CN101061098B - 新吡啶酮衍生物及其作为mGluR2-受体正性别构调节剂的用途 - Google Patents
新吡啶酮衍生物及其作为mGluR2-受体正性别构调节剂的用途 Download PDFInfo
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- CN101061098B CN101061098B CN2005800367503A CN200580036750A CN101061098B CN 101061098 B CN101061098 B CN 101061098B CN 2005800367503 A CN2005800367503 A CN 2005800367503A CN 200580036750 A CN200580036750 A CN 200580036750A CN 101061098 B CN101061098 B CN 101061098B
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- Prior art keywords
- ketone
- pyridine
- alkyl
- methoxyphenyl
- phenyl
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- 0 CC(C)N(C(*)=C(*(*)=C)C(*(C)C)=C1*)C1=O Chemical compound CC(C)N(C(*)=C(*(*)=C)C(*(C)C)=C1*)C1=O 0.000 description 9
- GUMBMEVYBJQQJU-UHFFFAOYSA-N CN(C)CCNc(cc1)ccc1C(C=C1)=CN(Cc(cc2)ccc2Cl)C1=O Chemical compound CN(C)CCNc(cc1)ccc1C(C=C1)=CN(Cc(cc2)ccc2Cl)C1=O GUMBMEVYBJQQJU-UHFFFAOYSA-N 0.000 description 1
- GFZGFLHZNDNZCT-UHFFFAOYSA-N COc(cc1)ccc1C(C=C1)=CN(Cc2nc(cc(cc3)F)c3[o]2)C1=O Chemical compound COc(cc1)ccc1C(C=C1)=CN(Cc2nc(cc(cc3)F)c3[o]2)C1=O GFZGFLHZNDNZCT-UHFFFAOYSA-N 0.000 description 1
- YNKMIRUPOPRESA-UHFFFAOYSA-N O=C1N(Cc2cc(F)ccc2)C=CC(OCCc2ccccc2)=C1 Chemical compound O=C1N(Cc2cc(F)ccc2)C=CC(OCCc2ccccc2)=C1 YNKMIRUPOPRESA-UHFFFAOYSA-N 0.000 description 1
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- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0420722.1 | 2004-09-17 | ||
| GB0420722A GB0420722D0 (en) | 2004-09-17 | 2004-09-17 | Novel allosteric modulators |
| PCT/EP2005/054636 WO2006030032A1 (en) | 2004-09-17 | 2005-09-16 | Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101061098A CN101061098A (zh) | 2007-10-24 |
| CN101061098B true CN101061098B (zh) | 2012-05-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2005800367503A Expired - Fee Related CN101061098B (zh) | 2004-09-17 | 2005-09-16 | 新吡啶酮衍生物及其作为mGluR2-受体正性别构调节剂的用途 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8399493B2 (https=) |
| EP (1) | EP1799646B1 (https=) |
| JP (2) | JP5179873B2 (https=) |
| KR (1) | KR20070085262A (https=) |
| CN (1) | CN101061098B (https=) |
| AU (1) | AU2005284098B2 (https=) |
| BR (1) | BRPI0515412A (https=) |
| CA (1) | CA2581144C (https=) |
| EA (1) | EA013740B1 (https=) |
| ES (1) | ES2527418T3 (https=) |
| GB (1) | GB0420722D0 (https=) |
| IL (1) | IL181742A0 (https=) |
| MX (1) | MX2007003006A (https=) |
| NO (1) | NO20071660L (https=) |
| NZ (1) | NZ554041A (https=) |
| SG (1) | SG155938A1 (https=) |
| TW (1) | TW200633982A (https=) |
| UA (1) | UA98098C2 (https=) |
| WO (1) | WO2006030032A1 (https=) |
| ZA (1) | ZA200703088B (https=) |
Families Citing this family (161)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0302486D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
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| RU2492170C9 (ru) | 2007-11-14 | 2013-12-27 | Орто-Макнейл-Янссен Фармасьютикалз, Инк. | Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2 |
| DE102008001056A1 (de) | 2008-04-08 | 2009-10-15 | Robert Bosch Gmbh | Umlenkeinrichtung für einen Strahl einer elektromagnetischen Welle |
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| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
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2004
- 2004-09-17 GB GB0420722A patent/GB0420722D0/en not_active Ceased
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2005
- 2005-09-16 EP EP05787278.0A patent/EP1799646B1/en not_active Expired - Lifetime
- 2005-09-16 ES ES05787278.0T patent/ES2527418T3/es not_active Expired - Lifetime
- 2005-09-16 CA CA2581144A patent/CA2581144C/en not_active Expired - Fee Related
- 2005-09-16 ZA ZA200703088A patent/ZA200703088B/xx unknown
- 2005-09-16 KR KR1020077008762A patent/KR20070085262A/ko not_active Ceased
- 2005-09-16 US US11/575,433 patent/US8399493B2/en not_active Expired - Fee Related
- 2005-09-16 NZ NZ554041A patent/NZ554041A/en not_active IP Right Cessation
- 2005-09-16 BR BRPI0515412-0A patent/BRPI0515412A/pt not_active IP Right Cessation
- 2005-09-16 SG SG200906238-1A patent/SG155938A1/en unknown
- 2005-09-16 UA UAA200703393A patent/UA98098C2/ru unknown
- 2005-09-16 WO PCT/EP2005/054636 patent/WO2006030032A1/en not_active Ceased
- 2005-09-16 EA EA200700617A patent/EA013740B1/ru not_active IP Right Cessation
- 2005-09-16 JP JP2007531759A patent/JP5179873B2/ja not_active Expired - Fee Related
- 2005-09-16 AU AU2005284098A patent/AU2005284098B2/en not_active Ceased
- 2005-09-16 MX MX2007003006A patent/MX2007003006A/es not_active Application Discontinuation
- 2005-09-16 CN CN2005800367503A patent/CN101061098B/zh not_active Expired - Fee Related
- 2005-09-19 TW TW094132375A patent/TW200633982A/zh unknown
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- 2007-03-06 IL IL181742A patent/IL181742A0/en not_active IP Right Cessation
- 2007-03-29 NO NO20071660A patent/NO20071660L/no not_active Application Discontinuation
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- 2012-12-20 US US13/721,230 patent/US20130109652A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP5179873B2 (ja) | 2013-04-10 |
| JP2013047254A (ja) | 2013-03-07 |
| AU2005284098B2 (en) | 2011-06-16 |
| JP2008513414A (ja) | 2008-05-01 |
| US8399493B2 (en) | 2013-03-19 |
| EA013740B1 (ru) | 2010-06-30 |
| IL181742A0 (en) | 2007-07-04 |
| GB0420722D0 (en) | 2004-10-20 |
| NZ554041A (en) | 2010-01-29 |
| EP1799646B1 (en) | 2014-12-10 |
| KR20070085262A (ko) | 2007-08-27 |
| NO20071660L (no) | 2007-06-15 |
| CA2581144C (en) | 2014-04-01 |
| MX2007003006A (es) | 2007-07-24 |
| ES2527418T3 (es) | 2015-01-23 |
| BRPI0515412A (pt) | 2008-07-22 |
| US20070213323A1 (en) | 2007-09-13 |
| WO2006030032A1 (en) | 2006-03-23 |
| CA2581144A1 (en) | 2006-03-23 |
| TW200633982A (en) | 2006-10-01 |
| EA200700617A1 (ru) | 2007-10-26 |
| AU2005284098A1 (en) | 2006-03-23 |
| ZA200703088B (en) | 2008-08-27 |
| SG155938A1 (en) | 2009-10-29 |
| JP5723850B2 (ja) | 2015-05-27 |
| UA98098C2 (ru) | 2012-04-25 |
| CN101061098A (zh) | 2007-10-24 |
| EP1799646A1 (en) | 2007-06-27 |
| US20130109652A1 (en) | 2013-05-02 |
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