CN107667117B - 激动型icos结合蛋白 - Google Patents

激动型icos结合蛋白 Download PDF

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CN107667117B
CN107667117B CN201680007876.6A CN201680007876A CN107667117B CN 107667117 B CN107667117 B CN 107667117B CN 201680007876 A CN201680007876 A CN 201680007876A CN 107667117 B CN107667117 B CN 107667117B
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icos
cells
cell
antibody
binding protein
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CN107667117A (zh
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刘耀斌
R.S.帕马
P.梅斯
D.奥利弗
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Aix Marseille Universite
Centre National de la Recherche Scientifique CNRS
Institut National de la Sante et de la Recherche Medicale INSERM
Institut Jean Paoli and Irene Calmettes
GlaxoSmithKline Intellectual Property Development Ltd
Original Assignee
Aix Marseille Universite
Centre National de la Recherche Scientifique CNRS
Institut National de la Sante et de la Recherche Medicale INSERM
Institut Jean Paoli and Irene Calmettes
GlaxoSmithKline Intellectual Property Development Ltd
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    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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CN201680007876.6A 2015-01-28 2016-01-26 激动型icos结合蛋白 Active CN107667117B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562108605P 2015-01-28 2015-01-28
US62/108,605 2015-01-28
US201562192331P 2015-07-14 2015-07-14
US62/192,331 2015-07-14
US201562247355P 2015-10-28 2015-10-28
US62/247,355 2015-10-28
PCT/IB2016/050383 WO2016120789A1 (en) 2015-01-28 2016-01-26 Agonistic icos binding proteins

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CN107667117A CN107667117A (zh) 2018-02-06
CN107667117B true CN107667117B (zh) 2021-12-28

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ZA201704818B (en) 2019-01-30
CA2974910A1 (en) 2016-08-04
WO2016120789A1 (en) 2016-08-04
KR20180002593A (ko) 2018-01-08
US20170313777A1 (en) 2017-11-02
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TWI717332B (zh) 2021-02-01
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BR112017016336A2 (pt) 2018-03-27
US20160362494A1 (en) 2016-12-15
US20220064299A1 (en) 2022-03-03
US20200123257A1 (en) 2020-04-23
CO2017007665A2 (es) 2017-10-20
US20200140551A1 (en) 2020-05-07
KR102315160B1 (ko) 2021-10-19
US20180334503A1 (en) 2018-11-22
US9771424B2 (en) 2017-09-26
US9738718B2 (en) 2017-08-22
PE20180120A1 (es) 2018-01-18
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US20170174767A1 (en) 2017-06-22
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CL2017001921A1 (es) 2018-03-16
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AU2016210867A1 (en) 2017-08-03
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