CN105492025A - 使用pd-1轴结合拮抗剂和tigit抑制剂治疗癌症的方法 - Google Patents

使用pd-1轴结合拮抗剂和tigit抑制剂治疗癌症的方法 Download PDF

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Publication number
CN105492025A
CN105492025A CN201480047388.9A CN201480047388A CN105492025A CN 105492025 A CN105492025 A CN 105492025A CN 201480047388 A CN201480047388 A CN 201480047388A CN 105492025 A CN105492025 A CN 105492025A
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China
Prior art keywords
tigit
agent
activity
expression
inhibits
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Pending
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CN201480047388.9A
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Chinese (zh)
Inventor
J·格罗根
R·J·约翰斯顿
B·欧文
J·哈克尼
X·于
D·伊顿
K·鲍尔斯
L·康普斯-阿格拉尔
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51300845&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN105492025(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Priority to CN202511326826.1A priority Critical patent/CN121197418A/zh
Publication of CN105492025A publication Critical patent/CN105492025A/zh
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CN201480047388.9A 2013-07-16 2014-07-16 使用pd-1轴结合拮抗剂和tigit抑制剂治疗癌症的方法 Pending CN105492025A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202511326826.1A CN121197418A (zh) 2013-07-16 2014-07-16 使用pd-1轴结合拮抗剂和tigit抑制剂治疗癌症的方法

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201361846941P 2013-07-16 2013-07-16
US61/846,941 2013-07-16
US201361865582P 2013-08-13 2013-08-13
US61/865,582 2013-08-13
US201461950754P 2014-03-10 2014-03-10
US61/950,754 2014-03-10
US201461985884P 2014-04-29 2014-04-29
US61/985,884 2014-04-29
US201461992109P 2014-05-12 2014-05-12
US61/992,109 2014-05-12
PCT/US2014/046896 WO2015009856A2 (en) 2013-07-16 2014-07-16 Methods of treating cancer using pd-1 axis binding antagonists and tigit inhibitors

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CN202511326826.1A Pending CN121197418A (zh) 2013-07-16 2014-07-16 使用pd-1轴结合拮抗剂和tigit抑制剂治疗癌症的方法

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Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018041120A1 (en) * 2016-08-31 2018-03-08 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric tigit
CN108254557A (zh) * 2017-12-26 2018-07-06 首都医科大学附属北京地坛医院 用cd8阳性的t细胞上pd-1和tigit确定hbv相关原发性肝癌预后的系统
CN108546298A (zh) * 2018-03-29 2018-09-18 中国人民解放军军事科学院军事医学研究院 一种特异性结合pd-1的单克隆抗体
CN108546299A (zh) * 2018-03-29 2018-09-18 中国人民解放军军事科学院军事医学研究院 解除pd-1对机体免疫抑制的靶向分子
CN109072226A (zh) * 2016-04-20 2018-12-21 国立大学法人筑波大学 调节性t细胞的激活剂及其应用
CN109071620A (zh) * 2015-05-28 2018-12-21 昂科梅德制药有限公司 Tigit结合剂和其用途
CN109154613A (zh) * 2016-04-15 2019-01-04 豪夫迈·罗氏有限公司 用于监测和治疗癌症的方法
WO2019062642A1 (zh) * 2017-09-29 2019-04-04 北京比洋生物技术有限公司 靶向pd-1或pd-l1且靶向vegf家族的双靶向融合蛋白及其用途
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