TW200633982A - Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors - Google Patents

Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors

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Publication number
TW200633982A
TW200633982A TW094132375A TW94132375A TW200633982A TW 200633982 A TW200633982 A TW 200633982A TW 094132375 A TW094132375 A TW 094132375A TW 94132375 A TW94132375 A TW 94132375A TW 200633982 A TW200633982 A TW 200633982A
Authority
TW
Taiwan
Prior art keywords
mglur2
compounds
receptors
diseases
positive allosteric
Prior art date
Application number
TW094132375A
Other languages
English (en)
Chinese (zh)
Inventor
Hassan Julien Imogai
Jose Maria Cid-Nunez
Guillaume Albert Jacques Duvey
Christelle Martine Bolea
Vanthea Nhem
Terry Patrick Finn
Poul Emmanuel Christian Le
Jean-Philippe Francois Christian Rocher
Robert Johannes Luetjens
Original Assignee
Janssen Pharmaceutica Nv
Addex Pharmaceuticals S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv, Addex Pharmaceuticals S A filed Critical Janssen Pharmaceutica Nv
Publication of TW200633982A publication Critical patent/TW200633982A/zh

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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  • Quinoline Compounds (AREA)
TW094132375A 2004-09-17 2005-09-19 Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors TW200633982A (en)

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GB0420722A GB0420722D0 (en) 2004-09-17 2004-09-17 Novel allosteric modulators

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TWI417296B (zh) * 2007-03-09 2013-12-01 Sanofi Aventis 經取代之二氫及四氫唑并嘧啶酮類，其製備及其用途

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SE0302486D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
US9512125B2 (en) 2004-11-19 2016-12-06 The Regents Of The University Of California Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
US7297700B2 (en) 2005-03-24 2007-11-20 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
ES2524922T3 (es) 2005-05-10 2014-12-15 Intermune, Inc. Derivados de piridona para modular el sistema de proteína cinasa activada por estrés
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