TWI717332B - Icos結合蛋白 - Google Patents

Icos結合蛋白 Download PDF

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Publication number
TWI717332B
TWI717332B TW105102393A TW105102393A TWI717332B TW I717332 B TWI717332 B TW I717332B TW 105102393 A TW105102393 A TW 105102393A TW 105102393 A TW105102393 A TW 105102393A TW I717332 B TWI717332 B TW I717332B
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Taiwan
Prior art keywords
icos
binding protein
cells
cell
antibody
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TW105102393A
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English (en)
Chinese (zh)
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TW201702267A (zh
Inventor
劉耀斌
雷達哈 帕瑪爾
派翠克 瑪雅斯
丹尼爾 奧利弗
Original Assignee
英商葛蘭素史克智慧財產發展有限公司
法國國家健康及醫學研究中心
尚波立及愛琳卡默茲中心
艾克斯 馬賽大學
法國國家研究科學中心
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    • C07ORGANIC CHEMISTRY
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3038Kidney, bladder
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069Reproductive system, e.g. ovaria, uterus, testes, prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71Decreased effector function due to an Fc-modification
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/75Agonist effect on antigen
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Immunology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Mycology (AREA)
  • Microbiology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
TW105102393A 2015-01-28 2016-01-26 Icos結合蛋白 TWI717332B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562108605P 2015-01-28 2015-01-28
US62/108,605 2015-01-28
US201562192331P 2015-07-14 2015-07-14
US62/192,331 2015-07-14
US201562247355P 2015-10-28 2015-10-28
US62/247,355 2015-10-28

Publications (2)

Publication Number Publication Date
TW201702267A TW201702267A (zh) 2017-01-16
TWI717332B true TWI717332B (zh) 2021-02-01

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TW105102393A TWI717332B (zh) 2015-01-28 2016-01-26 Icos結合蛋白

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US (9) US20180030136A1 (enExample)
EP (3) EP3250603B1 (enExample)
JP (3) JP6553197B2 (enExample)
KR (1) KR102315160B1 (enExample)
CN (1) CN107667117B (enExample)
AU (3) AU2016210867B2 (enExample)
BR (1) BR112017016336A2 (enExample)
CA (1) CA2974910A1 (enExample)
CL (1) CL2017001921A1 (enExample)
CO (1) CO2017007665A2 (enExample)
CR (1) CR20170351A (enExample)
DO (1) DOP2017000171A (enExample)
EA (1) EA036335B1 (enExample)
ES (1) ES2913871T3 (enExample)
IL (1) IL253508B (enExample)
JO (1) JO3745B1 (enExample)
MA (3) MA41414A (enExample)
MX (1) MX2017009758A (enExample)
MY (1) MY185845A (enExample)
PE (1) PE20180120A1 (enExample)
PH (1) PH12017501347B1 (enExample)
SG (1) SG11201705829TA (enExample)
TW (1) TWI717332B (enExample)
UA (1) UA124613C2 (enExample)
UY (1) UY36539A (enExample)
WO (1) WO2016120789A1 (enExample)
ZA (1) ZA201704818B (enExample)

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