CN1043997C - 2,6-二氨基嘌呤衍生物及其用途和含该衍生物的药物组合物 - Google Patents

2,6-二氨基嘌呤衍生物及其用途和含该衍生物的药物组合物 Download PDF

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Publication number
CN1043997C
CN1043997C CN94191527A CN94191527A CN1043997C CN 1043997 C CN1043997 C CN 1043997C CN 94191527 A CN94191527 A CN 94191527A CN 94191527 A CN94191527 A CN 94191527A CN 1043997 C CN1043997 C CN 1043997C
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China
Prior art keywords
amino
ethyl
ribofuranose
amide
deoxy
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Expired - Fee Related
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CN94191527A
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English (en)
Chinese (zh)
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CN1119440A (zh
Inventor
M·格雷格森
B·E·艾尔斯
G·B·埃万
F·埃利斯
J·奈特
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Glaxo Group Ltd
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Glaxo Group Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN94191527A 1993-01-20 1994-01-18 2,6-二氨基嘌呤衍生物及其用途和含该衍生物的药物组合物 Expired - Fee Related CN1043997C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9301000.7 1993-01-20
GB939301000A GB9301000D0 (en) 1993-01-20 1993-01-20 Chemical compounds

Publications (2)

Publication Number Publication Date
CN1119440A CN1119440A (zh) 1996-03-27
CN1043997C true CN1043997C (zh) 1999-07-07

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CN94191527A Expired - Fee Related CN1043997C (zh) 1993-01-20 1994-01-18 2,6-二氨基嘌呤衍生物及其用途和含该衍生物的药物组合物

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US (2) US5925624A (enExample)
EP (1) EP0680488B1 (enExample)
JP (1) JP3768232B2 (enExample)
KR (1) KR960700261A (enExample)
CN (1) CN1043997C (enExample)
AP (1) AP457A (enExample)
AT (1) ATE164849T1 (enExample)
AU (1) AU679714B2 (enExample)
CA (1) CA2153688A1 (enExample)
CZ (1) CZ187995A3 (enExample)
DE (1) DE69409503T2 (enExample)
DK (1) DK0680488T3 (enExample)
EC (1) ECSP941104A (enExample)
ES (1) ES2117249T3 (enExample)
FI (1) FI953489A7 (enExample)
GB (1) GB9301000D0 (enExample)
HU (1) HU211914A9 (enExample)
IL (1) IL108372A (enExample)
IS (1) IS4121A (enExample)
NO (1) NO305603B1 (enExample)
NZ (1) NZ259880A (enExample)
PE (1) PE54194A1 (enExample)
PL (1) PL309975A1 (enExample)
RU (1) RU2129561C1 (enExample)
SI (1) SI9400021A (enExample)
SK (1) SK281229B6 (enExample)
TW (1) TW267168B (enExample)
WO (1) WO1994017090A1 (enExample)
ZA (1) ZA94335B (enExample)

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ZA94335B (en) 1994-10-24
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