CA2886240A1 - Modulation of ire1 - Google Patents
Modulation of ire1 Download PDFInfo
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- CA2886240A1 CA2886240A1 CA2886240A CA2886240A CA2886240A1 CA 2886240 A1 CA2886240 A1 CA 2886240A1 CA 2886240 A CA2886240 A CA 2886240A CA 2886240 A CA2886240 A CA 2886240A CA 2886240 A1 CA2886240 A1 CA 2886240A1
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| WO2016004254A1 (en) * | 2014-07-01 | 2016-01-07 | The Regents Of The University Of California | Combined modulation of ire1 |
| US10053465B2 (en) | 2015-08-26 | 2018-08-21 | Incyte Corporation | Pyrrolopyrimidine derivatives as TAM inhibitors |
| WO2017152117A1 (en) | 2016-03-03 | 2017-09-08 | Cornell University | Small molecule ire1-alpha inhibitors |
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| CA3064837A1 (en) | 2017-06-01 | 2018-12-06 | Quentis Therapeutics, Inc. | Ire1 small molecule inhibitors |
| US10392367B2 (en) | 2017-06-01 | 2019-08-27 | Quentis Therapeutics, Inc. | IRE1 small molecule inhibitors |
| CN107446952B (zh) * | 2017-07-31 | 2020-04-28 | 苏州大学附属儿童医院 | 一种用于肠外营养相关性肝病药物的制备方法 |
| JP2020532589A (ja) * | 2017-09-01 | 2020-11-12 | オプティキラ リミテッド ライアビリティ カンパニー | Ｉｒｅ１阻害のための化合物および組成物 |
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| TWI748317B (zh) | 2019-01-03 | 2021-12-01 | 美商建南德克公司 | 吡啶并－嘧啶酮與喋啶酮化合物及使用方法 |
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| US12479818B2 (en) | 2019-05-15 | 2025-11-25 | Cornell University | Treatment of fibrosis with IRE1 small molecule inhibitors |
| CN112409361B (zh) * | 2019-08-23 | 2022-08-16 | 山东轩竹医药科技有限公司 | Tam抑制剂及其用途 |
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| JP2023550053A (ja) * | 2020-11-13 | 2023-11-30 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | Ｉｒｅ１アルファ阻害剤及びその使用 |
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| DE3406533A1 (de) | 1984-02-23 | 1985-08-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten |
| US5310731A (en) | 1984-06-28 | 1994-05-10 | Whitby Research, Inc. | N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents |
| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| JPS61109797A (ja) | 1984-11-01 | 1986-05-28 | Yuki Gosei Yakuhin Kogyo Kk | 標識化ヌクレオチドおよび標識化ポリヌクレオチド |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
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| WO1990003370A1 (en) | 1988-09-28 | 1990-04-05 | Microprobe Corporation | DERIVATIVES OF PYRAZOLO[3,4-d]PYRIMIDINE |
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| US8476282B2 (en) | 2008-11-03 | 2013-07-02 | Intellikine Llc | Benzoxazole kinase inhibitors and methods of use |
| WO2010059593A1 (en) | 2008-11-18 | 2010-05-27 | Intellikine, Inc. | Methods and compositions for treatment of ophthalmic conditions |
| JP5789252B2 (ja) | 2009-05-07 | 2015-10-07 | インテリカイン， エルエルシー | 複素環式化合物およびその使用 |
| CN101602768B (zh) | 2009-07-17 | 2012-05-30 | 河南省农科院农副产品加工研究所 | 一种芝麻素和芝麻林素的提纯方法 |
| KR102097664B1 (ko) | 2009-10-06 | 2020-04-06 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | Ｐｄｋ１ 저해제로서 유용한 헤테로시클릭 화합물 |
| US8980899B2 (en) | 2009-10-16 | 2015-03-17 | The Regents Of The University Of California | Methods of inhibiting Ire1 |
| WO2011094628A1 (en) * | 2010-01-28 | 2011-08-04 | University Of Washington | Compositions and methods for treating toxoplasmosis. cryptosporidiosis and other apicomplexan protozoan related diseases |
| CN110172051B (zh) | 2010-04-05 | 2023-03-07 | 复星弘创(苏州)医药科技有限公司 | IRE-1α抑制剂 |
| WO2011146882A1 (en) | 2010-05-21 | 2011-11-24 | Intellikine, Inc. | Chemical compounds, compositions and methods for kinase modulation |
| US8993617B2 (en) | 2010-11-10 | 2015-03-31 | The Board Of Trustees Of The Leland Stanford Junior University | Ire1alpha endonuclease specific inhibitor with cytotoxic activity |
| TWI592411B (zh) | 2011-02-23 | 2017-07-21 | 英特爾立秦有限責任公司 | 激酶抑制劑之組合及其用途 |
| SI3689878T1 (sl) * | 2011-07-19 | 2021-12-31 | Merck Sharp & Dohme B.V. | 4-imidazopiridazin-1-il-benzamidi in 4-imidazotriazin-1-il-benzamidi kot Btk-zaviralci |
| EP2548877A1 (en) * | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
| EP2751112B1 (en) | 2011-09-02 | 2019-10-09 | The Regents of The University of California | Substituted pyrazolo[3,4-d]pyrimidines and uses thereof |
| KR20150061651A (ko) | 2012-09-26 | 2015-06-04 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Ire1의 조절 |
| WO2016004254A1 (en) | 2014-07-01 | 2016-01-07 | The Regents Of The University Of California | Combined modulation of ire1 |
-
2013
- 2013-09-26 KR KR1020157010751A patent/KR20150061651A/ko not_active Withdrawn
- 2013-09-26 RU RU2015115631A patent/RU2015115631A/ru not_active Application Discontinuation
- 2013-09-26 BR BR112015006828A patent/BR112015006828A8/pt not_active Application Discontinuation
- 2013-09-26 CN CN201380061276.4A patent/CN104995192A/zh active Pending
- 2013-09-26 WO PCT/US2013/062039 patent/WO2014052669A1/en not_active Ceased
- 2013-09-26 CA CA2886240A patent/CA2886240A1/en active Pending
- 2013-09-26 JP JP2015534672A patent/JP2015532287A/ja active Pending
- 2013-09-26 MX MX2015003874A patent/MX2015003874A/es unknown
- 2013-09-26 SG SG11201502331RA patent/SG11201502331RA/en unknown
- 2013-09-26 AU AU2013323426A patent/AU2013323426A1/en not_active Abandoned
- 2013-09-26 EP EP13841491.7A patent/EP2900673A4/en not_active Withdrawn
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2015
- 2015-03-26 IL IL237970A patent/IL237970A0/en unknown
- 2015-03-26 US US14/670,088 patent/US10131668B2/en active Active
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2018
- 2018-10-02 US US16/149,606 patent/US10822340B2/en active Active
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2020
- 2020-09-24 US US17/031,132 patent/US11613544B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2015115631A (ru) | 2016-11-20 |
| JP2015532287A (ja) | 2015-11-09 |
| US20160024094A1 (en) | 2016-01-28 |
| SG11201502331RA (en) | 2015-04-29 |
| EP2900673A4 (en) | 2016-10-19 |
| CN104995192A (zh) | 2015-10-21 |
| EP2900673A1 (en) | 2015-08-05 |
| US10131668B2 (en) | 2018-11-20 |
| US10822340B2 (en) | 2020-11-03 |
| AU2013323426A1 (en) | 2015-04-23 |
| IL237970A0 (en) | 2015-05-31 |
| BR112015006828A2 (pt) | 2017-07-04 |
| MX2015003874A (es) | 2015-12-16 |
| KR20150061651A (ko) | 2015-06-04 |
| US20190084989A1 (en) | 2019-03-21 |
| US20210155626A1 (en) | 2021-05-27 |
| BR112015006828A8 (pt) | 2019-09-17 |
| WO2014052669A1 (en) | 2014-04-03 |
| US11613544B2 (en) | 2023-03-28 |
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