ME01612B - Proces za pripremu 4-[(1,6-dihidro-6-okso-2-pirimidinil)amino benzonitrila - Google Patents

Proces za pripremu 4-[(1,6-dihidro-6-okso-2-pirimidinil)amino benzonitrila

Info

Publication number
ME01612B
ME01612B MEP-2013-136A MEP13613A ME01612B ME 01612 B ME01612 B ME 01612B ME P13613 A MEP13613 A ME P13613A ME 01612 B ME01612 B ME 01612B
Authority
ME
Montenegro
Prior art keywords
dihydro
oxo
pyrimidinyl
preparing
ester
Prior art date
Application number
MEP-2013-136A
Other languages
English (en)
Inventor
Didier Philippe Robert Schils
Alfred Elisabeth Stappers
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Publication of ME01612B publication Critical patent/ME01612B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

Abstract

Ovaj pronalazak se odnosi na postupak za pripremu 4-[(1,6-dihidro-6-okso-2-pirimidinil)-amino]benzonitrila (I) započinjući sa esterom (II) 4-okso-1,6-dihidro-pirimidinilkarboksilne kiseline iz gvanidinskog derivata koji reaguje sa esterom alkoksimetilen malonske kiseline i daje ester (II) koji se konvertuje u (I), pri čemu pomenuta reakciona sekvenca može da se provodi u jednoj posudi.
MEP-2013-136A 2005-05-26 2006-05-24 Proces za pripremu 4-[(1,6-dihidro-6-okso-2-pirimidinil)amino benzonitrila ME01612B (me)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05104531 2005-05-26
US68599305P 2005-05-31 2005-05-31
EP06755299.2A EP1888537B1 (en) 2005-05-26 2006-05-24 Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino benzonitrile
PCT/EP2006/062606 WO2006125809A1 (en) 2005-05-26 2006-05-24 Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino benzonitrile

Publications (1)

Publication Number Publication Date
ME01612B true ME01612B (me) 2014-09-20

Family

ID=35822492

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2013-136A ME01612B (me) 2005-05-26 2006-05-24 Proces za pripremu 4-[(1,6-dihidro-6-okso-2-pirimidinil)amino benzonitrila

Country Status (20)

Country Link
US (2) US8101752B2 (me)
EP (1) EP1888537B1 (me)
JP (2) JP5148483B2 (me)
CN (1) CN101248051B (me)
AU (1) AU2006251163C1 (me)
BR (1) BRPI0611038B8 (me)
CA (1) CA2609716C (me)
DK (1) DK1888537T3 (me)
ES (1) ES2437202T3 (me)
HK (1) HK1123551A1 (me)
HR (1) HRP20131133T1 (me)
IN (1) IN2014DN04588A (me)
ME (1) ME01612B (me)
MX (1) MX2007014881A (me)
PL (1) PL1888537T3 (me)
PT (1) PT1888537E (me)
RS (1) RS53062B (me)
RU (1) RU2458056C2 (me)
SI (1) SI1888537T1 (me)
WO (1) WO2006125809A1 (me)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007014881A (es) * 2005-05-26 2008-02-15 Tibotec Pharm Ltd Procedimiento para preparar 4-(1,6-dihidro-6-oxo-2-pirimidinil) amino benzonitrilo.
WO2012125993A1 (en) 2011-03-17 2012-09-20 Teva Pharmaceutical Industries Ltd. Solid state forms of rilpivirine base, and rilipivirine salts
US10112972B2 (en) 2012-03-13 2018-10-30 Octapharma Ag Process for production of fibrinogen and fibrinogen produced thereby
CN103058936B (zh) * 2013-01-23 2016-01-06 宁波九胜创新医药科技有限公司 4-[(4-氯-2-嘧啶基)氨基]苯腈的制备方法
CN103193719B (zh) * 2013-04-08 2015-07-22 宁波九胜创新医药科技有限公司 一种4-[(4-羟基-2-嘧啶基)氨基]苯腈的制备方法
CN114933567B (zh) * 2022-04-29 2023-07-11 武汉工程大学 一种2-甲硫基-4-嘧啶酮的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE63502B1 (en) 1989-04-21 1995-05-03 Zeneca Ltd Aminopyrimidine derivatives useful for treating cardiovascular disorders
DE3923979A1 (de) 1989-07-20 1991-01-24 Merck Patent Gmbh Verfahren zur herstellung von aromatischen nitrilen
RU2037483C1 (ru) * 1989-07-20 1995-06-19 Мерк Патент Гмбх Способ получения замещенных ароматических нитрилов
WO1999050250A1 (en) * 1998-03-27 1999-10-07 Janssen Pharmaceutica N.V. Hiv inhibiting pyrimidine derivatives
OA11674A (en) * 1998-11-10 2005-01-12 Janssen Pharmaceutica Nv HIV Replication inhibiting pyrimidines.
EA005423B1 (ru) * 1999-09-24 2005-02-24 Янссен Фармацевтика Н.В. Противовирусные композиции
DK1282607T3 (en) * 2000-05-08 2016-02-01 Janssen Pharmaceutica Nv Prodrugs of HIV replication inhibiting pyrimidines
JO3429B1 (ar) * 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
EP1448556A1 (en) 2001-11-01 2004-08-25 Janssen Pharmaceutica N.V. Heteroaryl amines as glycogen synthase kinase 3beta inhibitors (gsk3 inhibitors)
CN101481356B (zh) * 2002-08-09 2012-07-11 詹森药业有限公司 制备4-[[4-[[4-(2-氰基乙烯基)-2,6-二甲基苯基]氨基]-2-嘧啶基]氨基]苄腈的方法
US7432378B2 (en) * 2003-09-30 2008-10-07 Janssen Pharmaceutica, N.V. Benzoimidazole compounds
MX2007014881A (es) * 2005-05-26 2008-02-15 Tibotec Pharm Ltd Procedimiento para preparar 4-(1,6-dihidro-6-oxo-2-pirimidinil) amino benzonitrilo.

Also Published As

Publication number Publication date
CA2609716A1 (en) 2006-11-30
RU2007148968A (ru) 2009-07-10
CA2609716C (en) 2014-10-14
AU2006251163C1 (en) 2012-07-12
CN101248051A (zh) 2008-08-20
MX2007014881A (es) 2008-02-15
ES2437202T3 (es) 2014-01-09
JP5148483B2 (ja) 2013-02-20
PL1888537T3 (pl) 2014-02-28
AU2006251163A1 (en) 2006-11-30
EP1888537B1 (en) 2013-09-11
HK1123551A1 (en) 2009-06-19
BRPI0611038B1 (pt) 2022-02-08
WO2006125809A1 (en) 2006-11-30
AU2006251163B2 (en) 2012-03-08
JP5580385B2 (ja) 2014-08-27
HRP20131133T1 (hr) 2014-01-03
BRPI0611038B8 (pt) 2022-10-25
IN2014DN04588A (me) 2015-07-10
RS53062B (en) 2014-04-30
SI1888537T1 (sl) 2014-01-31
PT1888537E (pt) 2013-11-26
BRPI0611038A2 (pt) 2010-08-10
JP2008545680A (ja) 2008-12-18
US8101752B2 (en) 2012-01-24
US20080171878A1 (en) 2008-07-17
US8618291B2 (en) 2013-12-31
EP1888537A1 (en) 2008-02-20
RU2458056C2 (ru) 2012-08-10
CN101248051B (zh) 2013-07-17
US20120083606A1 (en) 2012-04-05
JP2013040194A (ja) 2013-02-28
DK1888537T3 (da) 2013-12-09

Similar Documents

Publication Publication Date Title
ME01612B (me) Proces za pripremu 4-[(1,6-dihidro-6-okso-2-pirimidinil)amino benzonitrila
DK2057126T3 (da) Fremgangsmåde til fremstilling af 3-dihalomethyl-pyrazol-4-carboxylsyrederivater
HRP20220455T1 (hr) Modificirane aminokiseline koje sadrže azid grupu
MX2010001905A (es) Sal de metal alcalino de acido glutamico acido n,n-diacetico, un proceso para preparar dicha sal, y el uso de la misma.
MY156546A (en) Process for the regioselective preparation of 1-alkyl-3-haloalkylpyrazole-4-carboxylic acid derivatives
RS53455B (en) OPTIONS DERIVED FROM ActRIIB AND THEIR USE
DK1881957T3 (da) Fremgangsmåde til fremstilling af biproduktfattige methylglycin-N,N-diedikkesyre-trialkalimetalsalte
EA200970149A1 (ru) Производные n-(аминогетероарил)-1h-индол-2-карбоксамидов, их получение и их применение в терапии
MY175373A (en) Crystal form of phenylamino pyrimidine derivatives
MX2009005768A (es) Proceso para producir condimento.
BRPI0606676A2 (pt) processos para a preparação de derivados de ácido 4-(fenóxi-5-metil-pirimidin-4-ilóxi)piperidina-1-carboxì lico e compostos relacionados
MY148411A (en) Process for stably operating a continuous preparation process for obtaining acrolein or acrylic acid or a mixture thereof from propane
NO20082749L (no) Fremgangsmate for fremstilling av ferri-succinylkasein
TW200720243A (en) Process for stably operating a continuous preparation process for obtaining acrolein or acrylic acid or a mixture thereof from propane
NZ605608A (en) Method of synthesis of ferroquine by convergent reductive amination
TW200719889A (en) Amino acid derivatives
CY1113279T1 (el) Φαρμακευτικη συνθεση 271
CR9565A (es) Derivados del 4,5-diarilpirrol, su preparacion y su aplicacion en terapeutica
TW200722434A (en) Stereoselective synthesis of β-nucleosides
TW200740729A (en) Methods for preparing glutamic acid derivatives
HK1107984A1 (en) Pyrrolopyridine-2-carboxylic acid amide derivativeuseful as inhibitor of glycogen phosphorylase
ATE388154T1 (de) Kristalline form von cefdinir-ammoniumsalz als zwischenprodukt für die herstellung von reinem cefdinir
DK1765770T3 (da) Fremgangsmåde til fremstilling af gabapentin
ATE550326T1 (de) Als modulatoren von hdl einsetzbare verbindungen
DK1902033T3 (da) Fremgangsmåde til fremstilling af caboxamider