CN102105145A - 不适合二甲双胍治疗的患者的糖尿病的治疗 - Google Patents

不适合二甲双胍治疗的患者的糖尿病的治疗 Download PDF

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Publication number
CN102105145A
CN102105145A CN2009801293098A CN200980129309A CN102105145A CN 102105145 A CN102105145 A CN 102105145A CN 2009801293098 A CN2009801293098 A CN 2009801293098A CN 200980129309 A CN200980129309 A CN 200980129309A CN 102105145 A CN102105145 A CN 102105145A
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Prior art keywords
methyl
dpp
amino
inhibitor
patients
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CN2009801293098A
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English (en)
Chinese (zh)
Inventor
克劳斯.杜吉
伊娃.U.格雷夫莫迪
鲁丝.哈珀
汉斯-于尔根.沃勒
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41066454&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102105145(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Priority to CN201510477492.8A priority Critical patent/CN105126105A/zh
Priority to CN202011240887.3A priority patent/CN112656945A/zh
Publication of CN102105145A publication Critical patent/CN102105145A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • A61K38/22—Hormones
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2009801293098A 2008-08-06 2009-08-05 不适合二甲双胍治疗的患者的糖尿病的治疗 Pending CN102105145A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201510477492.8A CN105126105A (zh) 2008-08-06 2009-08-05 不适合二甲双胍治疗的患者的糖尿病的治疗
CN202011240887.3A CN112656945A (zh) 2008-08-06 2009-08-05 不适合二甲双胍治疗的患者的糖尿病的治疗

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US8662008P 2008-08-06 2008-08-06
US61/086,620 2008-08-06
EP08161989 2008-08-07
EP08161989.2 2008-08-07
US10591508P 2008-10-16 2008-10-16
EP08166827 2008-10-16
US61/105,915 2008-10-16
EP08166827.9 2008-10-16
PCT/EP2009/060170 WO2010015664A1 (en) 2008-08-06 2009-08-05 Treatment for diabetes in patients inappropriate for metformin therapy

Related Child Applications (3)

Application Number Title Priority Date Filing Date
CN201510477492.8A Division CN105126105A (zh) 2008-08-06 2009-08-05 不适合二甲双胍治疗的患者的糖尿病的治疗
CN202011240887.3A Division CN112656945A (zh) 2008-08-06 2009-08-05 不适合二甲双胍治疗的患者的糖尿病的治疗
CN201310480428.6A Division CN103550219A (zh) 2008-08-06 2009-08-05 不适合二甲双胍治疗的患者的糖尿病的治疗

Publications (1)

Publication Number Publication Date
CN102105145A true CN102105145A (zh) 2011-06-22

Family

ID=41066454

Family Applications (4)

Application Number Title Priority Date Filing Date
CN202011240887.3A Pending CN112656945A (zh) 2008-08-06 2009-08-05 不适合二甲双胍治疗的患者的糖尿病的治疗
CN2009801293098A Pending CN102105145A (zh) 2008-08-06 2009-08-05 不适合二甲双胍治疗的患者的糖尿病的治疗
CN201310480428.6A Pending CN103550219A (zh) 2008-08-06 2009-08-05 不适合二甲双胍治疗的患者的糖尿病的治疗
CN201510477492.8A Pending CN105126105A (zh) 2008-08-06 2009-08-05 不适合二甲双胍治疗的患者的糖尿病的治疗

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN202011240887.3A Pending CN112656945A (zh) 2008-08-06 2009-08-05 不适合二甲双胍治疗的患者的糖尿病的治疗

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201310480428.6A Pending CN103550219A (zh) 2008-08-06 2009-08-05 不适合二甲双胍治疗的患者的糖尿病的治疗
CN201510477492.8A Pending CN105126105A (zh) 2008-08-06 2009-08-05 不适合二甲双胍治疗的患者的糖尿病的治疗

Country Status (20)

Country Link
US (3) US8853156B2 (enExample)
EP (4) EP2990037A1 (enExample)
JP (4) JP2011529945A (enExample)
KR (4) KR20170043674A (enExample)
CN (4) CN112656945A (enExample)
AR (1) AR072920A1 (enExample)
AU (1) AU2009279085B2 (enExample)
CA (1) CA2732803C (enExample)
CO (1) CO6351714A2 (enExample)
EA (1) EA025484B1 (enExample)
EC (1) ECSP11010824A (enExample)
IL (1) IL209887A0 (enExample)
MA (1) MA32539B1 (enExample)
MX (1) MX338447B (enExample)
MY (2) MY170728A (enExample)
NZ (1) NZ590787A (enExample)
PE (1) PE20110222A1 (enExample)
TW (2) TWI447119B (enExample)
UY (1) UY32030A (enExample)
WO (1) WO2010015664A1 (enExample)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
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US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
MX2008014024A (es) 2006-05-04 2008-11-14 Boehringer Ingelheim Int Formas poliformas.
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20090938A1 (es) 2007-08-16 2009-08-08 Boehringer Ingelheim Int Composicion farmaceutica que comprende un derivado de benceno sustituido con glucopiranosilo
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
ZA201008998B (en) * 2008-08-06 2012-07-25 Boehringer Ingelheim Int Treatment for diabetes in patients inappropriate for metformin therapy
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