JO3745B1 - ناهضات بروتينات رابطة لل icos - Google Patents

ناهضات بروتينات رابطة لل icos

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Publication number
JO3745B1
JO3745B1 JOP/2016/0013A JOP20160013A JO3745B1 JO 3745 B1 JO3745 B1 JO 3745B1 JO P20160013 A JOP20160013 A JO P20160013A JO 3745 B1 JO3745 B1 JO 3745B1
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JO
Jordan
Prior art keywords
seq
cell
binding proteins
contact
icos binding
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JOP/2016/0013A
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English (en)
Inventor
Olive Daniel
Shah Parmar Radha
Mayes Patrick
Liu Yao-Bin
Original Assignee
Univ Aix Marseille
Glaxosmithkline Ip Dev Ltd
Inst Jean Paoli & Irene Calmettes
Centre National De La Receherche Scient
Inst Nat Sante Rech Med
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Publication of JO3745B1 publication Critical patent/JO3745B1/ar

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3023—Lung
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Immunology (AREA)
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Abstract

<strong><span dir="RTL">يتعلق الاختراع الحالي ببروتين رابط للـ</span>ICOS<span dir="RTL"> أو جزء ربط مولد ضد منه عبارة عن مساعد </span>to ICOS<span dir="RTL"> بشري ولا تحفز الإكمال، </span>ADCC<span dir="RTL">، أو </span>CDC<span dir="RTL"> عند ملامستها بخلية </span>T<span dir="RTL"> في الكائن الحي وطريقة علاج السرطان والأمراض المعدية و/أو مرض تعفن الدم بواسطة بروتين رابط للـ</span>ICOS<span dir="RTL"> المذكور أو جزء ربط مولد ضد منه. أيضا بروتينات رابطة للـ</span>ICOS<span dir="RTL"> أو أجزاء ربط مولد ضد منه وفقا للاختراع الحالي قادرة على تنشيط خلية </span>T<span dir="RTL"> عند ملامستها بالخلية </span>T<span dir="RTL"> المذكورة؛ تحفيز تكاثر خلية </span>T<span dir="RTL"> عند ملامستها بالخلية </span>T<span dir="RTL"> المذكورة و/أو إثارة إنتاج سيتوكين عند ملامستها بالخلية </span>T<span dir="RTL"> المذكورة. يتعلق الاختراع الحالي ببروتينات رابطة للـ</span>ICOS<span dir="RTL"> أو أجزاء ربط مولد ضد منه تتضمن واحد أو أكثر من: متوالية برقم هوية:1؛ متوالية برقم هوية:2؛ متوالية برقم هوية:3؛ متوالية برقم هوية:4؛ متوالية برقم هوية:5؛ و/أو متوالية برقم هوية:6.</span></strong>
JOP/2016/0013A 2015-01-28 2016-01-27 ناهضات بروتينات رابطة لل icos JO3745B1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562108605P 2015-01-28 2015-01-28
US201562192331P 2015-07-14 2015-07-14
US201562247355P 2015-10-28 2015-10-28

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JO3745B1 true JO3745B1 (ar) 2021-01-31

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US (9) US9771424B2 (ar)
EP (3) EP3250603B1 (ar)
JP (3) JP6553197B2 (ar)
KR (1) KR102315160B1 (ar)
CN (1) CN107667117B (ar)
AU (3) AU2016210867B2 (ar)
BR (1) BR112017016336A2 (ar)
CA (1) CA2974910A1 (ar)
CL (1) CL2017001921A1 (ar)
CO (1) CO2017007665A2 (ar)
CR (1) CR20170351A (ar)
DO (1) DOP2017000171A (ar)
EA (1) EA036335B1 (ar)
ES (1) ES2913871T3 (ar)
IL (1) IL253508B (ar)
JO (1) JO3745B1 (ar)
MA (3) MA41414A (ar)
MX (1) MX2017009758A (ar)
MY (1) MY185845A (ar)
PE (1) PE20180120A1 (ar)
PH (1) PH12017501347B1 (ar)
SG (1) SG11201705829TA (ar)
TW (1) TWI717332B (ar)
UA (1) UA124613C2 (ar)
UY (1) UY36539A (ar)
WO (1) WO2016120789A1 (ar)
ZA (1) ZA201704818B (ar)

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