PE20070374A1 - ANTICUERPOS ANTI-MAdCAM - Google Patents

ANTICUERPOS ANTI-MAdCAM

Info

Publication number
PE20070374A1
PE20070374A1 PE2006000803A PE2006000803A PE20070374A1 PE 20070374 A1 PE20070374 A1 PE 20070374A1 PE 2006000803 A PE2006000803 A PE 2006000803A PE 2006000803 A PE2006000803 A PE 2006000803A PE 20070374 A1 PE20070374 A1 PE 20070374A1
Authority
PE
Peru
Prior art keywords
seq
antibody
mod
variable region
heavy chain
Prior art date
Application number
PE2006000803A
Other languages
English (en)
Inventor
Nicholas Pullen
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of PE20070374A1 publication Critical patent/PE20070374A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

REFERIDA A UN ANTICUERPO MONOCLONAL QUE SE UNE ESPECIFICAMENTE A LA MOLECULA DE ADHESION CELULAR DE ADRESINA DE LA MUCOSA (MAdCAM), O PARTE DE UNION A ANTIGENO DEL MISMO, EL CUAL SE SELECCIONA DE ENTRE: a) UN ANTICUERPO QUE COMPRENDE LA REGION VARIABLE DE LA CADENA PESADA DE 6.22.2-MOD_V (SEC ID Nº:2), b) UN ANTICUERPO QUE COMPRENDE LA REGION VARIABLE DE LA CADENA LIGERA DE 6.34.2-MOD_SSQ, 6.34.2-MOD_QT, O 6.34.2-MOD_SSQ,QT (SEC ID Nº:8, 10, 12), UN ANTICUERPO QUE COMPRENDE LA REGION VARIABLE DE LA CADENA LIGERA DE 6.67.1-MOD_Y, 6.67.1-MOD_TAP, O 6.67.1-MOD_Y, TAP (SEC ID Nº:16, 18, 20), d) UN ANTICUERPO QUE COMPRENDE LA REGION VARIABLE DE LA CADENA PESADA DE 6.77.1-MOD_AS (SEC ID Nº:22), e) UN ANTICUERPO QUE COMPRENDE LA REGION VARIABLE DE LA CADENA PESADA DE 7.16.6_L (SEC ID Nº:28), f) UN ANTICUERPO QUE COMPRENDE LA REGION VARIABLE DE LA CADENA LIGERA DE 7.16.6_V, 7.16.6_S, O 7.16.6_VS (SEC ID Nº: 30, 32, 34), g) UN ANTICUERPO QUE COMPRENDE LA REGION VARIABLE DE LA CADENA LIGERA DE 7.16.6_V, 7.16.6_S, O 7.16.6_VS (SEC ID Nº:30, 32, 34) Y LA REGION VARIABLE DE LA CADENA PESADA DE 7.16.6_L (SEC ID Nº:28), h) UN ANTICUERPO QUE COMPRENDE LA REGION VARIABLE DE LA CADENA PESADA DE 9.8.2-ARGAYH, D (SEC ID Nº:36), i) UN ANTICUERPO QUE COMPRENDE LA REGION VARIABLE DE LA CADENA LIGERA DE 9.8.2-MOD (SEC ID Nº:38). DICHO ANTICUERPO ES UTIL EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS TALES COMO ENFERMEDAD INFLAMATORIA DEL INTESTINO
PE2006000803A 2005-07-08 2006-07-05 ANTICUERPOS ANTI-MAdCAM PE20070374A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69745305P 2005-07-08 2005-07-08

Publications (1)

Publication Number Publication Date
PE20070374A1 true PE20070374A1 (es) 2007-05-12

Family

ID=37637550

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000803A PE20070374A1 (es) 2005-07-08 2006-07-05 ANTICUERPOS ANTI-MAdCAM

Country Status (15)

Country Link
US (3) US20070009536A1 (es)
EP (1) EP1904531B1 (es)
JP (1) JP2009500390A (es)
AR (1) AR054539A1 (es)
AT (1) ATE483732T1 (es)
CA (1) CA2614314A1 (es)
DE (1) DE602006017373D1 (es)
DO (1) DOP2006000162A (es)
ES (1) ES2351057T3 (es)
GT (1) GT200600297A (es)
NL (1) NL1032132C2 (es)
PE (1) PE20070374A1 (es)
TW (1) TW200740844A (es)
UY (1) UY29653A1 (es)
WO (1) WO2007007173A2 (es)

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DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
CA2614622A1 (en) * 2005-07-11 2007-01-18 Pfizer Limited New combination of anti-madcam antibody and antifibrotic caspase inhibitor to treat liver fibrosis
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
CA2810295C (en) 2006-05-04 2017-11-14 Boehringer Ingelheim International Gmbh A polymeric form of 1-((4-methyl-quinazolin-2-yl)methyl)-3-7-(2-butyn-1-yl)-8-(3-(r)-aminopiperidin-1-yl)xanthine
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EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
KR20200118243A (ko) 2008-08-06 2020-10-14 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
EP2344195A2 (en) 2008-09-10 2011-07-20 Boehringer Ingelheim International GmbH Combination therapy for the treatment of diabetes and related conditions
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
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AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
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US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
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EP2731947B1 (en) 2011-07-15 2019-01-16 Boehringer Ingelheim International GmbH Substituted dimeric quinazoline derivative, its preparation and its use in pharmaceutical compositions for the treatment of type i and ii diabetes
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US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
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Also Published As

Publication number Publication date
DOP2006000162A (es) 2007-01-31
DE602006017373D1 (de) 2010-11-18
WO2007007173A3 (en) 2007-05-10
TW200740844A (en) 2007-11-01
ES2351057T3 (es) 2011-01-31
WO2007007173A2 (en) 2007-01-18
NL1032132C2 (nl) 2007-10-09
CA2614314A1 (en) 2007-01-18
AR054539A1 (es) 2007-06-27
ATE483732T1 (de) 2010-10-15
US20090214558A1 (en) 2009-08-27
US20070009536A1 (en) 2007-01-11
NL1032132A1 (nl) 2007-01-09
GT200600297A (es) 2007-02-14
EP1904531A2 (en) 2008-04-02
JP2009500390A (ja) 2009-01-08
US7935794B2 (en) 2011-05-03
US20110165167A1 (en) 2011-07-07
UY29653A1 (es) 2007-02-28
EP1904531B1 (en) 2010-10-06

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