CA2821886A1 - Solid compositions comprising a glp-1 agonist and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid - Google Patents
Solid compositions comprising a glp-1 agonist and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid Download PDFInfo
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- CA2821886A1 CA2821886A1 CA2821886A CA2821886A CA2821886A1 CA 2821886 A1 CA2821886 A1 CA 2821886A1 CA 2821886 A CA2821886 A CA 2821886A CA 2821886 A CA2821886 A CA 2821886A CA 2821886 A1 CA2821886 A1 CA 2821886A1
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- Prior art keywords
- glp
- mmol
- ethoxy
- amino
- carboxy
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- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 title claims abstract description 84
- 239000003877 glucagon like peptide 1 receptor agonist Substances 0.000 title claims abstract description 59
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title claims abstract description 54
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 title claims abstract description 42
- 229960002446 octanoic acid Drugs 0.000 title claims abstract description 42
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- DLSWIYLPEUIQAV-UHFFFAOYSA-N Semaglutide Chemical group CCC(C)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(O)=O)NC(=O)C(CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(N)=O)NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)C(C)(C)NC(=O)C(N)Cc1cnc[nH]1)C(C)O)C(C)O)C(C)C)C(=O)NC(C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CCCNC(N)=N)C(=O)NCC(O)=O DLSWIYLPEUIQAV-UHFFFAOYSA-N 0.000 claims description 35
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| PL3542790T3 (pl) | 2012-03-22 | 2024-02-26 | Novo Nordisk A/S | Kompozycje zawierające substancję dostarczającą i ich przygotowanie |
| JP6517690B2 (ja) | 2012-06-20 | 2019-05-22 | ノヴォ ノルディスク アー／エス | ペプチド及び送達剤を含む錠剤製剤 |
| DK2866825T3 (da) | 2012-07-01 | 2020-06-08 | Novo Nordisk As | Anvendelse af langstidsvirkende glp-1-peptider |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| JP6408998B2 (ja) | 2012-12-21 | 2018-10-17 | サノフイＳａｎｏｆｉ | 二重ｇｌｐ１／ｇｉｐまたは三方ｇｌｐ１／ｇｉｐ／グルカゴンアゴニスト |
| AU2014225822B2 (en) | 2013-03-05 | 2017-05-04 | Enteris Biopharma, Inc. | Pharmaceuticals for oral delivery |
| CN104055735B (zh) * | 2013-03-22 | 2016-08-03 | 深圳翰宇药业股份有限公司 | 一种萨摩鲁泰的脂质体及其制备方法 |
| MY172578A (en) * | 2013-05-02 | 2019-12-03 | Novo Nordisk As | Oral dosing of glp-1 compounds |
| EP3080149A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Dual glp-1/glucagon receptor agonists |
| WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
| WO2015086728A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| TW201609799A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重ｇｌｐ－１／ｇｉｐ受體促效劑 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| ES2630106T3 (es) * | 2014-10-07 | 2017-08-18 | Cyprumed Gmbh | Formulaciones farmacéuticas para la administración oral de fármacos peptídicos o proteicos |
| CN105777872B (zh) * | 2014-12-16 | 2019-06-07 | 深圳翰宇药业股份有限公司 | 一种萨摩鲁肽的纯化方法 |
| DK3244878T3 (da) | 2015-01-12 | 2022-10-17 | Enteris Biopharma Inc | Faste orale sammensætningsformer |
| US10265384B2 (en) * | 2015-01-29 | 2019-04-23 | Novo Nordisk A/S | Tablets comprising GLP-1 agonist and enteric coating |
| MX2017010220A (es) * | 2015-02-09 | 2018-02-21 | Entera Bio Ltd | Formulaciones para administracion oral de agentes activos con perfil de absorcion controlada. |
| WO2016168388A2 (en) | 2015-04-14 | 2016-10-20 | Palatin Technologies, Inc. | Therapies for obesity, diabetes and related indications |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物 |
| WO2017149070A1 (en) | 2016-03-03 | 2017-09-08 | Novo Nordisk A/S | Glp-1 derivatives and uses thereof |
| DK3448416T3 (da) | 2016-04-28 | 2022-10-03 | Novo Nordisk As | Semaglutid ved kardiovaskulære tilstande |
| CA3033259A1 (en) | 2016-08-17 | 2018-02-22 | Entera Bio Ltd. | Formulations for oral administration of active agents |
| JOP20190060A1 (ar) | 2016-09-26 | 2019-03-26 | Chugai Pharmaceutical Co Ltd | مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1 |
| EP3615002A4 (en) | 2017-04-25 | 2021-01-06 | Proteus Digital Health, Inc. | LISINOPRIL COMPOSITIONS CONTAINING AN INGERABLE EVENT MARKER |
| TWI797133B (zh) * | 2017-06-09 | 2023-04-01 | 丹麥商諾佛 儂迪克股份有限公司 | 用於經口投予的固體組成物 |
| US11291629B2 (en) | 2017-06-27 | 2022-04-05 | Bioserentach Co., Ltd. | Mucoadhesive oral preparation |
| RS65380B1 (sr) | 2017-08-24 | 2024-04-30 | Novo Nordisk As | Glp-1 kompozicije i njihova upotreba |
| EP3694538A1 (en) | 2017-10-12 | 2020-08-19 | Novo Nordisk A/S | Semaglutide in medical therapy |
| AR114353A1 (es) | 2018-02-02 | 2020-08-26 | Novo Nordisk As | Composiciones sólidas que comprenden un agonista del glp-1 y una sal del ácido n-(8-(2-hidroxibenzoil)amino)caprílico |
| TWI829687B (zh) * | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
| CN112912100A (zh) | 2018-10-26 | 2021-06-04 | 诺和诺德股份有限公司 | 稳定的司美鲁肽组合物及其用途 |
| MA54807A (fr) | 2019-01-24 | 2022-04-27 | Novo Nordisk As | Compacteur à rouleaux et procédé de granulation à sec utilisant un compacteur à rouleaux |
| MA55592A (fr) | 2019-04-10 | 2022-02-16 | Genfit | Polythérapie comprenant des composés de formule (i) et des agonistes du récepteur glp-1 |
| WO2021023855A1 (en) | 2019-08-07 | 2021-02-11 | Novo Nordisk A/S | Solid compositions comprising an egf(a) derivative and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid |
| JP2022543826A (ja) * | 2019-08-07 | 2022-10-14 | ノヴォ ノルディスク アー／エス | Ｐｙｙ化合物とｎ－（８－（２－ヒドロキシベンゾイル）アミノ）カプリル酸の塩とを含む固形組成物 |
| EP4025192B1 (en) * | 2019-09-02 | 2025-12-03 | Novo Nordisk A/S | Process for producing a tablet comprising glp-1 peptides |
| JP7615129B2 (ja) * | 2019-09-06 | 2025-01-16 | ノヴォ ノルディスク アー／エス | 医薬組成物における使用のための顆粒の分別のための方法および機器 |
| JP7670698B2 (ja) | 2019-11-06 | 2025-04-30 | ノヴォ ノルディスク アー／エス | 認知症におけるｇｌｐ－１受容体作動薬 |
| CN114641276A (zh) | 2019-11-07 | 2022-06-17 | 诺和诺德股份有限公司 | 包含glp-1激动剂、sglt2抑制剂和n-(8-(2-羟基苯甲酰基)氨基)辛酸的盐的固体组合物 |
| PE20221458A1 (es) | 2019-11-07 | 2022-09-21 | Novo Nordisk As | Composiciones solidas que comprenden un inhibidor de pcsk9 y una sal de acido n-(8-(2-hidroxibenzoil)amino)caprilico |
| WO2021219710A1 (en) | 2020-04-29 | 2021-11-04 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist and histidine |
| CN113735733B (zh) * | 2020-05-29 | 2024-04-26 | 杭州先为达生物科技股份有限公司 | N-[8-(2-羟基苯甲酰基)氨基]辛酸钾晶体多晶型物及其制备方法和用途 |
| KR20230015414A (ko) | 2020-05-29 | 2023-01-31 | 항저우 사이윈드 바이오사이언시즈 컴퍼니 리미티드 | 칼륨 n-[8-(2-히드록시벤조일)아미노]옥타노에이트결정 다형체 및 이의 제조 방법과 용도 |
| AU2021312323A1 (en) | 2020-07-22 | 2023-02-02 | Novo Nordisk A/S | Co-agonists at GLP-1 and GIP receptors suitable for oral delivery |
| CN112274633B (zh) * | 2020-09-16 | 2023-11-07 | 广州新济薇娜生物科技有限公司 | 索马鲁肽降糖减重微针贴片及其制备方法和应用 |
| CN112062690A (zh) * | 2020-11-11 | 2020-12-11 | 北京先为达生物科技有限公司 | N-[8-(2-羟基苯甲酰基)氨基]辛酸钾晶体多晶型物及其制备方法和用途 |
| CR20230308A (es) | 2020-12-11 | 2023-09-08 | Civi Biopharma Inc | Entrega oral de conjugados antisentido que tienen por blanco a pcsk9 |
| TWI850611B (zh) | 2020-12-18 | 2024-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | Glp-1及澱粉素受體之共促效劑 |
| FR3120189B1 (fr) | 2021-03-01 | 2024-11-29 | Farid Bennis | Composition pharmaceutique pour une administration par voie orale d’un agoniste du récepteur du GLP-1 |
| JP7772778B2 (ja) | 2021-03-24 | 2025-11-18 | 塩野義製薬株式会社 | 縮合環を有するｇｌｐ－１受容体作動薬を含有する医薬組成物 |
| US11667614B2 (en) | 2021-04-16 | 2023-06-06 | Navinta III Inc. | Process for the preparation of highly pure Salcaprozic Acid and pharmaceutically acceptable salts thereof |
| WO2022221629A1 (en) | 2021-04-16 | 2022-10-20 | Navinta Iii Inc | Process for the preparation of highly pure salcaprozic acid and pharmaceutically acceptable salts thereof |
| CA3216091A1 (en) | 2021-04-22 | 2022-10-27 | Henrik Oerum | Oral delivery of oligonucleotides |
| WO2022268213A1 (zh) * | 2021-06-25 | 2022-12-29 | 甘李药业股份有限公司 | 含glp-1化合物的药物组合物 |
| JP2024525377A (ja) | 2021-07-15 | 2024-07-12 | ノヴォ ノルディスク アー／エス | Ｎ－（８－（２－ヒドロキシベンゾイル）アミノ）カプリル酸の塩を含む錠剤 |
| KR20240035495A (ko) | 2021-07-16 | 2024-03-15 | 노보 노르디스크 에이/에스 | 나트륨 n-(8-(2-하이드록시벤조일)아미노)카프릴레이트 다형체 형태 a |
| US20230053812A1 (en) * | 2021-07-27 | 2023-02-23 | Aurobindo Pharma Ltd | Stable peptide formulations for oral use |
| WO2023012263A1 (en) | 2021-08-04 | 2023-02-09 | Novo Nordisk A/S | Solid oral peptide formulations |
| WO2023086499A1 (en) | 2021-11-10 | 2023-05-19 | I2O Therapeutics, Inc. | Ionic liquid compositions |
| EP4180060A1 (en) * | 2021-11-15 | 2023-05-17 | Adocia | Solid compositions comprising a peptide or a protein and an acylated amino acid |
| EP4299057A1 (en) * | 2022-06-30 | 2024-01-03 | Adocia | Solid compositions comprising a peptide or a protein and an acylated amino acid |
| TW202330584A (zh) | 2022-01-20 | 2023-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | 前藥及其用途 |
| AU2023226619A1 (en) * | 2022-02-24 | 2024-10-03 | Entera Bio Ltd. | Formulations comprising acid-neutralizing polymer for oral administration of glucagon-like peptide-1 and analogs thereof |
| EP4337244A4 (en) * | 2022-03-25 | 2025-03-12 | Beijing QL Biopharmaceutical Co., Ltd. | Pharmaceutical compositions of polypeptide conjugates and methods of using them |
| WO2024017139A1 (zh) * | 2022-07-20 | 2024-01-25 | 成都海博为药业有限公司 | 一种含有glp-1受体激动剂类似物的药物组合物 |
| JPWO2024063143A1 (enExample) | 2022-09-22 | 2024-03-28 | ||
| WO2024110614A1 (en) | 2022-11-25 | 2024-05-30 | Novo Nordisk A/S | Oral administration of peptide therapeutics, such as glp-1 |
| KR20250141711A (ko) | 2022-12-30 | 2025-09-29 | 알지파마 에이에스 | 경구 투여되는 폴리펩타이드 치료제의 전신 생체이용률을 증가시키는 조성물 및 방법 |
| WO2025017454A1 (en) * | 2023-07-14 | 2025-01-23 | Biophore India Pharmaceuticals Pvt. Ltd | Stable solid dispersions of salcaprozate with various active pharmaceutical ingredients |
| JP7755031B2 (ja) | 2023-11-30 | 2025-10-15 | ノヴォ ノルディスク アー／エス | Ｇｌｐ－１、ｇｉｐ、およびアミリン受容体の三重作動薬 |
| US20250326814A1 (en) | 2024-02-06 | 2025-10-23 | Opko Biologics Ltd. | Modified oxyntomodulin and methods of use thereof |
| WO2025220032A1 (en) * | 2024-04-16 | 2025-10-23 | Bhami's Research Laboratory, Pvt. Ltd. | Polypeptide formulations for oral delivery |
| CN118319871B (zh) * | 2024-04-19 | 2025-08-05 | 鲁南新时代生物技术有限公司 | 一种司美格鲁肽药物组合物 |
Family Cites Families (192)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ219575A (en) | 1986-03-12 | 1990-04-26 | Glaxo Group Ltd | Phosphate, substituted alkoxy, or amino-carbonyloxy derivatives of milbemycin, and pesticidal compositions |
| WO1991011457A1 (en) | 1990-01-24 | 1991-08-08 | Buckley Douglas I | Glp-1 analogs useful for diabetes treatment |
| US5545618A (en) | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
| DK39892D0 (da) | 1992-03-25 | 1992-03-25 | Bernard Thorens | Peptid |
| SG52542A1 (en) | 1993-03-29 | 1998-09-28 | Univ Cincinnati | Analogs of peptide yy and uses thereof |
| US5705483A (en) | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
| WO1995033474A1 (en) | 1994-06-03 | 1995-12-14 | Tsumura & Co. | Medicinal composition |
| US5512549A (en) | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
| US5574010A (en) | 1994-11-14 | 1996-11-12 | The Regents Of The University Of California | Treatment of pancreatic tumors with peptide YY and analogs thereof |
| US5869602A (en) | 1995-03-17 | 1999-02-09 | Novo Nordisk A/S | Peptide derivatives |
| BR9604880A (pt) | 1995-03-31 | 1998-05-19 | Emisphere Tech Inc | Composto composição forma de unidade de dosagem métodos para administração de um agente biologicamente ativo para preparar uma composição para administração de um agente ativo e para preparar um composto e composição farmacológica |
| US5650386A (en) | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
| US5866536A (en) | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| SE9600070D0 (sv) | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
| US7235627B2 (en) | 1996-08-30 | 2007-06-26 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| DK0944648T3 (da) | 1996-08-30 | 2007-07-02 | Novo Nordisk As | GLP-1 derivater |
| ATE366584T1 (de) | 1996-11-12 | 2007-08-15 | Novo Nordisk As | Verwendung von glp-1 peptiden |
| WO1998020885A1 (en) | 1996-11-13 | 1998-05-22 | University Of Cincinnati | Analogs of peptide yy and uses thereof |
| US5773647A (en) | 1997-02-07 | 1998-06-30 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| EP0908515A3 (en) | 1997-09-16 | 2000-04-26 | Smithkline Beecham Plc | Pancreatic polypeptide |
| EP1056774A1 (en) | 1998-02-27 | 2000-12-06 | Novo Nordisk A/S | N-terminally truncated glp-1 derivatives |
| ATE265224T1 (de) | 1998-02-27 | 2004-05-15 | Novo Nordisk As | Glp-1 derivate mit einem helix-gehalt über 25 , die partiell strukturierte mizellenartige aggregate bilden |
| AU3247799A (en) | 1998-02-27 | 1999-09-15 | Novo Nordisk A/S | Glp-1 derivatives of glp-1 and exendin with protracted profile of action |
| WO1999043707A1 (en) | 1998-02-27 | 1999-09-02 | Novo Nordisk A/S | N-terminally modified glp-1 derivatives |
| JP2002512175A (ja) | 1998-02-27 | 2002-04-23 | ノボ ノルディスク アクティーゼルスカブ | Ｇｌｐ−１類似体の誘導体類 |
| US6046167A (en) | 1998-03-25 | 2000-04-04 | University Of Cincinnati | Peptide YY analogs |
| AU4317899A (en) | 1998-06-08 | 1999-12-30 | Schering Corporation | Neuropeptide y5 receptor antagonists |
| SE9802080D0 (sv) | 1998-06-11 | 1998-06-11 | Hellstroem | Pharmaceutical composition for the treatment of functional dyspepsia and/or irritable bowel syndrome and new use of substances therein |
| EP1100530B1 (en) | 1998-07-31 | 2003-10-08 | Novo Nordisk A/S | In-vitro stimulation of beta cell proliferation |
| MY155270A (en) | 1998-09-24 | 2015-09-30 | Lilly Co Eli | Use of glp-1 or analogs in treatment of stroke |
| AU762012B2 (en) | 1998-12-07 | 2003-06-19 | Ipsen Pharma S.A.S. | Analogues of GLP-1 |
| WO2000046182A1 (en) | 1999-02-05 | 2000-08-10 | Emisphere Technologies, Inc. | Method of preparing alkylated salicylamides |
| WO2000048589A1 (en) | 1999-02-22 | 2000-08-24 | Emisphere Holdings, Inc. | Solid oral dosage form containing heparin or a heparinoid in combination with a carrier |
| US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
| ATE386508T1 (de) | 1999-02-22 | 2008-03-15 | Merrion Res I Ltd | Feste orale dosierungsform enthaltend einen resorptionsverstärker |
| BR0010705A (pt) | 1999-04-30 | 2002-02-05 | Amylin Pharmaceuticals Inc | Exendinas modificadas e agonistas da exendina |
| ATE252601T1 (de) | 1999-05-17 | 2003-11-15 | Conjuchem Inc | Lang wirkende insulinotrope peptide |
| US7601691B2 (en) | 1999-05-17 | 2009-10-13 | Conjuchem Biotechnologies Inc. | Anti-obesity agents |
| EP1076066A1 (en) | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptides for lowering blood glucose levels |
| GB9923436D0 (en) | 1999-10-04 | 1999-12-08 | American Home Prod | Pharmaceutical compositions |
| US6793934B1 (en) | 1999-12-08 | 2004-09-21 | Shire Laboratories, Inc. | Solid oral dosage form |
| AU2001275231A1 (en) | 2000-06-02 | 2001-12-11 | Emisphere Technologies, Inc. | Method of preparing salicylamides |
| US7049283B2 (en) | 2000-12-06 | 2006-05-23 | Novartis Ag | Pharmaceutical compositions for the oral delivery of pharmacologically active agents |
| SK288342B6 (en) | 2000-12-07 | 2016-03-01 | Lilly Co Eli | GLP-1 fusion proteins |
| EP1351984A2 (en) | 2000-12-13 | 2003-10-15 | Eli Lilly And Company | Amidated glucagon-like peptide-1 |
| US8273713B2 (en) | 2000-12-14 | 2012-09-25 | Amylin Pharmaceuticals, Llc | Methods of treating obesity using PYY[3-36] |
| US6589938B2 (en) | 2001-06-29 | 2003-07-08 | National University Of Singapore | Use of angiotensin I derivatives as an agent for the treatment and prevention of infarction-related cardiac injuries and disorders |
| US20030068356A1 (en) | 2001-07-10 | 2003-04-10 | Pather S. Indiran | Sequential drug delivery systems |
| AU2002317599B2 (en) | 2001-07-31 | 2008-04-03 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | GLP-1 exendin-4 peptide analogs and uses thereof |
| AU2002332054B2 (en) | 2001-09-24 | 2007-11-08 | Imperial Innovations Limited | Modification of feeding behavior |
| CA2466863A1 (en) | 2001-11-29 | 2003-06-05 | Emisphere Technologies, Inc. | Oral pharmaceutical compositions comprising cromolyn sodium and an acylated amino acid |
| US8058233B2 (en) | 2002-01-10 | 2011-11-15 | Oregon Health And Science University | Modification of feeding behavior using PYY and GLP-1 |
| AU2003201146B2 (en) | 2002-02-01 | 2008-04-17 | Pfizer Products Inc. | Dry granulated formulations of azithromycin |
| NZ534125A (en) * | 2002-02-20 | 2006-11-30 | Emisphere Tech Inc | A formulation comprising a GLP-1 compound and a delivery agent |
| EP1525219B1 (en) | 2002-07-04 | 2009-05-27 | Zealand Pharma A/S | Glp-1 and methods for treating diabetes |
| JP2004131398A (ja) | 2002-10-08 | 2004-04-30 | Taihei Chemical Industrial Co Ltd | 錠剤用滑沢剤 |
| EP1583549A4 (en) | 2003-01-17 | 2006-10-04 | Sod Conseils Rech Applic | YY PEPTIDE ANALOGS |
| WO2004067548A2 (en) | 2003-01-31 | 2004-08-12 | Theratechnologies Inc. | Chemically modified metabolites of regulatory peptides and methods of producing and using same |
| JP2006520818A (ja) | 2003-03-19 | 2006-09-14 | イーライ リリー アンド カンパニー | ポリエチレングリコール結合ｇｌｐ−１化合物 |
| CA2525168A1 (en) | 2003-05-14 | 2004-12-02 | Emisphere Technologies, Inc. | Compositions for delivering peptide yy and pyy agonists |
| US7572581B2 (en) | 2003-06-30 | 2009-08-11 | Roche Molecular Systems, Inc. | 2′-terminator nucleotide-related methods and systems |
| BRPI0412458A (pt) | 2003-07-11 | 2006-10-17 | Novartis Ag | composições farmacêuticas oralmente dosadas compreendendo um agente de liberação na forma micronizada |
| JP2007501811A (ja) | 2003-08-08 | 2007-02-01 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 治療的な関心対象のタンパク質に対する遅延分子の選択的な化学物質接合のためのガラクトースオキシダーゼの使用。 |
| CN101380476A (zh) | 2003-09-19 | 2009-03-11 | 诺沃挪第克公司 | 治疗肽的清蛋白结合型衍生物 |
| EP1670515A2 (en) | 2003-09-19 | 2006-06-21 | Novo Nordisk A/S | Albumin-binding derivatives of therapeutic peptides |
| JP2007537981A (ja) | 2003-09-19 | 2007-12-27 | ノボ ノルディスク アクティーゼルスカブ | 新規の血漿タンパク質親和性タグ |
| SI1687019T1 (en) | 2003-11-20 | 2018-04-30 | Novo Nordisk A/S | Propylene glycol-containing peptide formulations which are optimal for production and for use in injection devices |
| RU2006120079A (ru) | 2003-12-18 | 2008-01-27 | Ново Нордиск А/С (DK) | Производные глюкагоноподобного пептида-1 (glp-1) |
| KR20060109940A (ko) | 2003-12-18 | 2006-10-23 | 노보 노르디스크 에이/에스 | 알부민-유사제에 연결된 신규 ｇｌｐ-1 유사체 |
| US20060286129A1 (en) | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
| EP2335715A3 (en) | 2004-02-11 | 2013-12-18 | Amylin Pharmaceuticals, LLC | Pancreatic polypeptide family motifs and polypeptides comprising the same |
| AU2005211755B2 (en) | 2004-02-11 | 2012-03-15 | Amylin Pharmaceuticals, Llc | Hybrid polypeptides with selectable properties |
| US20090186811A1 (en) | 2004-03-17 | 2009-07-23 | Thue Schwartz | Y2 Selective Receptor Agonists for Therapeutic Interventions |
| EP1786458A2 (en) | 2004-03-17 | 2007-05-23 | 7TM Pharma A/S | Y2/y4 selective receptor agonists for therapeutic interventions |
| BRPI0507585A (pt) | 2004-03-17 | 2007-07-03 | 7Tm Pharmas As | agonistas seletivos do receptor y2 para intervenções terapêuticas |
| CA2560174A1 (en) | 2004-03-17 | 2005-09-29 | 7Tm Pharma A/S | Y4 selective receptor agonists for therapeutic interventions |
| WO2005099672A1 (en) | 2004-04-13 | 2005-10-27 | Ranbaxy Laboratories Limited | A modified release pharmaceutical formulation comprising amoxicillin and clavulanate |
| EA013518B1 (ru) | 2004-05-06 | 2010-06-30 | Эмисфире Текнолоджис, Инк. | Кристаллические полиморфные формы n-[8-(2-гидроксибензоил)амино]каприлата натрия |
| KR20070008720A (ko) | 2004-05-06 | 2007-01-17 | 에미스페어 테크놀로지스, 인코포레이티드 | 습윤 헤파린의 고체 투여형 |
| CA2565188C (en) * | 2004-05-14 | 2014-03-04 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| GB0412181D0 (en) | 2004-06-01 | 2004-06-30 | Celltech R&D Ltd | Biological products |
| WO2005121090A1 (en) | 2004-06-02 | 2005-12-22 | Abbott Laboratories | Substituted piperidines that have antiangiogenic activity |
| TW200611704A (en) | 2004-07-02 | 2006-04-16 | Bristol Myers Squibb Co | Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions |
| CN101010339B (zh) | 2004-07-02 | 2011-11-09 | 布里斯托尔-迈尔斯斯奎布公司 | 人类胰高血糖素样肽-1调节剂及它们在治疗糖尿病及相关病况中的用途 |
| EP1765408B1 (en) | 2004-07-08 | 2015-12-09 | Novo Nordisk A/S | Polypeptide protracting tags comprising a tetrazole moiety |
| NZ552558A (en) | 2004-07-12 | 2009-11-27 | Emisphere Tech Inc | Compositions for delivering peptide YY and PYY agonists |
| WO2006020207A2 (en) | 2004-07-19 | 2006-02-23 | University Of Cincinnati | Compounds for control of appetite |
| WO2006124047A2 (en) | 2004-08-13 | 2006-11-23 | Emisphere Technologies, Inc. | Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent |
| WO2006049681A2 (en) | 2004-08-30 | 2006-05-11 | Bayer Pharmaceuticals Corporation | Selective neuropeptide y2 receptor agonists |
| US7893017B2 (en) | 2004-10-07 | 2011-02-22 | Novo Nordisk A/S | Protracted GLP-1 compounds |
| EP2330126B1 (en) | 2004-10-07 | 2015-12-23 | Novo Nordisk A/S | Protracted exendin-4 compounds |
| EP1827780A4 (en) | 2004-12-09 | 2007-12-12 | Radial Corp Ltd | MATERIAL HANDLING FOR RADIAL SAWS OF WOOD |
| US7410949B2 (en) | 2005-01-18 | 2008-08-12 | Hoffmann-La Roche Inc. | Neuropeptide-2 receptor (Y-2R) agonists and uses thereof |
| ES2540929T3 (es) | 2005-02-01 | 2015-07-14 | Emisphere Technologies, Inc. | Sistema de administración de retención gástrica y liberación controlada |
| EP2256130B1 (en) | 2005-02-02 | 2013-09-25 | Novo Nordisk A/S | Novel insulin derivatives |
| JP2008531059A (ja) | 2005-03-04 | 2008-08-14 | バイオレクシス ファーマシューティカル コーポレーション | 改変トランスフェリン融合タンパク質 |
| GB0504857D0 (en) | 2005-03-09 | 2005-04-13 | Imp College Innovations Ltd | Novel compounds and their effects on feeding behaviour |
| WO2006097535A2 (en) | 2005-03-18 | 2006-09-21 | Novo Nordisk A/S | Peptide agonists of the glucagon family with secretin like activity |
| JP5755398B2 (ja) | 2005-03-18 | 2015-07-29 | ノヴォ ノルディスク アー／エス | 伸長されたｇｌｐ−１化合物 |
| TWI372629B (en) | 2005-03-18 | 2012-09-21 | Novo Nordisk As | Acylated glp-1 compounds |
| EP1863537A2 (en) | 2005-03-18 | 2007-12-12 | Novo Nordisk A/S | Dimeric peptide agonists of the glp-1 receptor |
| CA2603105A1 (en) | 2005-03-28 | 2006-10-05 | Dexcel Pharma Technologies Ltd. | Controlled absorption of statins in the intestine |
| TW200716679A (en) | 2005-05-26 | 2007-05-01 | Bristol Myers Squibb Co | N-terminally modified GLP-1 receptor modulators |
| WO2007008778A2 (en) | 2005-07-11 | 2007-01-18 | Nastech Pharmaceutical Company Inc. | Formulations for enhanced mucosal delivery of pyy |
| WO2007011958A2 (en) | 2005-07-15 | 2007-01-25 | Emisphere Technologies, Inc. | Intraoral dosage forms of glucagon |
| WO2007009894A2 (en) | 2005-07-18 | 2007-01-25 | Novo Nordisk A/S | Peptides for use in the treatment of obesity |
| SI3524261T1 (sl) | 2005-08-19 | 2024-02-29 | Amylin Pharmaceuticals, Llc | Exendin za uporabo pri zdravljenju sladkorne bolezni in zmanjševanju telesne teže |
| US20070049557A1 (en) | 2005-08-24 | 2007-03-01 | Hashim Ahmed | Solid pharmaceutical dosage forms comprising bisphosphonates and modified amino acid carriers |
| US8022035B2 (en) | 2005-09-21 | 2011-09-20 | 7Tm Pharma A/S | Y4 selective receptor agonists for therapeutic interventions |
| AU2005337101A1 (en) | 2005-09-21 | 2007-04-12 | 7Tm Pharma A/S | Y2 selective receptor agonists for therapeutic interventions |
| WO2007061434A2 (en) | 2005-11-10 | 2007-05-31 | Nastech Pharmaceutical Company Inc. | A pharmaceutical formulation of glp-1 and its use for treating a metabolic syndrome |
| KR101432313B1 (ko) | 2005-11-17 | 2014-08-20 | 노파르티스 아게 | 약제학적 조성물 |
| WO2007065808A2 (en) | 2005-12-07 | 2007-06-14 | F. Hoffmann-La Roche Ag | Neuropeptide-2 receptor-agonists |
| RU2008124109A (ru) | 2005-12-08 | 2010-01-20 | МДРНА, Инк. (US) | Чресслизистая доставка стабилизированных композиций эксендина |
| EP1963343A1 (en) | 2005-12-14 | 2008-09-03 | Novo Nordisk A/S | Polypeptide protracting tags |
| US20070197445A1 (en) | 2006-01-18 | 2007-08-23 | University Of Cincinnati | Compounds for control of appetite |
| JP5412273B2 (ja) | 2006-03-21 | 2014-02-12 | アミリン・ファーマシューティカルズ，リミテッド・ライアビリティ・カンパニー | ペプチド−ぺプチダーゼ阻害剤及びその使用 |
| CN105232482A (zh) | 2006-04-07 | 2016-01-13 | 默里昂研究Iii有限公司 | 包含增强剂的固体口服剂型 |
| WO2007121318A2 (en) | 2006-04-12 | 2007-10-25 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
| AU2007247109B2 (en) | 2006-05-09 | 2012-03-15 | Novo Nordisk A/S | Insulin derivative |
| EP2040731A4 (en) | 2006-06-09 | 2010-05-19 | Merrion Res Iii Ltd | SOLID DOSAGE FORM FOR ORAL ADMINISTRATION CONTAINING AN ACTIVATOR |
| JP5475443B2 (ja) | 2006-06-28 | 2014-04-16 | エミスフェアー・テクノロジーズ・インク | 硝酸ガリウム製剤 |
| GB0613196D0 (en) | 2006-07-03 | 2006-08-09 | Imp Innovations Ltd | Novel compounds and their effects on feeding behaviour |
| ES2296529B1 (es) | 2006-08-07 | 2009-04-01 | Laboratorios Farmaceuticos Rovi, S.A. | Composicion farmaceutica con promotores de absorcion. |
| WO2008023050A1 (en) | 2006-08-25 | 2008-02-28 | Novo Nordisk A/S | Acylated exendin-4 compounds |
| BRPI0716539A2 (pt) | 2006-09-07 | 2016-11-01 | Emisphere Tech Inc | métodos para sintetização de ácido n-(8-[2-hidroxibenzoil]amino) caprílico e de sal de sódio deste |
| CL2007002634A1 (es) | 2006-09-13 | 2008-05-16 | Smithkline Beecham Corp | Uso de una composicion que comprende al menos un polipeptido que tiene actividad de peptido-1 semejante a glucagon (glp-1) como agente hipoglucemiante de larga duracion. |
| WO2008039351A2 (en) | 2006-09-22 | 2008-04-03 | Novartis Ag | Method of manufacturing tablets containing pharmacologically active agents |
| GB0621973D0 (en) | 2006-11-03 | 2006-12-13 | Philogen Spa | Binding molecules and uses thereof |
| US20100069410A1 (en) | 2006-12-01 | 2010-03-18 | Emisphere Technologies Inc. | acyclovir formulations |
| US20090099074A1 (en) | 2007-01-10 | 2009-04-16 | Conjuchem Biotechnologies Inc. | Modulating food intake |
| EP2106405A2 (en) | 2007-01-18 | 2009-10-07 | Novo Nordisk A/S | Peptides for use in the treatment of obesity |
| EP2101822A2 (en) | 2007-01-18 | 2009-09-23 | Novo Nordisk A/S | Use of peptides in combination with surgical intervention for the treatment of obesity |
| EP2131810B1 (en) | 2007-03-02 | 2011-05-04 | Novartis AG | Oral administration of a calcitonin |
| GB0708226D0 (en) | 2007-04-27 | 2007-06-06 | 7Tm Pharma As | Y-receptor agonists |
| JP2011504871A (ja) | 2007-06-01 | 2011-02-17 | ノボ・ノルデイスク・エー／エス | 固体又は半固体担体中にペプチド薬剤を含む自然に分散可能なプレコンセントレイト |
| EP2171080A4 (en) | 2007-06-12 | 2010-10-27 | Glaxosmithkline Llc | PROCESS FOR DETECTING PROTEIN IN PLASMA |
| EP2500432A3 (en) | 2007-07-09 | 2012-12-19 | Imperial Innovations Limited | Analogues of human pancreatic polypeptide (hPP) and their effects on feeding behaviours |
| AU2008296444A1 (en) | 2007-08-29 | 2009-03-12 | The Regents Of The University Of California | Salicylanilide modified peptides for use as oral therapeutics |
| WO2009030774A1 (en) | 2007-09-05 | 2009-03-12 | Novo Nordisk A/S | Truncated glp-1 derivatives and their therapeutical use |
| EP2190460B1 (en) | 2007-09-05 | 2014-12-17 | Novo Nordisk A/S | Peptides derivatized with a-b-c-d- and their therapeutical use |
| JP5476304B2 (ja) | 2007-09-05 | 2014-04-23 | ノボ・ノルデイスク・エー／エス | グルカゴン様ペプチド−１誘導体及びそれらの医薬用途 |
| JP5385278B2 (ja) | 2007-09-11 | 2014-01-08 | モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト | 単独でまたはグルカゴン様ペプチドと組み合わせて用いる、医薬におけるペプチドｙｙの使用 |
| US8598314B2 (en) | 2007-09-27 | 2013-12-03 | Amylin Pharmaceuticals, Llc | Peptide-peptidase-inhibitor conjugates and methods of making and using same |
| CN101939023B (zh) | 2007-10-16 | 2016-08-03 | 百康有限公司 | 可经口给药的固体药物组合物及其方法 |
| WO2009059188A1 (en) | 2007-11-02 | 2009-05-07 | Emisphere Technologies, Inc. | Method of treating vitamin b12 deficiency |
| US20090124639A1 (en) | 2007-11-06 | 2009-05-14 | Emisphere Technologies Inc. | valacyclovir formulations |
| US20100317057A1 (en) | 2007-12-28 | 2010-12-16 | Novo Nordisk A/S | Semi-recombinant preparation of glp-1 analogues |
| BRPI0912615A2 (pt) | 2008-05-16 | 2016-01-26 | Novo Nordisk As | agonistas de receptor y2 e/ou y4 de longa ação |
| NZ591497A (en) * | 2008-08-18 | 2012-11-30 | Entera Bio Ltd | A compositions comprising a protein, a protease inhibitor and N-(8-[2-hydroxybenzoyl]amino)caprylate (SNAC) or N-(10[2-hydroxybenzoyl]amino)decanoate (SNAD) for diabetes mellitus treatment |
| CN102149411A (zh) | 2008-09-12 | 2011-08-10 | 诺沃—诺迪斯克有限公司 | 酰化肽或蛋白的方法 |
| US8299023B2 (en) | 2008-09-17 | 2012-10-30 | Hoffmann-La Roche Inc. | Neuropeptide-2 receptor (Y-2R) agonists |
| GB0817067D0 (en) | 2008-09-18 | 2008-10-22 | 7Tm Pharma As | Intestinal treatment |
| MY156811A (en) | 2008-10-15 | 2016-03-31 | Bayer Corpscience Ag | Use of dithiine-tetracarboximides for controlling phytopathogenic fungsi |
| WO2010052144A2 (en) | 2008-11-05 | 2010-05-14 | F. Hoffmann-La Roche Ag | Neuropeptide-2-receptor (y-2r) agonists and uses thereof |
| CN101463081B (zh) | 2009-01-12 | 2012-07-04 | 华东师范大学 | 一种glp-1衍生物 |
| CN106177958A (zh) | 2009-02-13 | 2016-12-07 | 勃林格殷格翰国际有限公司 | 包含dpp‑4抑制剂(利拉列汀)任选地组合其它抗糖尿病药的抗糖尿病药物 |
| MX2011008774A (es) | 2009-02-20 | 2011-10-24 | Ipsen Pharma Sas | Conjugados citotoxicos que tienen un compuesto de unión de receptores de neuropeptidos y. |
| ITRM20090347A1 (it) | 2009-07-03 | 2011-01-04 | Univ Siena | Dispositivo di analisi del sistema nervoso centrale attraverso l applicazione di stimoli di diversa natura combinati tra loro e lo studio delle corrispondenti reazioni. |
| AR077956A1 (es) | 2009-09-14 | 2011-10-05 | Bayer Cropscience Ag | Combinaciones de compuestos activos |
| US20130040877A1 (en) | 2009-09-18 | 2013-02-14 | Novo Nordisk A/S | Long-acting y2 receptor agonists |
| JP2013507414A (ja) | 2009-10-13 | 2013-03-04 | エフ．ホフマン−ラ ロシュ アーゲー | 神経ペプチド−２受容体（ｙ−２ｒ）アゴニスト |
| WO2011058165A1 (en) | 2009-11-13 | 2011-05-19 | Novo Nordisk A/S | Long-acting y2 receptor agonists |
| WO2011073328A1 (en) | 2009-12-16 | 2011-06-23 | Novo Nordisk A/S | Glp-1 receptor agonist compounds with a modified n-terminus |
| AU2010339907A1 (en) | 2009-12-16 | 2012-07-05 | Nod Pharmaceuticals, Inc. | Compositions and methods for oral drug delivery |
| US20110182985A1 (en) | 2010-01-28 | 2011-07-28 | Coughlan David C | Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof |
| WO2011109787A1 (en) | 2010-03-05 | 2011-09-09 | Conjuchem, Llc | Methods of administering insulinotropic peptides |
| GB2478849A (en) | 2010-03-16 | 2011-09-21 | Chiasma Inc | Improved pharmecutical compositions and methods of delivery |
| WO2011131646A1 (en) | 2010-04-20 | 2011-10-27 | Novo Nordisk A/S | Long-acting gastrin derivatives |
| CA2793715A1 (en) | 2010-04-30 | 2011-11-03 | Sanwa Kagaku Kenkyusho Co., Ltd. | Peptide for improving in vivo stability of physiologically active substance or the like and physiologically active substance with improved in vivo stability |
| CN107961377B (zh) | 2010-05-05 | 2022-11-22 | 勃林格殷格翰国际有限公司 | 组合疗法 |
| DE202010015867U1 (de) | 2010-11-25 | 2011-05-05 | Buchhalter, Thomas | Elektromechanische Halterung zur Aufnahme von Navigations- und Kommunikationsgeräte im KFZ |
| AU2011343190B2 (en) | 2010-12-16 | 2016-12-08 | Novo Nordisk A/S | Solid compositions comprising a GLP-1 agonist and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid |
| GB201101459D0 (en) | 2011-01-27 | 2011-03-16 | Imp Innovations Ltd | Novel compounds and thier effects on fedding behaviour |
| EP3225631B1 (en) | 2011-04-12 | 2019-01-09 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
| JP6006309B2 (ja) | 2011-07-08 | 2016-10-12 | アミリン・ファーマシューティカルズ, リミテッド・ライアビリティ・カンパニーAmylin Pharmaceuticals, Llc | 作用持続期間が増大し、免疫原性が減少した操作されたポリペプチド |
| PL3542790T3 (pl) | 2012-03-22 | 2024-02-26 | Novo Nordisk A/S | Kompozycje zawierające substancję dostarczającą i ich przygotowanie |
| EP2827885B1 (en) | 2012-03-22 | 2018-08-15 | Novo Nordisk A/S | Compositions of glp-1 peptides and preparation thereof |
| ES2715308T3 (es) | 2012-03-22 | 2019-06-03 | Novo Nordisk As | Composiciones que comprenden un agente de suministro y su preparación |
| US20150141336A1 (en) | 2012-05-29 | 2015-05-21 | Novo Nordisk A/S | Pancreatic Peptide Compounds and Use |
| JP6517690B2 (ja) | 2012-06-20 | 2019-05-22 | ノヴォ ノルディスク アー／エス | ペプチド及び送達剤を含む錠剤製剤 |
| DK2866825T3 (da) | 2012-07-01 | 2020-06-08 | Novo Nordisk As | Anvendelse af langstidsvirkende glp-1-peptider |
| MY172578A (en) | 2013-05-02 | 2019-12-03 | Novo Nordisk As | Oral dosing of glp-1 compounds |
| PE20151808A1 (es) | 2013-05-02 | 2015-12-16 | Glaxosmithkline Ip Dev Ltd | Peptidos terapeuticos |
| EP3068421B1 (en) | 2013-11-15 | 2019-04-17 | Novo Nordisk A/S | Selective pyy compounds and uses thereof |
| US10583172B2 (en) | 2013-11-15 | 2020-03-10 | Novo Nordisk A/S | HPYY(1-36) having a beta-homoarginine substitution at position 35 |
| MX2017010220A (es) | 2015-02-09 | 2018-02-21 | Entera Bio Ltd | Formulaciones para administracion oral de agentes activos con perfil de absorcion controlada. |
| MX392572B (es) | 2015-06-12 | 2025-03-24 | Novo Nordisk As | Compuestos del péptido yy (pyy) selectivos y sus usos. |
| CA2997343A1 (en) | 2015-10-07 | 2017-04-13 | Cyprumed Gmbh | Pharmaceutical formulations for the oral delivery of peptide drugs |
| AR114353A1 (es) | 2018-02-02 | 2020-08-26 | Novo Nordisk As | Composiciones sólidas que comprenden un agonista del glp-1 y una sal del ácido n-(8-(2-hidroxibenzoil)amino)caprílico |
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