PE54194A1 - Derivado de 2,6-diaminopurina, procedimiento para su preparacion y composicion farmaceutica que lo contiene - Google Patents
Derivado de 2,6-diaminopurina, procedimiento para su preparacion y composicion farmaceutica que lo contieneInfo
- Publication number
- PE54194A1 PE54194A1 PE1994244634A PE24463494A PE54194A1 PE 54194 A1 PE54194 A1 PE 54194A1 PE 1994244634 A PE1994244634 A PE 1994244634A PE 24463494 A PE24463494 A PE 24463494A PE 54194 A1 PE54194 A1 PE 54194A1
- Authority
- PE
- Peru
- Prior art keywords
- derived
- diaminopurine
- ilo
- leukocytes
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
Abstract
SE REFIERE A UN COMPUESTO DERIVADO DE 2,6-DIAMINOPURIN-BETA-D-RIBOFURANURONAMIDA DE FORMULA 1 DONDE: a) R1 ES HIDROGENO, UN GRUPO C3-C8, ALQUILO C1-C6; b) R2 ES: b.1) CICLOPENTILO o CICLOHEXILO SOLO O SUSTITUIDO POR UNO O DOS GRUPOS: ACILAMINO C2-C7, GUANIDINO, CARBOXILO, OXO, (CH2)pR3 o OH, NH2, METILAMINO, DIMETILAMINO, ACETAMIDO, TRIFLUOROACETAMIDO; b.2) PIRROLIDIN-3-ILO, PIPERIDIN-3-ILO, SOLO O SUSTITUIDOS POR HIDROGENO, ALQUILO C1-C3, BENCILO; b.3) -(CHR5)m(AlK2)nZ EL CUAL ES DE PREFERENCIA: -CH2CH2-IMIDAZOLILO; c) Q ES OXIGENO O AZUFRE Y R1-NH-C(=Q)- PUEDE SER ETILAMINOCARBONILO; d) pH ES FENILO; EL CUAL PUEDE INHIBIR LA FUNCION LEUCOCITARIA Y PROPORCIONAR PROTECCION CONTRA EL DANO TISULAR INDUCIDO POR LEUCOCITOS EN ENFERMEDADES DONDE LOS LEUCOCITOS ESTAN IMPLICADOS EN EL SITIO DE LA INFLAMACION, SIENDO UTILES COMO AGENTES ANTIINFLAMATORIOS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939301000A GB9301000D0 (en) | 1993-01-20 | 1993-01-20 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PE54194A1 true PE54194A1 (es) | 1995-01-06 |
Family
ID=10728948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1994244634A PE54194A1 (es) | 1993-01-20 | 1994-06-15 | Derivado de 2,6-diaminopurina, procedimiento para su preparacion y composicion farmaceutica que lo contiene |
Country Status (29)
Country | Link |
---|---|
US (2) | US5925624A (es) |
EP (1) | EP0680488B1 (es) |
JP (1) | JP3768232B2 (es) |
KR (1) | KR960700261A (es) |
CN (1) | CN1043997C (es) |
AP (1) | AP457A (es) |
AT (1) | ATE164849T1 (es) |
AU (1) | AU679714B2 (es) |
CA (1) | CA2153688A1 (es) |
CZ (1) | CZ187995A3 (es) |
DE (1) | DE69409503T2 (es) |
DK (1) | DK0680488T3 (es) |
EC (1) | ECSP941104A (es) |
ES (1) | ES2117249T3 (es) |
FI (1) | FI953489A (es) |
GB (1) | GB9301000D0 (es) |
HU (1) | HU211914A9 (es) |
IL (1) | IL108372A (es) |
IS (1) | IS4121A (es) |
NO (1) | NO305603B1 (es) |
NZ (1) | NZ259880A (es) |
PE (1) | PE54194A1 (es) |
PL (1) | PL309975A1 (es) |
RU (1) | RU2129561C1 (es) |
SI (1) | SI9400021A (es) |
SK (1) | SK281229B6 (es) |
TW (1) | TW267168B (es) |
WO (1) | WO1994017090A1 (es) |
ZA (1) | ZA94335B (es) |
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US6479487B1 (en) | 1998-02-26 | 2002-11-12 | Aventis Pharmaceuticals Inc. | 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines |
US6686366B1 (en) | 1998-06-02 | 2004-02-03 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
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GB9813565D0 (en) * | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
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GB9813535D0 (en) * | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
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EP0305643B1 (en) * | 1984-04-18 | 1994-01-05 | Whitby Research Incorporated | N-6 thienyl substituted adenosine derivatives as cardiac vasodilators |
US4663313A (en) * | 1984-10-26 | 1987-05-05 | Warner-Lambert Company | N6 -tricyclic adenosines for treating hypertension |
US4738954A (en) * | 1985-11-06 | 1988-04-19 | Warner-Lambert Company | Novel N6 -substituted-5'-oxidized adenosine analogs |
US5106837A (en) * | 1988-03-16 | 1992-04-21 | The Scripps Research Institute | Adenosine derivatives with therapeutic activity |
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WO1988003148A2 (en) * | 1986-10-31 | 1988-05-05 | Warner-Lambert Company | Heteroaromatic derivatives of adenoside |
EP0277917A3 (en) * | 1987-02-04 | 1990-03-28 | Ciba-Geigy Ag | Certain adenosine 5'-carboxamide derivatives |
US4968697A (en) * | 1987-02-04 | 1990-11-06 | Ciba-Geigy Corporation | 2-substituted adenosine 5'-carboxamides as antihypertensive agents |
LU87181A1 (fr) * | 1987-04-06 | 1988-11-17 | Sandoz Sa | Nouveaux derives de l'acide furannuronique,leur preparation et leur utilisation comme medicaments |
US5219840A (en) * | 1987-04-06 | 1993-06-15 | Sandoz Ltd. | Antihypertensive 9-(2,N6 -disubstituted adenyl) ribofuranuronic acid derivatives |
JP3090456B2 (ja) * | 1988-03-16 | 2000-09-18 | スクリップス クリニック アンド リサーチ ファウンデーション | 治療剤として有用な置換アデニン誘導体 |
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DE3924424A1 (de) * | 1989-07-24 | 1991-01-31 | Boehringer Mannheim Gmbh | Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung |
CA2028002A1 (en) * | 1989-10-19 | 1991-04-20 | Daniel P. Becker | Method of treating gastrointestinal motility disorders |
US5459255A (en) * | 1990-01-11 | 1995-10-17 | Isis Pharmaceuticals, Inc. | N-2 substituted purines |
DE4025879A1 (de) * | 1990-08-16 | 1992-02-20 | Sandoz Ag | Neue adenosin derivate, deren herstellung und verwendung |
FR2687678B1 (fr) * | 1992-01-31 | 1995-03-31 | Union Pharma Scient Appl | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant. |
ATE206432T1 (de) * | 1993-07-13 | 2001-10-15 | Nasa | A3 -adenosin -rezeptor agonisten |
-
1993
- 1993-01-20 GB GB939301000A patent/GB9301000D0/en active Pending
-
1994
- 1994-01-14 IS IS4121A patent/IS4121A/is unknown
- 1994-01-18 EP EP94905100A patent/EP0680488B1/en not_active Expired - Lifetime
- 1994-01-18 US US08/446,727 patent/US5925624A/en not_active Expired - Fee Related
- 1994-01-18 AU AU58851/94A patent/AU679714B2/en not_active Ceased
- 1994-01-18 RU RU95122754A patent/RU2129561C1/ru active
- 1994-01-18 DE DE69409503T patent/DE69409503T2/de not_active Expired - Lifetime
- 1994-01-18 AT AT94905100T patent/ATE164849T1/de not_active IP Right Cessation
- 1994-01-18 CN CN94191527A patent/CN1043997C/zh not_active Expired - Fee Related
- 1994-01-18 WO PCT/EP1994/000145 patent/WO1994017090A1/en not_active Application Discontinuation
- 1994-01-18 CA CA002153688A patent/CA2153688A1/en not_active Abandoned
- 1994-01-18 SK SK918-95A patent/SK281229B6/sk unknown
- 1994-01-18 ZA ZA94335A patent/ZA94335B/xx unknown
- 1994-01-18 JP JP51665294A patent/JP3768232B2/ja not_active Expired - Fee Related
- 1994-01-18 KR KR1019950702963A patent/KR960700261A/ko active IP Right Grant
- 1994-01-18 ES ES94905100T patent/ES2117249T3/es not_active Expired - Lifetime
- 1994-01-18 NZ NZ259880A patent/NZ259880A/en unknown
- 1994-01-18 CZ CZ951879A patent/CZ187995A3/cs unknown
- 1994-01-18 DK DK94905100T patent/DK0680488T3/da active
- 1994-01-18 AP APAP/P/1994/000613A patent/AP457A/en active
- 1994-01-18 PL PL94309975A patent/PL309975A1/xx unknown
- 1994-01-19 IL IL108372A patent/IL108372A/en not_active IP Right Cessation
- 1994-01-19 SI SI9400021A patent/SI9400021A/sl unknown
- 1994-05-30 TW TW083104895A patent/TW267168B/zh active
- 1994-06-14 EC EC1994001104A patent/ECSP941104A/es unknown
- 1994-06-15 PE PE1994244634A patent/PE54194A1/es not_active Application Discontinuation
-
1995
- 1995-06-28 HU HU95P/P00514P patent/HU211914A9/hu unknown
- 1995-07-19 NO NO952872A patent/NO305603B1/no not_active IP Right Cessation
- 1995-07-19 FI FI953489A patent/FI953489A/fi unknown
-
1997
- 1997-09-22 US US08/934,540 patent/US5889178A/en not_active Expired - Lifetime
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