CN104936970A - 用于hcv感染的2′-氯核苷类似物 - Google Patents
用于hcv感染的2′-氯核苷类似物 Download PDFInfo
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- CN104936970A CN104936970A CN201380064162.5A CN201380064162A CN104936970A CN 104936970 A CN104936970 A CN 104936970A CN 201380064162 A CN201380064162 A CN 201380064162A CN 104936970 A CN104936970 A CN 104936970A
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- Prior art keywords
- compound
- independently
- certain embodiments
- amino acid
- virus
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- 0 CC(C)(CCNC(OC)=O)C(SCCOP*Cc1ccccc1)=O Chemical compound CC(C)(CCNC(OC)=O)C(SCCOP*Cc1ccccc1)=O 0.000 description 10
- DQUIAZRZPVZHJL-UHFFFAOYSA-N CC(C)OC(NCCC(C)(C)C(SCCOPNCc1ccccc1)=O)=O Chemical compound CC(C)OC(NCCC(C)(C)C(SCCOPNCc1ccccc1)=O)=O DQUIAZRZPVZHJL-UHFFFAOYSA-N 0.000 description 1
- JAFCIMRMFVHIJR-WDXGCHLLSA-N CC(C)OP(OC1)(O[C@@H]([C@@H]2C)[C@@H]1O[C@H]2N(C=CC(N)=N1)C1=O)=O Chemical compound CC(C)OP(OC1)(O[C@@H]([C@@H]2C)[C@@H]1O[C@H]2N(C=CC(N)=N1)C1=O)=O JAFCIMRMFVHIJR-WDXGCHLLSA-N 0.000 description 1
- RDADKKWVCAFLQG-UHFFFAOYSA-N CC1C(N(C=CC(N2)=O)C2=O)OC(CO2)C1OP2=O Chemical compound CC1C(N(C=CC(N2)=O)C2=O)OC(CO2)C1OP2=O RDADKKWVCAFLQG-UHFFFAOYSA-N 0.000 description 1
- WLCLXHVBVRADLC-NKUHCKNESA-N CCC(C)(C[C@@H]1OC(C)(C)OC1)C(OCC)=O Chemical compound CCC(C)(C[C@@H]1OC(C)(C)OC1)C(OCC)=O WLCLXHVBVRADLC-NKUHCKNESA-N 0.000 description 1
- PQDWVKCVGHWOQF-CFMCSPIPSA-N CCC(N(C=CC(N1)=O)C1=O)O[C@@H](CC(C)C)COP(O)(OC(C)C)=O Chemical compound CCC(N(C=CC(N1)=O)C1=O)O[C@@H](CC(C)C)COP(O)(OC(C)C)=O PQDWVKCVGHWOQF-CFMCSPIPSA-N 0.000 description 1
- XRIFJOLVWIFLBW-UHFFFAOYSA-N CCOC(NCC(C)(C)C(SCCO)=O)=O Chemical compound CCOC(NCC(C)(C)C(SCCO)=O)=O XRIFJOLVWIFLBW-UHFFFAOYSA-N 0.000 description 1
- RNFGALHVGXFYIZ-HAOTZZCQSA-N CCOC(NCC(C)(C)C(SCCOP(OC1)OC(C)[C@@H]1O[C@H](C)N(C=CC(N1)=O)C1=O)=O)=O Chemical compound CCOC(NCC(C)(C)C(SCCOP(OC1)OC(C)[C@@H]1O[C@H](C)N(C=CC(N1)=O)C1=O)=O)=O RNFGALHVGXFYIZ-HAOTZZCQSA-N 0.000 description 1
- NTMFKMXGUQXBIK-UHFFFAOYSA-N CCOC(NCCC(C)(C)C(O)=O)=O Chemical compound CCOC(NCCC(C)(C)C(O)=O)=O NTMFKMXGUQXBIK-UHFFFAOYSA-N 0.000 description 1
- QYBZUDPPLKQSML-KDUPXHGPSA-N CCOC(NCCC(C)(C)C(SCCOP(NCc1ccccc1)(OC[C@H]([C@H]([C@@H]1C)O)OC1[n]1c(nc(N)nc2OCC)c2nc1)=O)=O)=O Chemical compound CCOC(NCCC(C)(C)C(SCCOP(NCc1ccccc1)(OC[C@H]([C@H]([C@@H]1C)O)OC1[n]1c(nc(N)nc2OCC)c2nc1)=O)=O)=O QYBZUDPPLKQSML-KDUPXHGPSA-N 0.000 description 1
- AIASTJPGHORCOF-UHFFFAOYSA-O CCOc1nc(N)nc2c1nc[n]2C(C1C)OC(CO[PH+](NCc2ccccc2)OCCSC(C(C)(C)CN)=O)C1N=O Chemical compound CCOc1nc(N)nc2c1nc[n]2C(C1C)OC(CO[PH+](NCc2ccccc2)OCCSC(C(C)(C)CN)=O)C1N=O AIASTJPGHORCOF-UHFFFAOYSA-O 0.000 description 1
- QXZLYSWGWQKZMY-UKHPNBTGSA-N C[C@@H]1[C@H]([n]2c3ncnc(N)c3cc2)O[C@H](CO)[C@H]1O Chemical compound C[C@@H]1[C@H]([n]2c3ncnc(N)c3cc2)O[C@H](CO)[C@H]1O QXZLYSWGWQKZMY-UKHPNBTGSA-N 0.000 description 1
- QGKGASXQTBQINX-UHFFFAOYSA-N O=C1NC=CCN1 Chemical compound O=C1NC=CCN1 QGKGASXQTBQINX-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/4965—Non-condensed pyrazines
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- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
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- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
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- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
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- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
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- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
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- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
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- Zoology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010637082.6A CN111848711A (zh) | 2012-10-08 | 2013-10-07 | 用于hcv感染的2′-氯核苷类似物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261711131P | 2012-10-08 | 2012-10-08 | |
| US61/711,131 | 2012-10-08 | ||
| US201361807249P | 2013-04-01 | 2013-04-01 | |
| US61/807,249 | 2013-04-01 | ||
| PCT/US2013/063731 WO2014058801A1 (en) | 2012-10-08 | 2013-10-07 | 2'-chloro nucleoside analogs for hcv infection |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010637082.6A Division CN111848711A (zh) | 2012-10-08 | 2013-10-07 | 用于hcv感染的2′-氯核苷类似物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104936970A true CN104936970A (zh) | 2015-09-23 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
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| CN201380064162.5A Pending CN104936970A (zh) | 2012-10-08 | 2013-10-07 | 用于hcv感染的2′-氯核苷类似物 |
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| CN115894458A (zh) * | 2022-08-31 | 2023-04-04 | 合肥华纳生物医药科技有限公司 | 一种新型修饰核苷及其在核酸药物中的应用 |
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