BR112013011244A2 - processo para a preparação de derivados e ácido 3-(6-amino-piridin-3il)-2-acrílico - Google Patents

processo para a preparação de derivados e ácido 3-(6-amino-piridin-3il)-2-acrílico

Info

Publication number
BR112013011244A2
BR112013011244A2 BR112013011244A BR112013011244A BR112013011244A2 BR 112013011244 A2 BR112013011244 A2 BR 112013011244A2 BR 112013011244 A BR112013011244 A BR 112013011244A BR 112013011244 A BR112013011244 A BR 112013011244A BR 112013011244 A2 BR112013011244 A2 BR 112013011244A2
Authority
BR
Brazil
Prior art keywords
preparation
pyridin
amino
acrylic acid
acid derivatives
Prior art date
Application number
BR112013011244A
Other languages
English (en)
Inventor
Napierski Bernd
Sommer Christian
Boehm Claudius
Klein Susanne
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of BR112013011244A2 publication Critical patent/BR112013011244A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

processo para a preparação de derivados de ácido 3-(6-amino-piridin-3il)-2-acrílico. a presente invenção refere-se a um processo para a preparação de derivados de ácido 3-(6-amino-piridin-3il)-2-acrílico. a presente invenção refere-se a um processo para a preparação de um composto de fórmula (i), que compreende reagir um composto de fórmula (iv) com o composto de fórmula vii, r15-a2-cho, e a novos compostos intermediários usados aqui.
BR112013011244A 2010-11-11 2011-11-08 processo para a preparação de derivados e ácido 3-(6-amino-piridin-3il)-2-acrílico BR112013011244A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10306246 2010-11-11
PCT/EP2011/069603 WO2012062730A1 (en) 2010-11-11 2011-11-08 Process for the preparation of 3-(6-amino-pyridin-3yl)-2-acrylic acid derivatives

Publications (1)

Publication Number Publication Date
BR112013011244A2 true BR112013011244A2 (pt) 2017-10-24

Family

ID=43901646

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013011244A BR112013011244A2 (pt) 2010-11-11 2011-11-08 processo para a preparação de derivados e ácido 3-(6-amino-piridin-3il)-2-acrílico

Country Status (14)

Country Link
US (1) US8940901B2 (pt)
EP (1) EP2638016B1 (pt)
JP (1) JP2013542235A (pt)
KR (1) KR20130130737A (pt)
CN (1) CN103201269A (pt)
AR (1) AR083818A1 (pt)
AU (1) AU2011328263A1 (pt)
BR (1) BR112013011244A2 (pt)
CA (1) CA2814911A1 (pt)
IL (1) IL225680A0 (pt)
MX (1) MX2013004193A (pt)
RU (1) RU2013126689A (pt)
SG (1) SG189420A1 (pt)
WO (1) WO2012062730A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2782575B1 (en) * 2011-11-25 2016-04-20 Sanofi Crystalline salts of r)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1h-imidazol-4-yl)-propionic acid
EP2782576B1 (en) * 2011-11-25 2016-05-18 Sanofi Sodium salt of (r)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1h-imidazol-4-yl)-propionic acid
CN111349043B (zh) * 2018-12-20 2022-09-27 上海医药工业研究院 用于制备派西尼布的中间体及其制备方法和应用
CN111690699A (zh) * 2020-05-19 2020-09-22 浙江工业大学 一种酶促在线合成3-（吡啶-2-氨基）丙羟肟酸的方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0405602A1 (en) 1989-06-30 1991-01-02 Laboratorios Vinas S.A. New Zinc derivatives of anti-inflammatory drugs having improved therapeutic activity
US6245774B1 (en) 1994-06-21 2001-06-12 Celltech Therapeutics Limited Tri-substituted phenyl or pyridine derivatives
JP2002508323A (ja) 1997-12-17 2002-03-19 メルク エンド カムパニー インコーポレーテッド インテグリン受容体拮抗薬
CA2317439A1 (en) 1998-01-14 1999-07-22 Wayne J. Brouillette Methods of synthesizing and screening inhibitors of bacterial nad synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections with inhibitors of bacterial nad synthetase enzyme
US6861448B2 (en) 1998-01-14 2005-03-01 Virtual Drug Development, Inc. NAD synthetase inhibitors and uses thereof
WO2002000651A2 (en) 2000-06-27 2002-01-03 Bristol-Myers Squibb Pharma Company Factor xa inhibitors
US6710058B2 (en) 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
WO2003013526A1 (en) 2001-08-08 2003-02-20 Merck & Co. Inc. Anticoagulant compounds
MXPA04005940A (es) 2002-01-22 2004-09-13 Pfizer Acidos 3-(imidazolil)-2-aminopropanoicos.
US20030199523A1 (en) 2002-02-28 2003-10-23 Snutch Terrance P. Heterocyclic calcium in channel blockers
WO2003091211A1 (fr) 2002-03-28 2003-11-06 Sumitomo Pharmaceuticals Co., Ltd. Composes d'heteroaryle
US8710232B2 (en) 2004-04-22 2014-04-29 Sanofi-Aventis Deutschland Gmbh Imidazole derivatives used as TAFIa inhibitors
DE102004020186A1 (de) 2004-04-22 2005-11-17 Aventis Pharma Deutschland Gmbh Heterocyclylessigsäuren als Inhibitoren von TAFla
NZ591366A (en) * 2008-09-11 2012-05-25 Pfizer Heteroaryls amide derivatives and their use as glucokinase activators
AU2009310841A1 (en) * 2008-10-29 2010-05-06 Taisho Pharmaceutical Co., Ltd. Compounds having TAFIa inhibitory activity
EP2430002B1 (en) 2009-05-15 2013-07-24 Sanofi Process for the preparation of a compound useful as an inhibitor of tafia
JP5778133B2 (ja) * 2010-03-18 2015-09-16 第一三共株式会社 シクロプロパンカルボン酸誘導体

Also Published As

Publication number Publication date
EP2638016A1 (en) 2013-09-18
US8940901B2 (en) 2015-01-27
CN103201269A (zh) 2013-07-10
MX2013004193A (es) 2013-06-05
AU2011328263A1 (en) 2013-05-30
CA2814911A1 (en) 2012-05-18
AR083818A1 (es) 2013-03-27
US20130245274A1 (en) 2013-09-19
EP2638016B1 (en) 2014-10-01
JP2013542235A (ja) 2013-11-21
IL225680A0 (en) 2013-06-27
KR20130130737A (ko) 2013-12-02
SG189420A1 (en) 2013-05-31
WO2012062730A1 (en) 2012-05-18
RU2013126689A (ru) 2014-12-20

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]