BRPI0611038B8 - Processo para preparar 4-(1,6-diidro-6-oxo-2-pirimidinil)amino benzonitrila e composto intermediário - Google Patents

Processo para preparar 4-(1,6-diidro-6-oxo-2-pirimidinil)amino benzonitrila e composto intermediário

Info

Publication number
BRPI0611038B8
BRPI0611038B8 BRPI0611038A BRPI0611038A BRPI0611038B8 BR PI0611038 B8 BRPI0611038 B8 BR PI0611038B8 BR PI0611038 A BRPI0611038 A BR PI0611038A BR PI0611038 A BRPI0611038 A BR PI0611038A BR PI0611038 B8 BRPI0611038 B8 BR PI0611038B8
Authority
BR
Brazil
Prior art keywords
dihydro
oxo
preparing
pyrimidinil
intermediate compound
Prior art date
Application number
BRPI0611038A
Other languages
English (en)
Inventor
Philippe Robert Schils Didier
Elisabeth Stappers Alfred
Original Assignee
Tibotec Pharm Ltd
Janssen R & D Ireland
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd, Janssen R & D Ireland, Janssen Sciences Ireland Uc filed Critical Tibotec Pharm Ltd
Publication of BRPI0611038A2 publication Critical patent/BRPI0611038A2/pt
Publication of BRPI0611038B1 publication Critical patent/BRPI0611038B1/pt
Publication of BRPI0611038B8 publication Critical patent/BRPI0611038B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCESSO PARA PREPARAR 4-(1,6-DIIDRO-6-OXO-2-PIRIMIDINIL)AMINO BENZONITRILA. A presente invenção refere-se a um processo para preparar 4-[(1,6-diidro-6-oxo-2-pirimidinil)-amino]benzonitrila (I) a partir de um éster de ácido 4-oxo-1,6-diidro-pirimidinilcarboxílico (II) ou a partir de um derivado de guanidina que é reagido com um éster de ácido alcóxi-metileno malônico para um éster (II) que é convertido a (I), cuja seqüência de reação pode ser um procedimento de um pote.
BRPI0611038A 2005-05-26 2006-05-24 Processo para preparar 4-(1,6-diidro-6-oxo-2-pirimidinil)amino benzonitrila e composto intermediário BRPI0611038B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP05104531.8 2005-05-26
EP05104531 2005-05-26
US68599305P 2005-05-31 2005-05-31
US60/685,993 2005-05-31
PCT/EP2006/062606 WO2006125809A1 (en) 2005-05-26 2006-05-24 Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino benzonitrile

Publications (3)

Publication Number Publication Date
BRPI0611038A2 BRPI0611038A2 (pt) 2010-08-10
BRPI0611038B1 BRPI0611038B1 (pt) 2022-02-08
BRPI0611038B8 true BRPI0611038B8 (pt) 2022-10-25

Family

ID=35822492

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0611038A BRPI0611038B8 (pt) 2005-05-26 2006-05-24 Processo para preparar 4-(1,6-diidro-6-oxo-2-pirimidinil)amino benzonitrila e composto intermediário

Country Status (20)

Country Link
US (2) US8101752B2 (pt)
EP (1) EP1888537B1 (pt)
JP (2) JP5148483B2 (pt)
CN (1) CN101248051B (pt)
AU (1) AU2006251163C1 (pt)
BR (1) BRPI0611038B8 (pt)
CA (1) CA2609716C (pt)
DK (1) DK1888537T3 (pt)
ES (1) ES2437202T3 (pt)
HK (1) HK1123551A1 (pt)
HR (1) HRP20131133T1 (pt)
IN (1) IN2014DN04588A (pt)
ME (1) ME01612B (pt)
MX (1) MX2007014881A (pt)
PL (1) PL1888537T3 (pt)
PT (1) PT1888537E (pt)
RS (1) RS53062B (pt)
RU (1) RU2458056C2 (pt)
SI (1) SI1888537T1 (pt)
WO (1) WO2006125809A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007014881A (es) * 2005-05-26 2008-02-15 Tibotec Pharm Ltd Procedimiento para preparar 4-(1,6-dihidro-6-oxo-2-pirimidinil) amino benzonitrilo.
WO2012125993A1 (en) 2011-03-17 2012-09-20 Teva Pharmaceutical Industries Ltd. Solid state forms of rilpivirine base, and rilipivirine salts
WO2013135684A1 (en) 2012-03-13 2013-09-19 Octapharma Ag Improved process for production of fibrinogen and fibrinogen produced thereby
CN103058936B (zh) * 2013-01-23 2016-01-06 宁波九胜创新医药科技有限公司 4-[(4-氯-2-嘧啶基)氨基]苯腈的制备方法
CN103193719B (zh) * 2013-04-08 2015-07-22 宁波九胜创新医药科技有限公司 一种4-[(4-羟基-2-嘧啶基)氨基]苯腈的制备方法
CN114933567B (zh) * 2022-04-29 2023-07-11 武汉工程大学 一种2-甲硫基-4-嘧啶酮的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE63502B1 (en) 1989-04-21 1995-05-03 Zeneca Ltd Aminopyrimidine derivatives useful for treating cardiovascular disorders
RU2037483C1 (ru) * 1989-07-20 1995-06-19 Мерк Патент Гмбх Способ получения замещенных ароматических нитрилов
DE3923979A1 (de) 1989-07-20 1991-01-24 Merck Patent Gmbh Verfahren zur herstellung von aromatischen nitrilen
TR200002760T2 (tr) * 1998-03-27 2000-12-21 Janssen Pharmaceutica N.V. HIV engelleyici pirimidin türevleri
UA70966C2 (uk) * 1998-11-10 2004-11-15 Янссен Фармацевтика Н.В. Піримідини, що інгібують реплікацію віл
ES2258018T3 (es) * 1999-09-24 2006-08-16 Janssen Pharmaceutica N.V. Dispersiones solidas antivirales.
EP1282607B1 (en) * 2000-05-08 2015-11-11 Janssen Pharmaceutica NV Prodrugs of hiv replication inhibiting pyrimidines
JO3429B1 (ar) * 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
EA007298B1 (ru) * 2001-11-01 2006-08-25 Янссен Фармацевтика Н.В. Гетероариламины в качестве ингибиторов гликогенсинтаза-киназы 3-бета (ингибиторов gsk3)
CN101481356B (zh) * 2002-08-09 2012-07-11 詹森药业有限公司 制备4-[[4-[[4-(2-氰基乙烯基)-2,6-二甲基苯基]氨基]-2-嘧啶基]氨基]苄腈的方法
TW200526637A (en) * 2003-09-30 2005-08-16 Janssen Pharmaceutica Nv Benzoimidazole compounds
MX2007014881A (es) * 2005-05-26 2008-02-15 Tibotec Pharm Ltd Procedimiento para preparar 4-(1,6-dihidro-6-oxo-2-pirimidinil) amino benzonitrilo.

Also Published As

Publication number Publication date
JP2008545680A (ja) 2008-12-18
PL1888537T3 (pl) 2014-02-28
US8101752B2 (en) 2012-01-24
US8618291B2 (en) 2013-12-31
RS53062B (en) 2014-04-30
AU2006251163A1 (en) 2006-11-30
JP5148483B2 (ja) 2013-02-20
JP5580385B2 (ja) 2014-08-27
DK1888537T3 (da) 2013-12-09
SI1888537T1 (sl) 2014-01-31
BRPI0611038B1 (pt) 2022-02-08
MX2007014881A (es) 2008-02-15
BRPI0611038A2 (pt) 2010-08-10
EP1888537A1 (en) 2008-02-20
US20120083606A1 (en) 2012-04-05
AU2006251163B2 (en) 2012-03-08
CA2609716C (en) 2014-10-14
RU2458056C2 (ru) 2012-08-10
US20080171878A1 (en) 2008-07-17
ES2437202T3 (es) 2014-01-09
ME01612B (me) 2014-09-20
AU2006251163C1 (en) 2012-07-12
HRP20131133T1 (hr) 2014-01-03
CN101248051B (zh) 2013-07-17
IN2014DN04588A (pt) 2015-07-10
RU2007148968A (ru) 2009-07-10
WO2006125809A1 (en) 2006-11-30
JP2013040194A (ja) 2013-02-28
HK1123551A1 (en) 2009-06-19
EP1888537B1 (en) 2013-09-11
CA2609716A1 (en) 2006-11-30
PT1888537E (pt) 2013-11-26
CN101248051A (zh) 2008-08-20

Similar Documents

Publication Publication Date Title
BRPI0611038B8 (pt) Processo para preparar 4-(1,6-diidro-6-oxo-2-pirimidinil)amino benzonitrila e composto intermediário
EA200702413A1 (ru) Способ получения 1-алкил-3-фенилурацилов
BRPI0500480A (pt) processo para a sìntese de (1s)-4,5-dimetóxi- 1-(metilaminometil)-benzociclobutano e sais de adição deste, e aplicação na sìntese de ivabradina e sais de adição desta com um ácido farmaceuticamente aceitável
CY1109854T1 (el) Παραγωγα αζαδικυκλο(3.1.0)εξανιου χρησιμα ως ρυθμιστες υποδοχεων d3 ντοπαμινης
CY1114548T1 (el) Διεργασιες για την παρασκευη azoxystrobin με τη χρηση dabco ως καταλυτη και νεα ενδιαμεσα που χρησιμοποιουνται στις διεργασιες
DE602004014650D1 (de) Wässrige silannanokomposite
DK1820792T3 (da) Fremgangsmåde til fremstilling af adamantanaminer
EA200701810A1 (ru) Производное изоксазолина и новый способ его получения
MX2010009401A (es) Forma cristalina de derivado de fenilamino pirimidina.
ATE529181T1 (de) Neuartiges dispersionsmittel und zusammensetzungen daraus
BR9812524A (pt) Processos e intermediários utilizáveis para produzir antifolatos
BR0213683A (pt) Hidrazono-malonitrilas
HU0201083D0 (pt)
BRPI0516994A (pt) processo para preparação de pirazóis
AR057555A1 (es) Un inhibidor de fosfodiesterasa-4 4-oxo-1-(3-sustituido fenil-1,4-dihidro-1,8-naftiridin-3-carboxamida y un procedimiento de preparacion del mismo
BRPI0409013A (pt) processos para preparação de um produto de reação, de uma composição farmacêutica, de uma composição agroquìmica, de uma composição de limpeza, de uma composição de tinta e de um refrigerador ou lubrificante
EA201071001A1 (ru) Способ получения комбретастатина
BRPI0808570B8 (pt) processo para a preparação de inibidores de glyt-1
ATE400574T1 (de) Pyrrolopyridin-2-karbonsäureamid-derivat zur verwendung als inhibitor gegen glykogenphosphorylase
BR0315055A (pt) Diamidas de ácido pirimidin-4,6-dicarboxìilco para a inibição seletiva de colagenases
BR112013011244A2 (pt) processo para a preparação de derivados e ácido 3-(6-amino-piridin-3il)-2-acrílico
BR112012008128B8 (pt) processos para a preparação de um composto da fórmula | e processo para a alquilação regiosseletiva de um composto da fórmula ||
BRPI0613568A2 (pt) Síntese de beta-lactama
BRPI0401037A (pt) Processo para a preparação de n-metil-dialquilaminas a partir de dialquilaminas secundárias e formaldeìdo
EA201101014A1 (ru) Сульфонамиды, предназначенные для лечения респираторных нарушений

Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: TIBOTEC PHARMACEUTICALS (IE)

B25D Requested change of name of applicant approved

Owner name: JANSSEN R AND D IRELAND (IE)

B25A Requested transfer of rights approved

Owner name: JANSSEN SCIENCES IRELAND UC (IE)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 239/46

Ipc: C07D 239/46 (2006.01), A61P 31/18 (2006.01)

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/05/2006, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: REFERENTE A RPI 2666 DE 08/02/2022, QUANTO AO QUADRO REIVINDICATORIO.