804T2 (de) | 1988-03-31 | 1995-02-23 | Mitsubishi Chem Ind | Acyclische 6-substituierte pyrimidin nukleosid-abkömmlinge und antivirale mittel, die dieselben als aktive mittel enthalten. |
JPH02308248A (ja) | 1989-05-24 | 1990-12-21 | Fuji Photo Film Co Ltd | アミノピリミジン系色素形成カプラーおよび該カプラーを含有するハロゲン化銀カラー写真感光材料 |
JP2895680B2 (ja) * | 1992-07-08 | 1999-05-24 | シャープ株式会社 | 磁気ヘッドおよびその製造方法 |
US5516775A (en) | 1992-08-31 | 1996-05-14 | Ciba-Geigy Corporation | Further use of pyrimidine derivatives |
CN1142817A (zh) | 1993-10-12 | 1997-02-12 | 杜邦麦克制药有限公司 | 1n-烷基-n-芳基嘧啶胺及其衍生物 |
US5691364A (en) * | 1995-03-10 | 1997-11-25 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
GB9523675D0 (en) * | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
AU725204B2 (en) | 1995-11-23 | 2000-10-05 | Janssen Pharmaceutica N.V. | Solid mixtures of cyclodextrins prepared via melt-extrusion |
KR100219922B1 (ko) * | 1996-05-16 | 1999-09-01 | 이서봉 | 신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법 |
GB9619284D0 (en) * | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
NO311614B1 (no) * | 1996-10-01 | 2001-12-17 | Janssen Pharmaceutica Nv | Substituerte diamino-1,3,5-triazinderivater |
GB9705361D0 (en) * | 1997-03-14 | 1997-04-30 | Celltech Therapeutics Ltd | Chemical compounds |
DE29704863U1 (de) * | 1997-03-17 | 1997-05-22 | Gesellschaft für Innenhochdruckverfahren mbH & Co. KG, 73441 Bopfingen | Achsschwinge |
ATE245641T1 (de) | 1998-02-17 | 2003-08-15 | Tularik Inc | Antivirale pyrimidinderivate |
HU230522B1 (hu) | 1998-03-27 | 2016-10-28 | Janssen Pharmaceutica N.V | HIV-gátló pirimidinszármazékok |
EP0945442A1 (en) * | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituted pyrimidine derivatives |
BRPI9909191B8 (pt) * | 1998-03-27 | 2021-07-06 | Janssen Pharmaceutica Nv | derivados de pirimidina inibidores do hiv, seu uso e composição farmacêutica que os compreende |
OA11674A (en) * | 1998-11-10 | 2005-01-12 | Janssen Pharmaceutica Nv | HIV Replication inhibiting pyrimidines. |
JP4969010B2 (ja) * | 2000-05-08 | 2012-07-04 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Hiv複製阻害性ピリミジンのプロドラッグ |
-
1999
- 1999-09-24 OA OA1200100113A patent/OA11674A/en unknown
- 1999-09-24 WO PCT/EP1999/007417 patent/WO2000027825A1/en active Application Filing
- 1999-09-24 TR TR2001/01306T patent/TR200101306T2/xx unknown
- 1999-09-24 JP JP2000581005A patent/JP3635238B2/ja not_active Expired - Lifetime
- 1999-09-24 AU AU62008/99A patent/AU762523C/en not_active Revoked
- 1999-09-24 ID IDW00200101015A patent/ID28376A/id unknown
- 1999-09-24 SK SK603-2001A patent/SK287269B6/sk active Protection Beyond IP Right Term
- 1999-09-24 HU HU1100091A patent/HU230394B1/hu unknown
- 1999-09-24 IL IL14302399A patent/IL143023A0/xx active Protection Beyond IP Right Term
- 1999-09-24 AP APAP/P/2001/002121A patent/AP1683A/en active
- 1999-09-24 UA UA2001042857A patent/UA70966C2/uk unknown
- 1999-09-24 KR KR1020017003576A patent/KR100658489B1/ko active IP Right Grant
- 1999-09-24 EE EEP200100252A patent/EE05086B1/xx active Protection Beyond IP Right Term
- 1999-09-24 HU HU0104177A patent/HU227453B1/hu active Protection Beyond IP Right Term
- 1999-09-24 EA EA200100536A patent/EA004049B1/ru active IP Right Revival
- 1999-09-24 PL PL347586A patent/PL204427B1/pl unknown
- 1999-09-24 CZ CZ20011533A patent/CZ301367B6/cs not_active IP Right Cessation
- 1999-09-24 CA CA002350801A patent/CA2350801C/en not_active Expired - Lifetime
- 1999-09-24 SK SK5012-2009A patent/SK287270B6/sk not_active IP Right Cessation
- 1999-09-24 NZ NZ511116A patent/NZ511116A/en not_active IP Right Cessation
- 1999-09-24 BR BRPI9915552A patent/BRPI9915552B8/pt not_active IP Right Cessation
- 1999-09-24 CN CNB998119180A patent/CN1214013C/zh not_active Expired - Lifetime
- 1999-11-01 DK DK99203590T patent/DK1002795T3/da active
- 1999-11-01 DE DE69941934T patent/DE69941934D1/de not_active Expired - Lifetime
- 1999-11-01 PT PT99203590T patent/PT1002795E/pt unknown
- 1999-11-01 AT AT02018455T patent/ATE455107T1/de not_active IP Right Cessation
- 1999-11-01 EP EP99203590A patent/EP1002795B1/en not_active Expired - Lifetime
- 1999-11-01 US US09/430,966 patent/US6878717B2/en not_active Expired - Lifetime
- 1999-11-01 SI SI9930275T patent/SI1002795T1/xx unknown
- 1999-11-01 DE DE122009000003C patent/DE122009000003I1/de active Pending
- 1999-11-01 ES ES99203590T patent/ES2193664T3/es not_active Expired - Lifetime
- 1999-11-01 ES ES02018455T patent/ES2338760T3/es not_active Expired - Lifetime
- 1999-11-01 DE DE69905683T patent/DE69905683T2/de not_active Expired - Lifetime
- 1999-11-01 AT AT99203590T patent/ATE233740T1/de active
- 1999-11-01 EP EP02018455A patent/EP1270560B1/en not_active Expired - Lifetime
- 1999-11-05 MY MYPI99004805A patent/MY121108A/en unknown
- 1999-11-09 AR ARP990105680A patent/AR024227A1/es active IP Right Grant
- 1999-12-23 TW TW088119614A patent/TWI238161B/zh not_active IP Right Cessation
-
2000
- 2000-07-26 HK HK00104633A patent/HK1025330A1/xx not_active IP Right Cessation
-
2001
- 2001-03-07 HR HRP20010161AA patent/HRP20010161B9/hr not_active IP Right Cessation
- 2001-04-04 NO NO20011696A patent/NO318801B1/no not_active IP Right Cessation
- 2001-04-06 BG BG105418A patent/BG65103B1/bg unknown
- 2001-05-09 ZA ZA200103769A patent/ZA200103769B/en unknown
-
2003
- 2003-02-14 HK HK03101063.7A patent/HK1048817B/zh not_active IP Right Cessation
- 2003-08-05 US US10/634,682 patent/US7037917B2/en not_active Expired - Lifetime
-
2005
- 2005-07-28 IL IL169949A patent/IL169949A/en not_active IP Right Cessation
- 2005-08-16 US US11/204,513 patent/US20050288278A1/en not_active Abandoned
-
2007
- 2007-10-31 US US11/930,835 patent/US8003789B2/en not_active Expired - Fee Related
-
2008
- 2008-07-17 HR HRP20080359AA patent/HRP20080359B1/hr not_active IP Right Cessation
- 2008-12-03 LT LTPA2008016C patent/LTC1002795I2/lt unknown
- 2008-12-10 CY CY2008021C patent/CY2008021I1/el unknown
-
2009
- 2009-01-13 NL NL300373C patent/NL300373I2/nl unknown
- 2009-01-22 FR FR09C0004C patent/FR09C0004I2/fr active Active
- 2009-02-18 LU LU91528C patent/LU91528I2/fr unknown
- 2009-02-23 NO NO2009003C patent/NO2009003I2/no unknown
-
2011
- 2011-02-18 AU AU2011200708A patent/AU2011200708A1/en active Pending
- 2011-07-06 US US13/177,188 patent/US8530655B2/en not_active Expired - Fee Related
-
2021
- 2021-03-29 NO NO2021015C patent/NO2021015I1/no unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UA70966C2 (uk) | Піримідини, що інгібують реплікацію віл | |
AP1610A (en) | HIV replication inhibiting pyrimidines. | |
AP1475A (en) | Trisubstituted 1, 3, 5-triazine derivatives for treatment of HIV infections. | |
AP1468A (en) | Hiv inhibiting pyrimidine derivatives. | |
MY176490A (en) | Pyrimidine derivatives for the prevention of hiv infection | |
DK0580459T3 (da) | Substituerede phenylimidazolidiner, deres anvendelse som lægemidler og farmaceutiske præparater med indhold deraf | |
DK0678026T3 (da) | Anvendelse af carbamazepin og oxcarbazepin ved fremstilling af lægemidler til behandling af Parkinsons sygdom og parkinsonisme-syndromer | |
JO3079B1 (ar) | ادويه اوليه من البريمدينات لمنع تكاثر فيروس نقص المناعه المكتسبه "الايدز" | |
MY141597A (en) | 2,4-disubstituted thiazolyl derivatives | |
CY1105596T1 (el) | Παραγωγα 2,4-δισυποκατεστημενης τριαζινης με δραση κατα του hiv | |
JO2321B1 (en) | 4-phenyl-pyridine derivatives | |
YU39503A (sh) | Derivati pirimidina | |
ATE500231T1 (de) | Hiv hemmende pyrimidin derivate | |
TW200628155A (en) | HIV replication inhibiting pyrimidines | |
DK0789702T3 (da) | Substituerede tetracykliske oxazepin- og thiazepinderivater med 5HT2-receptoraffinitet | |
CA2388840A1 (en) | Treatment of lymphomas, leukemias, breast carcinomas, astrocytomas, melanomas, leiomyomas, and related tumors |