CN103223174A - 用经不可切割接头连接的细胞结合剂美登木素生物碱偶联物靶向特定细胞群的方法、所述偶联物和制备所述偶联物的方法 - Google Patents

用经不可切割接头连接的细胞结合剂美登木素生物碱偶联物靶向特定细胞群的方法、所述偶联物和制备所述偶联物的方法 Download PDF

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CN103223174A
CN103223174A CN201310118580XA CN201310118580A CN103223174A CN 103223174 A CN103223174 A CN 103223174A CN 201310118580X A CN201310118580X A CN 201310118580XA CN 201310118580 A CN201310118580 A CN 201310118580A CN 103223174 A CN103223174 A CN 103223174A
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cell
maytansinoid
bonding agent
conjugate
antibody
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R·斯蒂夫斯
R·卢茨
R·查里
H·谢
Y·科夫通
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Immunogen Inc
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Immunogen Inc
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CN201310118580XA 2003-10-10 2004-10-12 用经不可切割接头连接的细胞结合剂美登木素生物碱偶联物靶向特定细胞群的方法、所述偶联物和制备所述偶联物的方法 Pending CN103223174A (zh)

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Application Number Priority Date Filing Date Title
US50990103P 2003-10-10 2003-10-10
US60/509,901 2003-10-10
US10/960,602 2004-10-08
US10/960,602 US8088387B2 (en) 2003-10-10 2004-10-08 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates

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