LU91528I2 - "Etravirine sous toutes formes couvertes par le brevet de base" - Google Patents
"Etravirine sous toutes formes couvertes par le brevet de base"Info
- Publication number
- LU91528I2 LU91528I2 LU91528C LU91528C LU91528I2 LU 91528 I2 LU91528 I2 LU 91528I2 LU 91528 C LU91528 C LU 91528C LU 91528 C LU91528 C LU 91528C LU 91528 I2 LU91528 I2 LU 91528I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- etravirine
- basic patent
- form covered
- covered
- basic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10779298P | 1998-11-10 | 1998-11-10 | |
US14396299P | 1999-07-15 | 1999-07-15 | |
PCT/EP1999/007417 WO2000027825A1 (fr) | 1998-11-10 | 1999-09-24 | Pyrimidines inhibant la replication du vih |
Publications (2)
Publication Number | Publication Date |
---|---|
LU91528I2 true LU91528I2 (fr) | 2009-04-20 |
LU91528I9 LU91528I9 (fr) | 2019-01-02 |
Family
ID=26805159
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LU91528C LU91528I2 (fr) | 1998-11-10 | 2009-02-18 | "Etravirine sous toutes formes couvertes par le brevet de base" |
Country Status (41)
Country | Link |
---|---|
US (5) | US6878717B2 (fr) |
EP (2) | EP1002795B1 (fr) |
JP (1) | JP3635238B2 (fr) |
KR (1) | KR100658489B1 (fr) |
CN (1) | CN1214013C (fr) |
AP (1) | AP1683A (fr) |
AR (1) | AR024227A1 (fr) |
AT (2) | ATE455107T1 (fr) |
AU (2) | AU762523C (fr) |
BG (1) | BG65103B1 (fr) |
BR (1) | BRPI9915552B8 (fr) |
CA (1) | CA2350801C (fr) |
CY (1) | CY2008021I1 (fr) |
CZ (1) | CZ301367B6 (fr) |
DE (3) | DE69905683T2 (fr) |
DK (1) | DK1002795T3 (fr) |
EA (1) | EA004049B1 (fr) |
EE (1) | EE05086B1 (fr) |
ES (2) | ES2338760T3 (fr) |
FR (1) | FR09C0004I2 (fr) |
HK (2) | HK1025330A1 (fr) |
HR (2) | HRP20010161B9 (fr) |
HU (2) | HU230394B1 (fr) |
ID (1) | ID28376A (fr) |
IL (2) | IL143023A0 (fr) |
LT (1) | LTC1002795I2 (fr) |
LU (1) | LU91528I2 (fr) |
MY (1) | MY121108A (fr) |
NL (1) | NL300373I2 (fr) |
NO (3) | NO318801B1 (fr) |
NZ (1) | NZ511116A (fr) |
OA (1) | OA11674A (fr) |
PL (1) | PL204427B1 (fr) |
PT (1) | PT1002795E (fr) |
SI (1) | SI1002795T1 (fr) |
SK (2) | SK287270B6 (fr) |
TR (1) | TR200101306T2 (fr) |
TW (1) | TWI238161B (fr) |
UA (1) | UA70966C2 (fr) |
WO (1) | WO2000027825A1 (fr) |
ZA (1) | ZA200103769B (fr) |
Families Citing this family (125)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU230394B1 (hu) * | 1998-11-10 | 2016-04-28 | Janssen Pharmaceutica N.V. | HIV-vírus szaporodását gátló pirimidin-származékok |
GB9914258D0 (en) * | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
BRPI0014271B1 (pt) | 1999-09-24 | 2021-06-22 | Janssen Pharmaceutica N.V. | Partícula consistindo em uma dispersão de sólidos, uso da dita partícula, dispersão de sólidos, forma de dosagem farmacêutica, bem como processos de preparação de dita partícula, dispersão e forma de dosagem |
DE19945982A1 (de) * | 1999-09-24 | 2001-03-29 | Knoll Ag | Geschwindigkeitsbestimmte Partikel |
WO2001025220A1 (fr) | 1999-10-07 | 2001-04-12 | Amgen Inc. | Inhibiteurs de triazine kinase |
WO2001060816A1 (fr) | 2000-02-17 | 2001-08-23 | Amgen Inc. | Inhibiteurs de kinases |
CA2406562C (fr) | 2000-05-08 | 2009-09-15 | Janssen Pharmaceutica N.V. | Pyrimidines et triazines inhibant la replication du vih |
ES2559273T3 (es) | 2000-05-08 | 2016-02-11 | Janssen Pharmaceutica Nv | Profármacos de pirimidinas que inhiben la replicación del VIH |
US7418471B2 (en) * | 2000-11-01 | 2008-08-26 | Snapnames.Com, Inc. | Domain name acquisition and management system and method |
US6958211B2 (en) | 2001-08-08 | 2005-10-25 | Tibotech Bvba | Methods of assessing HIV integrase inhibitor therapy |
US8101629B2 (en) | 2001-08-13 | 2012-01-24 | Janssen Pharmaceutica N.V. | Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile |
US7638522B2 (en) | 2001-08-13 | 2009-12-29 | Janssen Pharmaceutica N.V. | Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile |
JO3429B1 (ar) * | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
US7115617B2 (en) | 2001-08-22 | 2006-10-03 | Amgen Inc. | Amino-substituted pyrimidinyl derivatives and methods of use |
CA2463989C (fr) | 2001-10-17 | 2012-01-31 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Derives pyrimidine, compositions pharmaceutiques contenant ces composes, utilisation et procede de fabrication de ces composes |
WO2003032994A2 (fr) | 2001-10-17 | 2003-04-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Nouvelles pyrimidines substituees, procede permettant de les produire et leur utilisation comme medicament |
MXPA04004178A (es) | 2001-11-01 | 2004-09-06 | Janssen Pharmaceutica Nv | Heteroarilaminas como inhibidores de glucogeno cintasa cinasa 3beta. |
AU2002363174B2 (en) | 2001-11-01 | 2008-09-25 | Janssen Pharmaceutica N.V. | Amide derivatives as glycogen synthase kinase 3-beta inhibitors |
SE0104140D0 (sv) | 2001-12-07 | 2001-12-07 | Astrazeneca Ab | Novel Compounds |
TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
IL164007A0 (en) | 2002-03-13 | 2005-12-18 | Janssen Pharmaceutica Nv | New inhibitors of histone deacetylase |
BR0307599A (pt) | 2002-03-13 | 2005-02-01 | Janssen Pharmaceutica Nv | Derivados de sulfonilamino como inibidores de histona deacetilase |
GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
ATE380834T1 (de) * | 2002-05-03 | 2007-12-15 | Janssen Pharmaceutica Nv | Polymermikroemulsionen |
AR039540A1 (es) | 2002-05-13 | 2005-02-23 | Tibotec Pharm Ltd | Compuestos microbicidas con contenido de pirimidina o triazina |
AR040456A1 (es) | 2002-06-27 | 2005-04-06 | Bristol Myers Squibb Co | Piridina n-oxidos 2,4 -disubstituidos utiles como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana |
EP1534286B1 (fr) | 2002-07-29 | 2009-12-09 | Rigel Pharmaceuticals, Inc. | Procede de traitement ou de prevention de maladies auto-immunes au moyen de composes de 2,4-pyrimidinediamine |
CN102702111B (zh) | 2002-08-09 | 2014-12-17 | 詹森药业有限公司 | 制备4-[[4-[[4-(2-氰基乙烯基)-2,6-二甲基苯基]氨基]-2-嘧啶基]氨基]苄腈的方法 |
ES2677769T3 (es) | 2002-09-20 | 2018-08-06 | Alpharma Pharmaceuticals Llc | Subunidad secuestrante y composiciones y procedimientos relacionados |
NZ539823A (en) * | 2002-11-28 | 2008-04-30 | Schering Aktiengessellschaft | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents |
ES2295816T3 (es) | 2003-01-14 | 2008-04-16 | Arena Pharmaceuticals, Inc. | Derivados arilo y heteroarilo 1,2,3-trisustituidos como moduladores del metabolismo, y profilaxis y tratamiento de transtornos relacionados con los mismos, tales como la diabetes y la hiperglucemia. |
ES2311146T3 (es) * | 2003-02-07 | 2009-02-01 | Janssen Pharmaceutica Nv | 1,2,4-triazinas que inhiben el vih. |
BRPI0407329A (pt) | 2003-02-07 | 2006-01-10 | Janssen Pharmaceutica Nv | Derivados de pirimidina para a prevenção de infecção de hiv |
CL2004000306A1 (es) * | 2003-02-20 | 2005-04-08 | Tibotec Pharm Ltd | Compuestos derivados de pirimidina sustituidas con indano; proceso para su preparacion; composicion farmaceutica que lo comprende; combinacion farmaceutica; y su uso para el tratamiento o profilaxis de una enfermedad infecciosa. |
WO2004074244A2 (fr) * | 2003-02-20 | 2004-09-02 | Smithkline Beecham Corporation | Composes de pyrimidine |
US20060172010A1 (en) | 2003-07-17 | 2006-08-03 | Gael Lamoureux | Process for preparing particles containing an antiviral |
DK1656372T3 (da) | 2003-07-30 | 2013-07-01 | Rigel Pharmaceuticals Inc | 2,4-pyrimidindiaminforbindelser til anvendelse til behandling eller forebyggelse af autoimmunsygdomme |
ATE500254T1 (de) * | 2003-09-25 | 2011-03-15 | Janssen Pharmaceutica Nv | Die replikation von hiv hemmende purinderivate |
JP5213228B2 (ja) | 2004-03-02 | 2013-06-19 | ビルコ・ビーブイビーエイ | 臨床的カット−オフ値の推測 |
EP1598343A1 (fr) | 2004-05-19 | 2005-11-23 | Boehringer Ingelheim International GmbH | Dérivés de 2-arylaminopyrimidines comme des inhibiteurs de PLK |
MX2007001120A (es) | 2004-07-28 | 2007-03-15 | Janssen Pharmaceutica Nv | Derivados de indolil alquil sustituidos como nuevos inhibidores de la histona desacetilasa. |
US7923554B2 (en) | 2004-08-10 | 2011-04-12 | Janssen Pharmaceutica N.V. | HIV inhibiting 1,2,4-triazin-6-one derivatives |
CA2577467C (fr) * | 2004-09-30 | 2013-05-28 | Tibotec Pharmaceuticals Ltd. | 5-heterocyclyl-pyrimidines inhibitrices du vih |
AU2005288866B2 (en) | 2004-09-30 | 2012-07-26 | Janssen Sciences Ireland Uc | HIV inhibiting 5-substituted pyrimidines |
AU2005288865B2 (en) | 2004-09-30 | 2012-07-19 | Janssen Sciences Ireland Uc | HIV inhibiting 5-carbo- or heterocyclic substituted pyrimidines |
US8153640B2 (en) | 2004-10-29 | 2012-04-10 | Tibotec Pharmaceuticals Ltd. | HIV inhibiting bicyclic pyrimdine derivatives |
JP2008519073A (ja) * | 2004-11-08 | 2008-06-05 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | チプラナビル及びエトラビリンの同時投与によるhiv感染症の治療法 |
WO2006068770A1 (fr) | 2004-11-24 | 2006-06-29 | Rigel Pharmaceuticals, Inc. | Composes de spiro-2, 4-pyrimidinediamine et leurs utilisations |
CA2591948C (fr) | 2005-01-19 | 2013-11-12 | Rigel Pharmaceuticals, Inc. | Promedicaments de composes de 2,4-pyrimidinediamine et leurs utilisations |
WO2006079656A1 (fr) * | 2005-01-27 | 2006-08-03 | Tibotec Pharmaceuticals Ltd. | Derives 2-( 4-cyanophenylamino) de la pyrimidine, inhibiteurs du vih |
PL1853588T3 (pl) | 2005-02-16 | 2008-11-28 | Astrazeneca Ab | Związki chemiczne |
MX2007010051A (es) * | 2005-02-18 | 2007-09-21 | Tibotec Pharm Ltd | Derivados de oxido de 2-(4-cianofenilamino)pirimidina que inhiben el virus de inmunodeficiencia humana. |
DK1858861T3 (da) | 2005-03-04 | 2010-11-08 | Tibotec Pharm Ltd | HIV-inhiberende 2-(4-cyanophenyl)-6-hydroxylaminopyrimidiner |
MX2007014328A (es) | 2005-05-16 | 2008-02-12 | Astrazeneca Ab | Compuestos quimicos. |
PT1888537E (pt) * | 2005-05-26 | 2013-11-26 | Janssen R & D Ireland | Processo para preparar 4-[(1,6-dihidro-6-oxo-2-pirimidinil)amino benzonitrilo |
US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
JP5225079B2 (ja) | 2005-06-08 | 2013-07-03 | ライジェル ファーマシューティカルズ, インコーポレイテッド | Jak経路の阻害のための組成物および方法 |
KR20080059634A (ko) * | 2005-10-06 | 2008-06-30 | 유니버시티 오브 매사추세츠 | Hiv 복제를 억제하기 위한 시약의 조성물 및 합성법 |
AU2006307657B2 (en) | 2005-10-28 | 2010-10-28 | Astrazeneca Ab | 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer |
US8114876B2 (en) | 2006-01-19 | 2012-02-14 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
DE602007001190D1 (de) | 2006-01-19 | 2009-07-09 | Janssen Pharmaceutica Nv | Aminophenylderivate als neue inhibitoren von histondeacetylase |
JP5137849B2 (ja) | 2006-01-19 | 2013-02-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼのインヒビターとしての置換インドリル−アルキル−アミノ−誘導体 |
EP1991532B1 (fr) | 2006-02-24 | 2017-01-11 | Rigel Pharmaceuticals, Inc. | Compositions et méthodes destinées à l'inhibition de la voie jak |
BRPI0709266B8 (pt) | 2006-03-30 | 2021-05-25 | Janssen R & D Ireland | 5-(hidroximetileno e aminometileno) pirimidinas substituídas e composição farmacêutica que as compreende |
JP5078986B2 (ja) | 2006-03-30 | 2012-11-21 | テイボテク・フアーマシユーチカルズ | Hivを阻害する5−アミド置換されたピリミジン |
PE20080068A1 (es) | 2006-05-15 | 2008-03-17 | Boehringer Ingelheim Int | Compuestos derivados de pirimidina como inhibidores de la quinasa aurora |
CN101453989B (zh) | 2006-06-06 | 2012-06-13 | 泰博特克药品有限公司 | 制备tmc125喷雾干燥制剂的方法 |
ES2385612T3 (es) | 2006-06-19 | 2012-07-27 | Alpharma Pharmaceuticals, Llc | Composiciones farmacéuticas |
US20080233156A1 (en) * | 2006-10-11 | 2008-09-25 | Alpharma, Inc. | Pharmaceutical compositions |
US20100041687A1 (en) | 2006-12-06 | 2010-02-18 | Thone Daniel Joseph Christiaan | Hydrobromide salt of an anti-hiv compound |
BRPI0720858B8 (pt) | 2006-12-29 | 2021-05-25 | Janssen R & D Ireland | pirimidinas 6-substituídas inibidoras de hiv e composição farmacêutica que as compreende |
EP2781510B1 (fr) | 2006-12-29 | 2016-12-14 | Janssen Sciences Ireland UC | Pyrimidines 5,6-substitués inhibant le vih |
UA99459C2 (en) | 2007-05-04 | 2012-08-27 | Астразенека Аб | 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer |
EP2212298B1 (fr) | 2007-10-18 | 2013-03-27 | Concert Pharmaceuticals Inc. | Étravirine deutérée |
US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
US20100151014A1 (en) * | 2008-12-16 | 2010-06-17 | Alpharma Pharmaceuticals, Llc | Pharmaceutical composition |
WO2009079521A1 (fr) * | 2007-12-17 | 2009-06-25 | Alpharma Pharmaceuticals, Llc | Composition pharmaceutique |
MX2010012703A (es) | 2008-05-21 | 2010-12-21 | Ariad Pharma Inc | Derivados fosforosos como inhibidores de cinasa. |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
WO2009158571A1 (fr) | 2008-06-27 | 2009-12-30 | Avila Therapeutics And Uses Thereof | Composés hétéro-aryles et leurs utilisations |
US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
TW201016676A (en) * | 2008-10-03 | 2010-05-01 | Astrazeneca Ab | Heterocyclic derivatives and methods of use thereof |
US20110071158A1 (en) * | 2009-03-18 | 2011-03-24 | Boehringer Ingelheim International Gmbh | New compounds |
WO2010112411A1 (fr) | 2009-03-30 | 2010-10-07 | Tibotec Pharmaceuticals | Co-cristal d'étravirine et de nicotinamide |
EP2440559B1 (fr) | 2009-05-05 | 2018-01-10 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs d'egfr et procédés de traitement de troubles |
WO2010131118A2 (fr) * | 2009-05-12 | 2010-11-18 | Pliva Hrvatska D.O.O. | Formes polymorphes d'étravirine et leurs procédés de préparation |
BRPI1004934A2 (pt) | 2009-06-22 | 2016-11-29 | Emcure Pharmaceuticals Ltd | processo para a síntese de inibidor não nucleosídico de transcriptase reversa diarilpirimidínico |
US8153790B2 (en) | 2009-07-27 | 2012-04-10 | Krizmanic Irena | Process for the preparation and purification of etravirine and intermediates thereof |
GR1007010B (el) | 2009-10-08 | 2010-10-07 | Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), | Ινσουλινοειδη πεπτιδια |
EP3075730B1 (fr) | 2010-06-04 | 2018-10-24 | Genentech, Inc. | Dérivés d'aminopyrimidine comme modulateurs lrrk2 |
CA2803848A1 (fr) | 2010-06-28 | 2012-01-05 | Hetero Research Foundation | Procede de preparation d'intermediaire de l'etravirine et de polymorphes de l'etravirine |
WO2012021444A1 (fr) | 2010-08-10 | 2012-02-16 | Avila Therapeutics, Inc. | Sel de bésylate d'un inhibiteur de btk |
WO2012040279A1 (fr) | 2010-09-22 | 2012-03-29 | Arena Pharmaceuticals, Inc. | Modulateurs du récepteur gpr119 et traitement des troubles qui lui sont liés |
TWI545115B (zh) | 2010-11-01 | 2016-08-11 | 阿維拉製藥公司 | 雜環化合物及其用途 |
WO2012061303A1 (fr) | 2010-11-01 | 2012-05-10 | Avila Therapeutics, Inc. | Composés hétéroaryle et leurs utilisations |
JP5957003B2 (ja) | 2010-11-10 | 2016-07-27 | セルジーン アヴィロミクス リサーチ, インコーポレイテッド | 変異体選択的egfr阻害剤およびその使用 |
TW201302733A (zh) | 2010-11-10 | 2013-01-16 | Hoffmann La Roche | 作為lrrk2調節劑之吡唑胺基嘧啶衍生物 |
EP2702045B1 (fr) | 2011-04-26 | 2017-10-18 | Mylan Laboratories Ltd. | Nouveau procédé de préparation d'étravirine |
AU2012250517B2 (en) | 2011-05-04 | 2016-05-19 | Takeda Pharmaceutical Company Limited | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
WO2012170647A1 (fr) * | 2011-06-09 | 2012-12-13 | Assia Chemical Industriew Ltd. | Procédé pour la préparation d'étravirine et intermédiaires dans la synthèse de celle-ci |
US8729079B2 (en) | 2011-08-23 | 2014-05-20 | Endo Pharmaceuticals Inc. | Pyrimido-pyridazinone compounds and methods of use thereof |
US20130123498A1 (en) | 2011-10-19 | 2013-05-16 | Maja Sepelj MAJER | Process for the preparation of etravirine and intermediates in the synthesis thereof |
AR088570A1 (es) | 2011-10-28 | 2014-06-18 | Celgene Avilomics Res Inc | Metodos para tratar una enfermedad o trastorno relacionado con la tirosina quinasa de bruton |
WO2013109354A2 (fr) * | 2011-12-07 | 2013-07-25 | Texas Southern University | Formulations d'étravirine et leurs utilisations |
WO2013138495A1 (fr) | 2012-03-15 | 2013-09-19 | Celgene Avilomics Research, Inc. | Formes solides d'un inhibiteur de kinases du récepteur du facteur de croissance épidermique |
EP2825042B1 (fr) | 2012-03-15 | 2018-08-01 | Celgene CAR LLC | Sels d'inhibiteur de kinases du récepteur de facteur de croissance épidermique |
AU2013204563B2 (en) | 2012-05-05 | 2016-05-19 | Takeda Pharmaceutical Company Limited | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
WO2014068588A2 (fr) * | 2012-10-29 | 2014-05-08 | Biophore India Pharmaceuticals Pvt. Ltd. | Procédé de synthèse d'étravirine et ses intermédiaires |
WO2014072419A1 (fr) | 2012-11-08 | 2014-05-15 | Universiteit Antwerpen | Nouveaux composés anti-vih |
WO2014100748A1 (fr) | 2012-12-21 | 2014-06-26 | Celgene Avilomics Research, Inc. | Composés hétéroarylés et leurs utilisations |
WO2014094176A1 (fr) | 2012-12-21 | 2014-06-26 | Oncozyme Pharma Inc. | Utilisations et méthodes concernant le traitement de maladies ou d'affections hépatiques |
JP2016509012A (ja) | 2013-02-08 | 2016-03-24 | セルジーン アビロミクス リサーチ, インコーポレイテッド | Erk阻害剤およびそれらの使用 |
US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
US9492471B2 (en) | 2013-08-27 | 2016-11-15 | Celgene Avilomics Research, Inc. | Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase |
US9415049B2 (en) | 2013-12-20 | 2016-08-16 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
WO2016025561A1 (fr) | 2014-08-13 | 2016-02-18 | Celgene Avilomics Research, Inc. | Formes et compositions d'un inhibiteur d'erk |
NZ734220A (en) | 2015-01-06 | 2022-01-28 | Arena Pharm Inc | Methods of treating conditions related to the s1p1 receptor |
CN104926829A (zh) * | 2015-06-08 | 2015-09-23 | 山东大学 | 一种噻吩并嘧啶类衍生物及其制备方法和应用 |
MA42807A (fr) | 2015-06-22 | 2018-07-25 | Arena Pharm Inc | Sel l-arginine cristallin d'acide (r)-2-(7-(4-cyclopentyl-3-(trifluorométhyl)benzyloxy)-1,2,3,4-tétrahydrocyclo-penta[b]indol-3-yl)acétique (composé 1) pour une utilisation dans des troubles associés au récepteur de s1p1 |
CN110066273A (zh) * | 2019-06-05 | 2019-07-30 | 山东大学 | 一种含三氮唑环的单芳基嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用 |
US11529350B2 (en) | 2019-07-03 | 2022-12-20 | Sumitomo Pharma Oncology, Inc. | Tyrosine kinase non-receptor 1 (TNK1) inhibitors and uses thereof |
CN111217833B (zh) * | 2020-02-21 | 2021-03-16 | 山东大学 | 噻吩并[2,3-d]嘧啶类HIV-1非核苷类逆转录酶抑制剂及其制备方法和应用 |
CN111875548A (zh) * | 2020-07-16 | 2020-11-03 | 山东大学 | 一种5位芳环取代的二芳基嘧啶类衍生物及其制备方法与应用 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3459731A (en) | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
US4659363A (en) * | 1983-07-25 | 1987-04-21 | Ciba-Geigy Corporation | N-(2-nitrophenyl)-2-aminopyrimidine derivatives, the preparation and use thereof |
ATE60591T1 (de) * | 1984-06-25 | 1991-02-15 | Ciba Geigy Ag | Pyrimidinderivate wirksam als schaedlingsbekaempfungsmittel. |
KR950006713B1 (ko) | 1988-03-31 | 1995-06-21 | 미쓰비시 가세이 가부시끼가이샤 | 6-치환 비환식 피리미딘뉴클레오시드 유도체 및 그 유도체를 유효성분으로 하는 항 비루스제 |
JPH02308248A (ja) | 1989-05-24 | 1990-12-21 | Fuji Photo Film Co Ltd | アミノピリミジン系色素形成カプラーおよび該カプラーを含有するハロゲン化銀カラー写真感光材料 |
JP2895680B2 (ja) * | 1992-07-08 | 1999-05-24 | シャープ株式会社 | 磁気ヘッドおよびその製造方法 |
US5516775A (en) | 1992-08-31 | 1996-05-14 | Ciba-Geigy Corporation | Further use of pyrimidine derivatives |
JP3398152B2 (ja) | 1993-10-12 | 2003-04-21 | ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー | 1n−アルキル−n−アリールピリミジンアミンおよびその誘導体 |
US5691364A (en) * | 1995-03-10 | 1997-11-25 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
GB9523675D0 (en) * | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
NZ322907A (en) | 1995-11-23 | 1998-12-23 | Janssen Pharmaceutica Nv | Solid mixtures of cyclodextrins prepared via melt-extrusion |
KR100219922B1 (ko) * | 1996-05-16 | 1999-09-01 | 이서봉 | 신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법 |
GB9619284D0 (en) * | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
NO311614B1 (no) * | 1996-10-01 | 2001-12-17 | Janssen Pharmaceutica Nv | Substituerte diamino-1,3,5-triazinderivater |
GB9705361D0 (en) * | 1997-03-14 | 1997-04-30 | Celltech Therapeutics Ltd | Chemical compounds |
DE29704863U1 (de) * | 1997-03-17 | 1997-05-22 | Gesellschaft für Innenhochdruckverfahren mbH & Co. KG, 73441 Bopfingen | Achsschwinge |
NZ506417A (en) | 1998-02-17 | 2003-05-30 | Tularik Inc | Anti-viral pyrimidine derivatives |
KR100643419B1 (ko) * | 1998-03-27 | 2006-11-10 | 얀센 파마슈티카 엔.브이. | Hiv를 억제하는 피리미딘 유도체 |
CZ299380B6 (cs) | 1998-03-27 | 2008-07-09 | Janssen Pharmaceutica N. V. | Pyrimidinová sloucenina, použití této slouceniny pro prípravu léciva, farmaceutický prostredek tutoslouceninu obsahující, zpusob prípravy tohoto prostredku a uvedené slouceniny a kombinace a produktuvedenou slouceninu obsahující |
EP0945442A1 (fr) | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Dérivés de pyrimidine trisubstitués |
HU230394B1 (hu) * | 1998-11-10 | 2016-04-28 | Janssen Pharmaceutica N.V. | HIV-vírus szaporodását gátló pirimidin-származékok |
ES2559273T3 (es) * | 2000-05-08 | 2016-02-11 | Janssen Pharmaceutica Nv | Profármacos de pirimidinas que inhiben la replicación del VIH |
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